Category: 93-02-7

I found the field of Chemistry very interesting. Saw the article An Atom-Economic Efficient Synthesis of 1-Amidoalkyl-2-Naphthols Mediated By Hexachlorocyclotriphosphazene (HCCP) as a Novel Catalyst published in 2019.0. COA of Formula: C9H10O3, Reprint Addresses Singh, RK (corresponding author), Shivalik Coll Pharm, Dept Pharmaceut Chem, Nangal 140126, Punjab, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A multicomponent one-pot atom-economic reaction is performed for an efficient synthesis of 1-amidoalkyl-2-naphthol from aromatic aldehydes, beta-naphthol and amide/urea promoted by hexachlorocyclotriphosphazene (HCCP). Various techniques such as stirring, microwave irradiation and thermal technique (hot plate and oil bath) were used in different solvents for the synthesis of 1-amidoalkyl-2-naphthol derivatives with moderate to excellent yield. Among the four methods, microwave irradiation and oil bath heating provide high yield as compared to the hot plate heating and stirring method. The low yield may be due to the formation of undesired side-products due to non-uniform heating.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Singh, RK; Chaudhary, S; Prasad, DN; Kumar, S or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Halder, S in [Halder, Samiran] Charuchandra Coll, Dept Chem, 22 Lake Rd, Kolkata 700029, India published Vanadyl Acetylacetonate-Copper (II) Trifluoro Methane Sulfonate Catalyzed Eco-friendly Synthesis of Substituted Benzimidazoles in Aqueous Media in 2020.0, Cited 68.0. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Various substituted benzimidazoles have been successfully synthesized in aqueous medium by developing VO(acac)(2)-Cu(OTf)(2) catalytic system. A green synthetic protocol has been created in presence of water and cetyltrimethyl ammonium bromide (CTAB) system in an organic solvent free condition. This chemoselective cyclocondensation cumoxidation process occurred in aqueous media. In this suitable method easily synthesized 2-Substituted benzimidazoles with good yields and no 1,2-disubstituted by-products were noticed. Excellent yields, environmentally benign and mild reaction condition, easy purification of the desired products are the main attractive features of this newly devised method. [GRAPHICS]

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Halder, S or concate me.

Reference:
Isothiazole – Wikipedia,
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Recommanded Product: 93-02-7. Recently I am researching about GREEN FLUORESCENT PROTEIN; INTRAMOLECULAR PROTON-TRANSFER; AGGREGATION-INDUCED EMISSION; QUANTUM-CHEMICAL BENCHMARK; ELECTRONIC-PROPERTIES; PHOTOPHYSICS; DYNAMICS; STATES, Saw an article supported by the National Basic Research Program of ChinaNational Basic Research Program of China [2015CB931801]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473093, 21404070]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deng, HP; Yu, CY; Yan, DY; Zhu, XY. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

The tremendous gap of fluorescence emission of synthetic green fluorescent protein (GFP) chromophore to the protein itself makes it impossible to use for applications in molecular and cellular imaging. Here, we developed an efficient methodology to enhance the photoluminescence response of synthetic GFP chromophore analogues by constructing dual-self-restricted chromophores. Single self-restricted chromophores were first generated with 2,5-dimethoxy substitution on the aromatic ring, which were further modified with phenyl or 2,5-dimethoxy phenyl to form dualself-restricted chromophores. These two chromophores showed an obvious solvatofluorochromic color palette across blue to yellow with a maximum emission Stokes shift of 95 nm and dramatically enhanced fluorescence emission in various aprotic solvents, especially in hexane, where the QY reached around 0.6. Importantly, in acetonitrile and dimethyl sulfoxide, the fluorescence QYs of both chromophores were over 0.22, which were the highest reported so far in high polar organic solvents. Meanwhile, the fluorescence lifetimes also improved obviously with the maximum of around 4.5 ns. Theoretical calculations revealed a more favorable Miilliken atomic charge translocation over the double-bond bridge and illustrated much higher energy barriers for the Z/E photoisomerization together with larger bond orders compared with the GFP core chromophore, p-HBDI. Our work significantly improved the fluorescence emission of synthetic GFP chromophore analogues in polar solvents while reserved the multicolor emitting function, providing a solid molecular motif for engineering high-performance fluorescent probes.

