Tag: M.W=100-150

An article Synthesis of Bulky 1,1-Diarylalkanes by Copper-Catalyzed 1,2-Alkylarylation of Styrenes with alpha-Carbonyl Alkyl Bromides and Arenes involving C-H Functionalization WOS:000538650500001 published article about COUPLING REACTIONS; ALLYLIC ALCOHOLS; GAMMA-LACTONES; ALKENES; ARYLATION; 1,2-DIFUNCTIONALIZATION; HYDROARYLATION; CYCLIZATION in [Luo, Shu-Zheng; Min, Man-Yi; Wu, Yan-Chen; Jiang, Shuai-Shuai; Xiao, Yu-Ting; Song, Ren-Jie; Li, Jin-Heng] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China; [Li, Jin-Heng] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China in 2020, Cited 70. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Application In Synthesis of 1,3-Dimethoxybenzene

A copper and silver-promoted intermolecular 1,2-alkylarylation of styrenes with alpha-carbonyl alkyl bromides and arenes for producing highly bulky 1,1-diarylalkane derivatives has been developed. In this transformations, two new C-C bonds were formed in a single reaction step through C-Br bond cleavage and C(sp(2))-H functionalization. This protocol tolerates a variety of alpha-carbonyl alkyl bromides, including primary, secondary and tertiary alpha-bromoalkyl ketone esters.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Luo, SZ; Min, MY; Wu, YC; Jiang, SS; Xiao, YT; Song, RJ; Li, JH or concate me.. Application In Synthesis of 1,3-Dimethoxybenzene

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 151-10-0. In 2019 ORG LETT published article about ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY STEREOCENTERS; DOMINO REACTIONS; BIS(ETHYLENEDIOXYBORYL)METHIDE; DESYMMETRIZATION; CARBOBORATION; DEPROTONATION; DERIVATIVES; CARBANIONS; SULFURANES in [Zanghi, Joseph M.; Liu, Shuang; Meek, Simon J.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA in 2019, Cited 48. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

A single-pot Cu-catalyzed enantio- and diaster-eoselective tandem hydroboration/borylative cyclization of alkynes with ketones for the synthesis of carbocycles is reported. The reaction proceeds via desymmetrization and generates four contiguous stereocenters, including an all-carbon quaternary center. The method provides rapid access to [6,5]- and [5,5]-bicycles and cyclopentane products. Catalyst-controlled diastereoselectivity by selection of bisphosphine ligand is noted. Utility of the products is demonstrated by site- and chemoselective transformations that afford valuable alkenyl and allyl organoborons.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Zanghi, JM; Liu, S; Meek, SJ or concate me.. Recommanded Product: 151-10-0

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Nickel-catalyzed C-H bond trifluoromethylation of 8-aminoquinoline derivatives by acyl-directed functionalization WOS:000465285100016 published article about FLUORINE; ACTIVATION; ARENES; TRIFLUOROETHYLATION; PHARMACEUTICALS; HETEROARENES in [Liu, Xiaochong; Mao, Guijie; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Heilongjiang, Peoples R China; [Liu, Xiaochong; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Coll Heilongjiang Prov, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin 150080, Heilongjiang, Peoples R China in 2019, Cited 37. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Product Details of 99-04-7

A Ni(TFA)(2)-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C-H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF3 as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.

About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, XC; Mao, GJ; Qiao, JY; Xu, CZ; Liu, H; Ma, JJ; Sun, ZZ; Chu, WY or concate me.. Product Details of 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP in WILEY-V C H VERLAG GMBH published article about NATURAL-PRODUCT SYNTHESIS; ELECTROCATALYTIC APPROACH; MULTICOMPONENT REACTIONS; N-ACYL; AMIDES; AMINES; ISOIMIDES; OXIDATION in [Zhang, Xiaofeng; Cui, Ting; Zhao, Xin; Liu, Ping; Sun, Peipei] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China in 2020, Cited 61. Category: isothiazole. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 99-04-7. Zhang, KY; Khan, R; Chen, JC; Zhang, XX; Gao, Y; Zhou, YY; Li, KK; Tian, YX; Fan, BM in [Zhang, Keyang; Khan, Ruhima; Chen, Jingchao; Zhang, Xuexin; Gao, Yang; Zhou, Yongyun; Li, Kangkui; Tian, Youxian; Fan, Baomin] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China; [Zhou, Yongyun; Fan, Baomin] Inst Yunnan Minzu Univ, Sch Chem & Environm, Kunming 650500, Yunnan, Peoples R China published Directing-Group-Controlled Ring-Opening Addition and Hydroarylation of Oxa/azabenzonorbornadienes with Arenes via C-H Activation in 2020.0, Cited 101.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

