Rais, Afsha’s team published research in Trends in Heterocyclic Chemistry in 2009 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Related Products of 35272-19-6Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

The author of 《Microwave-assisted synthesis of benzisothiazoles and benzisoselenazoles》 were Rais, Afsha; Ankati, Haribabu; Biehl, Ed. And the article was published in Trends in Heterocyclic Chemistry in 2009. Related Products of 35272-19-6 The author mentioned the following in the article:

A microwave-mediated preparation and possible mechanism of benzisothiazole and benzisoselenazole formation are presented. The synthesis of the target compounds [i.e., 3-methyl-1,2-benzisothiazol-5-amine, 3-methyl-1,2-benzisoselenazol-5-amine] was achieved using sulfur or selenium and 1-(2-chloro-5-nitrophenyl)ethanone and ammonium acetate as starting materials. The experimental process involved the reaction of 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Related Products of 35272-19-6)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Related Products of 35272-19-6Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Solovyev, Andrey Y.’s team published research in Journal of Organic Chemistry in 2007 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds. These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole

《One-Pot Synthesis of Substituted 2-Aminobenzo[b]thiophenes》 was written by Solovyev, Andrey Y.; Androsov, Dmitry A.; Neckers, Douglas C.. Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole And the article was included in Journal of Organic Chemistry on April 13 ,2007. The article conveys some information:

Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler routes using primary and secondary amines resulted in a simple, efficient, three-component one-pot synthesis of 2-aminobenzo[b]thiophenes, e.g., I (R = Me, allyl, Bu, CH2Ph, CHMe2, cyclopentyl, cyclohexyl).3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole) was used in this study.

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds. These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

McKinnon, David M.’s team published research in Journal of Heterocyclic Chemistry in 1991 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Name: 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Name: 3-Methyl-5-nitrobenzoisothiazoleOn May 31, 1991, McKinnon, David M.; Abouzeid, A. A. published an article in Journal of Heterocyclic Chemistry. The article was 《Substituent interaction with ring sulfur in some heterocyclic compounds》. The article mentions the following:

The IR carbonyl absorptions of acetylbenzisothiazoles I (R, R1, R2 = H, COMe, SMe) are similar to 7-acetylbenzo[b]thiophenes, but are lower by approx. 15 cm-1 than the corresponding benzo[b]furans. The reasons for this are discussed. The results came from multiple reactions, including the reaction of 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Name: 3-Methyl-5-nitrobenzoisothiazole)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Name: 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Clarke, Kenneth’s team published research in Journal of Chemical Research, Synopses in 1980 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Reference of 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Clarke, Kenneth; Gleadhill, Brian; Scrowston, Richard M. published an article in Journal of Chemical Research, Synopses. The title of the article was 《Condensed isothiazoles. Part 7. Substitution reactions of 3-methyl-1,2-benzisothiazole and some of its 4- and 5-substituted derivatives》.Reference of 3-Methyl-5-nitrobenzoisothiazole The author mentioned the following in the article:

Some electrophilic formylation, chlorination, bromination and nitration reactions of the methylbenzisothiazole derivatives I (R = R1 = H; R = Br, NH2, NHAc, OH, OMe, R1 = H; R = H, R1 = Br) are described. I (R = H, R1 = Cl, Br, NO2) were prepared by deamination of the appropriate substitution products I (R = NH2, R1 = Cl, Br, NO2). Improved syntheses of 7-chloro- and -bromo-3-methyl-1,2-benzisothiazole are also reported. In addition to this study using 3-Methyl-5-nitrobenzoisothiazole, there are many other studies that have used 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Reference of 3-Methyl-5-nitrobenzoisothiazole) was used in this study.

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Reference of 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Haddock, E.’s team published research in Journal of the Chemical Society [Section] C: Organic in 1971 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.SDS of cas: 35272-19-6 These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.

《1,2,3-Benzothiadiazoles. V. Rearrangement of diazonium salts derived from 7-aminobenzisothiazoles》 was published in Journal of the Chemical Society [Section] C: Organic in 1971. These research results belong to Haddock, E.; Kirby, P.; Johnson, A. W.. SDS of cas: 35272-19-6 The article mentions the following:

Sandmeyer decomposition of 6 diazotized 7-aminobenzisothiazoles gave 1,2,3-benzothiadiazole-7-carboxaldehydes (I), but hypophosphorous acid decomposition removed the diazonium group. Decomposition of 4-chlorobenzisothiazole-7-diazonium chloride with CrCl2, SnCl2, Cu2Cl2, and FeCl2 in HCl showed that the relative extent of these competing reactions is governed by the oxidation potential for the metal cation to its higher oxidation state. In the experiment, the researchers used many compounds, for example, 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6SDS of cas: 35272-19-6)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.SDS of cas: 35272-19-6 These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Davis, Franklin A’s team published research in Journal of Organic Chemistry in 1995-09-22 | 104322-63-6

Journal of Organic Chemistry published new progress about Chiral synthons. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, COA of Formula: C10H15NO3S.

Davis, Franklin A.; Reddy, G. Venkat; Chen, Bang-Chi; Kumar, Anil; Haque, M. Serajul published the artcile< Enantioselective Synthesis of 2-Methyl-2-hydroxy-γ-butyrolactone and Its Application in the Asymmetric Synthesis of Frontalin and Mevalonolactone>, COA of Formula: C10H15NO3S, the main research area is asym hydroxylation methylbutyrolactone phenylisobutyrate; camphorsulfonyloxaziridine chiral auxiliary hydroxylation; frontalin formal asym synthesis; mevalonolactone asym synthesis.

