Category: 93-02-7

I found the field of Chemistry very interesting. Saw the article Facile Synthesis of Novel Pyrano-Pyrido-Carbazole Scaffolds Using Magnetic Fe(3)O(4)Nanoparticles as a Heterogeneous Green and Reusable Catalyst published in 2020.0. Computed Properties of C9H10O3, Reprint Addresses Verma, D (corresponding author), Vikram Univ, Sch Studies Chem & Biochem, Ujjain 456010, Madhya Pradesh, India.; Verma, D (corresponding author), Vikram Univ, Govt Coll, Ujjain 457114, Madhya Pradesh, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

We reported a novel series of pyrano-pyrido-carbazol derivatives (PPCDs) 6(a-o), synthesizedviathe reaction of 4-hydroxypyridocarbazolone (3), aryl/heteroaryl aldehyde (4), and malononitrile (5), in water using Fe(3)O(4)magnetite nanoparticles (Fe(3)O(4)MNPs) as a heterogeneous novel catalyst at room temperature just in 60 mins under ultrasound. For this propose, Fe(3)O(4)MNPs with particle size 23.4 +/- 0.9 nm was successfully synthesizedviaa one-step novel coprecipitation method in aqueous medium by the use of a new alkaline agenti. e. 2 -(ethylamino) ethanol and systematically characterized using field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), energy dispersive analysis of X-ray (EDAX), X-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS) and Fourier transformed infrared (FTIR). Fe(3)O(4)MNPs show remarkably dramatic dispersion stability as evident from zetapotential (zeta) value of -38.9 mV and hydrodynamic diameter (HD) of 238 nm and excellent specific surface area of 185 m(2)/g. Additionally, Fe(3)O(4)MNPs was easily separated after completion of the reaction, from the reaction mixture using the external magnet, and can be reused seven times without any considerable loss of its activity. The use of ultrasound made homogeneous dispersion of MNPs in water which accelerated the rate of reaction for the synthesis of PPCDs. This protocol has notable advantages like the synthesis of novel PPCDs with high yield in short reaction time, inexpensive catalyst, eco-safe, and also favour green chemistry protocol.

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Reference:
Isothiazole – Wikipedia,
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Authors Faudzi, SMM; Abdullah, MA; Manap, MRA; Ismail, AZ; Rullah, K; Aluwi, MFFM; Ramli, ANM; Abas, F; Lajis, NH in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about CURCUMIN ANALOGS; KAPPA-B; DERIVATIVES; INFLAMMATION; FLAVONOIDS; SYNTHASE in [Faudzi, Siti Munirah Mohd; Abdullah, Maryam Aisyah; Manap, Mohd Rashidi Abdull; Ismail, Ahmad Zaidi] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia; [Faudzi, Siti Munirah Mohd; Abas, Faridah; Lajis, Nordin H.] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia; [Rullah, Kamal] Int Islamic Univ Malaysia, Kuliyyah Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia; [Aluwi, Mohd Fadhlizil Fasihi Mohd; Ramli, Aizi Nor Mazila] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26300, Pahang, Malaysia; [Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia in 2020.0, Cited 40.0. Category: isothiazole. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E-2 (PGE(2)) suppression ability on IFN-gamma/LPS-induced RAW 264.7 macrophage cells. Results showed that none of the synthesized compounds were PAINS-associated molecules, with 3-(2,5-dimethoxyphenyl)-1-(1H-pyrrol-2-yl) prop-2-en-1-one (compound 16) exhibiting remarkable inhibition activity towards PGE(2) and NO production with IC50 values of 0.5 +/- 1.5 mu M and 12.1 +/- 1.5 mu M, respectively. Physicochemical and ADMET studies showed that majority of the compounds obey to Lipinski’s rule of five (RO5) having high blood brain barrier (BBB) penetration, human intestinal absorption (HIA), P- glycoprotein (PgP) inhibition and plasma binding protein (PPB) inhibition. The obtained atomic coordinates for the single-crystal XRD of 16 were then applied in a molecular docking simulation, and compound 16 was found to participate in a number of important binding interactions in the binding sites of ERK and mPGES-1. Based on these results, we have observed the potential of compound 16 as a new hit anti-inflammatory agent, and these findings could serve as a basis for further studies on its mechanism of action.

