Category: 93-02-7

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis of new alpha-aminophosphonates using nanoscale nickel-based metal-organic framework as a heterogeneous catalyst and their antibacterial activity published in 2020.0, Reprint Addresses Shimpi, NG (corresponding author), Univ Mumbai, Lab Mat Sci, Dept Chem, Mumbai 400098, Maharashtra, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

An elegant approach was presented for the synthesis of novel alpha-aminophosphonates: a three-component one-pot condensation of 3-(trifluoromethyl)aniline, substituted aromatic aldehydes, and diethyl phosphite using a nickel-based metal-organic framework (Ni-MOF). The Ni-MOF was synthesized using 4,4 ‘-biphenyldicarboxylic acid and further characterized using various techniques such as X-ray diffraction, Fourier-transform infrared, thermogravimetry/differential thermal analysis, Brunauer-Emmett-Teller, and field-emission scanning electron microscopy analyses. Ni-MOF seems to be an eco-friendly, an easily recyclable, and heterogeneous catalyst up to the eighth run with minimal reduction in its catalytic activity. The synthesized alpha-aminophosphonates were also investigated for antibacterial and antioxidant activities. In few cases, compounds 4a-4x show similar as well as higher antibacterial activity. Among the synthesized alpha-aminophosphonates, 4a-4x had more potent antibacterial activity against pathogenic bacteria while compounds 4h, 4m, 4n, 4q, 4u, 4v, and 4w exhibited significant antioxidant activity.

Welcome to talk about 93-02-7, If you have any questions, you can contact Rasal, SA; Dhavan, PP; Jadhav, BL; Shimpi, NG or send Email.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

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Kumar, D; Prakasham, AP; Gangwar, MK; Ghosh, P in [Kumar, Dharmendra; Prakasham, A. P.; Gangwar, Manoj Kumar; Ghosh, Prasenjit] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India published Solvent-free cyanosilylation of aromatic and heteroaryl aldehydes catalyzed by a cationic iron N-heterocyclic carbene complex at ambient temperature under UV irradiation in 2019.0, Cited 95.0. Name: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The cyanosilylation of aromatic aldehydes and heteroaryl aldehydes with trimethylsilyl cyanide (TMSCN) is efficiently catalyzed by an iron complex of the type {[3-isopropyl-1-(1R-phenylethyl)imidazol-2-ylidene]Fe(CO)(2)}I (3) in presence of UV light (lambda = 294 nm) in moderate to excellent yields under ambient temperature. The heteroaryl aldehydes exhibited higher yields than the aromatic ones, and the aromatic aldehydes, bearing electron donating groups (EDG), exhibited higher yields over the ones with the electron withdrawing groups (EWG). A proposed catalytic cycle initiates with an active species (A), formed by the dissociation from the iron complex (3), and proceeds via an aldehyde activated species (B), and that upon reaction with TMSCN gives the desired cyanosilylated product. Quite significantly, the initial active iron species (A) and the iron-bound alpha-cyanobenzyloxy species (C) have been detected by mass spectrometry. Additionally, the formation of species (C) was further corroborated by the observation of the formation of TMSI in Si-29 NMR experiment.

Name: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Kumar, D; Prakasham, AP; Gangwar, MK; Ghosh, P or send Email.

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Recently I am researching about ONE-POT SYNTHESIS; IONIC LIQUID; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; XANTHENE DERIVATIVES; NANO-CATALYST; GREEN; CHEAP, Saw an article supported by the APD Section, University of Mumbai, Mumbai [417]. Published in SPRINGER in DORDRECHT ,Authors: Karhale, S. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Name: 2,5-Dimethoxybenzaldehyde

A solid acid catalyst bearing sulphamic acid on sawdust (SA@Sawdust) was designed as a novel heterogeneous catalyst. The structure of prepared catalyst was assessed by various spectroscopic techniques such as FT-IR, field emission scanning electron microscopy and energy dispersive X-ray, thermogravimetric analysis, solid-state CP/MAS C-13-NMR spectroscopy, and CHNS analysis. The efficiency of prepared catalyst was explored for synthesis of diverse 1,8-dioxo-octahydroxanthene derivatives. The mild reaction conditions are found to be more compatible with a wide range of functional groups. The obtained products could be conveniently separated from the reaction mixture by simple filtration, and the catalyst is recovered and reused for next cycle without significant loss in catalytic efficiency. The alluring features of this synthetic route are operational simplicity, shorter reaction time, high conversion, wide substrate scope, easy work-up procedure, and reusability of catalyst.

