Category: 99-04-7

Name: 3-Methylbenzoic acid. In 2020 BIOORG MED CHEM LETT published article about SMALL-MOLECULE INHIBITOR; CARCINOMA IN-VITRO; ALPHA; DERIVATIVES; METABOLISM; ACTIVATOR; SIRTUINS; PATHWAY in [Dukanya; Metri, Prashant K.; Mohan, Surender; Basappa] Univ Mysore, Dept Studies Organ Chem, Lab Chem Biol, Mysore 570006, Karnataka, India; [Shanmugam, Muthu K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore; [Rangappa, Shobith] Adichunchanagiri Inst Mol Med, Bg Nagara 571448, Nagamangalatalu, India; [Rangappa, Kanchugarakoppal S.] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India in 2020, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A novel series of indazole tethered oxadiazoles (OTDs) derivatives were synthesized, characterized and screened for their anti-proliferative activity against hepatocellular carcinoma (HCC) cells. OTDs structure was further confirmed by Single-crystal X-ray diffraction studies. Among the tested OTDs, compound 2-(4-methoxyphenyl)-5-(1-methyl-1H-indazol-3-yl)-1,3,4 oxadiazole was found to inhibit the catalytical activity of SIRT2 and brings about apoptosis as shown by western blot analysis and flow cytometry data. Also, the tested OTDs were found to interact with the active site of human SIRT2 in silico but not with the cavity of co-crystal ligand 5-(3- hydroxypropyl)-3-(4-chlorophenyl)-1,2,4-oxadiazole, which indicate that these OTDs has potential in the development of SIRT2 inhibitors in liver cancer models.

About 3-Methylbenzoic acid, If you have any questions, you can contact Dukanya; Shanmugam, MK; Rangappa, S; Metri, PK; Mohan, S; Basappa; Rangappa, KS or concate me.. Name: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 3-Methylbenzoic acid. Liu, Y; Battaglioli, S; Lombardi, L; Menichetti, A; Valenti, G; Montalti, M; Bandini, M in [Liu, Yang; Battaglioli, Simone; Lombardi, Lorenzo; Menichetti, Arianna; Valenti, Giovanni; Montalti, Marco; Bandini, Marco] Univ Bologna, Alma Mater Studiorum, Dipartimento Chim Giacomo Ciamician, I-40126 Bologna, Italy; [Bandini, Marco] Consorzio CINMPIS, I-40126 Bologna, Italy published Visible-Light Photoredox Catalyzed Dehydrogenative Synthesis of Allylic Carboxylates from Styrenes in 2021, Cited 47. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

The visible-light photoredox/[Co(III)] cocatalyzed dehydrogenative functionalization of cyclic and acyclic styryl derivatives with carboxylic acids is documented. The methodology enables the chemo- and regioselective allylic functionalization of styryl compounds, leading to allylic carboxylates (32 examples) under stoichiometric acceptorless conditions. Intermolecular as well as intramolecular variants are documented in high yields (up to 82%). A mechanistic rationale is also proposed on the basis of a combined experimental and spectroscopic investigation.

About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, Y; Battaglioli, S; Lombardi, L; Menichetti, A; Valenti, G; Montalti, M; Bandini, M or concate me.. Application In Synthesis of 3-Methylbenzoic acid

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Bidentate Ru(ii)-NC complexes as catalysts for the dehydrogenative reaction from primary alcohols to carboxylic acids WOS:000471911200029 published article about SECONDARY ALCOHOLS; BETA-ALKYLATION; WATER; SALTS; CONVERSION; OXIDATION; BEARING; LIGAND; H-2; EFFICIENT in [Gong, Dawei; Hu, Bowen; Chen, Dafa] Harbin Inst Technol, Sch Chem Engn & Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, Harbin 150001, Heilongjiang, Peoples R China in 2019, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Recommanded Product: 3-Methylbenzoic acid

Four Ru(ii)-NC complexes were synthesized by one-step processes from the corresponding NC ligands with RuHCl(CO)(PPh3)(3). These complexes were tested as catalysts for alcohol dehydrogenative reactions, and complex {(C5H4N)-(C6H4)}RuCl(CO)(PPh3)(2) (1) showed the highest activity. With KOH as the nucleophile and 0.5 mol% catalyst loading, a series of carboxylic acids were synthesized in toluene without any oxidant. Catalyst 1 could be transformed to complex {(C5H4N)-(C6H4)}RuH(CO)(PPh3)(2) (6) when treated with KOH and benzyl alcohol. Complex 6 further reacted with PhCHO and H2O to generate product {(C5H4N)-(C6H4)}Ru(OCOPh)(CO)(PPh3)(2) (7). Complexes 6 and 7 exhibited similar efficiency to complex 1, suggesting that they can be regarded as the catalytic intermediates of 1.