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Aggarwal, R; Mamta; Sumran, G in [Aggarwal, Ranjana; Mamta] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India; [Sumran, Garima] DAV Coll Lahore, Dept Chem, Ambala City 134003, Haryana, India published An expeditious one-pot multicomponent synthesis of sterically hindered bis-1,2,4-triazolopyridazines under solvent-free conditions in 2019.0, Cited 33.0. Quality Control of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A simple and ecologically facile synthesis of sterically hindered 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b:3′,4′-f]pyridazines was accomplished via a three-component reaction sequence between 3,6-dihydrazinopyridazine, an aromatic or heteroaromatic aldehyde and iodobenzene diacetate (IBD) on grinding at room temperature. The 3,6-bis-arylidenehydrazinopyridazine intermediates, generated in situ, undergo oxidative cyclization to afford the title compounds. The present protocol has excellent yields, short reaction times, broad substrate scope, is a solvent-free greener synthesis, and has an easy purification of product. [GRAPHICS] .

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article 2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation WOS:000480235700064 published article about P53; ANTAGONISTS; ACTIVATION; DISCOVERY; GROWTH; CANCER in [Bazanov, Daniil R.; Savitskaya, Victoria Yu; Proskurnina, Marina, V; Lozinskaya, Natalia A.] Moscow MV Lomonosov State Univ, Dept Chem, 1 Leninskie Gory, Moscow 119992, Russia; [Pervushin, Nikolay, V; Kopeina, Gelina S.] Moscow MV Lomonosov State Univ, Dept Med, 1 Leninskie Gory, Moscow 119992, Russia; [Anikina, Lada, V; Proskurnina, Marina, V; Lozinskaya, Natalia A.] RAS, Inst Physiol Act Subst, 1 Northern Passage, Chernogolovka 142432, Moscow Region, Russia in 2019.0, Cited 26.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

Imidazoline-based small molecule inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents in cis-imidazoline core for biological activity of nutlin family compounds. Although the necessity of the substituents in the phenyl rings of cis-imidazoline has been shown, there are no studies in which the replacements of a halogen by other substituents have been investigated. A series of simple cis-imidazoline derivatives containing halogen, hydroxy and alkoxy-substituents were synthesized. The biological activity of the compounds was studied using assays of cytotoxicity (MTT) and p53 level. It was found that the hydroxyl-derivatives were not cytotoxic whereas the alkoxy analogues were the same or more active as halogen-substituted compounds in cell viability test. The synthesized alkoxy derivatives induced an increase of p53 level and did not promote necrotic cell death in the concentration up to 40 mu M.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 93-02-7. In 2020 BIOORG CHEM published article about GEWALD REACTION; KNOEVENAGEL CONDENSATION; MOLECULAR-PROPERTIES; CATALYTIC AMOUNT; DERIVATIVES; ANTICANCER; MECHANISM; APOPTOSIS; ACID; 2-AMINOTHIOPHENES in [Ismail, Magda M. F.; El-Zahabi, Heba S. A.; Ibrahim, Rabab S.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, Cairo 11754, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci Boys, Dept Zool, Cairo 11754, Egypt in 2020, Cited 55. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The discovery of the antiproliferative potential of tranilast prompted additional studies directed at understanding the mechanisms of tranilast action. Its inhibitory effect on cell proliferation depends principally on the capacity of tranilast to interfere with transforming growth factor beta (TGFOR1) signaling. This work summarizes design, synthesis and biological evaluation of sixteen novel tranilast analogs on different tumors such as PC-3, HepG-2 and MCF-7 cell lines. The in vitro cytotoxicity was evaluated using MTT assay showed that, twelve compounds out of sixteen showed higher cytotoxic activities (IC50’s 1.1-6.29 mu M), than that of the reference standard, 5-FU (IC50 7.53 mu M). The promising cytotoxic hits (4b, 7a, b and 14c-e), proved to be selective to cancer cells when their cytotoxicity’s are examined on human normal cell line (WI-38). Then they are investigated for their possible mode of action as TGFOR1 inhibitors; remarkable inhibition of TGFOR1 by these hits was observed at the range of IC50 0.087-3.276 mu M. The cell cycle analysis of the most potent TGFOR1 inhibitor, 4b revealed cell cycle arrest at G2/M phase on prostate cancer cells. Additionally, it is clearly indicated apoptosis induction at Pre-G1 phase, this is substantiated by significant increase in the expression on the tumor suppressor gene, p53 and up regulation the level of apoptosis mediator, caspase-3. In addition, in silico study was performed for validating the physicochemical and ADME properties which revealed that, all compounds are orally bioavailable with no side effects complying with Lipinski rule. The proposed mode of action can be further explored on the light of molecular modeling simulation of the most potent compounds, 4b and 14e which were docked into the active sites of TGFOR1 to predict their affinities toward the receptor.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020.0 RUSS J GEN CHEM+ published article about ANTIMICROBIAL ACTIVITY; ANTICANCER EVALUATION; KINASE INHIBITORS; DERIVATIVES; DISCOVERY; POTENT; ERK1/2 in [Abd-Elghaffar, H. S.; Mohamed, S. F.; Ibrahim, A. A.] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt; [El-Hashash, M. A.] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt; [Amr, A. E.; Al-Omar, M. A.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia; [Amr, A. E.] Natl Res Ctr, Appl Organ Chem Dept, Chem Ind Res Div, Cairo 12622, Egypt; [Nossier, E. S.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Riyadh 11451, Saudi Arabia in 2020.0, Cited 15.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 2,5-Dimethoxybenzaldehyde

