Category: 93-02-7

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives published in 2019.0. Category: isothiazole, Reprint Addresses Kim, I (corresponding author), Yonsei Univ, Coll Pharm, Incheon, South Korea.; Kim, I (corresponding author), Yonsei Univ, Yonsei Inst Pharmaceut Sci, Incheon, South Korea.; Kwon, HJ (corresponding author), Yonsei Univ, Chem Genom GRL, Dept Biotechnol, Seoul, South Korea.; Kim, SH (corresponding author), Korea Res Inst Chem Technol, Innovat Target Res Ctr, Therapeut & Biotechnol Div, Daejeon, South Korea.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A pyrrolo[1,2-a]pyrazine-based chemical territory was expanded via construction of new chemical library with distinctive substitution patterns, which was made possible by regiodivergent electrophilic acylation followed by aldol condensation. Biological screening of the compounds in this class revealed that the viability of human lymphoma U937 cells was strongly inhibited by 6b with a methoxy group at the o-position of the aromatic ring, but not by compounds 6t-w bearing a halogen at the o-position. Furthermore, 6x having a 2,4-dimethoxyphenyl group inhibited the survival of U937 cells more potently than 6b. In contrast, 6y possessing a 2,5-dimethoxyphenyl moiety did not show effective inhibition, implying the importance of orientation of the substituent(s) around the benzene ring. The anticancer action of 6x with safe therapeutic window could be associated with the FTase-p38 signaling axis.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kim, J; Park, M; Choi, J; Singh, DK; Kwon, HJ; Kim, SH; Kim, I or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Metwally, NH; Mohamed, MS; Ragb, EA in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about RAPID COLORIMETRIC ASSAY; BIOLOGICAL EVALUATION; DISCOVERY; IDENTIFICATION; MECHANISM; SURVIVAL; TARGETS; FAMILY; GROWTH in [Metwally, Nadia Hanafy; Mohamed, Mona Said; Ragb, Eman Ali] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt in 2019.0, Cited 40.0. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A novel series of pyrazolo[1,5-a]pyrimidines were synthesized and proved by their spectral and elemental analysis, some elected of the newly synthesized compounds were examined for their cytotoxic activity employing MTT assay on two cancer cell lines (Breast and Hela cancers). Compounds 5, 7e and 7i showed the higher cytotoxicity against two cancer cell lines with (IC50 = 13.91 +/- 1.4 and 22.37 +/- 1.8 mu M/L), (IC50 = 6.56 +/- 0.5 and 8.72 +/- 0.9 mu M/L) and (IC50 = 4.17 +/- 0.2 and 5.57 +/- 0.4 mu M/L) for two cancer cell lines breast and hela respectively, using doxorubicin as a reference drug. The most potent cytotoxic active compounds 5, 7e and 7i presented inhibitory activity against KDM (histone lysine demethylases) with IC50 = 4.05, 1.91 and 2.31 mu M, respectively. The most potent KDM inhibitor 7e (IC50 = 1.91 mu M) showed to cause cell cycle arrest at G2/M phase by 4 folds than control and induce total apoptotic effect by 10 folds more than control. In silico studies performed on the more potent cytotoxic active compounds 5, 7e and 7i included lipinisk’s rule of five. Moreover, molecular docking study was utilized to explore the binding mode of the most active compounds to the target enzyme (PDB-ID: 5IVE). Also, some bioinformatics studies were carried out for compounds 7e and 7i using Swiss ADME (Swiss Institute of bioinformatics 2018).