Recommanded Product: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Deng, HP; Yu, CY; Yan, DY; Zhu, XY or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors WOS:000450397300001 published article about ALZHEIMERS-DISEASE; BUTYRYLCHOLINESTERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASE-1; POTENT; ACETYLCHOLINESTERASE; DERIVATIVES; DISCOVERY; THERAPY; CANCER; CHALCONE in [Gao, Cheng-Zhi; Dong, Wei; Cui, Zhi-Wen; Yuan, Qiong; Wu, Qing-Ming; Min, Zhen-Li] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430081, Hubei, Peoples R China; [Hu, Xia-Min] Shanghai Univ Med & Hlth Sci, Coll Pharm, Shanghai, Peoples R China; [Han, Xianlin; Min, Zhen-Li] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA; [Xu, Yao] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan, Hubei, Peoples R China in 2019.0, Cited 37.0. Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 +/- 1.25 nM) and MDA-MB-436 cancer cell (11.62 +/- 2.15 mu M), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 +/- 0.91 mu M) which was stronger than neostigmine (12.01 +/- 0.45 mu M) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gao, CZ; Dong, W; Cui, ZW; Yuan, Q; Hu, XM; Wu, QM; Han, XL; Xu, Y; Min, ZL or concate me.. Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020.0 HETEROCYCLES published article about METAL PICRATE EXTRACTION; RING-CLOSING METATHESIS; BIOLOGICAL EVALUATION; MEDICINAL AGENTS; ADAMANTYL GROUP; DERIVATIVES; CHEMISTRY; THIAZOLE; LIGANDS; ACID in [Kotha, Sambasivarao; Cheekatla, Subba Rao] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India in 2020.0, Cited 97.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Here, we have established a new and simple synthetic approach to the pentacycloundecane containing cage oxazole unit in four steps. The synthesis begun with a cheap and readily available materials such as 2,5-dimethoxybenzaldehyde and endo-dicyclopentadiene. This approach relies on Van Leusen oxazole synthesis and [2+2] photocycloaddition as key steps. To the best of our knowledge, this is the first example of Cookson’s dione containing oxazole ring system. Some of these oxazole motifs are useful in bioorganic chemistry and our results are likely to draw the attention of medicinal chemists

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kotha, S; Cheekatla, SR or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Structure fragmentation studies of ring-substituted N-trifluoroacetyl-N-benzylphenethylamines related to the NBOMe drugs WOS:000508347200005 published article about 25I-NBOME; DERIVATIVES in [Almalki, Ahmad J.; Clark, C. Randall; DeRuiter, Jack] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA; [Almalki, Ahmad J.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah, Saudi Arabia in 2020.0, Cited 8.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Rationale The halogenated derivatives of N-(2-methoxy)benzyl-2,5-dimethoxyphenethylamine (25-NBOMe) such as the 4-bromo analogue (25B-NBOMe) represent a new class of hallucinogenic or psychedelic drugs. The purpose of this study was to determine the role of the electron-donating groups (halogen and dimethoxy) in the pathway of decomposition for the distonic molecular radical cation in the electron ionization mass spectrometry (EI-MS) process of the trifluoroacetamide (TFA) derivatives. Methods The systematic removal of substituents from the 4-halogenated 2,5-dimethoxyphenethylamine portion of the N-dimethoxybenzyl NBOMe analogues allowed an evaluation of structural effects on the formation of major fragment ions in the EI-MS of the TFA derivatives. All six regioisomeric dimethoxybenzyl-substituted analogues (2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-dimethoxy) for the four series of phenethyl aromatic ring substitution patterns were prepared, derivatized and analyzed via gas chromatography coupled with EI-MS. Results The analogues yield two unique radical cation fragments from the decomposition of the common distonic molecular radical cation. The substituted phenylethene radical cation (m/z 164) is the base peak or second most abundant ion in all six TFA-2,5-dimethoxyphenethylamine isomers. The dimethoxybenzyltrifloroacetamide radical cation (m/z 263) is the base peak or second most abundant ion in the 2- and 3-monomethoxyphenethylamine isomers. However, the 2- and 3-methoxyphenylethene radical cation (m/z 134) is among the five most abundant ions for each of these twelve isomers. Only one isomer in the phenethylamine series yields the corresponding unsubstituted phenylethene radical cation at m/z 104. Conclusions The decomposition of the hydrogen-rearranged distonic molecular radical cation favors formation of the dimethoxybenzyltrifloroacetamide (m/z 263) species for the less electron-rich phenethyl aromatic rings. The addition of electron-donating groups to the aromatic ring of the phenethyl group as in the NBOMe-type molecules shifts the decomposition of the common distonic molecular radical cation to favor the formation of the electron-rich substituted phenylethene radical cation.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Almalki, AJ; Clark, CR; DeRuiter, J or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about SODIUM DODECYL-SULFATE; POT 3-COMPONENT SYNTHESIS; CROSS-COUPLING REACTIONS; EFFICIENT SYNTHESIS; BIS(INDOLYL) METHANES; BIOLOGICAL-ACTIVITY; ISOPROPANOL-WATER; MICHAEL ADDITIONS; INDOLYL METHANES; ROOM-TEMPERATURE, Saw an article supported by the Chhatrapati Shahu Maharaj Research Training and Human Development Institute (SARTHI), Pune (Government of Maharashtra), India [CIN-U74999PN-2018NPL177394]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Patil, RC; Damate, SA; Zambare, DN; Patil, SS. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. HPLC of Formula: C9H10O3

