Category: 121-89-1

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, Safety of 3′-Nitroacetophenone, belongs to isothiazole compound, is a common compound. In a patnet, author is BAGGI, P, once mentioned the new application about 121-89-1.

3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide(3) readily reacts with oxazolones 2 and munchnones 7 affording with satisfactory yield 3-diethylamino-4,6-diaryl-3a,4-dihydro-3a-(4-methoxyphenyl)6aH-pyrrolo[3,4-d]isthiazole 1,1-dioxides 4 and 3-diethylamino-4,6-diaryl-5-alkyl-3a-(4-methoxyphenyl)-pyrrolo[3,4]isothiazole l,1-dioxides 8, respectively. The behaviour of the cycloadducts towards elevated temperatures and/or basic conditions was investigated. Under these conditions the primary products lost SO2 and diethylcyanamide affording 1-alkyl-2,3,5-triarylpyrroles 9 and 1H-2,3,5-triarylpyrroles 10. These latter were found to be better obtained through thermal decomposition of N-protected cycloadducts 8 and subsequent deprotecting the final pyrroles.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 121-89-1. Safety of 3′-Nitroacetophenone.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, belongs to isothiazole compound. In a document, author is Gruschinski, Sina, introduce the new discover, SDS of cas: 121-89-1.

The synthesis of air-sensitive 2, 6-diformyl-4-tert-butylthiophenol dioxime H3L3 was achieved by a Pd-mediated SC cleavage of the corresponding S-tert-butyl protected thioether. The novel ligand forms a dinuclear, neutral PdII2 complex, which is stabilized by two N…HO hydrogen bonds to give a pseudo-macrocyclic structure. The crystal structure of a PdII complex of an oxidized isothiazole derivative of H3L3 is also reported.

This is the end of this tutorial post, and I hope it has helped your research about 121-89-1, SDS of cas: 121-89-1.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Related Products of 121-89-1, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 121-89-1, Name is 3′-Nitroacetophenone, SMILES is CC(C1=CC=CC([N+]([O-])=O)=C1)=O, belongs to isothiazole compound. In a article, author is Teffera, Yohannes, introduce new discover of the category.

Compound 1, (7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine) is a potent, selective inhibitor of c-Met (mesenchymal-epithelial transition factor), a receptor tyrosine kinase that is often deregulated in cancer. Compound 1 displayed desirable pharmacolcinetic properties in multiple preclinical species. Glutathione trapping studies in liver microsomes resulted in the NADPH-dependent formation of a glutathione conjugate. Compound 1 also exhibited very high in vitro NADPH-dependent covalent binding to microsomal proteins. Species differences in covalent binding were observed, with the highest binding in rats, mice, and monkeys (1100-1300 pmol/mg/h), followed by dogs (400 pmol/mg/h) and humans (144 pmol/mg/h). This covalent binding to protein was abolished by coincubation with glutathione. Together, these in vitro data suggest that covalent binding and glutathione conjugation proceed via bioactivation to a chemically reactive intermediate. The cytochrome (CYP) P450 enzymes responsible for this bioactivation were identified as cytochrome P450 3A4, 1A2, and 2D6 in human and cytochrome P450 2A2, 3A1, and 3A2 in rats. The glutathione metabolite was detected in the bile of rats and mice, thus demonstrating bioactivation occurring in vivo. Efforts to elucidate the structure of the glutathione adduct led to the isolation and characterization of the metabolite by NMR and mass spectrometry. The analytical data confirmed conclusively that the glutathione conjugation was on the 4-C position of the isothiazole ring. Such P450-mediated bioactivation of an isothiazole or thiazole group has not been previously reported. We propose a mechanism of bioactivation via sulfur oxidation followed by glutathione attack at the 4-position with subsequent loss of water resulting in the formation of the glutathione conjugate. Efforts to reduce bioactivation without compromising potency and pharmacokinetics were undertaken in order to minimize the potential risk of toxicity. Because of the exemplary pharmacokinetic/pharmacodynamic (PK/PD) properties of the isothiazole group, initial attempts were focused on introducing alternative metabolic soft spots into the molecule. These efforts resulted in the discovery of 7-(2-methoxyethoxy)-N-((6-(3-methyl-5-isothiazolyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine (compound 2), with the major metabolic transformation occurring on the naphthyridine ring alkoxy substituent. However, a glutathione conjugate of compound 2 was produced in vitro and in vivo in a manner similar to that observed for compound 1. Furthermore, the covalent binding was high across species (360, 300, 529, 208, and 98 pmol/mg/h in rats, mice, dogs, monkeys, and humans, respectively), but coincubation with glutathione reduced the extent of covalent binding. The second viable alternative in reducing bioactivation involved replacing the isothiazole ring with bioisosteric heterocycles. Replacement of the isothiazole ring with an isoxazole or a pyrazole reduced the bioactivation while retaining the desirable PK/PD characteristics of compounds 1 and 2.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 121-89-1. Related Products of 121-89-1.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, belongs to isothiazole compound. In a document, author is ALBEROLA, A, introduce the new discover, Category: isothiazole.