An efficient method for the directing group controlled rhodium-catalyzed addition reaction of oxa/azabicylic alkenes with aromatic ketones and benzoic acids has been developed. The ketones and benzoic acids afforded different addition products when reacted with oxa/azabicyclic alkenes. The reaction between ketones and azabenzonorbornadienes furnished the ring-opening addition products. The reaction between benzoic acids and aza/oxabicyclic alkenes proceeded in the absence of silver salt, giving the 1:2 hydroarylation products in yields up to 96%.

Recommanded Product: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhang, KY; Khan, R; Chen, JC; Zhang, XX; Gao, Y; Zhou, YY; Li, KK; Tian, YX; Fan, BM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Computed Properties of C8H8O2. Authors Bai, QQ; Bai, ZB; Wang, H in AMER CHEMICAL SOC published article about in [Bai, Qingqing; Bai, Zengbing; Wang, Huan] Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, State Key Lab Coordinat Chem,Chem & Biomed Innova, Nanjing 210093, Jiangsu, Peoples R China in 2019, Cited 23. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Macrocyclic peptides are promising scaffolds of bioactive compounds and clinical therapeutics. Herein, we develop a strategy for the macrocyclization of biaryl-bridged peptides through late-stage Pd-catalyzed C(sp(2))-H arylation. This method displays broad substrate scope and high efficiency in the synthesis of peptide conjugates with various bioactive molecules. Furthermore, we applied this method to prepare peptide macrocycles with aryl-aryl cross-links. Our results show the effectiveness of backbone amide groups as directing groups in Pd-catalyzed C-H functionalization of peptides.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Bai, QQ; Bai, ZB; Wang, H or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors El Rayes, SM; Aboelmagd, A; Gomaa, MS; Fathalla, W; Ali, IAI; Pottoo, FH; Khan, FA in ROYAL SOC CHEMISTRY published article about EFFICIENT SYNTHESIS; TRICHLOROACETIMIDATE; ANTICANCER; NANOPARTICLES; APOPTOSIS in [El Rayes, Samir M.; Aboelmagd, Ahmed; Ali, Ibrahim A. I.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt; [Gomaa, Mohamed S.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmaceut, POB 1982, Dammam 31441, Saudi Arabia; [Fathalla, Walid] Port Said Univ, Dept Phys & Math, Fac Engn, Port Said, Egypt; [Pottoo, Faheem H.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmacol, POB 1982, Dammam 31441, Saudi Arabia; [Khan, Firdos Alam] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Stem Cell Res, POB 1982, Dammam 31441, Saudi Arabia in 2020, Cited 38. Category: isothiazole. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was transformed into the corresponding trichloroacetimidate or acetate by the reaction with trichloroacetonitrile and acetic anhydride, respectively. N-Alkyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropan-amides and methyl-2-[(3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoyl)amino] alkanoates were obtained by the reaction of corresponding acid or hydrazide with amines and amino acid esters via DCC and azide coupling methods. Methyl-3-aryl-3-(4-chlorophenyl)-2,2-dimethylpropanoates were obtained in good yields and short reaction time from the corresponding trichloroacetimidate or acetate by the reaction with C-active nucleophiles in the presence of TMSOTf (0.1 eq.%) via C-C bond formation. The antiproliferative and apoptotic activity were further studied with molecular docking. The 48 post-treatments showed that out of 24 compounds, 12 compounds showed inhibitory actions on HCT-116 cells, we have calculated the inhibitory action (IC50) of these compounds on HCT-116 and we have found that the IC50 values were in between 0.12 mg mL(-1) to 0.81 mg mL(-1). The compounds (7a & 7g) showed highest inhibitory activity (0.12 mg mL(-1)), whereas compound 7d showed the lowest inhibitory activity (0.81 mg mL(-1)). We have also examined inhibitory action on normal and non-cancerous cells (HEK-293 cells) and confirmed that action of these compounds was specific to cancerous cells. The cancerous cells were also examined for nuclear disintegration through staining with DAPI, (4 ‘,6-diamidino-2-phenylindole) is a blue-fluorescent DNA stain, and we have found that there was loss of DAPI staining in the compound treated cancerous cells. The compounds were found to potentially act through the HSP90 and TRAP1 mediated signaling pathway. Compounds 7a and 7g showed the highest selectivity to TRAP1 which explained its superior activity.