COA of Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Metwally, NH; Mohamed, MS; Ragb, EA or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article 1,10-Phenanthrolin-1-ium Trinitromethanide (1,10-PHTNM) as a Nano Molten Salt Catalyst With Y-Aromatic Counter Ion: Applications for Synthesis of Organic Compounds WOS:000455815600051 published article about ONE-POT SYNTHESIS; 1-METHYLIMIDAZOLIUM TRICYANOMETHANIDE; EFFICIENT CATALYST; REACTION MEDIA; DERIVATIVES; GREEN; LIQUID; 4,4′-(ARYLMETHYLENE)BIS(1H-PYRAZOL-5-OL); SOLVENT; ACETATE in [Dashteh, Mohammad; Baghery, Saeed; Zolfigol, Mohammad Ali] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Iran; [Bayat, Yadollah; Asgari, Asiye] Malek Ashtar Univ Technol, Fac Chem & Chem Engn, Tehran, Iran in 2019.0, Cited 57.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 2,5-Dimethoxybenzaldehyde

1,10-Phenanthrolin-1-ium trinitromethanide (1,10-PHTNM) as a novel nano molten slat with Y-aromatic counter ion was synthesized and fully characterized by using various techniques such as FT-IR, H-1 NMR, C-13 NMR, mass, TGA, DTG, XRD, SEM and TEM. A series of organic compounds include 1,4-dihydropyrano[2,3-c]pyrazoles, tetrahydrobenzo[b]pyran, pyrano[4,3-b]pyrans, bispyrazole, 1H-pyrazolo[3,4-b]quinolones, hexahydroacridine-1,8-diones and methylenebis(3-hydroxy-5,5-dimethylcyclohex-2-enones) were synthesized in the presence of 1,10-PHTNM as a novel and efficient proton sponge nano molten slat catalyst. According to the results of FT-IR, H-1 NMR, C-13 NMR, mass spectrum of 1,10-PHTNM and due to high electron charge density and none bonded repulsion of lone pair electrons between two nitrogen atoms (peri-effect), this catalyst is a type of proton sponge.

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Reference:
Isothiazole – Wikipedia,
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HPLC of Formula: C9H10O3. Authors Gein, VL; Buldakova, EA; Dmitriev, MV in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Gein, V. L.; Buldakova, E. A.] Perm State Pharmaceut Acad, Perm, Russia; [Dmitriev, M., V] Perm State Natl Res Univ, Perm, Russia in 2019.0, Cited 11.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Three-component reaction of methyl 4-aryl-2,4-dioxobutanoates with aromatic aldehyde and 2-aminoacetonitrile sulfate in glacial acetic acid in the presence of anhydrous sodium acetate afforded previously unknown (3-aroyl-2-aryl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetonitriles. The reaction involved intermediate formation of Schiff base, followed by Michael-type addition of the dioxo ester to the C=N bond and cyclization of the addition product, methyl 3-aroyl-4-aryl-4-(cyanomethylamino)-2-oxobutanoate. The cyclization product reacted with hydrazine hydrate at the aroyl carbonyl group to give the corresponding hydrazone which was converted in 1,4-dioxane to the cyclic form, [3,4-diaryl-6a-hydroxy-6-oxo-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazol-5(1H)-yl]acetonitrile, without elimination of the second water molecule. When the reaction of (3-aroyl-2-aryl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetomtriles with hydrazine hydrate was carried out in boiling acetic acid, [3,4-diaryl-6-oxo-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]acetonitriles were obtained as a result of dehydration of initially formed [3,4-diaryl-6a-hydroxy-6-oxo-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazol-5(1H)-yl]acetonitriles as shown by special experiment. The structures of [6a-hydroxy-6-oxo-3,4-diphenyl-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazol-5(1H)-yl]acetonitrile and [4-(4-methoxyphenyl)-6-oxo-3-phenyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]acetonitrile were determined by X-ray analysis.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Buldakova, EA; Dmitriev, MV or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about AUXILIARY BASIS-SETS; DENSITY-FUNCTIONAL METHODS; ZETA VALENCE QUALITY; GAUSSIAN-BASIS SETS; HIGH-FREQUENCY EPR; RIBONUCLEOTIDE REDUCTASE; GALACTOSE-OXIDASE; CORRELATION-ENERGY; CRYSTAL-STRUCTURE; PHOTOSYSTEM-II, Saw an article supported by the DSTDepartment of Science & Technology (India); CSIR, New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [09/028(1045)12018-EMR-I]; SERB-DST New Delhi, India [EMR/2016/005222]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Samanta, D; Saha, P; Ghosh, P. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Name: 2,5-Dimethoxybenzaldehyde

