Category: 93-02-7

I found the field of Chemistry very interesting. Saw the article Palladium Catalyzed Cross-Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2-b]quinazolinone published in 2019. SDS of cas: 93-02-7, Reprint Addresses Dabiri, M (corresponding author), Shahid Beheshti Univ, Fac Chem & Petr Sci, Dist 1,Daneshjou Blvd, Tehran 1983969411, Tehran Province, Iran.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-butyl hydroperoxide (TBHP) as the oxidant in good yield.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Three-Component Reaction of Dimedone with Aromatic Aldehydes and 5-Aminotetrazole WOS:000473192500004 published article about MULTICOMPONENT SYNTHESIS; LIBRARY in [Gein, V. L.; Prudnikova, A. N.; Kurbatova, A. A.; Novikova, V. V.; Rudakova, I. P.; Starikov, A. L.] Perm State Pharmaceut Acad, Ul Polevaya 2, Perm 614990, Russia; [Dmitriev, M. V.] Perm State Natl Res Univ, Perm, Russia in 2019.0, Cited 17.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Reactions of dimedone with aromatic aldehyde and 5-aminotetrazole monohydrate proceeded with the formation of 9-aryl-6,6-dimethyl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazoline-8(4H)-ones or 9-aryl-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-diones depending on the nature of substituent in aromatic aldehyde. Antimicrobial, antifungal and analgesic activities of the synthesized compounds were studied.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Prudnikova, AN; Kurbatova, AA; Dmitriev, MV; Novikova, VV; Rudakova, IP; Starikov, AL or concate me.

Reference:
Isothiazole – Wikipedia,
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Authors Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ in ROYAL SOC CHEMISTRY published article about LACTIM-LACTAM TAUTOMERISM; PHOTOPHYSICAL PROPERTIES; SUBSTITUTED IMIDAZOLES; SPECTROSCOPIC APPROACH; ANTIFUNGAL AGENTS; IONIC LIQUIDS; GREEN; OXIDATION; HYDROGEN; SYSTEM in [Kadu, Vikas D.; Mali, Ganesh A.; Khadul, Siddheshwar P.; Kothe, Gokul J.] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India in 2021.0, Cited 59.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

Recommanded Product: 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Harras, MF; Sabour, R; Ammar, YA; Mehany, ABM; Farrag, AM; Eissa, SI in [Harras, Marwa F.; Sabour, Rehab; Farrag, Amel M.; Eissa, Sally I.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, Cairo, Egypt; [Ammar, Yousry A.] Al Azhar Univ, Fac Sci Boys, Dept Organ Chem, Cairo, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci Boys, Dept Zool, Cairo, Egypt; [Eissa, Sally I.] Almaarefa Univ, Coll Pharm, Riyadh, Saudi Arabia published Design synthesis and cytotoxicity studies of some novel indomethacin-based heterocycles as anticancer and apoptosis inducing agents in 2021, Cited 48. Product Details of 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Indomethacin is a well-known nonsteroidal anti-inflammatory drug that has cytotoxic activity. In this study, a new series of structurally related indomethacin analogues was synthesized using simple chemical approaches, and their cytotoxic effects against five different human cancer cell lines (colon cancer cell lines HCT-116, HT-29 and Caco-2, hepatic cell line HepG-2 and breast cell line MCF-7) were evaluated. Most of the tested compounds displayed potent anti-cancer activity, especially against the three colon cancer cell lines. Among all tested derivatives, compound 12 demonstrated the most potent cytotoxic activity compared to the parent drug indomethacin and the reference compound 5-fluorouracil, with IC 50 values ranging 0.83-1.54 mu M. A mechanistic study of the most active compound against the HCT-116, HT-29 and Caco-2 cell lines revealed cell cycle arrest during the G2/M phase. Compound 12 was found to induce apoptosis through the up-regulation of Bax and p53 by 7.4 and 8.5-fold, respectively, and also the downregulation of Bcl-2 by 3.2-fold compared to the control. Western blot assay was performed on HCT-116 cells and demonstrated marked inhibition of CDK1 and Bcl-2 expression together with an increase in the expression of caspase-3, Bax and p53 in a concentration-dependent manner. Finally, a prediction of the chemo-informatic properties of compounds 11 and 12 indicated that they are orally bioavailable with no permeation of the blood-brain barrier. (C) 2020 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Harras, MF; Sabour, R; Ammar, YA; Mehany, ABM; Farrag, AM; Eissa, SI or concate me.. Product Details of 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Efficient preparation of 1,8-dioxo-octahydroxanthene derivatives by recyclable cobalt-incorporated sulfated zirconia (ZrO2/SO42-/Co) nanoparticles WOS:000490474600001 published article about ONE-POT SYNTHESIS; ACIDIC IONIC LIQUID; REUSABLE CATALYST; N-BUTANE; COMPLEX; OXIDE; ZRO2; EPOXIDATION; XANTHENES; OLEFINS in [Nasseri, Mohammad Ali; Kazemnejadi, Milad; Assadzadeh, Fahimeh; Alavi, Seyyedeh Ameneh; Allahresani, Ali] Univ Birjand, Fac Sci, Dept Chem, POB 97175-615, Birjand, Iran; [Mahmoudi, Boshra] Cihan Univ Sulaimani, Med Lab Dept, Sulaimani 46001, Kurdistan Regio, Iraq; [Mahmoudi, Boshra] Sulaimani Polytech Univ, Res Ctr, Sulaimani 46001, Kurdistan Regio, Iraq in 2019.0, Cited 67.0. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

