Category: 99-04-7

I found the field of Chemistry very interesting. Saw the article NBS-activated cross-dehydrogenative esterification of carboxylic acids with DMSO published in 2020. Name: 3-Methylbenzoic acid, Reprint Addresses Tang, L (corresponding author), Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Henan, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

The firstN-bromosuccinimide (NBS)-promoted transition metal-free cross-dehydrogenative esterification of carboxylic acids with dimethyl sulfoxide (DMSO) has been disclosed for formal C-O formationviaPummerer-type rearrangement. These transformations employ readily available carboxylic acids as the nucleophile and DMSO as the sulfur-containing carbon source and solvent under mild conditions, affording valuable (methylsulfinyl)methyl esters with a broad substrate scope. Furthermore, the developed protocol provides an efficient and straightforward method for the preparation of deuterated (methylsulfinyl)methyl esters by use of deuterium-labelled DMSO as the reagent.

Welcome to talk about 99-04-7, If you have any questions, you can contact Wu, Y; Zhang, MS; Zhang, YL; Li, MY; Feng, WS; Zheng, XK; Tang, L or send Email.. Name: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
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Name: 3-Methylbenzoic acid. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Cobalt-Catalyzed Reductive Alkylation of Amines with Carboxylic Acids published in 2019, Reprint Addresses Sundararaju, B (corresponding author), Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

Direct reductive alkylation of amines with carboxylic acid is carried out by using an inexpensive, air-stable cobalt/triphos catalytic system with molecular hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ-generated imine into the amine in a green catalytic process.

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Reference:
Isothiazole – Wikipedia,
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In 2021 SYNTHESIS-STUTTGART published article about METHYL KETONES; INTRAMOLECULAR CYCLIZATION; ELECTROPHILIC CYCLIZATION; MICHAEL ADDITION; ACCESS; STRATEGY; ANILINES; HYDROCHLORIDE; DERIVATIVES; INDOLES in [Zhou, Xiao-Yu; Chen, Xia] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China in 2021, Cited 63. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. HPLC of Formula: C8H8O2

Iodine-catalyzed oxidative C(sp(3))-H acyloxylation of acetone with carboxylic acids has been developed. The method employs iodide-as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids can be used, and 2-oxopropyl carboxylates are obtained with good to excellent yields.

HPLC of Formula: C8H8O2. Welcome to talk about 99-04-7, If you have any questions, you can contact Zhou, XY; Chen, X or send Email.

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Isothiazole – Wikipedia,
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Luo, FH; He, SH; Gou, Q; Chen, JY; Zhang, MZ in [Luo, Feihua] Yangtze Normal Univ, Coll Mat Sci & Engn, Fuling 408100, Peoples R China; [He, Shuhua; Gou, Quan; Chen, Jinyang; Zhang, Mingzhong] Yangtze Normal Univ, Sch Chem & Chem Engn, Fuling 408100, Peoples R China published Rhodium-catalyzed oxidative coupling of benzoic acids with propargyl alcohols: An efficient access to isocoumarins in 2021, Cited 40. Application In Synthesis of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

An efficient protocol of Rh(III)-catalyzed oxidative cyclization of benzoic acids with propargyl alcohols to give substituted isocoumarins under mild conditions was reported. A variety of substrates were applied in this reaction in yields up to 89%. (C) 2020 Elsevier Ltd. All rights reserved.

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Reference:
Isothiazole – Wikipedia,
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Recently I am researching about FACILE SYNTHESIS; DERIVATIVES; 1,3,4-THIADIAZOLE; ANTICANCER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21262012]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2016CFB400]. Published in CHINESE JOURNAL STRUCTURAL CHEMISTRY in FUJIAN ,Authors: Song, XJ; Wang, XM; Sun, Q; Huang, ST; Wang, Y. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. HPLC of Formula: C8H8O2