Stable phenoxyl radicals H-bonded to phenols were successfully isolated. The effect of the intermolecular Hbonding to the concerted proton coupled electron transfer (CPET) reactions of the aldimines and the stability and spin distribution of the H-bonded phenoxyls are reported. Salts of iminium-phenol derivatives as cations and the corresponding imine-phenolato derivatives coordinated to zinc(II) as anions, [Zn-II((ArO)-O-R)Cl-2](-)[(ArOH2)-O-R](+), were isolated, where ArOH are aldimine derivatives. Notably, [Zn-II((ArO)-O-R)Cl-2](-)[(ArOH2)-O-R](+) salts undergo CPET reactions in air affording phenoxyl analogues, [Zn-II(ArOH)Cl-2]center dot ArO center dot center dot CH3CN. [Zn-II((ArO)-O-R)Cl-2](-)[(ArOH2)-O-R](+) salts incorporate intermolecular iminium-phenolato, [(Zn)Ar-O–+HN=CH-] H-bonds, while [Zn-II(ArOH)Cl-2]center dot ArO center dot center dot CH3CN moieties contain intermolecular phenoxyl-phenol, [Ar-O-HO-Ar](center dot), H-bonds. The phenoxyls are presented in two forms, [(Zn)Ar-O-center dot—HO-Ar (zinc phenoxyl) <-> (Zn)Ar-OH—O-center dot-Ar (free phenoxyl)]. In crystals, the spin density scatters on both phenolic fragments corresponding to a delocalized state, while in solution the latter form has been calculated as a ground electronic state. The X-band EPR spectra of crystals, solutions and frozen glasses were analyzed. The powder spectra at g = 2.0030 +/- 0.0005 and the frozen glass spectra at g = 2.0075 +/- 0.0003 follow the hyperfine patterns due to N-14 (I = 1) nuclei. In fluid solutions, the g values of the hyperfine signals due to (14) N and H-1 nuclei are 2.0078 +/- 0.0001. 1-3 exhibit absorption bands at 350-390 nm due to pi ->pi* intraligand charge transfer (ILCT) transitions, while the radical species, in addition to pi ->pi transitions at 405-440 nm, display phenol to phenoxyl intervalence charge transfer (WCT) transitions at 600-650 nm. The cyclic voltammograms (CVs) of 1-3 depend on the scan rates; at lower scan rates (100-400 mV/s) the CPET reactions occur at -0.92 to -0.96 V versus Fc(+)/Fc couple, whereas at higher scan rates (1000-2400 mV/s), the oxidation occurs by the electron transfer (ET) path at 0.05-0.12 V. Thus, a potential shift of similar to 1.0 V is recorded due to CPET reactions facilitated by H-bonding.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Samanta, D; Saha, P; Ghosh, P or concate me.. Name: 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Quality Control of 2,5-Dimethoxybenzaldehyde. In 2020.0 J HETEROCYCLIC CHEM published article about RECEPTOR LIGANDS; INHIBITORS; DESIGN; BREAST; POTENT in [Metwally, Nadia H.; Ragab, Eman A.; Mohamed, Mona S.] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt in 2020.0, Cited 35.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Some novel N5-sulfonylated 4 were synthesized via sulfonylation of 5-amino-1H-pyrazole derivative 1 with arylsulfonyl chlorides. On the other hand, N1-alkylated pyrazoles 7 and 10 were synthesized through alkylation of compound 1 with each of chloroacetamides and ethylchloroacetate under different conditions. Condensation of compounds 4 and 7 with different aromatic aldehydes furnished the corresponding arylidene derivatives. In spite of, condensation of 10 with aromatic aldehydes afforded the 2-(5-amino-2-aryl-1H-pyrazol-1-yl)acetic acid. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. Also, the suggested mechanisms for their formation were studied. Additionally, some selected new compounds were screened against antimicrobial activity. Compound 7c exhibited a higher activity against Candida albicans (inhibition zone diameter [IZD] = 31.3 +/- 0.6 mm) than the standard antibiotic Nystatin (IZD = 21 +/- 0.5 mm). Also, compound 7c showed minimum inhibitory concentration = 125 and 250 mu g/mL against Klebsiella pneumonia and Staphylococcus aureus, respectively. Molecular docking study also was carried out for compound 7c.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Metwally, NH; Ragab, EA; Mohamed, MS or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about NITRIC-ACID; NANOCATALYST; CYCLOCONDENSATION; CHEMISTRY, Saw an article supported by the Payame Noor University. Safety of 2,5-Dimethoxybenzaldehyde. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Kalhor, M; Samiei, S; Mirshokraei, SA. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Microwave-activated synthesis is a special and remarkable technique in modern synthetic organic chemistry. In the current research, it is described the microwave-assisted synthesis of 2-aryl-4,5-dicarbonitrile imidazole derivatives via a one-step reaction between aromatic aldehydes and 2,3-diaminomaleonitrile (DAMN) using HNO3 as a metal-free catalyst and a strong oxidizing agent. The present methodology has significant advantages as like as one-step synthesis, shorter reaction times, available starting materials, and higher yields of products with easy purification process, cleaner reaction than the previously reported processes. The valuable benefits of this method have provided a promising prospect for easier, greener, and faster synthesis of diciano imidazoles.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kalhor, M; Samiei, S; Mirshokraei, SA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction WOS:000667711300005 published article about LACTIM-LACTAM TAUTOMERISM; PHOTOPHYSICAL PROPERTIES; SUBSTITUTED IMIDAZOLES; SPECTROSCOPIC APPROACH; ANTIFUNGAL AGENTS; IONIC LIQUIDS; GREEN; OXIDATION; HYDROGEN; SYSTEM in [Kadu, Vikas D.; Mali, Ganesh A.; Khadul, Siddheshwar P.; Kothe, Gokul J.] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India in 2021.0, Cited 59.0. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