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Name: 2,5-Dimethoxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Scalable Wolff-Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor published in 2019.0, Reprint Addresses Dallinger, D; Kappe, CO (corresponding author), Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria.; Dallinger, D; Kappe, CO (corresponding author), Karl Franzens Univ Graz, NAWI Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

A safe and scalable continuous flow strategy for Wolff-Kishner reductions that employs methanol as the solvent has been developed. The use of low-cost hydrazine as the reducing agent in combination with a caustic base provides an atom-efficient, environmentally friendly method for the deoxygenation of aldehydes and ketones to alkanes. Because of the required harsh and corrosive reaction conditions (200 degrees C, 50 bar), reactor materials such as stainless steel, glass, or any type of polymer have compatibility problems, rendering this process problematic on a production scale. The use of corrosion-resistant silicon carbide (SiC) as the reactor material opens up the possibility of performing Wolff-Kishner reductions on scale with a considerably improved safety profile. Methanol as the solvent significantly simplifies the workup procedure compared with the generally employed high-boiling solvents such as diethylene glycol. The continuous flow protocol was applied to a number of substrates and provided the desired products in good to high yields with space-time yields of up to 152 g L(-1)h(-1). In addition, a pharmaceutically valuable active pharmaceutical ingredient precursor was synthesized by employing this high-temperature/pressure Wolff-Kishner protocol.

Name: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Znidar, D; O’Kearney-McMullan, A; Munday, R; Wiles, C; Poechlauer, P; Schmoelzer, C; Dallinger, D; Kappe, CO or send Email.

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An article Iodine-DMSO-Catalyzed Chemoselective Biomimetic Aromatization of Tetrahydro-beta-carbolines-3-carboxylic Acid: Mechanism Study with DFT-Calculation WOS:000490895800024 published article about TETRAHYDRO-BETA-CARBOLINES; EUDISTOMIN-U; BIOLOGICAL EVALUATION; ASSISTED SYNTHESIS; ALKALOIDS; NORHARMANE; HARMANE; DERIVATIVES; UTILITY; OXIDATIONS in [Gaikwad, Sunil, V; Devkate, Manisha; Joshi, Rekha; Shinde, Rohit G.; Nikalje, Milind D.; Lokhande, Pradeep D.] Savitribai Phule Pune Univ, Ctr Adv Studies, Dept Chem, Pune 411007, Maharashtra, India; [Nadimetla, Dinesh N.; Bhosale, Sheshanath, V] Goa Univ, Sch Chem Sci, Taleigao Plateau 403206, Goa, India; [Al Kobaisi, Mohammad] Swinburne Univ Technol, Dept Chem & Biotechnol, FSET, Hawthorn, Vic 3122, Australia; [Gaikwad, Milind, V] Dr DY Patil ACS Coll, Dept Chem, Pune 411018, Maharashtra, India in 2019.0, Cited 57.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A new protocol for the chemoselective aromatization of tetrahydro-beta-carboline-3-carboxylic acids to direct biomimetic one step synthesis of beta-carboline-3-carboxylic acids 2 A-L using catalytic amount of I-2 in DMSO/H+ produces very good yield. This method was also successfully extended for the aromatization of tetrahydro-beta-carboline-3-methyl esters 5 A-G as well as one-step synthesis of Marinacarbolines-D analog, respectively. Further, the mechanism and role of iodine-DMSO in aromatization has been studied by Density Functional Theory Calculation.

