Category: isothiazole

936-16-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Potassium carbonate was dissolved in DMF, and 1,2-bezeneisothiazolin-1,1-dioxide (8) (1 equiv.) in dichloromethanewas added to the reaction solution, and stirred for overnight. Then,the reaction mixture was filtered through Celite, and washed with1 N HCl and saturated sodium hydrogen carbonate solution. Residualsolution was dried over magnesium sulfate, and concentratedin vacuo, and purified by column chromatography to afford the titlecompound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, 936-16-3

Reference£º
Article in Press; Hong, Jin Ri; Choi, Young Jin; Keum, Gyochang; Nam, Ghilsoo; Bioorganic and Medicinal Chemistry; (2017);,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

24340-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-Bromoisothiazole, cas is 24340-77-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

General procedure: General Procedure E: Preparation of Coupled Aryl and Heteroaryl Groups Using Buchwald Catalyzed Coupling Conditions Between an Organohalide in the Presence of a Tin Reagent (0331) [00219] A solution of organobromide (1.0 equivalent), organochloride (1.0 equivalent), hexabutylditin (1.0 equivalent) and Pd(dppf)Cl2?DCM (10 mol%) in anhydrous 1,4-dioxane (10 mL/mmol) was stirred at 100 oC under N2 overnight, then cooled and quenched with water (20 mL/mmol). The resulting mixture was extracted with EtOAc (20 mL/mmol x 3), the organic phases were separated and dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo, and the resulting residue was purified by silica gel column (0332) chromatography or preparative-TLC to afford the coupled ring system.

The chemical industry reduces the impact on the environment during synthesis,24340-77-0,4-Bromoisothiazole,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; LYSOSOMAL THERAPEUTICS INC.; SKERLJ, Renato, T.; BOURQUE, Elyse Marie Josee; LANSBURY, Peter, T.; GREENLEE, William, J.; GOOD, Andrew, C.; (309 pag.)WO2017/176961; (2017); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3-Piperazinobenzisothiazole hydrochloride, and cas is 87691-88-1, its synthesis route is as follows.

A 2 L reaction flask was charged with 88.5 g (lR, 2R) -1,2-cyclohexanedimethanol dimethanesulfonate, 71.8 g3- (1-piperazinyl) -1,2-benzisothiazole hydrochloride, 77.5 g of potassium carbonate and 1 L of acetonitrile were added and the mixture was heated under reflux with stirring. After the reaction is complete, hotFiltration, filter cake rinse with acetonitrile, the filtrate concentrated to dry under vacuum, in an off-white solid 104. 6g, 88% yield, HPLC purity is greater than99%, m.p. 228-230 C.

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Suzhou Er Ye Pharmaceutical Co., Ltd; Liu, Zhi; Wu, Yongfeng; Fan, Shengya; (5 pag.)CN105732644; (2016); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

24340-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-Bromoisothiazole, cas is 24340-77-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

To a reaction flask were added compound 41 (100 mg, 0.19 mmol), 4-bromoisothiazole (50 mg, 0.27 mmol), Pd(dppf)Cl2 (5 mg, 0.006 mmol) and sodium carbonate (60 mg, 0.558 mmol), 5 mL glycol dimethyl ether and 0.9 mL water were added, bubbled with nitrogen gas for 10 minutes, and the reaction was heated to 100 C in microwave and reacted for half an hours. After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatography to afford 58 mg of a product, yield: 63%. LC-MS(APCI): m/z = 485.3 (M+1)+. 1H NMR (400 MHz, CDCl3) delta 10.23 (s, 1H), 9.09 (s, 1H), 8.77 (d, J = 2.0 Hz, 1H), 8.72 (s, 1H), 8.10 (d, J = 2.0 Hz, 1H), 7.87 (d, J = 9.0 Hz, 2H), 7.34 (d, J = 8.7 Hz, 2H), 5.47 (d, J = 3.5 Hz, 1H), 4.94 (d, J = 51.5 Hz, 1H), 4.18 (s, 1H), 3.64 (ddd, J = 41.8, 13.5, 3.1 Hz, 1H), 3.43 – 3.38 (m, 1H), 3.02 (d, J = 11.9 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis,24340-77-0,4-Bromoisothiazole,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (51 pag.)EP3553057; (2019); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 4-Bromoisothiazole, and cas is 24340-77-0, its synthesis route is as follows.

10456] 0.150 g (0.67 mmol) of 2-[6-(1H-pyrazol-4-yl)py- ridin-2-yl]pyrimidine (cf. Step 3) were initially charged, and 0.350 g (1.07 mmol) of caesium carbonate, 4.81 mg (0.03 mmol) of copper(I) oxide, 18.4mg (0.13 mmol) of salicylaldoxime, 0.165 g (1.0 mmol) of 4-bromoisothiazole and 1 ml of N,N-dimethylformamide were added successively under argon. The reaction mixture was heated at 110 C. for 24 hours. After cooling, the solvent was removed on a rotary evaporator under reduced pressure and the residue was purified by medium pressure column chromatography (MPLC) with cyclohexane/acetone (100:0 to 0:100). This gave 4.7mg (2% of theory) of2-{6-[1 -(isothiazol-4-yl)-1 H-pyrazol-4-yl] pyridin-2-yl}pyrimidine.10457] HPLC-MS: log P (HCOOH)=1.65, log P (neutral)=1.64.