This study presents one-pot multicomponent preparation of 1,8-dioxo-octahydroxanthene derivatives under very mild conditions using cobalt-incorporated sulfated zirconia (ZrO2/SO42-/Co) as an efficient heterogeneous recyclable multifunctional nanocatalyst. The nanocatalyst was successfully characterized by FTIR, XRD, TGA, FE-SEM, TEM, ICP, and EDX analyses. The nanoparticles have a mean size of 13 nm, with a combination of the monoclinic-tetragonal crystal structure. A wide scope of aldehydes bearing different functional groups was condensed with dimedone and/or 1,3-cyclohexadione in water at room temperature with good-to-high yields at short reaction times. The catalyst can be efficiently recovered and reused several times without much loss of its activity. Besides, hot filtration test gives more insight into the heterogeneous nature of the catalyst. Finally, a plausible mechanism for this transformation was proposed. Graphical abstract A facile and convenient method for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed using cobalt-incorporated sulfated zirconia as an efficient recyclable nanocatalyst.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Nasseri, MA; Kazemnejadi, M; Mahmoudi, B; Assadzadeh, F; Alavi, SA; Allahresani, A or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C9H10O3. Recently I am researching about DERIVATIVES; COUMARIN; ANNULATION, Saw an article supported by the UGC, New Delhi (UGC) [22/06/2014(i) EU-V]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Rani, S; Kamra, N; Kumar, D; Kumar, A. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A series of furo[3,2-c]pyrones and furo[3,2-c]coumarins agents were efficiently synthesized and structure recognizable proof was performed by FTIR and NMR. The furo[3,2-c]pyrones and furo[3,2-c]coumarins were evaluated against three bacterial strains (Bacillus subtilis, Staphylococcus aureus and Escherichia coli) and two parasitic strains (Aspergillus niger and Candida albicans). The antimicrobial results demonstrated that a couple of compounds showed noteworthy outcomes relating to the standard medications. Compounds 6 b and 9 f indicated great action against Escherichia coli and Bacillus subtilis with MIC value 0.0108 mu mol/ml and 0.0120 mu mol/ml, respectively. Compound 9 f also showed better activity against fungal strains with MIC value 0.0120 mu mol/ml. Based on the outcomes of antimicrobial activities, docking study was performed to know the binding interface of furo[3,2-c]pyrones and furo[3,2-c]coumarins with DNA gyrase topoisomerase II.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rani, S; Kamra, N; Kumar, D; Kumar, A or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Inhibition of nitric oxide and prostaglandin E-2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies published in 2020.0. Safety of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Faudzi, SMM (corresponding author), Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E-2 (PGE(2)) suppression ability on IFN-gamma/LPS-induced RAW 264.7 macrophage cells. Results showed that none of the synthesized compounds were PAINS-associated molecules, with 3-(2,5-dimethoxyphenyl)-1-(1H-pyrrol-2-yl) prop-2-en-1-one (compound 16) exhibiting remarkable inhibition activity towards PGE(2) and NO production with IC50 values of 0.5 +/- 1.5 mu M and 12.1 +/- 1.5 mu M, respectively. Physicochemical and ADMET studies showed that majority of the compounds obey to Lipinski’s rule of five (RO5) having high blood brain barrier (BBB) penetration, human intestinal absorption (HIA), P- glycoprotein (PgP) inhibition and plasma binding protein (PPB) inhibition. The obtained atomic coordinates for the single-crystal XRD of 16 were then applied in a molecular docking simulation, and compound 16 was found to participate in a number of important binding interactions in the binding sites of ERK and mPGES-1. Based on these results, we have observed the potential of compound 16 as a new hit anti-inflammatory agent, and these findings could serve as a basis for further studies on its mechanism of action.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Faudzi, SMM; Abdullah, MA; Manap, MRA; Ismail, AZ; Rullah, K; Aluwi, MFFM; Ramli, ANM; Abas, F; Lajis, NH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C9H10O3. In 2020.0 CHEMISTRYSELECT published article about ORGANIC HALIDES; CONVENIENT OXIDATION; CARBONYL-COMPOUNDS; SELECTIVE METHOD; MILD OXIDATION; ALDEHYDES; CONVERSION; OXYGENATION; INHIBITORS; ALCOHOLS in [Aman, Hasil; Chen, Yuan-Ching; Tu, Jing-Wen; Chang, Chia-Chi; Chuang, Gary Jing] Chung Yuan Christian Univ, Dept Chem, Chungli 32023, Taiwan in 2020.0, Cited 41.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

