Category: 99-04-7

An article Spectroscopic Study on Aqueous Uranyl(VI) Complexes with Methoxy- and Methylbenzoates: Electronic and Steric Effects of the Substituents WOS:000584351700054 published article about EQUILIBRIUM-CONSTANTS; AROMATIC-ACIDS; URANIUM(VI); CRYSTAL; ION; BENZOATE; MODEL; EXAFS in [Choi, Seonggyu; Yun, Jong-Il] Korea Adv Inst Sci & Technol, Dept Nucl & Quantum Engn, Daejeon 34141, South Korea in 2020, Cited 36. Safety of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Aqueous complexation of uranyl(VI) ions with methoxy- and methylbenzoates in 0.1 M NaClO4 solutions was studied by means of UV-vis absorption and Raman spectroscopy. The predominance of 1:1 complexation (uranyl to ligand) was verified for all uranyl carboxylates under acidic conditions (-log [H+] < 3.2), and absorption spectra, stability constants, and symmetric stretching frequencies of the uranyl group of the complexes were determined for the first time. For meta- and parasubstituted benzoates, a linear free energy relationship (LFER) was observed between the equilibrium constants for the protonation (log beta(p)) and uranyl complexation (log beta(U)) reactions, and the electronic effects of the substituents were successfully described by the Hammett equation. In the case of ortho-substituted benzoates, the stability constant of uranyl 2-methoxybenzoate is slightly lower than the LFER trend, which is generally explained by the destabilization of cross-conjugation in the uranyl complex due to the steric hindrance between the reaction center and adjacent methoxy group. On the contrary, the stability constant of uranyl 2-methylbenzoate is comparable to the LFER trend, implying that the steric effect is relatively insignificant for the smaller methyl group. The utility of such thermodynamic correlations between the uranyl-substituted benzoates is useful for the molecular understanding and predictive modeling of chemical interactions between actinyl(VI) ions and various organic carboxyl groups. About 3-Methylbenzoic acid, If you have any questions, you can contact Choi, S; Yun, JI or concate me.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors WOS:000592527300006 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; IN-VITRO; BINDING; AGENTS; MICROTUBULES; PHENSTATIN in [Wang, Guangcheng; Gong, Zipeng; Huang, Yong] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang, Peoples R China; [Wang, Guangcheng] Jishou Univ, Coll Chem & Chem Engn, Jishou, Peoples R China; [Peng, Zhiyun] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai, Peoples R China; [Liu, Wenjing; Ma, Xue; Li, Yongjun] Guizhou Med Univ, Minist Educ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Guiyang, Peoples R China; [Liu, Wenjing] Guizhou Med Univ, Sch Pharm, Guiyang, Peoples R China; [Tang, Juan] Guizhou Med Univ, Affiliated Hosp, Guiyang, Peoples R China in 2020, Cited 32. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Quality Control of 3-Methylbenzoic acid

A series of benzophenone derivatives bearing naphthalene moiety were designed, synthesized, characterized by H-1 NMR, C-13 NMR, and HRMS and evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7). Most of the tested derivatives showed good to moderate cytotoxicity against MCF-7 cell line. Among them, compound 4u (IC50 = 1.47 +/- 0.14 mu M) was found to be the most active compound, which is more active than the standard drug cisplatin (IC50 = 15.24 +/- 1.27 mu M). In vitro tubulin polymerization in-hibition assay, EBI competition assay, cell cycle analysis, and cell apoptosis assay identified that compound 4u was a new tubulin polymerization inhibitor by targeting the colchicine binding site. Besides, molecular docking study showed that compound 4u has high binding affinities with the colchicine binding site of tubulin through hydrogen bond, cation-pi, and hydrophobic interaction.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, GC; Liu, WJ; Tang, J; Ma, X; Gong, ZP; Huang, Y; Li, YJ; Peng, ZY or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about AEROBIC OXIDATION; SELECTIVE OXIDATION; RUTHENIUM CATALYST; WATER; METAL; COMPLEXES; ALDEHYDES; SALTS; CONVERSION; AMIDATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21502062]; Scientific Research Program Guiding Project of Hubei Provincial Department of Education [B2019135]; Teacher’s Scientific Research Ability Cultivation Fund, Hubei University of Arts and Science (Natural Science) [2018kypy001]; Open Foundation of Discipline of Hubei University of Arts and Science [XK2019038]; Tomsk Polytechnic University Competitiveness Enhancement Program [VIU69-2019]. Safety of 3-Methylbenzoic acid. Published in MDPI in BASEL ,Authors: Wang, WQ; Cheng, H; Yuan, Y; He, YQ; Wang, HJ; Wang, ZQ; Sang, W; Chen, C; Verpoort, F. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

