Category: 99-04-7

Formula: C8H8O2. In 2019.0 TURK J CHEM published article about INSECTICIDAL ACTIVITY; SULFONE DERIVATIVES; ANTIBACTERIAL ACTIVITIES; ANTIFUNGAL ACTIVITY; BIOLOGICAL-ACTIVITY; IN-VITRO; BEARING; JTS-653; ANALOGS; DESIGN in [Yu, Gang; Chen, Shunhong; He, Feng; Luo, Dexia; Zhang, Yu; Wu, Jian] Guizhou Univ, Key Lab Green Pesticides & Agr Bioengn, Minist Educ, Guiyang, Guizhou, Peoples R China in 2019.0, Cited 37.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g-6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L-1.

Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Yu, G; Chen, SH; He, F; Luo, DX; Zhang, Y; Wu, J or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, HJ; Lian, YQ; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, HQ; Bertin, J; Marquis, RW in AMER CHEMICAL SOC published article about NOD1 VARIATION; IDENTIFICATION; ASSOCIATION; DOMAIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; BINDING in [Haffner, Curt D.; Charnley, Adam K.; Casillas, Linda; Cox, Julie A.; Elban, Mark A.; Goodwin, Nicole C.; Gough, Peter J.; Haile, Pamela A.; Knapp-Reed, Beth; Kreatsoulas, Constantine; Lakdawala, Ami S.; Li, Huijie; Lian, Yiqian; Lipshutz, David; Mehlmann, John F.; Ouellette, Michael; Romano, Joseph; Shewchuk, Lisa; Shu, Arthur; Votta, Bartholomew J.; Zhou, Huiqiang; Bertin, John; Marquis, Robert W.] GlaxoSmithKline, 1250 South Collegeville Rd, Collegeville, PA 19426 USA; [Convery, Maire A.] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England; [Aquino, Christopher J.] CJAMedChem LLC, 1600 W Bromfield Dr, Hillsborough, NC 27599 USA; [Hughes, Terry V.] Janssen Res & Dev LLC, POB 776, Spring House, PA 19477 USA in 2019.0, Cited 34.0. Quality Control of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide 11 represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, HJ; Lian, YQ; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, HQ; Bertin, J; Marquis, RW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Yadav, MS; Singh, SK; Agrahari, AK; Singh, AS; Tiwari, VK in GEORG THIEME VERLAG KG published article about in [Yadav, Mangal S.; Singh, Sumt K.; Agrahari, Anand K.; Singh, Anoop S.; Tiwari, Vinod K.] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 64.0. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A diverse range of ureas, N-acylureas, carbamates, and thiocarbamates has been synthesized in good to excellent yields by reacting N-acylbenzotriazoles individually with amines or amides or phenols or thiols in the presence of diphenylphosphoryl azide (DPPA) as a suitable azide donor in anhydrous toluene at 110 degrees C for 3-4 hours. In this route, DPPA was found to be a good alternative to trimethylsilyl azide and sodium azide for the azide donor in Curtius degradation. The high reaction yields, one-pot and metal-free conditions, straightforward nature, easy handling, use of readily available reagents, and in many cases avoidance of column chromatography are the notable features of the devised protocol.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Yadav, MS; Singh, SK; Agrahari, AK; Singh, AS; Tiwari, VK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Cp2TiCl2-Catalyzed Carboxylation of Aryl Chlorides with Carbon Dioxide in the Presence of n-BuMgCl WOS:000535187200003 published article about PALLADIUM-CATALYZED CARBOXYLATION; GRIGNARD-REAGENTS; BENZYL CHLORIDES; HALIDES; TRANSFORMATION; COMPLEXES; INSERTION; ALKENES; ESTERS in [Hang, Wei; Yi, Yaping; Xi, Chanjuan] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China; [Xi, Chanjuan] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020, Cited 56. Quality Control of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Cp2TiCl2-catalyzed carboxylation of aryl chlorides with carbon dioxide to afford benzoic acids in good yields has been achieved in the presence of n-BuMgCl. The reaction proceeds by a sequential magnesium halide exchange reaction and carboxylation with CO2 in a wide variety of aryl chlorides under mild conditions.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Hang, W; Yi, YP; Xi, CJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Han, J; Zhou, W; Zhang, PC; Wang, HM; Zhang, RH; Wu, HH; Zhang, JL in [Han, Jie; Zhou, Wei; Zhang, Pei-Chao; Wang, Huamin; Zhang, Ronghua; Wu, Hai-Hong; Zhang, Junliang] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China; [Zhang, Junliang] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China published Design and Synthesis of WJ-Phos, and Application in Cu-Catalyzed Enantioselective Boroacylation of 1,1-Disubstituted Allenes in 2019, Cited 78. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

