Heterocyclic Building Blocks-Isothiazole

On November 8, 1988, Grove, Scott L. published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Wood preservatives containing transition metal carboxylates and isothiazolones. And the patent contained the following:

Wood preservatives comprise a transition metal carboxylate and a isothiazolone I [R1 = C1-18 alkyl, alkenyl, or alkynyl, C≤12 cycloalkyl (C3-6 ring); R2, R3 = H, halo, lower alkyl]. A slurry of dithio-N,N-dimethylpropionamide in ethylene dichloride was treated with SO2Cl2 to give I (R1 = Me, R2 = R3 = H)-HCl and I (R1 = Me, R2 = H, R3 = Cl). A wood preservative composition comprised Cu naphthenate 8, I (R1 = octyl, R2 = R3 = Cl) 2, Atlas G 1096 10, Atlas G 3300 2% and the balance mineral spirits. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to metal carboxylate isothiazolone wood preservative, Agrochemical Bioregulators: Invertebrate and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 4, 2017, Verheyen, Geert R.; Braeken, Els; Van Deun, Koen; Van Miert, Sabine published an article.SDS of cas: 26172-54-3 The title of the article was Evaluation of existing (Q)SAR models for skin and eye irritation and corrosion to use for REACH registration. And the article contained the following:

The performance of the (Q)SAR models Derek Nexus, Toxtree and Case Ultra for the prediction of skin and eye irritation/corrosion is investigated. For irritation and corrosion of the skin, 117 compounds and for the eye, 125 compounds were listed. The balance between the groups pos. and neg. for irritation and corrosion was maintained. The obtained predictions were compared with exptl. data and the numbers of true and false positives and negatives were determined Based on these results several performance parameters of the tested (Q)SAR models were calculated Despite all the efforts to make good and valid models, the results indicate a poor predictivity of the current models: a lot of compounds were not predicted, were out of the applicability domain or were predicted wrong. Considering the authors’ results, it can be concluded that the tested models are not yet sufficiently powerful for implementation. Possibly the training-sets used within the current models are not yet comprehensive enough or the incorporated data are not of enough quality. Although the use of these models as stand-alone evaluation is not recommended, these models can be of value as weight-of-evidence in the context of expert knowledge in an Integrated Approach to Testing and Assessment. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to qsar modeling skin eye irritation corrosion, accuracy, corrosion, irritation, modelling, performance indicator, qsar, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 4, 1996, Kurrle-Weittenhiller, Angelika; Schmidt, Axel published a patent.Application of 26172-54-3 The title of the patent was Preservative mixture for diagnostic test fluids. And the patent contained the following:

A preservative mixture, especially for the preservation of test fluids in an α-amylase test kit, contains the Na salt of mercaptopyridine N-oxide combined with another preservative. The disclosed diagnostic test kit contains as preservatives mercaptopyridine N-oxide Na salt, a compound of the isothiazolone group, and especially 2-alkyl-3-(2H)-isothiazolone HCl with 1-8 C atoms in the 2-alkyl group, or a mixture of preservatives. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to amylase determination test kit preservative, mercaptopyridine oxide preservative test kit, isothiazolone compound preservative test kit, Enzymes: Analysis (Determination-Detection) and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On October 10, 2012, Zhang, Weiming; Li, Yaopin; Sun, Dafeng; Ma, Shihong published a patent.SDS of cas: 26172-54-3 The title of the patent was Natural olive oil and its derivative-containing shampoo and its preparation. And the patent contained the following:

