Month: January 2022

Formula: C7H4F2O2. Authors Lin, TT; Li, JC; Liu, LP; Li, YQ; Jiang, HL; Chen, KX; Xu, P; Luo, C; Zhou, B in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China; [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Xu, Pan; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Chem Biol,Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Zhou, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng; Zhou, Bing] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China in 2021, Cited 39. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Cyclin-dependent kinases play significant roles in cell cycle progression and are promising targets for cancer therapy. However, most potent CDK inhibitors lack the balance between efficacy and safety because of poor selectivity. Given the roles of CDK2 in tumorigenesis, selective CDK2 inhibition may provide therapeutic benefits against certain cancer. In this study, a series of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives were designed, synthesized, and evaluated. The most selective compound DC-K2in212 in this series exhibited high potency towards CDK2 and had effective anti-proliferative activity against A2058 melanoma cell line and MV4-11 leukemia cell line while exhibiting low toxic effect on human normal cell lines MRC5 and LX2. The molecular modeling illustrated that compound DC-K2in212 had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1. Further biological studies revealed that compound DC-K2in212 suppressed CDK2-associated downstream signaling pathway, blocked cell cycle progression, and induced cellular apoptosis. Therefore, compound DC-K2in212 could serve as a potential CDK2 inhibitor for further development. (c) 2021 Elsevier Masson SAS. All rights reserved.

Formula: C7H4F2O2. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Scalable Wolff-Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor WOS:000497260800016 published article about MICROWAVE CHEMISTRY; BATCH; SAFETY in [Znidar, Desiree; Dallinger, Doris; Kappe, C. Oliver] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria; [Znidar, Desiree; Dallinger, Doris; Kappe, C. Oliver] Karl Franzens Univ Graz, NAWI Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria; [O’Kearney-McMullan, Anne; Munday, Rachel] AstraZeneca, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire, England; [Wiles, Charlotte] Chemtrix BV, Galvaniweg 8A, NL-6101 XH Echt, Netherlands; [Poechlauer, Peter; Schmoelzer, Christoph] Patheon Austria GmbH & Co KG, Sankt Peter Str 25, A-4020 Linz, Austria in 2019.0, Cited 45.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Formula: C9H10O3

A safe and scalable continuous flow strategy for Wolff-Kishner reductions that employs methanol as the solvent has been developed. The use of low-cost hydrazine as the reducing agent in combination with a caustic base provides an atom-efficient, environmentally friendly method for the deoxygenation of aldehydes and ketones to alkanes. Because of the required harsh and corrosive reaction conditions (200 degrees C, 50 bar), reactor materials such as stainless steel, glass, or any type of polymer have compatibility problems, rendering this process problematic on a production scale. The use of corrosion-resistant silicon carbide (SiC) as the reactor material opens up the possibility of performing Wolff-Kishner reductions on scale with a considerably improved safety profile. Methanol as the solvent significantly simplifies the workup procedure compared with the generally employed high-boiling solvents such as diethylene glycol. The continuous flow protocol was applied to a number of substrates and provided the desired products in good to high yields with space-time yields of up to 152 g L(-1)h(-1). In addition, a pharmaceutically valuable active pharmaceutical ingredient precursor was synthesized by employing this high-temperature/pressure Wolff-Kishner protocol.

Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Znidar, D; O’Kearney-McMullan, A; Munday, R; Wiles, C; Poechlauer, P; Schmoelzer, C; Dallinger, D; Kappe, CO or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article KF-Al(2)O(3)as a Base Heterogeneous Catalyst for the Synthesis of 2-Substituted Benzoxazoles and Benzothiazoles under Mild Reaction Conditions at Room Temperature WOS:000561108100009 published article about ONE-POT SYNTHESIS; EFFICIENT CATALYST; BIOLOGICAL EVALUATION; BENZIMIDAZOLES; DERIVATIVES; KF/AL2O3; AZOLES; NANOPARTICLES; CYCLIZATIONS; STABILITY in [Bahadorikhalili, Saeed; Sardarian, Ali Reza] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 71454, Iran in 2020, Cited 46. Application In Synthesis of Benzoic anhydride. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

A convenient synthesis of 2-substituted benzothiazoles and benzoxazoles from the reactiono-aminophenol oro-aminothiophenol with acyl chlorides or acid anhydrides has been accomplished. The various carboxylic acid derivatives were reacted witho-aminophenol oro-aminothiophenol in the presence of KF-Al(2)O(3)as a base heterogeneous catalyst to form correspondence benzothiazoles and benzoxazoles in high yields, and the catalyst showed a good recyclability.