An effective approach for the synthesis of aryl aldehydes from the corresponding benzylbromides was accomplished. Without need of additional additives or stoichiometric oxidants, this environmental friendly and milder version of Kornblum oxidation simply utilized the irradiation of visible light in DMSO under O-2, and is compatible with the substrate with different functional groups.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Aman, H; Chen, YC; Tu, JW; Chang, CC; Chuang, GJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; DISCOVERY, Saw an article supported by the University of HyderabadUniversity of Hyderabad; SERBDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [EMR/2016/003801]; UGC-SAP-DRS-1. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Jangir, N; Padhi, SK. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. HPLC of Formula: C9H10O3

Hydroxynitrile lyase (HNL) catalyzed enantioselective C-C bond formation is an efficient approach to synthesize chiral cyanohydrins which are important building blocks in the synthesis of a number of fine chemicals, agrochemicals and pharmaceuticals. Immobilization of HNL is known to provide robustness, reusability and in some cases also enhances activity and selectivity. We optimized the preparation of immobilization of Baliospermium montanum HNL (BmHNL) by cross linking enzyme aggregate (CLEA) method and characterized it by SEM. Optimization of biocatalytic parameters was performed to obtain highest % conversion and ee of (S)-mandelonitrile from benzaldehyde using CLEA-BmHNL. The optimized reaction parameters were: 20 min of reaction time, 7 U of CLEA-BmHNL, 1.2 mM substrate, and 300 mM citrate buffer pH 4.2, that synthesized (S)-mandelonitrile in 99% ee and 60% conversion. Addition of organic solvent in CLEA-BmHNL biocatalysis did not improve in % ee or conversion of product unlike other CLEA-HNLs. CLEA-BmHNL could be successfully reused for eight consecutive cycles without loss of conversion or product formation and five cycles with a little loss in enantioselectivity. Eleven different chiral cyanohydrins were synthesized under optimal biocatalytic conditions in up to 99% ee and 59% conversion, however the % conversion and ee varied for different products. CLEA-BmHNL has improved the enantioselectivity of (S)mandelonitrile synthesis compared to the use of purified BmHNL. Nine aldehydes not tested earlier with BmHNL were converted into their corresponding (S)-cyanohydrins for the first time using CLEA-BmHNL. Among the eleven (S)-cyanohydrins syntheses reported here, eight of them have not been synthesized by any CLEA-HNL. Overall, this study showed preparation, characterization of a stable, robust and recyclable biocatalyst i.e. CLEA-BmHNL and its biocatalytic application in the synthesis of different (S)-aromatic cyanohydrins.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Jangir, N; Padhi, SK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis of some 5-arylidene-2-(4-acetamidophenylimino)-thiazolidin-4-one derivatives and exploring their breast anticancer activity WOS:000510027200001 published article about BIOLOGICAL EVALUATION; 1,3-THIAZOLIDIN-4-ONE DERIVATIVES; CYTOTOXIC ACTIVITY; AGENTS; IDENTIFICATION; 4-THIAZOLIDINONES; ANTIOXIDANT; INHIBITORS; DESIGN; CANCER in [Abumelha, Hana M. A.] Princess Nourah Bint Abdulrahman Univ, Fac Sci, Dept Chem, Riyadh 84428, Saudi Arabia; [Saeed, Ali] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt in 2020.0, Cited 31.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3

Ten 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-one derivatives 6a-k were synthesized and evaluated for their anticancer activity against MCF-7 cell line (breast adenocarcinoma). The synthetic approach involves cyclocondensation of N,N ‘-bis(4-acetamidophenyl)-thiourea (3) with ethyl bromoacetate in ethanol and sodium acetate to furnish the 2-(4-acetamidophenylimino)-4-thiazolidinone derivative 4, which underwent Knoevenagel condensation reaction with some substituted aldehydes to afford the targeted 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-ones 6a-k. The 4-chlorobenzylidene-thiazolidin-4-one compound 6h exhibited strong inhibitory effect on the growth of breast cancer cell with IC50 (58.33 +/- 1.74 mu M), very close to that of the reference drug doxorubicin (IC50 48.06 +/- 0.36 mu M).

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abumelha, HMA; Saeed, A or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com