Category: isothiazole

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chem. & Pharm. Bull. (Tokyo) called Bromination of pyrimidines by N-bromosuccinimide, Author is Nishiwaki, Tarozaemon, which mentions a compound: 6307-44-4, SMILESS is SC1=CC(C)=NC(N)=N1, Molecular C5H7N3S, Safety of 2-Amino-6-methylpyrimidine-4-thiol.

cf. CA 54, 24777h. Pyrimidines having potentially tautomeric groups at the 2-, 4-, or 6-position were brominated preferentially at the 5-position by N-bromosuccinimide (I) in HOAc. Thus, 0.01 mole pyrimidine in 20 ml. HOAc was treated with 0.01 mole I 1 hr. at 100°. The precipitate was collected and crystallized to give N:CR1N:CR2.CBr:CR3 (R1, R2, R3, m.p., and % yield given): OH, OH, H, 295° 59; OH, OH, Me, 248°, 76; H, OH, OH, 264°, 61; NH2, OH, H, 275°, 83; NH2, OH, Me, 249°, 61; NH2, H, H, 239-40°, 62; NH2, Cl, Cl, 235-6°, 63; NH2, Me, Me, 183-4°, 75; NH2, Ph, Me, 125-8°, 70; Cl, Cl, NH2, 155-7°, 79; SMe, OH, H, 252°, 41; SMe, OH, Me, 246°, 21; SMe, OH, NH2, -, 60; SMe, Cl, NH2, 164-5°, 66; SEt, OH, H, 185-7.5°, 47. An ionic mechanism was postulated as yields were improved by addition of AlCl3, FeCl3, SnCl4, and picric acid and not reduced by radical inhibitors. The bromination by I of O- and S-alkylpyrimidines, 1,3,4-trimethyluracil, and 2,4-dichloro-6-methylpyrimidine by this method was not successful.

The article 《Bromination of pyrimidines by N-bromosuccinimide》 also mentions many details about this compound(6307-44-4)Safety of 2-Amino-6-methylpyrimidine-4-thiol, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Oriented Circular Dichroism Analysis of Chiral Surface-Anchored Metal-Organic Frameworks Grown by Liquid-Phase Epitaxy and upon Loading with Chiral Guest Compounds. Author is Gu, Zhi-Gang; Buerck, Jochen; Bihlmeier, Angela; Liu, Jinxuan; Shekhah, Osama; Weidler, Peter G.; Azucena, Carlos; Wang, Zhengbang; Heissler, Stefan; Gliemann, Hartmut; Klopper, Wim; Ulrich, Anne S.; Woell, Christof.

Oriented CD (OCD) is explored and successfully applied to study chiral surface-anchored metal-organic frameworks (SURMOFs) based on camphoric acid (D- and Lcam) [Cu2(Dcam)2x(Lcam)2-2x(dabco)]n (dabco = 1,4-diazabicyclo-[2.2.2]-octane). The three-dimensional chiral SURMOFs with high-quality orientation were grown on quartz glass plates by using a layer-by-layer LPE method. The growth orientation, as determined by XRD, could be switched between the [001] and [110] direction by using either OH- or COOH-terminated substrates. These SURMOFs were characterized by using OCD, which confirmed the ratio as well as the orientation of the enantiomeric linker mols. Theor. computations demonstrate that the OCD band intensities of the enantiopure [Cu2(Dcam)2(dabco)]n grown in different orientations are a direct result of the anisotropic nature of the chiral SURMOFs. Finally, the enantiopure [Cu2(Dcam)2(dabco)]n and [Cu2(Lcam)2(dabco)]n SURMOFs were loaded with the two chiral forms of Et lactate [(+)-ethyl-D-lactate and (-)-ethyl-L-lactate]. An enantioselective enrichment of >60% was observed by OCD when the chiral host scaffold was loaded from the racemic mixture

The article 《Oriented Circular Dichroism Analysis of Chiral Surface-Anchored Metal-Organic Frameworks Grown by Liquid-Phase Epitaxy and upon Loading with Chiral Guest Compounds》 also mentions many details about this compound(560-09-8)Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Category: isothiazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about A novel and efficient synthesis of camphorquinone from camphoric acid. Author is Tan, Qitao; Wang, Yunying; Li, Daliang; Wen, Jiwu; You, Tianpa.