Application In Synthesis of Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Bahadorikhalili, S; Sardarian, AR or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors He, C; Xuan, J; Rao, PR; Xie, PP; Hong, X; Lin, XF; Ding, HF in WILEY-V C H VERLAG GMBH published article about TRANSANNULAR DIELS-ALDER; ENANTIOSELECTIVE TOTAL-SYNTHESIS; ASYMMETRIC TOTAL-SYNTHESIS; SOFT CORAL; FURANOPHANE APPROACH; CHATANCIN; STRATEGY; KETONES; DITERPENOIDS; ANNULATION in [He, Chuan; Xuan, Jun; Rao, Peirong; Xie, Pei-Pei; Hong, Xin; Lin, Xufeng; Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China; [Ding, Hanfeng] Nankai Univ, Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2019, Cited 53. COA of Formula: C14H10O3. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

A concise and divergent approach for the total syntheses of four cembrane diterpenoids, namely (+)-sarcophytin, (+)-chatancin, (-)-3-oxochatancin, and (-)-pavidolideB, has been developed, and it also led to the structural revision of (-)-isosarcophytin. The key steps of the strategy feature a double Mukaiyama Michael addition/elimination, a Helquist annulation, two substrate-controlled facial-selective hydrations, and a pinacol rearrangement. The described syntheses not only achieved these natural products in an efficient manner, but also provided insight into the biosynthetic relationship between the two different skeletons.

COA of Formula: C14H10O3. Bye, fridends, I hope you can learn more about C14H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Xu, P; Lopez-Rojas, P; Ritter, T in AMER CHEMICAL SOC published article about in [Xu, Peng; Lopez-Rojas, Priscila; Ritter, Tobias] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany in 2021.0, Cited 49.0. Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 degrees C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Welcome to talk about 99-04-7, If you have any questions, you can contact Xu, P; Lopez-Rojas, P; Ritter, T or send Email.. Formula: C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Theoretical Studies on the Fluorescence Enhancement of Benzaldehydes by Intermolecular Hydrogen Bonding WOS:000457816300012 published article about PICOSECOND LASER PHOTOLYSIS; PROTON-TRANSFER ESIPT; ELECTRON-TRANSFER; RADIATIONLESS DEACTIVATION; MOLECULAR-MECHANISM; STATE; RELAXATION; DYNAMICS; PHOTOPHYSICS; FLUORENONE in [Su, Yan; Li, Keyao; Yu, Xueke] Dalian Univ Technol, Minist Educ, Key Lab Mat Modificat Laser Electron & Ion Beams, Dalian 116024, Peoples R China in 2019.0, Cited 38.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Density functional theory and its time-dependent extension are employed to investigate the intermolecular hydrogen-bonding- (Inter-HB-) induced fluorescence enhancement of benzaldehydes. The fluorescence quenching mechanism of benzaldehydes in chloroform is attributed to the low energy gap between the lowest pi pi* and n pi* states at Franck-Condon (FC) point and conical interaction between pi pi** and n pi* states. The Inter-HB between the aldehyde group of benzaldehydes and methanol can considerably increase the energy gap between pi pi* and n pi* states at the FC point, and this type of hydrogen bond is strengthened in the excited pi pi* state, thereby precluding the nonradiative transition from n pi* state and enhancing fluorescence. The Inter-HB between the hydroxy group of benzaldehydes and methanol is considerably stronger than that between the aldehyde group of benzaldehydes and methanol; which has a little effect on the energy gap of pi pi* and n pi* states. Therefore, if Inter-HB exists between the hydroxy group of benzaldehydes and methanol, then it will play an important role in ground and excited pi pi* states, and fluorescence enhancement by Inter-HB between the aldehyde group of benzaldehydes and methanol will be absent. Our proposed mechanism can explain the experimental observations and differs from that of proximity effects.

Recommanded Product: 93-02-7. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. I found the field of Chemistry very interesting. Saw the article An Improved N-Acylation of 1 H -Benzotriazole Using 2,2-Dipyridyldisulfide and Triphenylphosphine published in 2019, Reprint Addresses Tiwari, VK (corresponding author), Banaras Hindu Univ, Dept Chem, Inst Sci, Varanasi 221005, Uttar Pradesh, India.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

A novel path has been developed for the conversion of carboxylic acids into the corresponding N -acylbenzotriazoles by using 2,2-dipyridyl disulfide/PPh (3) in anhydrous dichloromethane in the presence of 1 H -benzotriazole. Mild reaction conditions, short reaction time, easy in handling, wide substrate scope, availability of reagents involved, and moreover avoiding the use of base makes this protocol quite useful for the laboratory practices for N -acylbenzotriazole synthesis.

