Heterocyclic Building Blocks-Isothiazole

Synthetic Route of 288-16-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Synthetic Route of 288-16-4, Name is Isothiazole, molecular formula is C3H3NS. In a Article, authors is Nguyen, Thuy£¬once mentioned of Synthetic Route of 288-16-4

14N Nuclear quadrupole coupling and methyl internal rotation in the microwave spectrum of 2-methylpyrrole

Using two molecular jet Fourier transform microwave spectrometers, the rotational spectrum of 2-methylpyrrole was recorded in the frequency range from 2 to 40 GHz. From the torsional splittings due to the internal rotation of the methyl group a barrier height of 279.7183(26) cm?1 was deduced. Because of the 14N nucleus, all lines show a quadrupole hyperfine structure. The microwave spectra were analysed using the XIAM and BELGI-Cs-hyperfine codes. The XIAM code enabled us to reproduce the whole data set with a root-mean-square deviation of 5.6 kHz while the BELGI-Cs-hyperfine code could provide a better root-mean-square almost by a factor of 2 compared to that of XIAM. The experimental results were complemented by quantum chemical calculations. The values of the methyl torsional barrier and the 14N nuclear quadrupole coupling constants are discussed and compared with other methyl substituted pyrroles as well as other aromatic five-membered rings.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S, Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide. In a Article, authors is Abramovitch, Rudolph A.£¬once mentioned of Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

FLASH VACUUM PYROLYSIS OF alpha-TOLUENESULFONYL AZIDE

The flash vacuum pyrolysis of alpha-toluenesulfonyl azide (1) gave bibenzyl (2), 2-(beta-phenethyl)pyridine (3), and 2,1-benzisothiazole 2,2-dioxide (4); an authentic sample of the latter was prepared from 2-bromo-alpha-toluenesulfonamide and potassium amide in liquid ammonia.FVP of benzenesulfonyl azide using benzene as carrier gas gave some diphenylamine, but not in the absence of benzene.

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Dennehy, Mariana and a compound is mentioned, category: isothiazole, Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, introducing its new discovery. category: isothiazole

Unusual coordination in a silver thionate complex. Synthesis, structural characterization and theoretical calculations of dinuclear and polynuclear silver(I) thiosaccharinates with pyridine and 1,10-phenanthroline

Treatment of Ag6(tsac)6 (tsac = thiosaccharinate anion) with pyridine (py) and 1,10-phenanthroline (o-phen) each affords two novel silver(I)-thiosaccharinate complexes: dinuclear [Ag2(tsac)2py] (1) and polynuclear [Ag(tsac)(o-phen)]n (2). Both crystal structures have been determined by X-ray diffraction and spectroscopic structural analysis (IR and Raman, UV-Vis, 1H and 13C NMR) have also been made for both compounds. Thermal stability analysis (TGA and DTA) of complex 1 are used to confirm the strength of the pyridine coordination to the silver ion. The molecular structure of complex 1 shows some astonishing characteristics. The two silver atoms are in different environments: one of them is surrounded by two S atoms, while the other completes its coordination sphere by three N atoms, two from the thiosaccharinate anions and the third from a pyridine molecule. The short Ag(1)-Ag(2) contact distance, 2.9681(8) A, indicates an interaction between the two silver metal atoms exists. Complex 2 shows a thiosaccharinate molecule bridging two silver atoms through the exocyclic S atom while the o-phenanthroline ligand is coordinated as a bidentate N,N chelate, forming a polynuclear chain. Quantum chemical calculations confirm the argentophilic character of the Ag-Ag interaction in complex 1, and its structure and vibrational assignments were correlated and confirmed theoretically.