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Isothiazole – Wikipedia,
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HPLC of Formula: C9H10O3. In 2019.0 BIOORG CHEM published article about DRUG-RESISTANT TUBERCULOSIS; TRANS-CINNAMIC ACID; PARALLEL SYNTHESIS; DERIVATIVES; INHIBITORS; DOCKING in [Upare, Abhay Atmaram; Gadekar, Pradip K.; Sivaramakrishnan, H.] Piramal Enterprises Ltd, Dept Proc Dev, Lighthall A Wing, Hiranandani Business PK, Sakivihar Rd, Mumbai 400072, Maharashtra, India; [Naik, Nishigandha] Haffkine Inst Training Res & Testing, Acharya Donde MargPorel, Mumbai 400012, Maharashtra, India; [Khedkar, Vijay M.] Shri Vile Parle Kelavani Mandars Inst Pharm, Dept Pharmaceut Chem, Mumbai Agra Natl Hwy, Dhule 424001, Maharashtra, India; [Sarkar, Dhiman; Choudhari, Amit] CSIR, Natl Chem Lab, Combi Chem Bio Resource Ctr, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Upare, Abhay Atmaram; Roopan, S. Mohana] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Chem Heterocycles & Nat Prod Res Lab, Vellore 632014, Tamil Nadu, India in 2019.0, Cited 26.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with oxadiazole. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound 32 displayed potent anti-tubercular activity (IC50= 0.045 mu g/mL). Molecular docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the experimental findings providing a platform for structure based hit-to-lead development.

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An article Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action WOS:000489305700020 published article about BETA-HEMATIN FORMATION; IN-VITRO; POTENTIAL ANTIMALARIAL; MOLECULAR-MECHANISM; HEMOZOIN FORMATION; MALARIA; ANTICANCER; QUERCETIN; DERIVATIVES; INHIBITION in [Charris, Jaime E.; Monasterios, Melina C.; Acosta, Maria E.; Rodriguez, Miguel A.; Gamboa, Neira D.] Cent Univ Venezuela, Fac Pharm, Biochem Unit, Organ Synth Lab, Los Chaguaramos 1041-A, Caracas 47206, Venezuela; [Martinez, Gricelis P.; Mijares, Michael R.] Cent Univ Venezuela, Fac Pharm, Biotechnol Unit, Los Chaguaramos 1041-A, Caracas 47206, Venezuela; [Rojas, Hector R.; Mijares, Michael R.; De Sanctis, Juan B.] Cent Univ Venezuela, Fac Med, Inst Immunol, Los Chaguaramos 1050-A, Caracas 50109, Venezuela; [De Sanctis, Juan B.] Palacky Univ, Fac Med, Inst Mol & Translat Med, Hnevotinska 1333-5, Olomouc 77900, Czech Republic in 2019, Cited 62. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of quinoline-chalcone (E)-1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one (4, 5), and quinoline-pyrazoline hybrids 7-Chloro-N-[3 or 4-(4,5-dihydro-5-(phenyl-substituted)-1H-pyrazol-3-yl] phenyl) quinoline-4-amine (6, 7) were synthesized with the aim of achieving an antimalarial and anticancer dual action. Most of the compounds showed significant inhibition (%>80) of beta-hematin formation. The existing structures were tested in vivo as potential antimalarials in mice infected with P. berghei ANKA, chloroquine susceptible strain. Some of the compounds exhibited antimalarial activity comparable to that of chloroquine. Moreover, the compounds induce cell death on two human cancer cell lines (Jurkat E6.1 and HL60) without affecting the primary culture of human lymphocytes. Flow cytometry analysis confirmed the increase in apoptotic cell death after 24 h. Based on the structural analysis, these quinoline hybrids represent new compounds potentially useful for malaria end leukemia treatments.

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Recently I am researching about TERMINAL ARYL ALKENES; C-N; ANALOGS; CONDENSATION; DERIVATIVES; ACYLATION; C-SP3-H; ESTERS, Saw an article supported by the DST-NRF Indo-South Africa Joint research project [DST/INT/South Africa/P-19/2016]; DST, New DelhiDepartment of Science & Technology (India); UGC, New DelhiUniversity Grants Commission, India; MNIT Jaipur. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sharma, R; Yadav, L; Yadav, RK; Chaudhary, S. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Quality Control of 2,5-Dimethoxybenzaldehyde

An efficient, cost-effective, transition-metal-free, oxidative C-H cross-dehydrogenative coupling via a C-H bond functionalization protocol for the regioselective direct C-3 acylation/benzoylation of substituted 2H-Indazoles 1a-m with substituted aldehydes 2a-q/benzyl alcohols 5a-e/styrenes 6a-e is reported. The operationally simple protocol proceeds in the presence of tert-butyl peroxybenzoate (TBPB) as an oxidant in chlorobenzene (PhCl) as a solvent at 110 degrees C for 24 h under an inert atmosphere, which furnished a diverse variety of substituted 3-(acyl/benzoyl)-2H-indazoles 3a-q/4a-l in up to 87% yields. The reaction involves a free-radical mechanism and proceeds via the addition of an in situ generated acyl radical (from aldehydes/benzyl alcohols/styrenes) on 2H-indazoles. The functional group tolerance, broad substrate scope, control/competitive experiments and gram-scale synthesis and its application to the synthesis of anti-inflammatory agent 11 and novel indazole-fused diazepine 13 further signify the versatile nature of the developed methodology.