Category: isothiazole. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Citric Acid/MCM-48 Catalyzed Multicomponent Reaction: An Efficient Method for the Novel Synthesis of Quinoline Derivatives WOS:000472522700023 published article about ONE-POT SYNTHESIS; MOLECULAR DOCKING; REUSABLE CATALYST; ANTICANCER; FACILE; DISCOVERY; GREEN in [Akpotu, Samson O.; Moodley, Brenda; Maddila, Suresh; Jonnalagadda, Sreekantha B.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chilten Hills,Private Bag 54001, ZA-4000 Durban, South Africa; [Akpotu, Samson O.; Ofomaja, Augustine] Vaal Univ Techol, Dept Chem, PBag X021, ZA-1900 Vanderbijlpak, South Africa; [Vamsi, Boddu; Maddila, Suresh] GITAM Univ, GITAM Inst Sci, Dept Chem, Visakhapatnam, Andhra Pradesh, India in 2019.0, Cited 44.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A facile, efficient and suitable green approach has been designated for the one-pot synthesis of quinoline derivatives in the presence of citric acid doped MCM-48 (CAMCM-48) as a heterogeneous catalyst. The prepared material was characterized by using various techniques like P-XRD, SEM, TEM, TGA, FTIR and structural properties was determined by BET analysis. The reaction progressed efficiently under ethanol solvent system at room temperature condition to afford the corresponding products. This protocol offers many advantages such as simple synthesis, easy work-up, short reaction times (15 min), good stability, reusability and no chromatographic separation techniques plus excellent yields (91-98%).

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Akpotu, SO; Moodley, B; Vamsi, B; Ofomaja, A; Maddila, S; Jonnalagadda, SB or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Taha, RH; El-Shafiey, ZA; Salman, AA; Mansour, MM in [Taha, Rania H.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia; [Taha, Rania H.; El-Shafiey, Zienab A.; Salman, Aida A.; Mansour, Mai M.] Al Azhar Univ, Fac Sci Girls, Dept Chem, Yousef Abbas Str, Cairo, Egypt published A study of a newly synthesized ligand and its metal complexes in bulk and nano size and metal uptake efficiency in 2020, Cited 23. Recommanded Product: Benzoic anhydride. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

A newly synthesized ligand derived from 2-amino thiophenol and benzoic anhydride and its Co(II), Cd(II), La(III) (in bulk and nano size), and Gd(III) complexes was investigated and characterized. The maximum elimination capacity of the newly synthesized ligand was investigated towards the removal of Co(II), Cd(II), La(III), and Gd(III) ions from aqueous solutions. It was found that the ligand has the best removal ability for Cd(II) metal of 98.66% at a concentration of 0.03 mg/L.

Welcome to talk about 93-97-0, If you have any questions, you can contact Taha, RH; El-Shafiey, ZA; Salman, AA; Mansour, MM or send Email.. Recommanded Product: Benzoic anhydride

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Visible-light induced enhancement in the multi-catalytic activity of sulfated carbon dots for aerobic carbon-carbon bond formation published in 2019. HPLC of Formula: C8H10O2, Reprint Addresses Sarma, TK (corresponding author), Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Khandwa Rd, Indore 453552, India.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

The development of carbonaceous materials as metal-free catalysts integrating different types of catalysis in a single system represents a significant advance in cascade/tandem organic synthesis. Zero-dimensional carbon dots with tuneable optical properties and easily modifiable surface functionalities can be harnessed as a carbocatalyst for merging photooxidation and acid-catalyzed reactions in one pot. Herein, we explore carbon dots decorated with hydrogen sulfate groups as a photocatalyst for the dehydrogenative cross-coupling of xanthenes with ketones, arenes and 1,3-dicarbonyl compounds that showed high efficiency and selectivity under visible-light irradiation. The sulphated carbon dots demonstrate dual catalytic properties, wherein they induced the rapid photooxidation of xanthenes in the presence of molecular oxygen to form a hydroperoxy intermediate followed by coupling of nucleophiles catalysed by the acidic surface functional groups. The methodology represents an operationally simple pathway for the generation of C-C coupling products in a short reaction time with wide substrate scopes under mild conditions. The catalyst is easily separable and can be reused over multiple cycles with good efficiency.

Welcome to talk about 151-10-0, If you have any questions, you can contact Sarma, D; Majumdar, B; Sarma, TK or send Email.. HPLC of Formula: C8H10O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com