N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas 4a similar to 4i were designed and synthesized as antitumor agents, and their structures were characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. The single crystal of compound 4a, C17H13FN4OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) angstrom, beta = 93.320(3)degrees, V = 1572.4(5) angstrom(3), Z = 4, F(000) = 704, D-c = 1.438 g/cm(3), mu = 0.228 mm(-1), R = 0.0600 and wR = 0.1448 for 2743 independent reflections (R-int = 0.0418) and 2174 observed ones (I > 2 sigma(I)). The in vitro antitumor activities of compounds 4a similar to 4i were preliminarily evaluated by the standard MTT assay.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 3-Methylbenzoic acid. Authors Sessa, F; Olsson, M; Soderberg, F; Wang, F; Rahm, M in WILEY-V C H VERLAG GMBH published article about in [Sessa, Francesco; Olsson, Martina; Soderberg, Fredrik; Rahm, Martin] Chalmers Univ Technol, Dept Chem & Chem Engn, SE-41296 Gothenburg, Sweden; [Wang, Fang] Univ Rhode Isl, Dept Chem, 140 Flagg Rd, Kingston, RI 02881 USA in 2021.0, Cited 91.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The quantum mechanically calculable Q descriptor is shown to be a potent quantifier of chemical reactivity in complex molecules – it shows a strong correlation to experimentally derived field effects in non-aromatic substrates and Hammett sigma(m) and sigma(p) parameters. Models for predicting substituent effects from Q are presented and applied, including on the elusive pentazolyl substituent. The presented approach enables fast computational estimation of substituent effects, and, in extension, medium-throughput screening of molecules and compound design. An experimental dataset is suggested as a candidate benchmark for aiding the general development and comparison of electronic structure analyses. It is here used to evaluate the experimental quantum chemistry (EQC) framework for chemical bonding analysis in larger molecules.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 3-Methylbenzoic acid. Authors Wang, R; Liu, H; You, YY; Wang, XY; Lv, BB; Cao, LQ; Xue, JY; Xu, YG; Shi, L in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Wang, Ru; Liu, Hu; You, Yuan-Yuan; Wang, Xin-Yu; Lv, Bing-Bing; Cao, Li-Qin; Xu, Yun-Gen; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China; [Xue, Jia-Yu] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Jiangsu Prov Key Lab Plant Ex Situ Conservat, Nanjing 210014, Peoples R China in 2021, Cited 29. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

VEGF/VEGFR-2 signaling plays a critical part in tumor angiogenesis. Inhibition of this pathway has been considered as a promising approach for cancer treatment. In this work, a series of 6,7-dimethoxy-4-anilinoquinazoline derivatives bearing diarylamide moiety were designed, synthesized and evaluated as potent inhibitors of VEGFR-2 kinase. Their in vitro antiproliferation activities against two human cancer cell lines Hep-G2 and MCF-7 have also been determined. Among them, compound 14b exhibited the most potent inhibitory activity against VEGFR-2 with IC50 value of 0.016 +/- 0.002 mu M and it showed the most potent antiproliferative effect against Hep-G2 and MCF-7 with IC50 values at low-micromolar range. Molecular docking studies revealed that these compounds represented by the most potent compound 14b could bind well to the ATP-binding site of VEGFR-2, which suggested that compound 14b could be a potential anticancer agent targeting VEGFR-2.

Application In Synthesis of 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Wang, R; Liu, H; You, YY; Wang, XY; Lv, BB; Cao, LQ; Xue, JY; Xu, YG; Shi, L or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 99-04-7. In 2021 ORG LETT published article about DIRECT ORTHO ARYLATION; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; BOND; PALLADIUM; HYDROARYLATION; OLEFINATION; ARYL; ALKYNES; ACTIVATION in [Hu, Zhiyong; Belitz, Florian; Zhang, Guodong; Papp, Florian; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany in 2021, Cited 68. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

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,Isothiazole – ScienceDirect.com

An article In silico ADME predictions and in vitro antibacterial evaluation of 2-hydroxy benzothiazole-based 1,3,4-oxadiazole derivatives WOS:000560919000015 published article about DISCOVERY; ANTICONVULSANT; INHIBITORS; POTENT in [Alghamdi, Afnan Ahmed; Alam, Mohammad Mahboob; Nazreen, Syed] Albaha Univ, Fac Sci, Dept Chem, Albaha, Saudi Arabia in 2020.0, Cited 25.0. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

In the present work, a library of fifteen 2-hydroxy benzothiazole-linked 1,3,4 -oxadiazole derivatives have been synthesized and confirmed using different analytical techniques. All of the synthesized compounds have been tested for antibacterial and in silico pharmacokinetic studies for the first time. From the ADME predictions, compound 4 showed the highest in silico absorption percentage (86.77%), while most of the compounds showed more than 70% absorption. All of the compounds comply with the Lipinski rule of 5, suggesting that the compounds possess good drug likeness properties upon administration. Furthermore, all of the compounds follow the Veber rule, indicating good bioavailability and good intestinal absorption. The antibacterial results exhibited excellent to moderate activity. Compounds 5, 9, 12, 14, 15, 16, and 17 were the most active compounds against the tested bacterial strains. Compound 14 showed comparable MIC 6.25 +/- 0.2 mu g/disc to the standard drug amoxicillin against the tested Gram-positive bacterial strains. Compounds 5, 14, 17 exhibited MIC 12.5 +/- 0.8 mu g/disc, which was comparable to the standard drug against E. faecalis. It can be concluded that the synthesized compound could be used as a lead molecule in the development of new antibacterial agents with high efficacy.

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Reference:
Isothiazole – Wikipedia,
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An article Palladium-Catalyzed Tandem Dehydrogenative [4+2] Annulation of Terminal Olefins with N-Sulfonyl Amides via C-H Activations WOS:000526894000073 published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Product Details of 99-04-7

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Product Details of 99-04-7. Welcome to talk about 99-04-7, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com