Quality Control of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Sharma, R; Yadav, L; Yadav, RK; Chaudhary, S or send Email.

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An article Weak Bases-Mediated Modified Favorskii Reaction-Type Direct Alkynylation/(E)-Alkenylation: A Unified Rapid Access to alpha,beta-Unsaturated Ketones and Propargyl Alcohols WOS:000498438500001 published article about CARBONYLATIVE HECK REACTIONS; CATALYTIC ALKYNYLATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; ALDEHYDES; CHALCONE; DERIVATIVES; HYDROXIDE; ALKYNES; ACIDS in [Tiwari, Mohit K.; Yadav, Lalit; Shyamlal, Bharti Rajesh Kumar; Chaudhary, Sandeep] Malaviya Natl Inst Technol Jaipur, Lab Organ & Med Chem, Dept Chem, Jawaharlal Nehru Marg, Jaipur 302017, Rajasthan, India in 2019.0, Cited 76.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Category: isothiazole

Herein, we report an unprecedented, fast, highly efficient, transition-metal-free, modified Favorskii reaction-type direct alkynylation and (E)-alkenylation protocol towards the synthesis of alpha,beta-unsaturated ketones and propargyl alcohols that proceeds using the combination of Cs2CO3 and Et3N as weak bases in up to 99% yields. In this reaction, aromatic aldehydes afforded alpha,beta-unsaturated ketones and aliphatic aldehydes furnished propargyl alcohols, respectively. A proposed mechanistic pathway illustrates the involvement of weak base-assisted propargylation of carbonyl compounds followed by allenol-enone tautomerism to furnish (E)-alkenylated product.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Tiwari, MK; Yadav, L; Shyamlal, BRK; Chaudhary, S or concate me.

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An article Design, green one-pot synthesis and molecular docking study of novel N,N-bis(cyanoacetyl)hydrazines and bis-coumarins as effective inhibitors of DNA gyrase and topoisomerase IV WOS:000521282300012 published article about CYANOACETIC ACID HYDRAZIDE; HETEROCYCLIC-COMPOUNDS; ANTICANCER ACTIVITY; ESCHERICHIA-COLI; DERIVATIVES; PYRIDINE; ANTIBACTERIAL; THIOPHENE; THIAZOLE; PYRAZOLE in [Metwally, Nadia Hanafy; Abdallah, Sanaa Osman; Mohsen, Marwa Maher Abdel] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt in 2020.0, Cited 42.0. Name: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A novel, quick, environmentally safe, and one-pot synthesis of a series of N,N-bis(cyanoacetyl)hydrazine derivatives, bis-imino-2H-chromenes and bis-2-oxo-2H-chromene derivatives have been designed. Some selected newly synthesized compounds were investigated in vitro for their antibacterial activity. Compound 5j is the most toxic compound against Staphylococcus aureus with activity index 171%, followed by compound 15b with activity index 136% compared to standard drug ampicillin. Moreover, compound 15a is the most toxic compound against Escherichia coli with activity index 111% compared to standard drug gentamicin. Minimum inhibitory concentration (MIC) was carried out for compounds with high antibacterial activity. Compound 5j has good MIC (7.8 mu g/ml) against Staphylococcus aureus while 15a has good MIC (31.25 mu g/ml) against Streptococcus mutans which is better than MIC of the standard drug ampicillin (MIC = 62.5 mu g/ml). Compounds 5j, 5k, 15a, 15b and 15e which have good MIC values were introduced to enzyme assay against DNA gyrase and topoisomerase IV. The results showed that compound 15a can strongly inhibit DNA gyrase and topoisomerase IV (IC50 = 27.30 and 25.52 mu M respectively), compared to methotrexate as the standard drug (IC50 = 29.01 and 23.55 mu M respectively). Structure-activity relationships were also discussed based on the biological and docking simulation results.

Name: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Metwally, NH; Abdallah, SO; Mohsen, MMA or send Email.

Reference:
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