Camphorquinone, an important fine chem. and medicinal product derived from camphor, was efficiently synthesized from easily available camphoric acid. The key steps include acyloin condensation using Me3SiCl as a scavenger of alkoxides and oxidation of the bis(trimethylsilyl) derivative by bromine in CCl4. The new method offers an efficient alternative synthesis of camphorquinone.

The article 《A novel and efficient synthesis of camphorquinone from camphoric acid》 also mentions many details about this compound(560-09-8)Category: isothiazole, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Application In Synthesis of Aluminum(III) sulfate xhydrate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Aluminum(III) sulfate xhydrate, is researched, Molecular Al2H8O13S3, CAS is 17927-65-0, about Alkaline, mental, and acidic ranges [in papermaking]. Author is Volkel, H.-G.; Weigl, J..

The manufacturing of papers is described under acidic and neutral operating conditions. The fabrication of papers under these conditions is based on the use of Al2(SO4)3.18H2O and CaCO3 as white pigments. The competing reactions of these 2 reagents are described and their advantages and disadvantages for paper production are discussed in relation to the pH value and the wood content of the papers.

The article 《Alkaline, mental, and acidic ranges [in papermaking]》 also mentions many details about this compound(17927-65-0)Application In Synthesis of Aluminum(III) sulfate xhydrate, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Erkin, A. V.; Klaptyuk, I. V.; Gurzhii, V. V.; Yuzikhin, O. S.; Krutikov, V. I. published an article about the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4,SMILESS:SC1=CC(C)=NC(N)=N1 ).Computed Properties of C5H7N3S. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:6307-44-4) through the article.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

The article 《Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms》 also mentions many details about this compound(6307-44-4)Computed Properties of C5H7N3S, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Product Details of 17927-65-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Aluminum(III) sulfate xhydrate, is researched, Molecular Al2H8O13S3, CAS is 17927-65-0, about Deuterium/hydrogen fractionation in sulfate hydrate-water systems. Author is Pradhananga, Trinetra M.; Matsuo, Sadao.

The D/H fractionation factors (α) of some of the sulfate hydrate-H2O systems were measured. A dependence of α on cationic parameters and M-H2O distance was found. The D/H fractionation factors of various hydrate-water systems were divided into 2 groups with respect to their α values: one having α < 1 and the other α > 1. There is almost no change in α for crystal-H2O systems having SO42- as the anion of the 1st transition metal ion series from Fe2+ to Zn2+, except for Cu2+. This is related to the common structure of the hydration sphere of cations and the common distance of M-H2O. The exceptional case for Cu2+ is attributed to the distorted structure of octahedra surrounding Cu2+. A similar type of behavior of protons leading to the residual entropy was found in some of the crystal-H2O systems having α > 1.

The article 《Deuterium/hydrogen fractionation in sulfate hydrate-water systems》 also mentions many details about this compound(17927-65-0)Product Details of 17927-65-0, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-6-methylpyrimidine-4-thiol(SMILESS: SC1=CC(C)=NC(N)=N1,cas:6307-44-4) is researched.SDS of cas: 17927-65-0. The article 《Inhibition studies of Pyrimidine class of compounds on Enoyl-ACP reductase enzyme》 in relation to this compound, is published in Journal of Computer Science & Systems Biology. Let’s take a look at the latest research on this compound (cas:6307-44-4).

