With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288-16-4,Isothiazole,as a common compound, the synthetic route is as follows.
Compound 1 (20 g, 0.235 mol) was added under stirring with nitrogen to dry 100 ml of ether and stirred to dissolve,And then cooled to 0 C or lower, to which n-butyllithium (0.24 mol)During the dropwise addition, the temperature was kept below 0 C, and the reaction was carried out until the compound 1 was added.To the reaction solution was added bromine (0.5 mol), and the mixture was kept at 0 C or less during the dropping,After completion of the dropwise addition, the temperature was gradually raised to room temperature, and after stirring for half an hour, the hydrochloric acid solution (2N, 500 ml)Quenching reaction.The aqueous phase was extracted with ether (200 ml * 3) and discarded. The organic phases were combined,Sodium dithionite solution (100ml * 2), dried over anhydrous sodium sulfate, filtered and concentrated to dryness,A yellow oily compound was prepared.In this step, the ether can also be replaced with a solvent such as methyl ether, dimethyl ether, tetrahydrofuran, 1,4-dioxane and the like.
288-16-4, As the paragraph descriping shows that 288-16-4 is playing an increasingly important role.
Reference£º
Patent; Tianjin Jinyao Group Co., Ltd.; Ge Yu; Li Yanfeng; (33 pag.)CN106892912; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com