Category: 99-04-7

Recently I am researching about C-H ALKYLATION; ARENES; ARYLATION; EPOXIDES; LIGANDS; META, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772139, 21572149]; Jiangsu Province Natural Science Found for Distinguished Young Scholars [BK20180041]; Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]; PAPD Project. HPLC of Formula: C8H8O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhou, KH; Zhu, Y; Fan, WT; Chen, YJ; Xu, X; Zhang, JY; Zhao, YS. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A palladium-catalyzed carboxylic acid-directed cross-coupling of an ortho-C(sp(2)) atom of aromatic acids with aliphatic aziridines to construct the beta-arylethylamine skeleton via C-H activation has been developed. The reaction proceeded under mild conditions with great substrate scope. Meanwhile, the beta-arylethylamine skeleton in drugs or bioactive compounds could be easily generated in a single step. A catalytic amount of cesium carbonate was crucial to realizing the selective beta-arylethylamine synthesis.

HPLC of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, KH; Zhu, Y; Fan, WT; Chen, YJ; Xu, X; Zhang, JY; Zhao, YS or concate me.

Reference:
Isothiazole – Wikipedia,
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In 2020 EUR J MED CHEM published article about LUNG-CANCER; METABOLISM; EXPRESSION; IDENTIFICATION; AZD7545 in [Xiang, Sichuan; Huang, Ding; He, Qiaolin; Li, Jie; Zhang, Shao-Lin; He, Yun] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China; [Tam, Kin Yip] Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China in 2020, Cited 26. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Application In Synthesis of 3-Methylbenzoic acid

Most cancer cells feature an altered glucose metabolism from oxidative phosphorylation to cytoplasmic glycolysis. Pyruvate dehydrogenase kinases (PDKs) and lactate dehydrogenase A (LDHA) play crucial roles in promotion of glycolysis, thus the inhibition of both enzymes is considered a promising strategy for developing of anticancer therapeutics. Herein, we describe the first discovery of series novel dual inhibitors targeting PDKs and LDHA. We identified 6 hits from a library database containing 485465 compounds through a high-throughput virtual screening assay. Hit-to-lead optimization enabled us to discover two compounds, namely 20e and 20k, which inhibited PDKs with IC50 values of 0.8, and 1.6 mu M, respectively, and inhibited LDHA with IC50 values of 0.15 and 0.7 mu M, respectively. Meanwhile, the two compounds reduced A549 cell proliferation with EC50 values of 13.2, and 15.7 mu M. Furthermore, 20e and 20k decreased the lactate formation, and increased oxygen consumption, suggesting the two compounds modulated the glucose metabolic pathways in cancer cells. (C) 2020 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Xiang, SC; Huang, D; He, QL; Li, J; Tam, KY; Zhang, SL; He, Y or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 99-04-7. In 2020 ANGEW CHEM INT EDIT published article about ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITION; ALDOL ADDITIONS; COMPLEXES; LACTONES; REGIOSELECTIVITY; SUBSTITUTION; MECHANISM; BOND in [Jette, Carina, I; Stoltz, Brian M.] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA; [Tong, Z. Jaron; Hadt, Ryan G.] CALTECH, Arthur Amos Noyes Lab Chem Phys, Pasadena, CA 91125 USA in 2020, Cited 45. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Herein, we report a Cu-catalyzed enantioselective allylic alkylation using a gamma-butyrolactone-derived silyl ketene acetal. Critical to the development of this work was the identification of a novel mono-picolinamide ligand with the appropriate steric and electronic properties to afford the desired products in high yield (up to 96 %) and high ee (up to 95 %). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range of functionality are well-tolerated. Spectroscopic studies reveal that a Cu-I species is likely the active catalyst, and DFT calculations suggest ligand sterics play an important role in determining Cu coordination and thus catalyst geometry.

Product Details of 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Jette, CI; Tong, ZJ; Hadt, RG; Stoltz, BM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Li, ZZ; Xin, WX; Wang, Q; Zhu, MY; Zhou, HC in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Li, Zezhong; Xin, Weixiang; Wang, Qing; Zhu, Mingyan; Zhou, Huchen] Shanghai Jiao Tong Univ, Sch Pharm, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China in 2021, Cited 17. Product Details of 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The protozoan parasite Trypanosoma brucei (T. brucei) causes human African trypanosomiasis (HAT), which is a fatal and neglected disease in the tropic areas, and new treatments are urgently needed. Leucyl-tRNA synthetase (LeuRS) is an attractive target for the development of antimicrobial agents. In this work, starting from the hit compound thiourea ZCL539, we designed and synthesized a series of amides as effective T. brucei LeuRS (TbLeuRS) synthetic site inhibitors. The most potent compounds 74 and 91 showed IC50 of 0.24 and 0.25 mM, which were about 700-fold more potent than the starting hit compound. The structure-activity relationship was also discussed. These compounds provided a new scaffold and lead compounds for further development of antitrypanosomal agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Product Details of 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Li, ZZ; Xin, WX; Wang, Q; Zhu, MY; Zhou, HC or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about BIOLOGICAL EVALUATION; DIABETES-MELLITUS; INHIBITORS; ANTIBACTERIAL; PYRIMIDINE; DIET, Saw an article supported by the . Computed Properties of C8H8O2. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Reddy, BN; Ruddarraju, RR; Kiran, G; Pathak, M; Reddy, ARN. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A new series of Pyrazolo[3,4-d]pyrimidine containing amide derivatives (8 a-l) were designed, synthesized, and evaluated for their in vitro alpha-amylase inhibitory activity. The IC50 values of the target compounds ranged from 1.60 +/- 0.48 to 2.04 +/- 1.20 mu M as compared to the standard acarbose 1.73 +/- 0.05 mu M. All the Pyrazolo[3,4-d]pyrimidine amide derivatives displayed good inhibitory activities, while seven analogs (8 d, 8 f, 8 g, 8 h, 8 i, 8 j and 8 k) exhibited more or less equipotent activity with IC50 values 1.77 +/- 2.84, 1.65 +/- 0.45, 1.66 +/- 2.24, 1.73 +/- 0.37, 1.60 +/- 0.48, 1.75 +/- 0.36 and 1.64 +/- 0.03 mu M respectively. Further, the most potent alpha-amylase inhibitors 8 d and 8 k were also screened for their in vivo antidiabetic activity against alloxan induced diabetic rat model at the dose of 25 and 50 mg/kg. Oral administration of these tested compounds significantly reduced the fasting blood glucose levels in dose dependent manner. The hypoglycemic effects of these compounds were more evident at 3 h and 5 h after administration of tested compounds which was similar to the effect displayed by the positive control. In addition, the binding energies calculated from the docking studies with the alpha-amylase enzyme (PDB ID: 1HNY) and biological activities indicate that the compounds containing nitro moiety on the phenyl group contributed significantly towards the antidiabetic activity.