24340-77-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,24340-77-0 ,4-Bromoisothiazole, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; BAYER CROPSCIENCE AG; Koehler, Adeline; Bretschneider, Thomas; Muehlthau, Friedrich August; Fuesslein, Martin; Jeschke, Peter; Fischer, Reiner; Voerste, Arnd; Malsam, Olga; Ilg, Kerstin; US2015/284380; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

288-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Isothiazole, cas is 288-16-4,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Under nitrogen, compound l (20 g, 0.235 mol) was added to dry 100 ml of ether and stirred and dissolved(0.24 mol 1) was added dropwise thereto at a temperature below 0 C, and the mixture was kept at 0 C or less during the dropwise addition.Temperature reaction until no compound 1.To the reaction solution was added dropwise bromine (0.5 mol)During the dropping process, it is kept below 0 C,After the dropwise addition, slowly rise to room temperature,After stirring for half an hour, the reaction was quenched by the addition of hydrochloric acid solution (2N, 500 ml).Layered,The aqueous phase was treated with ether (200 ml * 3)After extraction,Combined organic phase,Sodium dithionite solution (100 ml * 2),Dried over anhydrous sodium sulfate,Filtered and concentrated to dry,To give a yellow oily compound.

The chemical industry reduces the impact on the environment during synthesis,288-16-4,Isothiazole,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Tianjin Jinyao Group Co., Ltd.; Li Jing; He Guangjie; Yang Xinyi; Wang Shuli; Chen Liying; Hu Xiaoyun; Sun Liang; (35 pag.)CN106890141; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 6-Bromobenzo[d]isothiazole-3-carboxylic acid, and cas is 677304-75-5, its synthesis route is as follows.

The following procedure was used to prepare benzisothiazole fer/-butyl esters:Di-ferz’-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-l,2- benzisothiazole-3-carboxyIic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-buty alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 0C for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 5Og) and the eluent was concentrated to provide the ester product in 99% yield.The following ester was prepared using this method:tert-Butyl S-brorno-l^-benzisothiazole-S-carboxylate. tert-Butyl -bromo-l^-benzisothiazole-S-carboxylate.

677304-75-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,677304-75-5 ,6-Bromobenzo[d]isothiazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3,4-Dichloroisothiazole-5-carboxylic acid, and cas is 18480-53-0, its synthesis route is as follows.

SYNTHESIS EXAMPLE 1 Process (a): After thionyl chloride (10 ml) had been added to 3,4-dichloro-5-isothiazole-carboxylic acid (0.99 g), the mixture was refluxed by heating for 2 hours. The excess of thionylchloride was then distilled off under reduced pressure, and 3,4-dichloro-5-isothiazolecarboxylic acid chloride was obtained.

18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Assmann, Lutz; Kitagawa, Yoshinori; Ishikawa, Koichi; Yamazaki, Daiei; Sawada, Haruko; Araki, Yasuo; Sakuma, Haruhiko; Kinbara, Taro; Imanishi, Kinya; US2003/13750; (2003); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3-Bromoisothiazole, and cas is 55512-82-8, its synthesis route is as follows.

To a reaction flask were added compound 5 (200 mg, 0.392 mmol), 3-bromoisothiazole (96 mg, 0.588 mmol), Pd(dppf)Cl2 (32 mg, 0.02 mmol) and sodium carbonate (126 mg, 1.18 mmol), 2 mL glycol dimethyl ether and 0.4 mL water were added, bubbled with nitrogen gas for 10 minutes, heated to 120 C in microwave and reacted for 0.5 hour. After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatography to afford 84 mg of a product, yield: 46%. LC-MS(APCI): m/z = 467.3(M+1)+; 1H NMR (400 MHz, DMSO) delta 10.17 (s, 1H), 9.04 (s, 1H), 8.90 (s, 1H),8.76 (d, J = 2.3 Hz, 1H), 8.05 (d, J = 2.3 Hz, 1H), 7.86 (d, J = 9.1 Hz, 2H), 7.33 (d, J = 8.8 Hz, 2H), 4.86 (d, J = 3.4 Hz, 1H), 4.21 (s, 1H), 3.41 (dd, J = 17.0, 9.3 Hz, 1H), 3.29 – 3.18 (m, 2H), 2.90 (d, J = 11.1 Hz, 1H), 1.89 – 1.80 (m, 1H), 1.75 (s, 1H).

55512-82-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,55512-82-8 ,3-Bromoisothiazole, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (51 pag.)EP3553057; (2019); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, and cas is 27148-03-4, its synthesis route is as follows.

A solution of thiosaccharin (tsacH) (0.084 g, 0.425 mmol) in chloroform (10 cm3) was added to a solution of [Pt(kappa2-dppm)2]Cl2 (0.22 g, 0.22 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution which was filtered and reduced to half volume. Methanol (2 cm3) was added and the mixture was set aside to evaporate slowly at room temperature. The pale yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (85%). 11: pale yellow solid, 85% yield. 1H NMR: delta 7.57 (d, J 7.60 Hz, 4H, Ar), 7.50-6.80 (m, 44 H, Ar), 3.46 (br, 4H, CH2); 31P{1H} NMR: 253 K 18.1 (br), -30.4 (br) ppm; 298 K 16.8 (vbr), -28.1 (vbr) ppm; 333 K -23.3 (vbr) ppm; IR(KBr) 3053w, 2932w, 1431s, 1313vs, 1159vs, 994s, 800s, 694s, 378m cm-1; Elemental Anal. Calc. for PtN2S4P4O4C64H52¡¤0.5CH2Cl2. Found: C, 55.42 (55.00); H, 3.79 (3.66); N: 2.00 (1.97)%.

27148-03-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,27148-03-4 ,Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Al-Jibori, Subhi A.; Al-Jibori, Mohamed H.S.; Hogarth, Graeme; Inorganica Chimica Acta; vol. 398; (2013); p. 117 – 123;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com