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Electric Literature of 27148-03-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Electric Literature of 27148-03-4

Structural study of thiosaccharin by single crystal X-ray diffraction and infrared spectroscopy

The structure of thiosaccharin (1,2-benzisothiazol-3(2H)-thione 1,1-dioxide) has been investigated by X-ray diffraction and infrared spectroscopic methods.The compound crystallizes in the orthorhombic space group Fdd2 with a = 26.591(3), b = 25.058(3), c = 4.934(5) Angstroem, Z = 16.The structure consists of thiosaccharin molecules bonded to each other through N-H<*>O intermolecular hydrogen bonds.The infrared spectra of the thiosaccharin at room and liquid-nitrogen temperature were recorded.The spectral features in the N-H stretching region were correlated with the crystallographic data on the geometry of the N-H<*>O hydrogen bonding.In an attempt to assign the bands due to the SO2 stretching modes, the spectrum of thiosaccharin was compared with that of saccharin (1,2-benzoisothiazole-3(2H)-one, 1,1-dioxide.KEY WORDS: Thiosaccharin, infrared spectra, crystal structure polymorphs.

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: isothiazole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS

Ozone disrupts adsorption of Rhododendron tomentosum volatiles to neighbouring plant surfaces, but does not disturb herbivore repellency

The perennial evergreen woody shrub, Rhododendron tomentosum, confers associational resistance against herbivory and oviposition on neighbouring plants through passive adsorption of some of its constitutively emitted volatile organic compounds (VOCs). The adsorption process is dependent on transport of VOCs in the air. In polluted atmospheres, the VOCs may be degraded and adsorption impeded. We studied the effect of elevated ozone regimes on the adsorption of R. tomentosum volatiles to white cabbage, Brassica oleracea, and the oviposition of the specialist herbivore Plutella xylostella on the exposed plants. We found evidence for adsorption and re-emission of R. tomentosum volatiles by B. oleracea plants. Ozone changed the blend of R. tomentosum volatiles and reduced the amount of R. tomentosum volatiles recovered from B. oleracea plants. However, plants exposed to R. tomentosum volatiles received fewer P. xylostella eggs than control plants exposed to filtered air irrespective of whether R. tomentosum volatiles mixed with ozone. Ozone disrupts a volatile mediated passive plant-to-plant interaction by degrading some compounds and reducing the quantity available for adsorption by neighbouring plants. The change, however, did not affect the deterrence of oviposition by P. xylostella, suggesting that aromatic companion plants of Brassica crops may confer pest-deterring properties even in ozone-polluted environments. Ozone breaks down R. tomentosum VOCs and disrupts their passive adherence to neighbouring plant surfaces; this however does not affect the associational resistance R. tomentosum volatiles confer on neighbouring plants.

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Reference of 272-16-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a Article£¬once mentioned of 272-16-2

Removal of pollutants and reduction of bio-toxicity in a full scale chemical coagulation and reverse osmosis leachate treatment system

Removals of pollutants and toxic organic compounds and reduction in bio-toxicity of leachate along an operating full-scale leachate treatment system utilizing chemical coagulation, sand filtration, microfiltration (MF) and reverse osmosis (RO) membrane were evaluated. High pollutant removals were achieved mainly by coagulation and sand filtration. Major toxic organic pollutants, i.e. DEHP, DBP and bisphenol A were removed by 100%, 99.6% and 98.0%. Acute toxicity test using water flea, Nile Tilapia and common carp and genotoxicity (Comet assay) were conducted to determine toxicity reduction in leachate along the treatment. Ammonia was found to be the main acute toxic compounds in leachate as determined by LC50 but the effect of organic substances was also observed. DNA damage in fish exposed to diluted raw leachate (10% of LC50) was found to be 8.9-24.3% and it was subsequently decreased along the treatment. Correlation between pollutants and its bio-toxicity was established using multivariable analyses.

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Synthetic Route of 272-16-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Synthetic Route of 272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a Article, authors is Pedras, M. Soledade C.£¬once mentioned of Synthetic Route of 272-16-2

Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans

Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo[5,4-b]indole. Screening of these compounds for inhibition of brassilexin detoxification in cultures of L. maculans indicated that 4-(2-chlorophenyl)isothiazole had the largest effect on the rate of brassilexin detoxification. However, the most antifungal compound among the potential inhibitors, isothiazolo[5,4-b]quinoline, did not appear to affect the metabolism of brassilexin noticeably, suggesting that growth inhibition is not sufficient to slow down the rate of brassilexin detoxification. Furthermore, it was determined that 4-arylisothiazoles as well as isothiazolo[5,4-b]thianaphthene displayed antifungal activity against L. maculans.