A clean and highly efficient protocol for green synthesis of bis(indole)methanes and bis(pyrazolyl)methanes has been successfully achieved by using a naturally sourced bio-surfactant, chickpea leaf exudates (CLE), as a Bronsted acid-type catalyst. The reaction proceeds smoothly with CLE in alcoholic medium at 60 degrees C in a very short reaction time, and therefore it is a green, environmentally sound alternative to the existing protocols. In comparison to the reported conventional methods, this synthetic pathway complies with several key requirements of green chemistry principles such as avoiding the use of any toxic/hazardous catalyst and additives/promoters, the use of a biodegradable catalyst obtained from renewable resources, auxiliary solvent conditions, and reusability of the catalyst. Thus, the reported protocol offers an attractive option because of its ecological safety, straightforward work-up procedure and excellent values of green chemistry metrics as compared with other reported methods.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Patil, RC; Damate, SA; Zambare, DN; Patil, SS or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design, Synthesis and Antibacterial Evaluation of Hybrid Curcumin Based Pyrazole Derivatives published in 2020.0. Quality Control of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Jha, AM (corresponding author), BN Mandal Univ, MLT Coll Saharsa, Dept Chem, Madhepura 852201, Bihar, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Present work demonstrates synthesis and antibacterial property of new pyrazole derivatives. A series of new Curcumin based dihydropyrazoles has been synthesized with an objective to evaluate their antibacterial property. Dihydropyrazoles analogues were synthesized using Curcumin based chalcones and differently substituted phenylhydrazine derivatives. We used the previously designed Curcumin based chalconesto react with phenylhydrazine derivatives in ethanol in a catalyst free medium to afford new dihydropyrazole derivatives. Effect of substituent on reactivity was also studied. All the synthesized pyrazole analogues were characterized using proton and carbon NMR, Mass spectroscopy and IR techniques. Effect of substituent on reactivity was explained on the basis of electronic effect generated due to groups on phenyl ring. Presence of dd (double doublet) in proton NMR spectrum of Dihydropyrazoles was also explained due to presence of optically active carbon of pyrazole ring. The synthesized library was screened for their inhibitory activity against 4 different bacterial strains 1. E. Coli (ATCC 9637), 2. Pseudomonas aeruginosa (ATCC BAA-427), 3. Staphylococcus aureus (ATCC 25923) and 4. Klebsiella pneumonia (ATCC 27736). Out of all the compounds evaluated, the compounds that exhibited IC50 value greater than 50 mu M, were considered to be inactive. We established an important SAR based on the structure dependent inhibitory potential of screened dihydropyrazoles. Two compounds 4e and 4t having nitro and benzyl substitution respectively were showing the best inhibitory potential against Gram Positive bacterial strain Staphylococcus aureus with MIC value of 1.56 mu g/ml. Compounds having Chloro and Methoxy substitution were found to be less effective against screened bacterial strains. Compounds 4a and 4b were selective towards Staphylococcus aureus species with the MIC value of 1.56 mu g/ml for each. These pyrazole analogues were not showing inhibitory potential against other screened bacterial strains.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Jha, AM; Alam, MM or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 93-02-7. Authors Wadhwa, P; Jain, P; Jadhav, HR in BENTHAM SCIENCE PUBL LTD published article about in [Wadhwa, Pankaj; Jain, Priti; Jadhav, Hemant R.] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India; [Wadhwa, Pankaj] Lovely Profess Univ, Lovely Sch Pharmaceut Sci, Phagwara 144401, Punjab, India; [Jain, Priti] RC Patel Inst Pharmaceut Educ & Res, Shirpur, Dhule, India in 2021.0, Cited 18.