About 3-Methylbenzoic acid, If you have any questions, you can contact Reddy, BN; Ruddarraju, RR; Kiran, G; Pathak, M; Reddy, ARN or concate me.. Computed Properties of C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Table salt as a catalyst for the oxidation of aromatic alcohols and amines to acids and imines in aqueous medium: effectively carrying out oxidation reactions in sea water WOS:000465398000010 published article about ABUNDANT METAL-CATALYSTS; SELECTIVE OXIDATION; CARBOXYLIC-ACIDS; C-H; DEHYDROGENATIVE OXIDATION; PROMOTED OXIDATION; AEROBIC OXIDATION; ORGANIC-REACTIONS; GREEN CHEMISTRY; EARTH in [Hazra, Susanta; Kushawaha, Ajay Kishor; Yadav, Deepak; Dolui, Pritam; Deb, Mayukh; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2019, Cited 79. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Application In Synthesis of 3-Methylbenzoic acid

A simple, efficient, sustainable and economical method for the oxidation of alcohols and amines has been developed based on chloride, a sea abundant anionic catalyst for the practical synthesis of a wide range of carboxylic acids, ketones and imines. Oxidation of aromatic alcohols was carried out using NaCl (20 mol%) as the catalyst, NaOH (50 mol%) and aq. TBHP (4 equiv.) as the oxidant in 55-92% isolated yields. Oxidation of aromatic amines to imines was achieved by using only 20 mol% of NaCl and aq. TBHP (4 equiv.) in 32-93% isolated yields. The chlorine species formed during the reaction as the active oxidation catalyst has been identified as ClO2- for alcohols and ClO-/ClO2- for amines by control experiments. This method is mostly free from chromatographic purification, which makes it suitable for large-scale synthesis. We have scaled up to 30 gram scale the synthesis of carboxylic acids and imines in good yields and have also carried out efficiently this new method using filtered sea water as the solvent and catalyst.

About 3-Methylbenzoic acid, If you have any questions, you can contact Hazra, S; Kushawaha, AK; Yadav, D; Dolui, P; Deb, M; Elias, AJ or concate me.. Application In Synthesis of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes WOS:000515216200046 published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. Product Details of 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Product Details of 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C8H8O2. I found the field of Chemistry very interesting. Saw the article Ru-Catalyzed (E)-Specific ortho-C-H Alkenylation of Arenecarboxylic Acids by Coupling with Alkenyl Bromides published in 2021, Reprint Addresses Goossen, LJ (corresponding author), Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

About 3-Methylbenzoic acid, If you have any questions, you can contact Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ or concate me.. Formula: C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Hsieh, CE; Jiang, YM; Chou, CM in AMER CHEMICAL SOC published article about RADICAL CYCLIZATION; RAPID ACCESS; ETHERIFICATION; REARRANGEMENT; CONSTITUENTS; DERIVATIVES; GENERATION; PHENOL in [Hsieh, Cheng-En; Jiang, Yu-Min; Chou, Chih-Ming] Natl Univ Kaohsiung, Dept Appl Chem, 700 Kaohsiung Univ Rd, Kaohsiung 81148, Taiwan in 2019.0, Cited 55.0. Recommanded Product: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A strategy toward the preparation of substituted allyl aryl ethers from benzoic acids via a dearomatization and decarboxylative allylation (DcA) reaction is presented. The benzoic acids undergo a dearomatization to give alkylated 2,5-cyclohexadienyl ketoesters which are subjected to a palladium-catalyzed DcA reaction, providing a variety of functionalized allyl aryl ethers. In addition, the combination of a resonance stabilized DcA reaction with a Claisen rearrangement for the synthesis of multisubstituted phenols and applying to dihydroplicatin B derivative synthesis is also presented.

About 3-Methylbenzoic acid, If you have any questions, you can contact Hsieh, CE; Jiang, YM; Chou, CM or concate me.. Recommanded Product: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM in AMER CHEMICAL SOC published article about in [Zhou, Jing-Ya; Liu, Rui-Qing; Wang, Cheng-Yi; Zhu, Yong-Ming] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China in 2020, Cited 40. Name: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Transition metal-catalyzed cross-couplings have been widely employed in the synthesis of many important molecules in synthetic chemistry for the construction of diverse C-C bonds. Conventional cross-coupling reactions require active electrophilic coupling partners, such as organohalides or sulfonates, which are not environmentally friendly enough. Herein, we disclose the first nickel-catalyzed Suzuki-Miyaura cross-coupling of aryl anhydrides and arylboronic acids for the synthesis of biaryls in a decarbonylation manner. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents in this process.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com