Recommanded Product: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Gong, DW; Hu, BW; Chen, DF or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020 J ORGANOMET CHEM published article about OXIDANT-FREE DEHYDROGENATION; FERRITE NANOPARTICLES; N-ALKYLATION; AMINES; CONVERSION; COMPLEXES; EFFICIENT; SALTS; WATER; H-2 in [Yazdani, Elahe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran in 2020, Cited 46. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. COA of Formula: C8H8O2

A novel silver nano magnetic catalyst was devised for dehydrogenative oxidation of aromatic and aliphatic alcohols to the corresponding acid with water as the sole oxygen source and hydrogen gas as the only byproduct. The designed catalytic system advantages from easy recovery of magnetic materials i.e. magnetic decantation, being economically viable and environmentally friendly. Furthermore, the catalytic reaction is able to reduce aryl nitro compounds in the absence of any reducing agent. (C) 2020 Elsevier B.V. All rights reserved.

About 3-Methylbenzoic acid, If you have any questions, you can contact Yazdani, E; Heydari, A or concate me.. COA of Formula: C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Guerra, J; Bajwa, B; Kumar, P; Vazquez, S; Krishnan, VV; Maitra, S in AMER CHEMICAL SOC published article about NUCLEAR-MAGNETIC-RESONANCE; CHEMICAL-EXCHANGE; NMR; BARRIERS in [Guerra, Jacob; Bajwa, Bhvandip; Kumar, Prarthana; Vazquez, Salvador; Krishnan, Viswanathan V.; Maitra, Santanu] Calif State Univ Fresno, Dept Chem, Fresno, CA 93740 USA; [Krishnan, Viswanathan V.] Univ Calif Davis, Dept Pathol & Lab Med, Davis, CA 95616 USA in 2020.0, Cited 40.0. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The concept of enthalpy-entropy compensation (EEC) is one of the highly debated areas of thermodynamics. The conformational change due to restricted double-bond rotation shows a classic two-site chemical exchange phenomenon and has been extensively studied. Fifty-four analogs of N,N-diethyl-m-toluamide (DEET) as a model system were synthesized to study the thermodynamics of the partial amide bond character using nuclear magnetic resonance (NMR) spectroscopy. Line-shape analysis as a function of temperature is used to estimate the chemical exchange. Eyring analysis was then used to convert the chemical exchange rates to determine the transition state enthalpy and entropy of the molecules. The experimental design follows selective variations that perturb one aspect of the molecular system and its influence on the observed thermodynamic effect. The results of the study demonstrate that amide bond resonance in analogs of DEET follows an EEC mechanism. Simple modifications made to DEET’s structural motif alter both the enthalpy and entropy of the system and were limited overall to a temperature compensation factor, T-beta = 292.20 K, 95% CI [290.66, 293.73]. We suggest EEC as a model to describe the kinetic compensation seen in chemical exchange phenomena in analogs of DEET.

About 3-Methylbenzoic acid, If you have any questions, you can contact Guerra, J; Bajwa, B; Kumar, P; Vazquez, S; Krishnan, VV; Maitra, S or concate me.. SDS of cas: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Abel-Snape, X; Whyte, A; Lautens, M in [Abel-Snape, Xavier; Whyte, Andrew; Lautens, Mark] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada published Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis in 2020, Cited 49. Name: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