The highly enantioselective copper-catalyzed three-component boroacylation of 1,1-disubstituted allenes is reported by using a class of chiral ligands (WJ-Phos), delivering various functionalized organoboron compounds bearing an all-carbon stereocenter in moderate to good yields with high enantioselectivities. WJ-Phos is a ferrocene-derived chiral sulfinamide phosphine ligand and can be easily synthesized in gram-scale from readily available starting materials in short steps. The salient features of this reaction include moderate to good yields, high enantioselectivities, gram-scale synthesis, diverse synthetic transformations, and the development of a new chiral ligand.

SDS of cas: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Han, J; Zhou, W; Zhang, PC; Wang, HM; Zhang, RH; Wu, HH; Zhang, JL or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Switchable Synthesis of Arylalkynes and Phthalides via Controllable Palladium-Catalyzed Alkynylation and Alkynylation-Annulation of Benzoic Acids with Bromoalkynes WOS:000476957000032 published article about C-H BONDS; FUNCTIONALIZATIONS; COORDINATION; ALKYNES in [Shi, Shuai; Chen, Cui-Hong; Chai, Yun; Zhang, Li-Ting; Li, Jia-Wei; Liu, Bin; Liu, Yue-Jin; Zeng, Ming-Hua] Hubei Univ, Dept Hubei Collaborat Innovat Ctr Adv Chem Mat, Minist Educ, Key Lab Synth & Applicat Organ Funct Mol, Wuhan 430062, Hubei, Peoples R China; [Shi, Shuai; Chen, Cui-Hong; Chai, Yun; Zhang, Li-Ting; Li, Jia-Wei; Liu, Bin; Liu, Yue-Jin; Zeng, Ming-Hua] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China; [Zeng, Ming-Hua] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Dept Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China in 2019.0, Cited 50.0. Recommanded Product: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A ligand-promoted palladium (II)-catalyzed synthesis of arylalkynes and phthalides from benzoic acids and bromoalkynes via carboxylate-assisted ortho-C-H activation is reported. A series of phthalides with various functional groups are prepared via ortho-alkynylation and alkynylation-annulation. Moreover, the key ortho-alkynylated products are also obtained by controlling the reaction conditions. In addition, heteroaryl acids could react smoothly to form the corresponding alkynylation and cyclization products.

Recommanded Product: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Shi, S; Chen, CH; Chai, Y; Zhang, LT; Li, JW; Liu, B; Liu, YJ; Zeng, MH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 3-Methylbenzoic acid. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CH3, 3-CF3O and 3-CHF2O groups at the C2-benzoate position published in 2020.0, Reprint Addresses Ojima, I (corresponding author), SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

It has been shown that inclusion of CF3O and CHF2O groups to drug candidates often improve their pharmacological properties, especially metabolic stability, membrane permeability and PK profile. Moreover, the unique non-spherical structure of the OCHF2 group can provide interesting and beneficial characteristics. Accordingly, new 3rd-generation taxoids, bearing 3-OCF3 or 3-OCF2H (and 3-CH3 for comparison) at the C2 benzoate moiety, were synthesized and their potencies against drug-sensitive and drug-resistant cancer cell lines examined. In this study, our previous SAR studies on 3rd-generation taxoids were expanded to disclose that CH3, CF3O and CHF2O groups are well tolerated at this position and enhance potency, especially against MDR-cancer cell lines so that these taxoids can virtually overcome MDR. These new taxoids exhibit up to 7 times higher cytotoxicity (IC50) than paclitaxel against drug-sensitive cancer cell lines (MCF7 and LCC6-WT) and 2-3 orders of magnitude higher potency than paclitaxel against drug-resistant ovarian, breast and colon cancer cell lines with MDR-phenotype (NCI/ADR, LCC6-MDR and LDL-1), as well as pancreatic cancer cell line, CFPAC-1. Since it has been shown that a bulky group at this position reduces potency, it is noteworthy that rather bulky CF3O and CHF2O groups are well tolerated. Molecular modeling analysis indicated the favorable van der Waals interactions of CF3O and CHF2O groups in the binding site. It is also worthy of note that new taxoids, bearing a CHF2O group at the C2 benzoate position (1-06 series), exhibited the highest potencies against MDR-cancer cell lines and cancer stem cell (CSC)-enriched cancer cell lines. These new 3rd-generation taxoids are promising candidates for highly potent chemotherapeutic agents, as well as payloads for tumor-targeting drug conjugates such as antibody-drug conjugates (ADCs).