The transition-metal-catalyzed alcohol dehydrogenation to carboxylic acids has been identified as an atom-economical and attractive process. Among various catalytic systems, Ru-based systems have been the most accessed and investigated ones. With our growing interest in the discovery of new Ru catalysts comprising N-heterocyclic carbene (NHC) ligands for the dehydrogenative reactions of alcohols, we designed and prepared five NHC/Ru complexes ([Ru]-1-[Ru]-5) bearing different ancillary NHC ligands. Moreover, the effects of ancillary and additional ligands on the alcohol dehydrogenation with KOH were thoroughly explored, followed by the screening of other parameters. Accordingly, a highly active catalytic system, which is composed of [Ru]-5 combined with an additional NHC precursor L5, was discovered, affording a variety of acid products in a highly efficient manner. Gratifyingly, an extremely low Ru loading (125 ppm) and the maximum TOF value until now (4800) were obtained.

Safety of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, WQ; Cheng, H; Yuan, Y; He, YQ; Wang, HJ; Wang, ZQ; Sang, W; Chen, C; Verpoort, F or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides WOS:000465007200007 published article about BOND; AMINOCARBONYLATION; TRANSFORMATIONS; IODIDES; ARYL in [Bi, Xiaojing; Li, Junchen; Shi, Enxue; Li, Yu; Liu, Ying; Wang, Hongmei; Xiao, Junhua] State Key Lab NBC Protect Civilian, Beijing, Peoples R China in 2019, Cited 14. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. COA of Formula: C8H8O2

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

COA of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Bi, XJ; Li, JC; Shi, EX; Li, Y; Liu, Y; Wang, HM; Xiao, JH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 99-04-7. Recently I am researching about GROUP-11 METAL(I) COMPOUNDS; COPPER-CATALYZED SYNTHESIS; LEWIS-BASE ADDUCTS; STEREOSELECTIVE-SYNTHESIS; NITROGEN ANALOGS; ROOM-TEMPERATURE; CARBOXYLIC-ACIDS; AMIDE SYNTHESIS; FACILE ACCESS; ALKYNE, Saw an article supported by the NNSFCNational Natural Science Foundation of China (NSFC) [21472107, 21372142]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Yang, WG; Huang, DY; Zeng, XB; Zhang, JL; Wang, XY; Hu, YF. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from an ynone-participated CuAAC/ring-opening method. Its unique structure allowed it to react with aryl carboxylic acids to give N-aroylsulfonamides via a novel Mumm-type rearrangement. (C) 2018 Elsevier Ltd. All rights reserved.

About 3-Methylbenzoic acid, If you have any questions, you can contact Yang, WG; Huang, DY; Zeng, XB; Zhang, JL; Wang, XY; Hu, YF or concate me.. Recommanded Product: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine as insecticidal agents WOS:000515759700001 published article about ASYMMETRIC-SYNTHESIS; RESISTANCE; INHIBITORS; ALKALOIDS in [Che, Zhi-Ping; Yang, Jin-Ming; Zhang, Song; Sun, Di; Tian, Yue-E; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang] Henan Univ Sci & Technol, Coll Forestry, Dept Plant Protect, Lab Pesticidal Design & Synth, Luoyang 471023, Peoples R China in 2021, Cited 25. Application In Synthesis of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Endeavor to discover biorational natural products-based insecticides, two series (27) of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially derivatives 6l and 6o exhibited the best insecticidal activity with final mortality rates of 75.0% and 71.4%, respectively. Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-substitution is well tolerated; the configuration of C8/9 position is important for insecticidal activity, and 9S-configuration is optimal; 6′-OCH3 moiety is not necessary, removal of it is also acceptable.