Present work is aimed to identify and understand the inhibiting nature of Pyrimidine class of compounds to enoyl acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the main receptor proteins used in drug discovery for screening anti-leprosy agents. Series of Pyrimidine based compounds are virtually designed using the mol. mechanic technique. The designed mols. were docked using with crystal structure of Enoyl-ACP reductase (PDB ID: 2NTV) using Autodock mol. docking software. The method uses rigid-protein and flexible ligand-techniques to acquire maximum conformations of ligand mols. The docking results were evaluated using the acquired binding energy values for each ligand-protein complex. Those mols. having higher neg. binding energy values with higher hydrogen bonds are selected for further anal. The selected mols. show better hydrophobic, electrostatic and steric interactions with receptor protein. It is reported that the presence of -CH2OH at R1 and -C6H5 at R2 and R3 positions enhance the neg. binding energy (ΔG kcal mol-1) values. Particularly -OC6H5 at R1 and -OH at R2 help in increasing the interactions between ligand and protein. The results show the mol. level interactions and inhibit the receptor protein.

The article 《Inhibition studies of Pyrimidine class of compounds on Enoyl-ACP reductase enzyme》 also mentions many details about this compound(6307-44-4)Formula: C5H7N3S, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) study of some organic acids. II, published in 1963, which mentions a compound: 560-09-8, Name is (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, Molecular C10H16O4, Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid.

cf. CA 59, 8105f. The DTA and TGA curves of 5-aminosalicylic, 5-nitrosalicylic, acetylsalicylic, 5-bromosalicylic, salicylhydroxamic, α,β-dibromosuccinic, m-cresoxyacetic, p-bromomandelic, d-camphoric, diphenic, picric, 2,4-dimethoxybenzoic, m-hydroxybenzoic, 3,4-dihydroxybenzoic (1.5H2O), 4-hydroxy-3-methoxybenzoic, and tropic acids were obtained from ambient to 350°. The DTA curves are useful for identifying the acids.

The article 《Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) study of some organic acids. II》 also mentions many details about this compound(560-09-8)Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides, published in 1993-02-28, which mentions a compound: 6307-44-4, mainly applied to pyrimidinone regioselective thiation Lawesson reagent; nucleoside pyrimidinone regioselective thiation Lawesson reagent, Reference of 2-Amino-6-methylpyrimidine-4-thiol.

Convenient and high-yield regioselective thiation procedures based on the use of the Lawesson reagent in different solvents, are described for conversion of the 2- and 4-keto, and 2,4-diketo pyrimidines to the corresponding 2(4)-thio, and 2,4-dithio, derivatives This method is applicable to thiation of the 4-keto groups of 5,6-dihydropyrimidinones and pyrimidine nucleosides. The mild reaction conditions employed are such that it is the method of choice for compounds with labile glycosidic bonds, of choice for compounds with labile glycosidic bonds, such as 5,6-dihydropyrimidine nucleosides and the 2′,3′-dideoxynucleosides currently of interest as antiretroviral, including anti-HIV, agents.

The article 《High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides》 also mentions many details about this compound(6307-44-4)Reference of 2-Amino-6-methylpyrimidine-4-thiol, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tan, Qitao; Wang, Yunying; Li, Daliang; Wen, Jiwu; You, Tianpa researched the compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ).Safety of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid.They published the article 《A novel and efficient synthesis of camphorquinone from camphoric acid》 about this compound( cas:560-09-8 ) in Synthesis. Keywords: camphorquinone preparation. We’ll tell you more about this compound (cas:560-09-8).

Camphorquinone, an important fine chem. and medicinal product derived from camphor, was efficiently synthesized from easily available camphoric acid. The key steps include acyloin condensation using Me3SiCl as a scavenger of alkoxides and oxidation of the bis(trimethylsilyl) derivative by bromine in CCl4. The new method offers an efficient alternative synthesis of camphorquinone.

The article 《A novel and efficient synthesis of camphorquinone from camphoric acid》 also mentions many details about this compound(560-09-8)Safety of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com