About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, CW; Wang, X; Sun, Y; Taouil, AK; Yan, S; Botchkina, GI; Ojima, I or concate me.. Name: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article N-Sulfonyl acetylketenimine as a highly reactive intermediate for synthesis of N-Aroylsulfonamides WOS:000456353200007 published article about GROUP-11 METAL(I) COMPOUNDS; COPPER-CATALYZED SYNTHESIS; LEWIS-BASE ADDUCTS; STEREOSELECTIVE-SYNTHESIS; NITROGEN ANALOGS; ROOM-TEMPERATURE; CARBOXYLIC-ACIDS; AMIDE SYNTHESIS; FACILE ACCESS; ALKYNE in [Yang, Weiguang; Huang, Dayun; Zeng, Xiaobao; Zhang, Jianlan; Wang, Xinyan; Hu, Yuefei] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China in 2019, Cited 60. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Category: isothiazole

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from an ynone-participated CuAAC/ring-opening method. Its unique structure allowed it to react with aryl carboxylic acids to give N-aroylsulfonamides via a novel Mumm-type rearrangement. (C) 2018 Elsevier Ltd. All rights reserved.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Yang, WG; Huang, DY; Zeng, XB; Zhang, JL; Wang, XY; Hu, YF or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Wu, Y; Zhang, MS; Zhang, YL; Li, MY; Feng, WS; Zheng, XK; Tang, L in ROYAL SOC CHEMISTRY published article about O BOND FORMATION; C-H LACTONIZATION; DIMETHYL-SULFOXIDE; CATALYZED C(SP(2))-H; EXPEDIENT SYNTHESIS; PUMMERER REACTION; METHYL KETONES; FACILE ACCESS; STRATEGY; FUNCTIONALIZATION in [Wu, Ya; Zhang, Mengsha; Zhang, Yanli; Li, Mingyang; Feng, Weisheng; Zheng, Xiaoke] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China; [Wu, Ya; Zhang, Mengsha; Zhang, Yanli; Li, Mingyang; Feng, Weisheng; Zheng, Xiaoke] Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou 450046, Henan, Peoples R China; [Tang, Lin] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Henan, Peoples R China in 2020, Cited 75. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The firstN-bromosuccinimide (NBS)-promoted transition metal-free cross-dehydrogenative esterification of carboxylic acids with dimethyl sulfoxide (DMSO) has been disclosed for formal C-O formationviaPummerer-type rearrangement. These transformations employ readily available carboxylic acids as the nucleophile and DMSO as the sulfur-containing carbon source and solvent under mild conditions, affording valuable (methylsulfinyl)methyl esters with a broad substrate scope. Furthermore, the developed protocol provides an efficient and straightforward method for the preparation of deuterated (methylsulfinyl)methyl esters by use of deuterium-labelled DMSO as the reagent.

SDS of cas: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Wu, Y; Zhang, MS; Zhang, YL; Li, MY; Feng, WS; Zheng, XK; Tang, L or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; INHIBITORS; BINDING; HYBRIDS, Saw an article supported by the Science and Technology Research Program of Shandong Academy of Medical Sciences [2017-16]; Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2018LH021]; Innovation Project of Shandong Academy of Medical Sciences. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Hu, YH; Yang, J; Zhang, Y; Liu, KC; Liu, T; Sun, J; Wang, XJ. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. SDS of cas: 99-04-7

The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3-(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 +/- 0.011 mu M and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 +/- 0.017 mu M. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.

SDS of cas: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Hu, YH; Yang, J; Zhang, Y; Liu, KC; Liu, T; Sun, J; Wang, XJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com