About 3-Methylbenzoic acid, If you have any questions, you can contact Che, ZP; Yang, JM; Zhang, S; Sun, D; Tian, YE; Liu, SM; Lin, XM; Jiang, J; Chen, GQ or concate me.. Application In Synthesis of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article One-Pot Process to Carborano-Coumarin via Catalytic CascadeDehydrogenative Cross-Coupling WOS:000514936900001 published article about CAGE B-H; O-CARBORANES; ORTHO-ARYLATION; BORON CLUSTERS; DRUG DISCOVERY; GAMMA-LACTAMS; BENZOIC-ACIDS; BONDS; RHODIUM; FUNCTIONALIZATION in [Quan, Yangjian; Xie, Zuowei] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China in 2020, Cited 89. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Formula: C8H8O2

Ir-catalyzed cascade dehydrogenative CH/BH and BH/OH cross-coupling of carboranyl carboxylic acid with readily available benzoic acid has been achieved, leading to the facile synthesis of previously unavailable carborano-coumarin in a simple one-pot process. Two cage B-H, one aryl C-H and one O-H bonds are activated to construct efficiently new B-C and B-O bonds. The cascade cyclization can stop at the first B-H/C-H cross-coupling step by tuning the reaction conditions, resulting in a series of alpha-carboranyl benzoic acid and aryl carborane derivatives. Control experiments indicate that B-H/C-H dehydrocoupling proceeds preferentially over B-H/O-H dehydrocoupling, and both directing groups and oxidants are crucial for this reaction. An iridium(V) intermediate is proposed to be involved in the catalytic cycle.

Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Au, YK; Lyu, HR; Quan, YJ; Xie, ZW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020.0 CHEMCATCHEM published article about CATALYZED H/D EXCHANGE; WEAK-COORDINATION; OXIDASE CATALYSIS; LABELED COMPOUNDS; N-HETEROCYCLES; ACTIVATION; DEUTERIUM; COMPLEXES; DISCOVERY; TRITIUM in [Mueller, Valentin; Ackermann, Lutz] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Weck, Remo; Derdau, Volker] Sanofi Aventis Deutschland GmbH, R&D, Integrated Drug Discovery, Isotope Chem, Ind Pk Hochst, D-65926 Frankfurt, Germany in 2020.0, Cited 105.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Recommanded Product: 3-Methylbenzoic acid

Well-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by a broad functional group tolerance in an operationally-simple manner, allowing the isotope labeling of challenging pharmaceuticals and bioactive heterocyclic motifs. The synthetic power of our method was highlighted by the selective tritium-labeling of repaglinide, an antidiabetic drug, providing access to defined tritium labeled therapeutics.

About 3-Methylbenzoic acid, If you have any questions, you can contact Muller, V; Weck, R; Derdau, V; Ackermann, L or concate me.. Recommanded Product: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Nickel-catalyzed C-H bond trifluoromethylation of 8-aminoquinoline derivatives by acyl-directed functionalization WOS:000465285100016 published article about FLUORINE; ACTIVATION; ARENES; TRIFLUOROETHYLATION; PHARMACEUTICALS; HETEROARENES in [Liu, Xiaochong; Mao, Guijie; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Heilongjiang, Peoples R China; [Liu, Xiaochong; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Coll Heilongjiang Prov, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin 150080, Heilongjiang, Peoples R China in 2019, Cited 37. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Product Details of 99-04-7

A Ni(TFA)(2)-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C-H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF3 as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.

About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, XC; Mao, GJ; Qiao, JY; Xu, CZ; Liu, H; Ma, JJ; Sun, ZZ; Chu, WY or concate me.. Product Details of 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP in WILEY-V C H VERLAG GMBH published article about NATURAL-PRODUCT SYNTHESIS; ELECTROCATALYTIC APPROACH; MULTICOMPONENT REACTIONS; N-ACYL; AMIDES; AMINES; ISOIMIDES; OXIDATION in [Zhang, Xiaofeng; Cui, Ting; Zhao, Xin; Liu, Ping; Sun, Peipei] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China in 2020, Cited 61. Category: isothiazole. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com