Category: 99-04-7

An article Synthesis ofN-methylated amines from acyl azides using methanol WOS:000555663000015 published article about CROSS-COUPLING REACTIONS; CARBOXYLIC-ACIDS; N-METHYLATION; CATALYZED METHYLATION; EFFICIENT; ALKYLATION; NITRILES; STRATEGY; DEHYDROGENATION; SECONDARY in [Chakrabarti, Kaushik; Dutta, Kuheli; Kundu, Sabuj] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India in 2020, Cited 48. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The transformation of acyl azide derivatives intoN-methylamines was developed using methanol as the C1 sourceviathe one-pot Curtius rearrangement and borrowing hydrogen methodology. Following this protocol, various functionalisedN-methylated amines were synthesized using the (NNN)Ru(ii) complex from carboxylic acidsviaan acyl azide intermediate. Several kinetic studies and DFT calculations were carried out to support the mechanism and also to determine the role of the Ru(ii) complex and base in this transformation.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Chakrabarti, K; Dutta, K; Kundu, S or concate me.

Reference:
Isothiazole – Wikipedia,
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Computed Properties of C8H8O2. Authors Zhang, XG; Wang, PG; Zhu, LW; Chen, BH in ELSEVIER SCIENCE INC published article about in [Zhang, Xueguo; Wang, Peigen; Zhu, Liangwei; Chen, Baohua] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2021, Cited 54. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins and isoquinolinones have been realized via Rh(III)-catalyzed C-H activation. Diazo compounds act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhang, XG; Wang, PG; Zhu, LW; Chen, BH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019 CHEM COMMUN published article about HECK REACTIONS; FUNCTIONALIZATION; ACTIVATION; ARYLATION; RHODIUM; ALKYNES; ARENES; OXYGEN; SCOPE in [Kalsi, Deepti; Barsu, Nagaraju; Chakrabarti, Sagnik; Dahiya, Pardeep; Sundararaju, Basker] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India; [Rueping, Magnus] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany in 2019, Cited 64. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Name: 3-Methylbenzoic acid

A mild, environment-friendly protocol has been developed to carry out the [4+2] annulation of aryl amides with unactivated olefins. A range of sterically and electronically diverse aryl amides and unactivated olefins were successfully employed under the developed conditions to get a variety of dihydroisoquinolinones in good-to-excellent yields.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Kalsi, D; Barsu, N; Chakrabarti, S; Dahiya, P; Rueping, M; Sundararaju, B or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C8H8O2. In 2019.0 ACS MED CHEM LETT published article about NOD1 VARIATION; IDENTIFICATION; ASSOCIATION; DOMAIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; BINDING in [Haffner, Curt D.; Charnley, Adam K.; Casillas, Linda; Cox, Julie A.; Elban, Mark A.; Goodwin, Nicole C.; Gough, Peter J.; Haile, Pamela A.; Knapp-Reed, Beth; Kreatsoulas, Constantine; Lakdawala, Ami S.; Li, Huijie; Lian, Yiqian; Lipshutz, David; Mehlmann, John F.; Ouellette, Michael; Romano, Joseph; Shewchuk, Lisa; Shu, Arthur; Votta, Bartholomew J.; Zhou, Huiqiang; Bertin, John; Marquis, Robert W.] GlaxoSmithKline, 1250 South Collegeville Rd, Collegeville, PA 19426 USA; [Convery, Maire A.] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England; [Aquino, Christopher J.] CJAMedChem LLC, 1600 W Bromfield Dr, Hillsborough, NC 27599 USA; [Hughes, Terry V.] Janssen Res & Dev LLC, POB 776, Spring House, PA 19477 USA in 2019.0, Cited 34.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide 11 represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.

Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, HJ; Lian, YQ; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, HQ; Bertin, J; Marquis, RW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Enhancing supercritical fluid chromatographic efficiency: Predicting effects of small aqueous additives published in 2020. Category: isothiazole, Reprint Addresses Armstrong, DW (corresponding author), Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Supercritical fluid chromatography is becoming more prevalent, particularly in industry. This is due to the inexpensive, and more importantly, environmentally benign carbon dioxide that is used as the major component of the mobile phase. Water is minimally miscible with carbon dioxide at temperatures and pressures commonly used in SFC. However, the introduction of a polar alcohol modifier component increases the solubility of water in carbon dioxide. Previously, the addition of small amounts of water in the mobile phase was shown to provide significant gains in efficiency in chiral supercritical fluid chromatography, especially with polar stationary phases. In this work, we report the effect of the addition of small amounts of water on efficiency and retention factor with four different SFC stationary phases used for achiral analysis namely FructoShell-N (native cyclofructan-6), SilicaShell (bare silica), PoroShell 120 EC C18 (octadecyl silica) and Xselect C18 SB. This is the first reported use of FructoShell-N, a cyclofructan derivatized phase for SFC applications. We devised a predictive test to determine which analytes show an increase in efficiency using their known chemical constants (logK(ow), pK(a), PSA and H-sum). We also use discriminant analysis to elucidate the most important analyte parameters that contribute to water enhanced efficiency gains. (C) 2020 Elsevier B.V. All rights reserved.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Khvalbota, L; Roy, D; Wahab, MF; Firooz, SK; Machynakova, A; Spanik, I; Armstrong, DW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Chen, JK; Jin, LC; Zhou, J; Jiang, XP; Yu, CM in PERGAMON-ELSEVIER SCIENCE LTD published article about EFFICIENT SYNTHESIS; BOND FUNCTIONALIZATIONS; ACTIVATION; INDOLES; DERIVATIVES; ANNULATION; INSERTION; ISONITRILES; BENZAMIDES; CYANATION in [Chen, Jinkang; Yu, Chuanming] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China; [Jin, Licheng; Zhou, Jian; Jiang, Xinpeng; Yu, Chuanming] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 55.0. Quality Control of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