The asym. hydroxylation of the enolates of (R)-menthyl 2-methyl-3-phenylpropionate (I) and 2-methyl-γ-butyrolactone (II) with (camphorylsulfonyl)oxaziridines was studied. The stereoselectivities of the tertiary α-hydroxy carbonyl products were highly dependent on the enolate structure, the oxidizing reagents, and the reaction conditions. While high diastereoselectivity (up to 94%) was obtained for enolates of I with substoichiometric amounts of (camphorylsulfonyl)oxaziridine, the yields were unsatisfactory. On the other hand, the enantioselective α-hydroxylation of the sodium enolate of II with [(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine afforded α-hydroxy lactone in 70% yield and 84% ee. The enantiomeric excess was improved to >93% ee by crystallization of the corresponding benzoate. The utility of both enantiomers of the benzoate was demonstrated in the formal asym. synthesis of (1S,5R)-(-)-frontalin and in the asym. synthesis of (R)-(-)-mevalonolactone.

Journal of Organic Chemistry published new progress about Chiral synthons. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, COA of Formula: C10H15NO3S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Polywka, Mario E C’s team published research in Chimica Oggi in 1992-10-31 | 104322-63-6

Chimica Oggi published new progress about Chiral synthons. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Category: isothiazole.

Polywka, Mario E. C. published the artcile< Camphor based auxiliaries for asymmetric synthesis>, Category: isothiazole, the main research area is camphor chiral auxiliary asym synthesis review; bornanesultam chiral auxiliary review; oxaziridine camphorsulfonyl chiral auxiliary review.

A review of chiral auxiliaries, e.g. bornane-10,2-sultams, N-acylsultams, and (camphorsulfonyl)oxaziridines in asym. synthesis of amino acids, aldol condensations, and asym. alkylations with 14 references

Chimica Oggi published new progress about Chiral synthons. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Category: isothiazole.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Bunnage, Mark E’s team published research in Tetrahedron: Asymmetry in 1994-02-28 | 104322-63-6

Tetrahedron: Asymmetry published new progress about Absolute configuration. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application In Synthesis of 104322-63-6.

Bunnage, Mark E.; Burke, Anthony J.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of (2S,3R)-3-amino-2-hydroxydecanoic acid: the unknown amino acid component of microginin>, Application In Synthesis of 104322-63-6, the main research area is asym synthesis aminohydroxydecanoic acid; absolute configuration microginin aminohydroxydecanoic acid.

3-Amino-2-hydroxydecanoic acid (AHDA) is an unusual amino acid purported to occur in the recently isolated angiotensin-converting enzyme inhibitor microginin. In order to elucidate the stereochem. of the naturally occurring material, and thus complete the structural assignment of microginin, both the (2R,3R)-anti-diastereoisomer and the (2S,3R)-syn-diastereoisomer of AHDA have been prepared Comparison of the 1H and 13C NMR spectroscopic data of the synthetic amino acids with that reported for the naturally occurring material indicates that the relative stereochem. of the AHDA found in microginin is syn. The absolute stereochem. of the natural amino acid is shown to be (2S,3R) by comparison of its reported CD spectrum with that recorded for the synthetic material prepared herein.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application In Synthesis of 104322-63-6.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Josien, Hubert’s team published research in Tetrahedron in 1997-06-30 | 104322-63-6

Tetrahedron published new progress about Radical cyclization. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Josien, Hubert; Curran, Dennis P. published the artcile< Synthesis of (S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles>, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide, the main research area is mappicine synthesis; radical cascade isonitrile.

(S)-mappicine (I) and mappicine ketone were prepared from Me acetoacetate by a strategy featuring a radical cascade reaction of II with Ph isonitrile as the key step. The introduction of the hydroxy group of (S)-mappicine occurred with moderate selectivity through asym. hydroxylation.

Tetrahedron published new progress about Radical cyclization. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Davis, Franklin A’s team published research in Journal of Organic Chemistry in 1990-06-08 | 104322-63-6

Journal of Organic Chemistry published new progress about Oxidation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Davis, Franklin A.; Weismiller, Michael C. published the artcile< Enantioselective synthesis of tertiary α-hydroxy carbonyl compounds using [(8,8-dichlorocamphoryl)sulfonyl]oxaziridine>, Formula: C10H15NO3S, the main research area is carbonyl compound alpha hydroxy asym synthesis; chlorocamphorylsulfonyloxaziridine oxidizing agent; tetralone enolate oxidation asym oxaziridine.

Very high stereoinduction, generally 90-95% ee, is observed for the asym. oxidation of 2-substituted-1-tetralone enolates to 2-hydroxy-2-substituted-1-tetralones by (+)-(8,8-dichlorocamphorylsulfonyl)oxaziridine (I), a new oxaziridine type. Not only are these tertiary-α-hydroxy carbonyl compounds difficult to prepare, enantiomerically pure, via other methods, but they are also models for several biol. active compounds This new asym. oxidizing reagent also affords exceptional ee’s for the asym. oxidation of acyclic ketone enolates as well. For example, oxidation of the sodium enolate of 1-phenylpropanone with I affords (S)-2-hydroxy-1-phenylpropanone in greater than 95% ee. I is prepared in two steps, in good overall yield, from (camphorsulfonyl)imine II. The results of this study demonstrate that modification of the oxaziridine active site is an efficient method for improving enolate oxidation stereoselectivities.

Journal of Organic Chemistry published new progress about Oxidation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com