Heterocyclic Building Blocks-Isothiazole

4-Bromoisothiazole, cas is 24340-77-0, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,24340-77-0

General procedure: 2 wt% DL-alpha-Tocopherolmethoxypolyeneglycol succinate solution (1.5 mL) was added to a mixture of 5-methoxycarbonylbenzofuran-2-MIDA boronate (200 mg, 0.604 mmol), (dtbpf)PdCl2 (32 mg, 0.048 mmol) and bromobenzene (95 mg, 0.604 mmol) under N2. Et3N (0.25 mL, 1.81 mmol) was added to thesuspension under N2. The reaction mixture was vigorously stirred at 40 C for 22 h under N2. Theresulting mixture was diluted with water to form a precipitate, which was filtered, washed with water anddissolved with CHCl3. The obtained organic solutions were dried over Na2SO4 and concentrated. Theresidue was purified by flash chromatography (SiO2, AcOEt : hexane = 30 : 70) to give 143.0 mg (94%)of white powde;

With the rapid development of chemical substances, we look forward to future research findings about 4-Bromoisothiazole

Reference£º
Article; Sakurai, Yohji; Heterocycles; vol. 94; 7; (2017); p. 1322 – 1336;,
Isothiazole – Wikipedia
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Name is 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 936-16-3, its synthesis route is as follows.,936-16-3

A mixture of C105 (80 mg, 0.16 mmol), C113 (39.3 mg, 0.232 mmol), cesium carbonate (114 mg, 0.350 mmol), and potassium iodide (28.9 mg, 0.174 mmol) in /V,/V-dimethylformamide (2 mL) was stirred at 80 ¡ãC for 16 hours. The reaction mixture was then diluted with ethyl acetate (30 mL), washed with saturated aqueous sodium chloride solution (3 x 30 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Preparative thin layer chromatography on silica gel (Eluent: 1 :3 ethyl acetate / petroleum ether) provided the product as a light yellow oil. Yield: 55 mg, 94 muetaiotaomicronIota, 59percent. LCMS m/z 607.0 [M+Na+].

With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide

Reference£º
Patent; PFIZER INC.; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BUTLER, Christopher Ryan; GILBERT, Adam Matthew; HELAL, Christopher John; JOHNSON, Douglas Scott; MCALLISTER, Laura Ann; MONTGOMERY, Justin Ian; O’NEIL, Steven Victor; ROGERS, Bruce Nelsen; VERHOEST, Patrick Robert; WEBB, Damien; (236 pag.)WO2017/21805; (2017); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Add 5 mmol of compound I-1 to a 250 ml two-neck round bottom flask. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) is 6 mmol, 1-hydroxybenzotriazole (HOBT) was 5.13 mmol, dissolved in dichloromethane solution and stirred in an ice bath for 15 minutes. A solution of the amine in dichloromethane (25 ml) was added to the reaction system. Then 6 mmol of Et3N was added and the reaction mixture was stirred at room temperature for 16 hours. After the reaction is completed, wash with water (2 ¡Á 60 ml) and saturated with brine (80 ml)Wash the organic layer, The organic layer was dried over MgSO4 and concentrated under reduced vacuo. The residue is purified by 100-200 mesh silica gel column chromatography to give compound II-1. The eluent is petroleum ether: ethyl acetate at 60-90 degrees Celsius.Its volume ratio is 4:1, yield 70%; white solid, melting point 125-126%,

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3,4-Dichloroisothiazole-5-carboxylic acid, 18480-53-0

Reference£º
Patent; Nankai University; Fan Zhijin; Yang Dongyan; Li Zhengming; Wang Haixia; Guo Xiaofeng; Zhang Nailou; Wu Qifan; Yu Bin; Zhou Shuang; (21 pag.)CN110041287; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

7716-66-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Chlorobenzo[d]isothiazole, cas is 7716-66-7,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

An eggplant type flask was charged with 3-chloro(1,2-benzisothiazole) (14 g, 200 mmol) and piperazine anhydride (6.8 g, 40 mmol) and heated at 125 ¡ã C. for 24 hours. After completion of the reaction, 52 ml of ice- In addition, quench, add 3.2 g of 50percent NaOH solution, stir for 5 min, extract with CH 2 Cl 2 50 ml * 3, wash the organic layer with 50 ml each of ice water * 2, 50 ml * 2 of saturated brine * 2 and anhydrous MgSO4 To give 4- (1,2-benzisothiazol-3-yl)piperazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Chlorobenzo[d]isothiazole, 7716-66-7

Reference£º
Patent; JIANGSU HENGYI PHARMACEUTICAL COMPANY LIMITED; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; Li, JIANQI; PENG, SHAOPING; CAI, WANGPING; GAO, KAI; (39 pag.)JP5714152; (2015); B2;,
Isothiazole – Wikipedia
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18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

3,4-Dichloroisothiazole-5-carboxylic acid (CAS 18480-53-0, 34.8 mg, 0.18 mmol) was dissolved in DMF (200 iL). HBTU (83 mg, 0.22 mmol) and TEA (61.1 iL, 0.44 mmol) were added. The solution was stirred for 6 mm and then 4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride (Example 49b, 35 mg, 0.15 mmol) in DMF (400 iL) and TEA (61.1 iL, 0.44 mmol) was added. The reaction mixture was stirred at rt for 1 h and then purified by preparative HPLC to give 3,4-dichloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isothiazole-5-carboxamid (15 mg, 28percent).1H NMR (500 MHz, CDCI3) 5 ppm 0.87 (d, 3 H) 1.12 (d, 3 H) 2.26 – 2.36 (m, 1 H) 5.75 (dd, 1 H)7.74 (d, 1 H) 7.86 (d, 2 H) 8.12 (d, 2 H).MS (ESI) m/z 379.7 [M-H]