A comparative study of reactions of 3-methyl-5-phenylisoxazole and 3-methyl-5-phenylisothiazole with electrophilic compounds in the presence of n-BuLi, LICA or LICA-TMEDA is reported. By using LICA-TMEDA, regioselective reactions of the heterocyclic compounds at the C-3 methyl group are obtained. With n-BuLi or LICA and the isoxazole derivative a product mixture at the C-4 position and the C-3 methyl group is found. In the case of isothiazole compound, only with methyl iodide and n-BuLi, the dialkylated product at both positions is formed.

I am very proud of our efforts over the past few months and hope to 121-89-1 help many people in the next few years. Category: isothiazole.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

COA of Formula: https://www.ambeed.com/products/121-89-1.html, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 121-89-1, Name is 3′-Nitroacetophenone, SMILES is CC(C1=CC=CC([N+]([O-])=O)=C1)=O, belongs to isothiazole compound. In a article, author is Aitken, Kati M., introduce new discover of the category.

Synthetic approaches to 1,3,4-oxadiazole have been investigated and an improved method involving dehydration of N,N’-diformylhydrazine with P2O5 in polyphosphoric acid is described. The C-13 NMR spectrum of this compound is reported for the first time including determination of (1)J(C-H) and (3)J(C-H).

COA of Formula: https://www.ambeed.com/products/121-89-1.html, Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. I hope my blog about 121-89-1 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, Related Products of 121-89-1, belongs to isothiazole compound, is a common compound. In a patnet, author is Emamian, Saeed Reza, once mentioned the new application about 121-89-1.

DFT methods have been used to study the hetero Diels-Alder reaction of thiazole and isothiazole with thiophen-2,5-dione. The thermodynamic and kinetic parameters were calculated. The relative stabilities of the transition structures corresponding to the endo/exo stereoisomers have been rationalized on the basis of the secondary molecular orbital interactions. NBO analysis was carried out to calculate the synchronicity index. It was shown that all reactions are synchronous. A HOMO-LUMO energy gap shows both reactions are normal electron demand.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New research progress on 121-89-1 in 2021. Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 121-89-1, Name is 3′-Nitroacetophenone, formurla is C8H7NO3. In a document, author is Gruschinski, Sina, introducing its new discovery. Application In Synthesis of 3′-Nitroacetophenone.

The synthesis of air-sensitive 2, 6-diformyl-4-tert-butylthiophenol dioxime H3L3 was achieved by a Pd-mediated SC cleavage of the corresponding S-tert-butyl protected thioether. The novel ligand forms a dinuclear, neutral PdII2 complex, which is stabilized by two N…HO hydrogen bonds to give a pseudo-macrocyclic structure. The crystal structure of a PdII complex of an oxidized isothiazole derivative of H3L3 is also reported.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 121-89-1, Application In Synthesis of 3′-Nitroacetophenone.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, belongs to isothiazole compound. In a document, author is SWAYZE, EE, introduce the new discover, Recommanded Product: 3′-Nitroacetophenone.

Several derivatives of the new imidazo[4,5-d]isothiazole ring system have been synthesized from the appropriately substituted isothiazolediamines. The reaction of 3-methyl-4,5-diaminoisothiazole (4a) with diethoxy-methyl acetate gave a low yield of 3-methylimidazo[4,5-d]isothiazole (5a). However, the analogous reaction of 4,5-diaminoisothiazole (4b) with diethoxymethyl acetate failed to yield the parent imidazo[4,5-d]isothiazole ring system. The diamines 4a and 4b were readily cyclized with thiocarbonyldiimidazole to give the unstable thiones 6a and 6b, which were alkylated in situ to afford good yields of the corresponding 5-methylthioimidazo[4,5-d]isothiazoles 7a and 7b, respectively. Neither of these compounds could be reduced to the corresponding 5-unsubstituted derivatives via treatment with Raney nickel. To the best of our knowledge, this is the first report of the imidazo[4,5-d]isothiazole ring system.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 121-89-1, Recommanded Product: 3′-Nitroacetophenone.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021. Reference of 121-89-1, You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 121-89-1, Name is 3′-Nitroacetophenone, SMILES is CC(C1=CC=CC([N+]([O-])=O)=C1)=O, belongs to isothiazole compound. In a article, author is Teffera, Yohannes, introduce new discover of the category.

