While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 1719-19-3, Name is 2-Methyl-4-phenylbut-3-yn-2-ol, molecular formula is C11H12O, belongs to isothiazole compound. In a document, author is Zeng, Li-Fan, introduce the new discover, Quality Control of 2-Methyl-4-phenylbut-3-yn-2-ol.
Three new types of aryl diketo acid (ADK) isosteres were designed by conversion of the biologically labile 1,3-diketo unit into heteroaromatic motif such as isoxazole, isothiazole, or 1H-pyrazole to improve the physicochemical property of ADK-based HIV-1 integrase (IN) inhibitors. The synthesis of the heteroaromatic carboxylic acids was established by employing phenyl beta-diketoester or benzaldehyde as the starting material and 1,3-dipolar cycloaddition as the key reaction. Of the compounds tested, the 3-benzyloxyphenyl-substituted isoxazole carboxylic acid displayed the best IN inhibitory and antiviral activities, with N-hydroxylamidation enhancing the in vitro and in vivo potency. These findings are important for further optimization of ADK-based IN inhibitors. (c) 2008 Elsevier Ltd. All rights reserved.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1719-19-3. Quality Control of 2-Methyl-4-phenylbut-3-yn-2-ol.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com