A new series of fused 1,3-indandione derivatives has been synthesized and evaluated for anti-proliferative activity. 2-Alkene-1,3-indandione derivatives have been used as the precursors of a number of tricyclic compounds. The latter have been tested for anti-proliferative activity.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. In 2020.0 HETEROCYCLES published article about METAL PICRATE EXTRACTION; RING-CLOSING METATHESIS; BIOLOGICAL EVALUATION; MEDICINAL AGENTS; ADAMANTYL GROUP; DERIVATIVES; CHEMISTRY; THIAZOLE; LIGANDS; ACID in [Kotha, Sambasivarao; Cheekatla, Subba Rao] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India in 2020.0, Cited 97.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Here, we have established a new and simple synthetic approach to the pentacycloundecane containing cage oxazole unit in four steps. The synthesis begun with a cheap and readily available materials such as 2,5-dimethoxybenzaldehyde and endo-dicyclopentadiene. This approach relies on Van Leusen oxazole synthesis and [2+2] photocycloaddition as key steps. To the best of our knowledge, this is the first example of Cookson’s dione containing oxazole ring system. Some of these oxazole motifs are useful in bioorganic chemistry and our results are likely to draw the attention of medicinal chemists

Category: isothiazole. Welcome to talk about 93-02-7, If you have any questions, you can contact Kotha, S; Cheekatla, SR or send Email.

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Isothiazole – Wikipedia,
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An article Novel 2-(2,5-methoxy-phenyl) imidazo [4,5-f] – [1,10] phenanthrolin platinum(II) complex display high anticancer activity via dysfunction of mitochondrial signaling pathway WOS:000459840400018 published article about G-QUADRUPLEX DNA; TELOMERASE ACTIVITY; CHIRAL COMPLEXES; CELL APOPTOSIS; II COMPLEXES; LIGANDS; BINDING; INHIBITION; RUTHENIUM; -NO2 in [Bin, Yi-Dong; Yang, Yan; Zhang, Hua-Xin] Guangxi Univ, Sch Chem & Chem Engn, 100 Daxuedong Rd, Nanning 530004, Peoples R China; [Yang, Yan; Luo, Xu-Jian] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, 1303 Jiaoyudong Rd, Yulin 537000, Peoples R China in 2019.0, Cited 33.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A novel Pt(II) complex of [Pt-II(MPP)(OPD)]Cl center dot H2O (MPP-Pt) (OPD = o-phenylenediamine) with 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin (H-MPP) was synthesized and fully characterized. In MPP-Pt complex, the Pt(II) ion adopts a four-coordinated square planar geometry. MPP-Pt exhibited selective cytotoxicity against human carcinoma (A549), hepatoblastoma (Hep-G2), ovarian (SK-OV-3), cervical (HeLa) and gastric adenocarcinoma (MGC80-3) cell lines with IC50 values in the micromolar range (0.31-9.48 mu M), but low cytotoxicity toward HL-7702 normal cells. Various experiments showed that MPP-Pt complex caused cell apoptosis via mitochondrial dysfunction in HeLa cells, as shown by the up-regulation expression of p27, apaf-1, p21, cytochrome c (cyc c) and p53 levels, loss of mitochondrial membrane potential (MMP) and the down-regulation expression of bcl-2 protein level.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Synthesis of new alpha-aminophosphonates using nanoscale nickel-based metal-organic framework as a heterogeneous catalyst and their antibacterial activity published in 2020.0. Application In Synthesis of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Shimpi, NG (corresponding author), Univ Mumbai, Lab Mat Sci, Dept Chem, Mumbai 400098, Maharashtra, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