Category: isothiazole. About 1,3-Dimethoxybenzene, If you have any questions, you can contact El Rayes, SM; Aboelmagd, A; Gomaa, MS; Fathalla, W; Ali, IAI; Pottoo, FH; Khan, FA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Cu-Catalysed carboxylation of aryl boronic acids with CO2 published in 2019. Recommanded Product: 3-Methylbenzoic acid, Reprint Addresses Mo, FY (corresponding author), Peking Univ, Coll Engn, Dept Energy & Resources Engn, Beijing 100871, Peoples R China.; Mo, FY (corresponding author), Jiangsu Donghai Silicon Ind S&T Innovat Ctr, Donghai Cty 222300, Jiangsu, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A copper/N-heterocyclic carbene (NHC) catalysed carboxylation of aryl boronic acids under one atmospheric pressure of CO2 has been developed. A wide range of aryl boronic acids was transformed into benzoic acid derivatives in moderate to high yields. The carboxylation method shows excellent functional group compatibility, and sensitive functional groups such as carbonyls, esters, and nitriles were tolerated. Mechanistic studies revealed the vital role of the base in promoting the transmetalation step for this copper-catalysed carboxylation.

About 3-Methylbenzoic acid, If you have any questions, you can contact Nayal, OS; Hong, JT; Yang, Y; Mo, FY or concate me.. Recommanded Product: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Oxidative umpolung selenocyanation of ketones and arenes: An efficient protocol to the synthesis of selenocyanates WOS:000520609400003 published article about METAL-FREE SYNTHESIS; ORGANIC SELENOCYANATES; SELENIUM; SELENAZOFURIN; DERIVATIVES; STRATEGY; DESIGN in [Cui, Jianguo; Wei, Meizhen; Pang, Liping; Xiao, JunAn; Gan, Chunfang; Guo, Jiali; Xie, Chuanfang; Zhu, Qiming; Huang, Yanmin] Nanning Normal Univ, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China; [Cui, Jianguo] Beibuwan Univ, Guangxi Coll & Univ Key Lab Beibu Gulf Oil & Nat, Qinzhou 535000, Peoples R China in 2020, Cited 51. Recommanded Product: 151-10-0. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A practical method for the umpolung selenocyanation of aryl ketones, alkyl ketones, beta-ketoesters and electron-rich arenes has been developed, affording various selenocyanates in moderate to excellent yields. This transformation proceeds by an oxidative umpolung selenocyanation through nitrogen oxides-mediated electrophilic selenocyanation process. This method is simpler, more efficient, and less costly than precedent methods. Further transformations of the arylselenocyanate was performed to prove the synthetic utility of this methodology. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Cui, JG; Wei, MZ; Pang, LP; Xiao, JA; Gan, CF; Guo, JL; Xie, CF; Zhu, QM; Huang, YM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Palladium(II)/Copper(II)-Catalyzed C-H Sulfidation or Selenation of Arenes Leading to Unsymmetrical Sulfides and Selenides published in 2019. Category: isothiazole, Reprint Addresses Sakai, N (corresponding author), Tokyo Univ Sci RIKADAI, Dept Pure & Appl Chem, Fac Sci & Technol, Noda, Chiba 2788510, Japan.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

A novel palladium(II)/copper(II)-catalyzed sulfidation of the C-H bond in electron-rich arenes and in pentafluorobenzene with disulfides was developed. This catalytic system can be used to efficiently produce various types of either unsymmetrical aryl sulfides or alkyl aryl sulfides. The present protocol could also be applied to the direct preparation of unsymmetrical aryl selenides via C-H selenation.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Nishino, K; Tsukahara, S; Ogiwara, Y; Sakai, N or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com