Compound 1, (7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine) is a potent, selective inhibitor of c-Met (mesenchymal-epithelial transition factor), a receptor tyrosine kinase that is often deregulated in cancer. Compound 1 displayed desirable pharmacolcinetic properties in multiple preclinical species. Glutathione trapping studies in liver microsomes resulted in the NADPH-dependent formation of a glutathione conjugate. Compound 1 also exhibited very high in vitro NADPH-dependent covalent binding to microsomal proteins. Species differences in covalent binding were observed, with the highest binding in rats, mice, and monkeys (1100-1300 pmol/mg/h), followed by dogs (400 pmol/mg/h) and humans (144 pmol/mg/h). This covalent binding to protein was abolished by coincubation with glutathione. Together, these in vitro data suggest that covalent binding and glutathione conjugation proceed via bioactivation to a chemically reactive intermediate. The cytochrome (CYP) P450 enzymes responsible for this bioactivation were identified as cytochrome P450 3A4, 1A2, and 2D6 in human and cytochrome P450 2A2, 3A1, and 3A2 in rats. The glutathione metabolite was detected in the bile of rats and mice, thus demonstrating bioactivation occurring in vivo. Efforts to elucidate the structure of the glutathione adduct led to the isolation and characterization of the metabolite by NMR and mass spectrometry. The analytical data confirmed conclusively that the glutathione conjugation was on the 4-C position of the isothiazole ring. Such P450-mediated bioactivation of an isothiazole or thiazole group has not been previously reported. We propose a mechanism of bioactivation via sulfur oxidation followed by glutathione attack at the 4-position with subsequent loss of water resulting in the formation of the glutathione conjugate. Efforts to reduce bioactivation without compromising potency and pharmacokinetics were undertaken in order to minimize the potential risk of toxicity. Because of the exemplary pharmacokinetic/pharmacodynamic (PK/PD) properties of the isothiazole group, initial attempts were focused on introducing alternative metabolic soft spots into the molecule. These efforts resulted in the discovery of 7-(2-methoxyethoxy)-N-((6-(3-methyl-5-isothiazolyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine (compound 2), with the major metabolic transformation occurring on the naphthyridine ring alkoxy substituent. However, a glutathione conjugate of compound 2 was produced in vitro and in vivo in a manner similar to that observed for compound 1. Furthermore, the covalent binding was high across species (360, 300, 529, 208, and 98 pmol/mg/h in rats, mice, dogs, monkeys, and humans, respectively), but coincubation with glutathione reduced the extent of covalent binding. The second viable alternative in reducing bioactivation involved replacing the isothiazole ring with bioisosteric heterocycles. Replacement of the isothiazole ring with an isoxazole or a pyrazole reduced the bioactivation while retaining the desirable PK/PD characteristics of compounds 1 and 2.

Reference of 121-89-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect. I hope my blog about 121-89-1 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Chemical Research Letters, April 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, Category: isothiazole, belongs to isothiazole compound, is a common compound. In a patnet, author is BAGGI, P, once mentioned the new application about 121-89-1.

3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide(3) readily reacts with oxazolones 2 and munchnones 7 affording with satisfactory yield 3-diethylamino-4,6-diaryl-3a,4-dihydro-3a-(4-methoxyphenyl)6aH-pyrrolo[3,4-d]isthiazole 1,1-dioxides 4 and 3-diethylamino-4,6-diaryl-5-alkyl-3a-(4-methoxyphenyl)-pyrrolo[3,4]isothiazole l,1-dioxides 8, respectively. The behaviour of the cycloadducts towards elevated temperatures and/or basic conditions was investigated. Under these conditions the primary products lost SO2 and diethylcyanamide affording 1-alkyl-2,3,5-triarylpyrroles 9 and 1H-2,3,5-triarylpyrroles 10. These latter were found to be better obtained through thermal decomposition of N-protected cycloadducts 8 and subsequent deprotecting the final pyrroles.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 121-89-1. Category: isothiazole.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com