An efficient synthesis of functionalized iminoisoindolinone derivatives has been achieved via a mild electrochemical oxidative C-H/N-H functionalizationfintramolecular annulations with isocyanides in undivided cell equipped with a nickel cathode. In the presence of earth abundant cobalt catalyst, versatile iminoisoindolinone derivatives obtained in good yields and in a sustainable manner by using electricity as an oxidant in place of stoichiometric amount of silver and copper salts. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Chen, JK; Jin, LC; Zhou, J; Jiang, XP; Yu, CM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C8H8O2. In 2021.0 RSC ADV published article about ESTERS; ACID; MECHANOCHEMISTRY; ULTRASOUND; CHALLENGES; MICROWAVE; MITSUNOBU; REAGENT; OIL in [Zheng, Lei; Sun, Chen; Xu, Wenhao; Su, Weike] Zhejiang Univ Technol, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China; [Xu, Wenhao; Su, Weike; Yu, Jingbo] Zhejiang Univ Technol, Natl Engn Res Ctr Proc Dev Act Pharmaceut Ingredi, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China; [Dushkin, Alexandr V.; Polyakov, Nikolay] Inst Solid State Chem & Mechanochem, Novosibirsk, Russia in 2021.0, Cited 55.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I-2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)(3), esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I-2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed.

About 3-Methylbenzoic acid, If you have any questions, you can contact Zheng, L; Sun, C; Xu, WH; Dushkin, AV; Polyakov, N; Su, WK; Yu, JB or concate me.. Formula: C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Gao, H; Lin, S; Zhang, SN; Chen, WJ; Liu, XW; Yang, G; Lerner, RA; Xu, HT; Zhou, Z; Yi, W in [Gao, Hui; Lin, Shuang; Chen, Weijie; Liu, Xiawen; Zhou, Zhi; Yi, Wei] Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Prot, State Key Lab Resp Dis, Sch Pharmaceut Sci, Guangzhou 511436, Guangdong, Peoples R China; [Gao, Hui; Lin, Shuang; Chen, Weijie; Liu, Xiawen; Zhou, Zhi; Yi, Wei] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; [Zhang, Shuning; Yang, Guang; Xu, Hongtao] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; [Zhang, Shuning; Yang, Guang; Xu, Hongtao] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Lerner, Richard A.] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA published gem-Difluoromethylene Alkyne-Enabled Diverse C-H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins in 2021.0, Cited 107.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Using gem-difluoromethylene alkynes as effectors, unprecedented diverse C-H activation/[4+2] annulations of simple benzoic acids are reported. The chemodivergent reaction outcomes are well-tuned by Rh/Ir-catalyzed system; in the Rh-III catalysis, 3-alkenyl-1H-isochromen-1-one and 3,4-dialkylideneisochroman-1-one skeletons are afforded in a solvent-dependent manner whereas difluoromethylene-substituted 1H-isochromen-1-ones are generated under the Ir-III-catalyzed system. Mechanistic studies revealed that unusually double beta-F eliminations and fluorine effect-induced regioselective reductive elimination are independently involved to enable distinct reaction modes for divergent product formations. Besides, synthetic application in both the derivatization of obtained diene products and the on-DNA synthesis of DNA-tagged difluorinated isocoumarin have been demonstrated, which manifested great potential for synthetic utility of the developed protocols.

About 3-Methylbenzoic acid, If you have any questions, you can contact Gao, H; Lin, S; Zhang, SN; Chen, WJ; Liu, XW; Yang, G; Lerner, RA; Xu, HT; Zhou, Z; Yi, W or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Fe(III)-catalyzed oxidative coupling of alkylnitriles with aromatic carboxylic acids: Facile access to cyanomethyl esters published in 2019. Formula: C8H8O2, Reprint Addresses Sun, HM (corresponding author), Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

The first oxidative coupling of alkylnitriles with aromatic carboxylic acids using di-tert-butyl peroxide (DTBP) as oxidant was achieved under the catalysis of ionic Fe(III) complexes bearing an imidazolinium cation. This protocol features nontoxic iron catalysis, direct alpha-C(sp(3))-H bond oxidative esterification of alkylnitriles, non-prefunctionalized starting materials, and a broad substrate scope with outstanding steric hindrance tolerance, providing a novel, straightforward, and green approach toward cyanomethyl ester synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C8H8O2. Recently I am researching about C-H; IODINE; FUNCTIONALIZATION; LACTONIZATION; ALKYLATION; EFFICIENT; CARBON, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21801214, 21572126]; Higher Education Institution Key Research Project Plan of Henan Province of China [20B150019]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chen, RX; Wang, KK; Wang, ZY; Miao, CQ; Wang, DD; Zhang, AA; Liu, LT. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A novel tetrabutylammonium iodide (TBAI)-promoted three-component reaction of carboxylic acid with alkene and alcohol has been developed, which represents facile and straightforward access to polysubstituted gamma-lactone skeletons in moderate-to-good yields. This methodology is distinguished by the use of a commercial catalyst and readily available starting materials, wide substrate scope, and operational simplicity. Mechanistic studies suggested that this transformation went through a radical process.

Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Chen, RX; Wang, KK; Wang, ZY; Miao, CQ; Wang, DD; Zhang, AA; Liu, LT or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com