Category: 1003-07-2

Running characteristics and failure analysis of seawater membrane treatment was written by Wang, Lei;Zhang, Yantao;Xu, Bin. And the article was included in Shuichuli Jishu in 2015.Synthetic Route of C3H3NOS This article mentions the following:

The characteristics of seawater membrane treatment system and the common failures were introduced to analyze and find out the relationship between the membrane pollution, equipment damage and the maintenance based on high salt concentration, high organic matter, high hardness, and rich in microorganisms. The author presented a method of enhancing the maintenance and transformation in the aspects of water quality, dosing, online meter, pneumatic valve, corrosion, equipment body. Good results were achieved after the long-term practice. In the condition of normal desalination rate and recovery rate, chem. washing cycle was greatly extended, from three times of a year to once a year, so the equipment reliability was greatly improved. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.Synthetic Route of C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Self-healing coatings for inhibiting corrosion of ferrous metals exposed to preservative-treated bamboo was written by Wang, Qingping;Cao, Jinzhen;Liu, Xing-e;Yang, Shumin;Jiang, Mingliang. And the article was included in Journal of Wood Science in 2020.Formula: C3H3NOS This article mentions the following:

This study aims to provide an effective method of inhibiting the corrosion of ferrous metals exposed to preservative-treated bamboo, thereby prolonging material service life and reducing maintenance costs. The synthesis and characterization of microcapsules were first described. The characterization included the particle size, surface morphol., thermal stability, and core content of microcapsules. The results showed that microcapsules had good thermal stability and high core loading. Then, the self-healing performance and corrosion resistance of self-healing coatings were evaluated. The results indicated that self-healing coatings can identify and heal the damage automatically and had a more pos. effect on inhibiting metal corrosion. Also, the mech. properties of self-healing coatings were analyzed. The results demonstrated that microcapsule embedment did not almost affect the mech. properties of self-healing coatings. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Formula: C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Formula: C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Simultaneously detecting chlorophenols and isothiazolinones in food contact paper packaging materials using ultrahigh-performance liquid chromatography tandem mass spectrometry was written by Zhang, Cong;Huang, Jin-feng;Cai, Wei-hong;Li, Xiu-ying;Guo, Xin-dong;He, Min-heng;Feng, Xiang. And the article was included in Xiandai Shipin Keji in 2015.Safety of Isothiazol-3(2H)-one This article mentions the following:

A comprehensive anal. method was developed to simultaneously detect chlorophenols and isothiazolinones (Ml, CMI, BIT, 2,4-DCP, 2,4,6-TCP, 2,3,4,6-TCP, PCR and OPP) in food contact paper packaging materials using ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) and solid phase extraction (SPE). The paper samples were subjected to ultrasonic methanol extraction, concentrated, and purified with an Oasis HLB SPE cartridge. The extract was separated in a Phenomenex Kinetex C18 column (100 mm × 3.0 mm, 2.6μm) using gradient elution with a methanol-water mobile phase. The MS/MS anal. was performed in electrospray ionization mode with multiple reaction monitoring (MRM) and separated into two segments of pos. and neg. ionization modes. Eight compounds were identified by retention lime and the ratio of characteristic ions, and these were quantified using the external standard methods. Under optimal conditions, the calibration curves for the eight analytes were linear within the range of 2.0 to 400μg/L, with correlation coefficients more than 0.997. The quantitation limits of the method (S/N = 10) for the eight compounds were 10 to 30μg/kg. The mean recoveries for paper samples at spiked concentration levels of 10 to 300μg/kg were between 80.3% and 107%, while the relative standard deviations (RSDs, n = 6) ranged from 3.5% to 9.3%. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Safety of Isothiazol-3(2H)-one).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.Safety of Isothiazol-3(2H)-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Persistence of Isothiazolinones in Clothes After Machine Washing was written by Marrero-Aleman, Gabriel;Borrego, Leopoldo;Gonzalez Antuna, Ana;Macias Montes, Ana;Perez Luzardo, Octavio. And the article was included in Dermatitis in 2021.Category: isothiazole This article mentions the following:

Sensitization to methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) is a worldwide problem. Washing machine detergents are suspected to cause cutaneous symptoms in highly sensitized patients. Little is known about the persistence of isothiazolinones in clothes that have been washed. The aim of the study was to analyze the possible persistence of MI, MCI, benzisothiazolinone, and octylisothiazolinone in common fabrics after machine washing. Different clothes (cotton, polyester, linen, and wool) were collected, and 4 types of wash were done (control, standard, standard + conditioner, and standard + double rinse). The samples were analyzed using ultrahigh-performance liquid chromatog. The results showed that the concentrations of isothiazolinones were very low, independent of the type of material or wash. The highest levels were found in the control wash (hand wash), reaching a maximum of 0.4 ppm in the linen. Our findings suggest that it is not necessary to recommend that patients sensitized to MI avoid isothiazolinones in machine detergents or fabric conditioners or to double rinse. However, after using the detergent for hand washing (the control in our study), there may remain sufficient concentrations of isothiazolinones in clothes to produce symptoms in highly sensitized patients. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Category: isothiazole).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Compound preparation of biocide in reclaimed water used as circulating cooling water was written by Han, Yi;Tian, Yi-mei;Wu, Ping;Su, Wei-na;Ma, Yuan. And the article was included in Zhongguo Jishui Paishui in 2013.HPLC of Formula: 1003-07-2 This article mentions the following:

When reclaimed water was used as industrial circulating cooling water, the increasing number of microorganisms would affect heat transfer effect of heat pipes and reduce pipeline service life. The best sterilization doses of four common monomeric biocides in 4 times concentrated water from a Tianjin reclaimed water plant were measured by plate count method. Two kinds of compound biocides were obtained by the orthogonal test at the best doses, and the sterilization effect of the compound biocides was verified through the dynamic experiments The results showed that the best doses of four kinds of biocides were: stabilized chlorine dioxide and sodium hypochlorite 6 mg/L, isothiazolinone 95 mg/L, geramine 120 mg/L, resp., in the condition of the quantity of heterotrophic bacteria about 10⁶ CFU/mL, and the inactivation rate of heterotrophic bacteria was over 94% when used only one of these biocides. The two kinds of compound biocides were: stabilized chlorine dioxide 3 mg/L, isothiazolinone 50 mg/L, geramine 30 mg/L and stabilized chlorine dioxide 4 mg/L, isothiazolinone 40 mg/l., sodium hypochlorite 2 mg/L. Their disinfecting rates were more than 99%. The dynamic test indicated that the disinfecting time of the two kinds of compound biocides could last more than 7 d and bactericidal effect was good when the quantity of heterotrophic bacteria was about 10⁷ CFU/mL. The first kind of compound biocide was more suitable for power plant circulating cooling system sterilization after considering economic factors. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2HPLC of Formula: 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.HPLC of Formula: 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Identification of fungi from children’s shoes and application of a novel antimicrobial agent on shoe insole was written by Li, Hui;Zhou, Jin;Shi, Rui;Chen, Wuyong. And the article was included in African Journal of Biotechnology in 2011.Application In Synthesis of Isothiazol-3(2H)-one This article mentions the following:

Thirteen strains of fungi were isolated from 12 shoes worn by children aged 6-12 for a period of more than half a year consisting of 5 strains of yeasts and 8 strains of molds. Through morphol. observation and 18S rDNA sequence anal., the 5 strains of yeasts were identified as follows: Cryptococcus neoformans, Candida albicans, Cryptococcus albidus, Rhodotorula mucilaginosa, and Candida utilis. While the 8 strains of molds characterized and classified by point cropping, insert method, and imprint method were resp. Mucor (2 subspecies), Chain cell mold, Aspergillus (3 subspecies), and Penicillium (2 subspecies). In order to protect children’s feet from being infected by the fungi, a novel nano antimicrobial composite containing nano ZnO and isothiazolinone was prepared and was used to treat the children’s insole by spraying. The inhibitory effects of the nano antimicrobial composite treated insole against yeasts and molds from children’s shoes were evaluated by the inhibition zone and the inhibition ratio method. The results show that the insole treated with 2% nano antimicrobial composite could inhibit the growth of tested microorganism effectively, which could also achieve >97% inhibition ratio against the entire tested fungi. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Application In Synthesis of Isothiazol-3(2H)-one).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Application In Synthesis of Isothiazol-3(2H)-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Micropollutants in urban stormwater: occurrence, concentrations, and atmospheric contributions for a wide range of contaminants in three French catchments was written by Gasperi, J.;Sebastian, C.;Ruban, V.;Delamain, M.;Percot, S.;Wiest, L.;Mirande, C.;Caupos, E.;Demare, D.;Kessoo, M. Diallo Kessoo;Saad, M.;Schwartz, J. J.;Dubois, P.;Fratta, C.;Wolff, H.;Moilleron, R.;Chebbo, G.;Cren, C.;Millet, M.;Barraud, S.;Gromaire, M. C.. And the article was included in Environmental Science and Pollution Research in 2014.Quality Control of Isothiazol-3(2H)-one This article mentions the following:

This study aimed at: (a) providing information on the occurrence and concentration ranges in urban stormwater for a wide array of pollutants (n = 77); (b) assessing whether despite the differences between various catchments (land use, climatic conditions, etc.), the trends in terms of contamination level are similar; and (c) analyzing the contribution of total atm. fallout (TAF) with respect to sources endogenous to this contamination. The studied contaminants include conventional stormwater contaminants (polycyclic aromatic hydrocarbons (PAHs), Zn, Cu, Pb, etc.), in addition to poorly or undocumented pollutants such as nonylphenol and octylphenol ethoxylates (NPnEO and OPnEO), bisphenol A (BPA), polybrominated di-Ph ethers (PBDEs), a wide variety of pesticides, and various metals of relevance (As, Ti, Sr, V). Sampling and anal. were performed using homogeneous methods on three urban catchments with different land use patterns located in three distinct French towns. For many of these pollutants, the results do not allow highlighting a significant difference in stormwater quality at the scale of the three urban catchments considered. Significant differences were, however, observed for several metals (As, Cr, Cu, Ni, Sr and Zn), PAHs, and PBDEs, though this assessment would need to be confirmed by further experiments The pollutant distributions between dissolved and particulate phases were found to be similar across the three exptl. sites, thus suggesting no site dependence. Lastly, the contributions of TAF to stormwater contamination for micropollutants were quite low. This finding held true not only for PAHs, as previously demonstrated in the literature, but also for a broader range of mols. such as BPA, NPnEO, OPnEO, and PBDEs, whose high local production is correlated with the leaching of urban surfaces, buildings, and vehicles. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Quality Control of Isothiazol-3(2H)-one).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Quality Control of Isothiazol-3(2H)-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Evaluation of bactericidal performances of different bactericides on sulfate reducing bacteria was written by Gao, Jian-fu;Li, Jin;Jing, Chao-wen. And the article was included in Gongye Yongshui Yu Feishui in 2013.Synthetic Route of C3H3NOS This article mentions the following:

The bactericidal performances of three kinds of bactericides: NaClO, 1227 and isothiazolinone, on sulfate reducing bacteria (SRB) in circulating water were investigated by static cultivation; the changes of SRB cellular morphol. and corrosion morphol. of SS316L stainless steel test specimen were observed using SEM. The results showed that, NaClO obtained its best bactericidal performance in 12 h, which was shorter than the required time (24 h) for 1227 and isothiazolinone getting their optimal bactericidal performance. However, the antibacterial duration of NaClO was short, which was only 24 h; on the contrary, 1227 had the longest antibacterial duration, which was about 1 wk. Under the optimal conditions, the highest bactericidal rates of NaClO, 1227 and isothiazolinone reached 86.71%, 89.70% and 79.70% resp. Along with time, the cell structure of SRB was decomposed from partially to totally, and the cells disintegrated completely in 7 h. In the circulating cooling water with SRB inoculation, a layer of uneven distribution biofilm was formed on the surface of SS316L, which showed that, the corrosion of SS316L caused by SRB was mainly represented as pitting corrosion. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Synthetic Route of C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice was written by Ko, Eun-A.;Jin, Byung-Ju;Namkung, Wan;Ma, Tonghui;Thiagarajah, Jay R.;Verkman, A. S.. And the article was included in Gut in 2014.Product Details of 1003-07-2 This article mentions the following:

Background Rotavirus is the most common cause of severe secretory diarrhoea in infants and young children globally. The rotaviral enterotoxin, NSP4, has been proposed to stimulate calcium-activated chloride channels (CaCC) on the apical plasma membrane of intestinal epithelial cells. We previously identified red wine and small mol. CaCC inhibitors. Objective To investigate the efficacy of a red wine extract and a synthetic small mol., CaCC_inh-A01, in inhibiting intestinal CaCCs and rotaviral diarrhoea. Design Inhibition of CaCC-dependent current was measured in T84 cells and mouse ileum. The effectiveness of an orally administered wine extract and CaCC_inh-A01 in inhibiting diarrhoea in vivo was determined in a neonatal mouse model of rotaviral infection. Results Screening of ∼150 red wines revealed a Cabernet Sauvignon that inhibited CaCC current in T84 cells with IC₅₀ at a ∼1:200 dilution, and higher concentrations producing 100% inhibition. A >1 kdalton wine extract prepared by dialysis, which retained full inhibition activity, blocked CaCC current in T84 cells and mouse intestine. In rotavirus-inoculated mice, oral administration of the wine extract prevented diarrhoea by inhibition of intestinal fluid secretion without affecting rotaviral infection. The wine extract did not inhibit the cystic fibrosis chloride channel (CFTR) in cell cultures, nor did it prevent watery stools in neonatal mice administered cholera toxin, which activates CFTR-dependent fluid secretion. CaCC_inh-A01 also inhibited rotaviral diarrhoea. Conclusions Our results support a pathogenic role for enterocyte CaCCs in rotaviral diarrhoea and demonstrate the antidiarrhoeal action of CaCC inhibition by an alc.-free, red wine extract and by a synthetic small mol. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Product Details of 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part III was written by Thyssen, Jacob P.;Gimenez-Arnau, Elena;Lepoittevin, Jean-Pierre;Menne, Torkil;Boman, Anders;Schnuch, Axel. And the article was included in Contact Dermatitis in 2012.Formula: C3H3NOS This article mentions the following:

The statistical evidence on the incidence and morbidity of skin contact allergy (contact dermatitis) cases in the European Union before and after the safety limits were set is presented. The evidence is used to assess the possible effect of the limits in the reduction/prevention of the incidence and morbidity of contact dermatitis. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Formula: C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Formula: C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com