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Isothiazole – Wikipedia,
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An article Tetrabutylammonium-Bromide-Promoted Synthesis of Spirooxindoles through Alkyne-Aldehyde C-C Coupling and 1,3-Dipolar Cycloaddition Using Ytterbium Triflate Catalyst WOS:000542426900029 published article about HECK REACTION; AZOMETHINE YLIDES; AMINO-ACIDS; DERIVATIVES; SPIROPYRROLIZIDINES; HETEROCYCLES; CHEMISTRY; PALLADIUM; PROTOCOL; KETONES in [Teja, Chitrala; Khan, Fazlur Rahman Nawaz] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India in 2020.0, Cited 37.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 93-02-7

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Efficient Synthesis of Medicinally Important Benzylidene-indolin-2-one Derivatives Catalyzed by Biodegradable Amino Sugar Meglumine WOS:000469516900013 published article about 3-COMPONENT COMBINATORIAL SYNTHESIS; ONE-POT; INHIBITORS; DESIGN in [Patel, Chetananda; Kumar, Amit; Patil, Pooja; Sharma, Abha] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Raebareli, India in 2019.0, Cited 23.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

An efficient synthesis of biologically important benzylidene-indolin-2-one derivatives using meglumine as green catalyst and ethanol:water as reaction media at 78 degrees C has been developed. The effects of reaction conditions such as solvents, temperature, and amount of catalyst were investigated. The present methodology offers many advantages such as simple procedure, less time taking to complete the reaction, high yield of products, and clean reaction profile.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Patel, C; Kumar, A; Patil, P; Sharma, A or concate me.. Recommanded Product: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com