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aim: To design, synthesis and in vitro evaluation of 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives as HIV integrase strand transfer inhibitors. Background: Human immunodeficiency virus-1 (HIV-1), a member of retroviridae family, is the primary causative agent of acquired immunodeficiency syndrome (AIDS). Three enzymes viz: integrase (IN), reverse transcriptase (RT) and protease play important role in its replication cycle. HIV-1 integrase is responsible for the incorporation of viral DNA into human chromosomal DNA by catalyzing two independent reactions, 3′-processing (3′-P) and strand transfer (ST), which are observed as the point of no-return in HIV infection. Objective: To develop inhibitors against HIV integrase strand transfer step. Methods: Our previous results indicated that tetrahydro pyrimidine-5-carboxamide derivatives are potent HIV-1 IN inhibitors (unpublished results from our laboratory). Taking clue from above studies and our own experience, we hypothesized 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues (14a to 14n) as inhibitors of HIV-1 Integrase strand transfer. Prototype compound 14 can be viewed as hybrid structure having characteristics of dihydropyrimidine derivatives 10-12 and tyrphostin 13. Results: A total of fourteen derivatives of 4-oxo-6-substituted phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (14a-14n) were synthesized and evaluated using HIV-1 Integrase Assay Kit (Xpressbio Life Science Products, USA). The percentage inhibition of all compounds was investigated at 10 mu M concentration and IC50 value of few highly active compounds was studied. The obtained results were validated by in silico molecular docking study using Glide (maestro version 9.3, Schrodinger suite) in extra precision (XP) mode. Conclusion: Fourteen 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues were synthesized and evaluated for HIV-1 IN inhibitory activity. Three compounds 14a, 14e, and 14h exhibited significant percentage inhibition of HIV-1 IN. There was good in vitro – in silico correlation. However, none of the derivative was active against HIV-1 and HIV-2 below their cytotoxic concentration. It needs to be seen whether these compounds can be explored further for their anti-HIV or cytotoxic potential.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Wadhwa, P; Jain, P; Jadhav, HR or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)-O Bonds Enabled by Chromium Catalysis WOS:000529959000001 published article about CARBON-HETEROATOM BONDS; GRIGNARD-REAGENTS; AROMATIC KETONES; ARYL HALIDES; NI; ETHERS; ACTIVATION; CLEAVAGE; EXPLORATION; ANISOLES in [Tang, Jinghua; Yang, Shangru; Cong, Xuefeng; Luo, Meiming; Zeng, Xiaoming] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China; [Liu, Liu Leo] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA in 2020.0, Cited 60.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Category: isothiazole

We report here the first example of cross-coupling between two different and unactivated C(aryl)-O bonds with chromium catalysis. The combination of a low-cost Cr(II) salt, 4,4′-di-tart-butyl-2,2′-dipyridyl (dtbpy) as the ligand, and magnesium as the reductant shows high reactivity in promoting the reductive cross-coupling of aryl methyl ether derivatives with aryl esters by cleavage and coupling of two different C(aryl)-O bonds under mild conditions. The formation of active low-valent Cr species by reduction of CrCl2 with Mg can be considered, which prefers to initially activate the C(aryl)-O bond of phenyl methyl ether with the chelation help of dtbpy and an o-imine auxiliary. The subsequent consecutive reduction, second C(aryl)-O activation, and reductive elimination allow for the achievement of selective cross-coupling of C(aryl)-O/C(aryl)-O bonds.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Tang, JH; Liu, LL; Yang, SR; Cong, XF; Luo, MM; Zeng, XM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com