An ortho-amination, ipso-C-H arylation mediated by palladium/norbornene cooperative catalysis is reported. This reaction proceeds through a sequential intermolecular C-N bond formation process followed by intramolecular C-H activation of a tethered arene. The products, aminated phenanthridinones, were generated in moderate to good yields. This method is also applicable to the formation of dibenzazepinones.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Abel-Snape, X; Whyte, A; Lautens, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Hameed, S; Kanwal; Seraj, F; Rafique, R; Chigurupati, S; Wadood, A; Rehman, AU; Venugopal, V; Salar, U; Taha, M; Khan, KM in [Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Chigurupati, Sridevi] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 52571, Saudi Arabia; [Wadood, Abdul; Rehman, Ashfaq Ur] Abdul Wali Khan Univ, Dept Biochem, Computat Med Chem Lab, UCSS, Mardan, Pakistan; [Venugopal, Vijayan] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia; [Salar, Uzma] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan; [Taha, Muhammad; Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia published Synthesis of benzotriazoles derivatives and their dual potential as alpha-amylase and alpha-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies in 2019, Cited 29. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Benzotriazoles (4-6) were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7-40). The synthetic compounds (7-40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS, H-1-, and C-13 NMR. These molecules were examined for their anti-hyperglycemic potential hence were evaluated for alpha-glucosidase and alpha-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 mu M against alpha-glucosidase and alpha-amylase enzymes, respectively. The synthetic compounds were divided into two categories A and B, in order to understand the structure-activity relationship. Compounds 25 (IC50 = 2.41 +/- 131 mu M), (IC50 = 2.5 +/- 1.21 mu M), 36 (IC50= 2.12 +/- 1.35 M), (IC50 = 2.21 +/- 1.08 mu M), and 37 (IC50 = 2.00 +/- 1.22 mu M), (IC50 = 2.04 +/- 1.4 mu M) with chloro substitution/s at aryl ring were found to be most active against alpha-glucosidase and alpha-amylase enzymes. Molecular docking studies on all compounds were performed which revealed that chloro substitutions are playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic molecules have shown competitive mode of inhibition against alpha-amylase and non-competitive mode of inhibition against alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 3-Methylbenzoic acid, If you have any questions, you can contact Hameed, S; Kanwal; Seraj, F; Rafique, R; Chigurupati, S; Wadood, A; Rehman, AU; Venugopal, V; Salar, U; Taha, M; Khan, KM or concate me.. Recommanded Product: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 3-Methylbenzoic acid. In 2020 CHEM-EUR J published article about THERMAL-DECOMPOSITION; NITRILE IMINES; DERIVATIVES; SELECTIVITY; LIGHT in [Green, Luke; Livingstone, Keith; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland; [Green, Luke; Bertrand, Sophie; Peace, Simon] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England in 2020, Cited 38. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

About 3-Methylbenzoic acid, If you have any questions, you can contact Green, L; Livingstone, K; Bertrand, S; Peace, S; Jamieson, C or concate me.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Saxena, P; Maida, N; Kapur, M in ROYAL SOC CHEMISTRY published article about ONE-POT SYNTHESIS; BOND FUNCTIONALIZATIONS; BENZOFURAN DERIVATIVES; ACTIVATION; MILD; INHIBITORS; AMIDATION; INDOLES; THIOPHENES; ARENES in [Saxena, Paridhi; Maida, Neha; Kapur, Manmohan] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, MP, India in 2019.0, Cited 52.0. Name: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A simple and effective Pd(ii)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions is reported. The significance of the arylation is highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Saxena, P; Maida, N; Kapur, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Computed Properties of C8H8O2. In 2021.0 APPL SURF SCI published article about FREE SELECTIVE OXIDATION; C-H BONDS; NONHEME IRON(IV)-OXO COMPLEX; FUNCTIONALIZED SBA-15; MESOPOROUS SILICA; BENZYLIC OXIDATION; DIOXYGEN ACTIVATION; IMMOBILIZED SBA-15; HYDROGEN-PEROXIDE; REUSABLE CATALYST in [Zahedi, Saeedeh; Safaei, Elham] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran in 2021.0, Cited 131.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

An iron (II) tetramethylated tetrapyridinoporphyrazine (FeII(2,3-tmtppa)) grafted onto sulfonated SBA-15 (SBA15@n-Pr-SO3@Fetmtppa)) has been synthesized. The catalyst was characterized using X-ray diffraction, nitrogen adsorption?desorption measurements, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, thermogravimetric analysis and scanning electron microscopy. XRD, XPS and ICP analyses confirmed the incorporation of iron (II) ion onto the surface of functionalized support. TGA and BET diagrams, FESEM and TEM images showed the grafting of (FeII(2,3-tmtppa)) on SBA-15 with mesoporous structure and ordered channels after immobilization process. This catalyst is able to perform C-H oxidation reaction of alkanes including toluene and ethylbenzene derivatives in the presence of molecular oxygen under the mild reaction in water. The hot filtration and reusability tests of the catalyst were studied which showed that the C-H activation reaction proceeds via heterogeneous pathway and catalyst is recoverable for at least 5 times.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Zahedi, S; Safaei, E or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com