The title shampoo contains polyethylene glycol-7 olive oil carboxylic acid sodium 10-20, polyether lauryl sodium sulfate 1-6, sodium olivoyl glutamate 1-10, olivamidopropyl betaine 1-10, ethylene glycol stearate 1-2, oliveamide MEA 1-5, olivoyl hydrolyzed wheat protein 0.1-2, polydimethylsiloxane 0.5-3, polyethylene glycol-7 olivate 0.5-5, sodium chloride 0.1-2, polyquaternium-10 0.5-1, citric acid 0.05-1, hydroxypropyl methylcellulose 0.01-1, methylisothiazolinone 0.01-0.1, chloro-methylisothiazolinone 0.01-0.1, essence 0.1-2% and water. The preparation method comprises heating deionized water in water phase pot to 70~90°C, adding polyquaternium-10 and hydroxypropyl methylcellulose, stirring to effect dissolution, adding polyethylene glycol-7 olive oil carboxylic acid sodium, polyether lauryl sodium sulfate, sodium olivoyl glutamate, olivamidopropyl betaine and olivoyl hydrolyzed wheat protein to dissolve, pumping to vacuum emulsifying pot, adding ethylene glycol stearate, oliveamide MEA and polydimethylsiloxane, stirring to effect dissolution, keeping at the temperature for 20 min, vacuum homogenizing for 5~10 min, stirring to cool to 45°C, removing vacuum, adding olyethylene glycol-7 olivate, sodium chloride, methylisothiazolinone, chloro-methylisothiazolinone and essence, mixing well, and adjusting pH to 6.0-7.5 with citric acid. The title shampoo is characterized with low irritation and high foam. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to olive oil derivative shampoo, Essential Oils and Cosmetics: Hair Preparations and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 25, 1989, Amick, David R. published a patent.Product Details of 26172-54-3 The title of the patent was Stabilization of non-aqueous solutions of 3-isothiazolones as preservatives for cosmetics. And the patent contained the following:

A 0.5-10 weight% solution of isothiazolones [I; R = halo; R1 = H, halo C1-4 alkyl; Y = C1-8 alkyl, (halo-substituted) C2-8 alkenyl or alkynyl, C5-8 cycloalkyl, PhCH2, 3,4-Cl2C6H3CH2, 4-MeOC6H4CH2, 4-ClC6H4CH2, 3,4-Cl2C6H3, 4-MeOC6H4] is stabilized in 90-99 weight% dipropylene glycol, polypropylene glycol, 1,5-pentanediol, or PhCH2OH. A 1% solution of I (R = H; R1 = Cl; Y = Me) (II) in dipropylene glycol showed no loss of II at 65° after 6 wk. A nitrate and nitrate-free hair shampoo was formulated containing 2 ppm active biocide (by addition of a dipropylene glycol solution of a mixture of II and I (R = R1 = H, Y = Me) 3, NaCl 2, and H2O 3%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to isothiazolone solution stabilization cosmetic preservative, Essential Oils and Cosmetics: Hair Preparations and other aspects.Product Details of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 22, 2018, Luo, Weixiao; Gan, Yiwu; Hu, Xiaofei; Bao, Xingyan; Liu, Jiali published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Reagent and method for detecting blood potassium ion by apotryptophanase. And the patent contained the following:

The invention relates to the tech. field of blood pyruvate detection, and particularly to an optimized pyruvate detection reagent with high sensitivity. The reagent comprises reagent 1, reagent 2 and reagent 3. The reagent 1 comprises buffer (tris(hydroxymethyl)aminomethane hydrochloride), EDTA·Na2, sodium chloride, protectant, tryptophan, LDH, NADH, surfactant (lauryldimethylamine oxide), and preservative. The reagent 2 comprises buffer, EDTA·Na2, sodium chloride, protectant, apotryptophanase, and preservative. The reagent 3 comprises potassium chloride, sodium chloride, Triton-100 and preservative. By specifically selecting corresponding interference-removing components for different interfering substances, the reagent has ensured accuracy and specificity, good stability and low cost. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to blood potassium ion apotryptophanase spectrometry, Biochemical Methods: Spectral and Related Methods and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 18, 2017, Zhang, Qiang; Gao, Peng; Zhou, Da; Zhao, Lili; Liu, Yunhui; Huan, Luheng published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Method for improving stability of dyeing grade sodium alginate. And the patent contained the following:

The method comprises the steps, soaking brown algae, washing for first time, digesting, diluting, filtering, calcifying, decalcifying, washing for second time, dewatering to obtain alginic acid, performing solid phase neutralization reaction to obtain sodium alginate, adding solid preservative, granulating, drying, cooling, crushing, adding liquid preservative and solid complexing agent, cooling, and finishing product packaging. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to improvement stability dyeing grade sodium alginate, Industrial Carbohydrates: Mucilages, Gums, and Pectins and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 30, 2007, Aleksic, Maja; Thain, Emma; Gutsell, Stephen J.; Pease, Camilla K.; Basketter, David A. published an article.Computed Properties of 26172-54-3 The title of the article was The role of non-covalent protein binding in skin sensitization potency of chemicals. And the article contained the following:

Skin sensitization is a delayed hypersensitivity reaction caused by repeated exposure to common natural and synthetic chem. allergens. It is thought that small chem. sensitizers (haptens) are required to form a strong irreversible bond with a self protein/peptide and generate an immunogenic hapten-protein complex in order to be recognized by the immune system and stimulate T cell proliferation. The sensitizers are usually electrophilic chems. that are directly reactive with proteins or reactive intermediates (metabolites) of chem. inert compounds (prohaptens). Sensitizing chems. are also capable of weak, non-covalent association with proteins and there is an ongoing debate about the role of weak interactions of chems. and proteins in the chem. of allergy. The non-covalent interactions are reversible and thus have a major impact on skin/epidermal bioavailability of chem./reactive metabolites. We investigated the relationship between the relative level of non-covalent association to a model protein and their relative potencies as determined by the EC3 values in the murine local lymph node assay (LLNA) for a number of chems. Using human serum albumin as a model protein, we determined that no observable relationship exists between the two parameters for the chems. tested. Therefore, at least for this model protein, non-covalent interactions appear not to be a key determinant of allergen potency. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3

The Article related to skin sensitization potency noncovalent protein binding, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Computed Properties of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 16, 2018, Lin, Lijuan; Zhou, Hecheng; Liu, Jun published a patent.HPLC of Formula: 26172-54-3 The title of the patent was Plastic steel zipper lacquer oil capable of endowing plastic steel zipper with acid resistance, salt spray resistance and water washing resistance. And the patent contained the following:

The title plastic steel zipper lacquer oil comprises first composition and second composition which are packaged sep. The first composition comprises (by weight parts, the same below) epoxy resin 80-83, ethylene glycol monobutyl ether 4-6, black slurry 8-12, leveling agent 0.4-0.6, and adhesion promoter 2-4. The second composition comprises epoxy curing agent 25-35, ethylene glycol monobutyl ether 30-50 and isobutanol 25-35. The invention also provides preparation method and application method of the plastic steel zipper lacquer oil. The inventive plastic steel zipper lacquer oil can be coated on surface of POM plastic steel zipper, and has labor-saving effect and time-saving effect when in use. POM plastic steel zipper coated with the lacquer oil has bright surface, acid resistance, salt spray resistance, and water washing resistance. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to plastic steel zipper lacquer oil capable endowing acid resistance, Coatings, Inks, and Related Products: Related Products and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 1, 2021, Wei, Zhengxi; Fang, Yuhong; Gosztyla, Maya L.; Li, Andrew J.; Huang, Wenwei; LeClair, Christopher A.; Simeonov, Anton; Tao, Dingyin; Xia, Menghang published an article.HPLC of Formula: 26172-54-3 The title of the article was A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers. And the article contained the following:

Chem.-peptide conjugation is the mol. initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatog./UV (HPLC/UV) detection method to quantify chem.-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput, sensitivity and accuracy, an automated 384-well plate-based RapidFire solid-phase extraction (SPE) system coupled with tandem mass spectrometry (MS/MS) DPRA was developed and validated in the presence of a newly designed internal standard Compared to the HPLC/UV-based DPRA, the automated SPE-MS/MS-based DPRA improved throughput from 16 min to 10 s per sample, and substrate peptides usage was reduced from 100 mM to 5μM. When implementing the SPE-MS/MS-based DPRA into a high-throughput platform, we found 10 compounds that depleted lysine peptide and 24 compounds that depleted cysteine peptide (including 7 unreported chems. from 55 compounds we tested) in a concentration-response manner. The adduct formation between cysteine and cinnamic aldehyde and ethylene glycol dimethacrylate were further analyzed using high-performance liquid chromatog. time-of-flight mass spectrometry (HPLC-TOF-MS) to confirm the conjugation. Overall, the automated SPE-MS/MS-based platform is an efficient, economic, and accurate way to detect skin sensitizers. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to skin sensitizer spe msms based dpra, direct peptide reaction assay (dpra), high throughput mass spectrometry, rapidfire-ms/ms, Toxicology: Chemicals (Household, Industrial, General) and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com