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3,4-Dichloroisothiazole-5-carboxylic acid, 18480-53-0

Reference£º
Patent; ACTURUM LIFE SCIENCE AB; LINDE, Christian Erik; PAULSEN, Kim; SOHN, Daniel; SVENSSON, Mats A; VALLIN, Karl S A; WEIGELT, Dirk; MINIDIS, Alexander; WO2014/184235; (2014); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

936-16-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Step 1. To a mixture of 6-methyl-2,4-dichloropyrimidine (162 mg, 0.994 mmol) and 1 (185 mg, 1.1 mmol) in anhydrous CH3CN (4 mL) was added K2CO3 (274 mg, 2 mmol), the mixture was stirred at 80¡ãC for 3 hrs. Concentration under reduced pressure resulted in 11 (130 mg), which was submitted to the next step without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, 936-16-3

Reference£º
Patent; NUMERATE, INC.; RAIMUNDO, Brian; KOLTUN, Elena S.; GRIFFIN, John; STANGELAND, Eric; (93 pag.)WO2018/49324; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

936-16-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 30Ethyl 1 -[4-(1 ,1 -dioxido-1 ,2-benzisothiazol-2(3H)-yl)phenyl]-3-[[(frapis-4- methylcyclohexyl)carbonyl](1-methylethyl)amino]-1H-pyrazole-4-carboxylateA solution of Intermediate 5 (108 mg), 2,3-dihydro-1 ,2-benzisothiazole 1 ,1 -dioxide (35 mg), copper (I) iodide (4 mg), potassium carbonate (58 mg) and (IR^RJ-lambda/./V-dimethyl-i ^- cyclohexanediamine (12 mg) in DMF (4 mL) was heated in a microwave at 100¡ã C, 300 W for 1 h and then evaporated to dryness. The residue was dissolved in ethyl acetate and washed sequentially with aqueous sodium bicarbonate solution, water and 2M HCI, dried using a EPO hydrophobic frit and evaporated to dryness. The crude product was then purified by MDAP HPLC to give the title compound. MS calcd for (C30H36N4O5 + H)+: 565 MS found (electrospray): (M+H)+ = 565

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, 936-16-3

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/39146; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

After 10 g of 50 mmol of 3,4-dichloro-isothiazole carboxylic acid II was added to 100 ml flask was added 30 ml of thionylchloride, refluxed for 5 hours, thionyl chloride was distilled off at atmospheric pressure, the residue was water pump vacuumdistillation at 100-110 degrees C compound fraction collected between 10.6 g yellow solid 3,4-dichloro-isothiazole carboxylicacid chloride III, a yield of 96.3percent, 3,4-dichloro-isothiazole carboxylic acid chloride III prepared a pro rata amount of expanded orreduced, the volume of the reaction vessel according to the corresponding scaled up or down, a commercially availablecompound II has the same effect.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 18480-53-0, 3,4-Dichloroisothiazole-5-carboxylic acid

Reference£º
Patent; Jiangxi Tianren Ecology Co., Ltd.; Nankai University; Chen, Xiaoyan; Liu, Xiping; Fan, Zhijin; Liang, Xiaowen; Li, Yuedong; Mao, Wutao; Li, Juanjuan; Wang, Dun; Wang, Shuhua; Zhou, Lifeng; Ji, Xiaotian; HUA, XUEWEN; (23 pag.)CN102942565; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

10271-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Isothiazole-5-carboxylic acid, cas is 10271-85-9,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Example 318 (12 mg, 0.029 mmol), isothiazole-5-carboxylic acid (7.38 mg, 0.057 mmol) and triethylamine (7.97 mul, 0.057 mmol) were suspended in toluene (1 mL) in a pressure rated 1 dram vial. Diphenylphosphoryl azide (15.73 mg, 0.057 mmol) was added to the mixture which was heated to 110 C for 3 hours. The crude reaction mixture was purified by reverse phase HPLC (Method D, 65-100% 20 min, 100% 5 min) to yield Example 621 (1.3 mg, 2.38 mmol, 8% yield). C-MS: Method H, RT = 1.25 min, MS (ESI) m/z: 546.10 (M+H)+. 1HNMR (500 MHz, DMSO-d6) delta 8.77 (s, 1H), 8.62 (s, 1H), 8.21 (s, 1H), 8.02-8.12 (m, 1H), 7.88 (s, 1H), 6.81 (s, 1H), 4.61-4.69 (m, 2H), 4.46-4.56 (m, 2H), 4.10 (s, 3H), 3.19 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10271-85-9, Isothiazole-5-carboxylic acid

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

111248-89-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, cas is 111248-89-6,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of 1 ,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg, 1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 pL, 6.62 mmol). The reaction was stirred for 6 h at RT and was then quenched with a saturated solution of ammonium chloride. The reaction mixture was concentrated and purified by column chromatography (cyclohexane/acetone) to afford the title compound as a white solid (270 mg, 89%). 1H NMR (500 MHz, CDCl3) ppm = 7.37 – 7.32 (m, 1 H), 7.27 – 7.24 (m, 1 H), 7.02 (td, J=7.6, 1.0, 1 H), 6.73 (d, J=8.0, 1 H), 4.34 (s, 2H), 3.14 (s, 3H). Rt = 2.07 min (HPLC method C).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, 111248-89-6

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, kai; STIEBER, Frank; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; WO2014/63778; (2014); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com