An elegant approach was presented for the synthesis of novel alpha-aminophosphonates: a three-component one-pot condensation of 3-(trifluoromethyl)aniline, substituted aromatic aldehydes, and diethyl phosphite using a nickel-based metal-organic framework (Ni-MOF). The Ni-MOF was synthesized using 4,4 ‘-biphenyldicarboxylic acid and further characterized using various techniques such as X-ray diffraction, Fourier-transform infrared, thermogravimetry/differential thermal analysis, Brunauer-Emmett-Teller, and field-emission scanning electron microscopy analyses. Ni-MOF seems to be an eco-friendly, an easily recyclable, and heterogeneous catalyst up to the eighth run with minimal reduction in its catalytic activity. The synthesized alpha-aminophosphonates were also investigated for antibacterial and antioxidant activities. In few cases, compounds 4a-4x show similar as well as higher antibacterial activity. Among the synthesized alpha-aminophosphonates, 4a-4x had more potent antibacterial activity against pathogenic bacteria while compounds 4h, 4m, 4n, 4q, 4u, 4v, and 4w exhibited significant antioxidant activity.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019.0 ACS CHEM NEUROSCI published article about POTENTIAL ANTICANCER AGENTS; BIOLOGICAL EVALUATION; PATHWAY ACTIVATION; OXIDATIVE STRESS; CURCUMIN; PIPLARTINE; MECHANISMS; INHIBITORS; DISCOVERY; OCCLUSION in [Li, Ge; Zheng, Yuantie; Yao, Jiali; Hu, Linya; Liu, Qunpeng; Ke, Furong; Feng, Weixiao; Zhao, Ya; Yan, Pencheng; He, Wenfei; Qiu, Peihong; Wu, Jianzhang] Wenzhou Med Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou 325035, Zhejiang, Peoples R China; [Feng, Weixiao; Li, Wulan] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; [Zhao, Ya; Deng, Hui] Wenzhou Med Univ, Dept Periodont, Hosp & Sch Stomatol, 373 West Xueyuan Rd, Wenzhou 325035, Zhejiang, Peoples R China; [Liu, Qunpeng] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China in 2019.0, Cited 50.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Product Details of 93-02-7

The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia-reperfusion injury (CIRI) in stroke. Piperlongumine (PL), a natural alkaloid, has a great potential as a neuroprotective agent, but it also has obvious toxicity. Moreover, its neuroprotective effects remain to be improved. In this study, we designed a series of novel PL analogs by hybridizing the screened low-toxicity diketene skeleton with antioxidant effect and the 3,4,5-trimethoxyphenyl group, which may increase the antioxidant activity of PL. The intermediate was synthesized by a novel green synthesis method, and 34 compounds were obtained. The compounds without obvious cytotoxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound decreased significantly by reduction of the carbon-carbon double bonds of the Michael acceptor in the diketene skeleton. More importantly, further study revealed that compound A9, which has the best activity, can confer protection for cells against oxidative stress and attenuate brain injury in vivo. Overall, this study provided a promising drug candidate for the treatment of CIRI and guided the further development of drug research in oxidative stress-mediated diseases.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com