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Electric Literature of 288-16-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Electric Literature of 288-16-4, Name is Isothiazole, molecular formula is C3H3NS. In a Article, authors is Kong, Ronald£¬once mentioned of Electric Literature of 288-16-4

Metabolism and disposition of ataluren after oral administration to mice, rats, dogs, and humans

Ataluren is a unique small molecule developed for the treatment of diseases caused by nonsense mutations, which result in premature termination of ribosomal translation and lack of full-length protein production. This study investigated the in vivo metabolism and disposition of ataluren in mice, rats, dogs, and humans. After single oral administration of [14C]ataluren, the overall recovery of radioactivity was ?93.7%, with approximately 39%, 17%-21%, 12%, and 55% in the urine and 54%, 70%-72%, 80%, and 47% in the feces from intact mice, rats, dogs, and humans, respectively. In bile duct-cannulated (BDC) rats, approximately 10%, 7%, and 82% of the dose was recovered in the urine, feces, and bile, respectively, suggesting that biliary secretion was a major route for the elimination of ataluren in the rats. Ataluren was extensively metabolized after oral administration, and the metabolic profiles of ataluren were quantitatively similar across all species. Unchanged ataluren was the dominant radioactive component in plasma. Ataluren acyl glucuronide was the most prominent metabolite in plasma of all species and the dominant metabolite in BDC rat bile and human urine, whereas the oxadiazole cleavage products were the major or prominent metabolites in the feces of all species. Overall, the results indicate that phase I metabolism is negligible and that the pathway largely involves glucuronidation. No other circulatory conjugation metabolite was detected across investigated species. SIGNIFICANCE STATEMENT Ataluren is a novel carboxylic acid-containing small molecule drug for treating nonsense mutation Duchenne muscular dystrophy. In vivo metabolism and disposition after a single dose of the drug were investigated in mice, rats, dogs, and humans. Phase I metabolism of ataluren was negligible, and the pathway largely involves glucuronidation. No other circulatory conjugation metabolite was detected across investigated species.

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Synthetic Route of 18480-53-0, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a Patent£¬Which mentioned a new discovery about 18480-53-0

SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS

The invention relates to substituted heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stress tolerance in plants with respect to abiotic stress, and also for strengthening plant growth and/or for increasing plant yield.

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Synthetic Route of 272-16-2, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Synthetic Route of 272-16-2, name is Benzo[d]isothiazole, introducing its new discovery.

Volatile composition and sensory and quality attributes of quince (Cydonia oblonga Mill.) fruits as affected by water stress

No information exists on the effect of water deficit on quince (Cydonia oblonga Mill.) fruit quality characteristics. In this paper, the effect of withholding irrigation water in the middle of the rapid fruit growth period on yield, main fruit physicochemical characteristics, sensory profile, and volatile composition of quince (cv. BA-29) was studied. The linear fruit growth phase was seen to be a critical phenological period for the marketable yield of quince because water deficit decreased the fruit weight, size, and moisture content. Also, this period was clearly critical for the fruit’s chemical characteristics. Water deficit induced important changes in an important number of the identified volatile compounds, characterized by decreases on pear, pineapple and apple sensory descriptors and increases on the green-herbaceous sensory descriptors. Moreover, total soluble solids increased and the total polyphenols content and antioxidant activity decreased as a result of water deficit effect, even though the still high levels of total polyphenols, regardless of the fruit water status, suggested that quinces can be used as an important source of natural antioxidants. The fruit sensory analysis indicated that the peel colour intensity of fruits from the water deficit treatment increased and fruit flesh texture improved. Indeed, the main handicaps for its consumption as fresh fruit (corkiness and fibreness) severely decreased and crunchiness increased.

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