Tag: M.W=100-150

Product Details of 151-10-0. In 2020 J ORG CHEM published article about ENANTIOSELECTIVE SYNTHESIS; ALLYLIC ALKYLATION; BRONSTED ACID; ARYLATION; 3-ARYLOXINDOLES; CONSTRUCTION; CATALYSTS; ISATINS; LIGAND in [Rokade, Balaji, V; Guiry, Patrick J.] Univ Coll Dublin UCD, Ctr Synth & Chem Biol CSCB, Synth & Solid State Pharmaceut Ctr SSPC, Sch Chem, Dublin 4, Ireland in 2020, Cited 38. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

alpha-Aryl oxindoles are accessed from isatin via a two-step procedure involving a phospha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure. The use of 1,1,1,3,3,3-hexafluoro-2-propanol as solvent significantly extended the reaction substrate scope to include relatively less electron-rich arenes including benzene. This new alkylation method is fast and straightforward and allows for the direct introduction of the oxindole moiety onto a range of aromatic compounds including phenols. Additionally, the application of arylated products was shown in decarboxylative asymmetric allylation and protonation.

Product Details of 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Rokade, BV; Guiry, PJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors El Rayes, SM; Aboelmagd, A; Gomaa, MS; Fathalla, W; Ali, IAI; Pottoo, FH; Khan, FA in ROYAL SOC CHEMISTRY published article about EFFICIENT SYNTHESIS; TRICHLOROACETIMIDATE; ANTICANCER; NANOPARTICLES; APOPTOSIS in [El Rayes, Samir M.; Aboelmagd, Ahmed; Ali, Ibrahim A. I.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt; [Gomaa, Mohamed S.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmaceut, POB 1982, Dammam 31441, Saudi Arabia; [Fathalla, Walid] Port Said Univ, Dept Phys & Math, Fac Engn, Port Said, Egypt; [Pottoo, Faheem H.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmacol, POB 1982, Dammam 31441, Saudi Arabia; [Khan, Firdos Alam] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Stem Cell Res, POB 1982, Dammam 31441, Saudi Arabia in 2020, Cited 38. Safety of 1,3-Dimethoxybenzene. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was transformed into the corresponding trichloroacetimidate or acetate by the reaction with trichloroacetonitrile and acetic anhydride, respectively. N-Alkyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropan-amides and methyl-2-[(3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoyl)amino] alkanoates were obtained by the reaction of corresponding acid or hydrazide with amines and amino acid esters via DCC and azide coupling methods. Methyl-3-aryl-3-(4-chlorophenyl)-2,2-dimethylpropanoates were obtained in good yields and short reaction time from the corresponding trichloroacetimidate or acetate by the reaction with C-active nucleophiles in the presence of TMSOTf (0.1 eq.%) via C-C bond formation. The antiproliferative and apoptotic activity were further studied with molecular docking. The 48 post-treatments showed that out of 24 compounds, 12 compounds showed inhibitory actions on HCT-116 cells, we have calculated the inhibitory action (IC50) of these compounds on HCT-116 and we have found that the IC50 values were in between 0.12 mg mL(-1) to 0.81 mg mL(-1). The compounds (7a & 7g) showed highest inhibitory activity (0.12 mg mL(-1)), whereas compound 7d showed the lowest inhibitory activity (0.81 mg mL(-1)). We have also examined inhibitory action on normal and non-cancerous cells (HEK-293 cells) and confirmed that action of these compounds was specific to cancerous cells. The cancerous cells were also examined for nuclear disintegration through staining with DAPI, (4 ‘,6-diamidino-2-phenylindole) is a blue-fluorescent DNA stain, and we have found that there was loss of DAPI staining in the compound treated cancerous cells. The compounds were found to potentially act through the HSP90 and TRAP1 mediated signaling pathway. Compounds 7a and 7g showed the highest selectivity to TRAP1 which explained its superior activity.

Safety of 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact El Rayes, SM; Aboelmagd, A; Gomaa, MS; Fathalla, W; Ali, IAI; Pottoo, FH; Khan, FA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 151-10-0. In 2021 J ELECTROCHEM SOC published article about COPPER-CATALYZED SYNTHESIS; THIAZOLOPYRIDINES; BENZOTHIAZOLES; VORTIOXETINE; VALDECOXIB; ANNULATION; NELFINAVIR; INHIBITOR; CELECOXIB; ALCOHOLS in [Wang, Xin-Xing; Chen, Cheng; Shi, Hai-Zhu; Zhang, Guo-Wei; Tang, Yu; Zhang, Chun-Gu; Wu, Ming-Yu; Feng, Shun] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China in 2021, Cited 59. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

A metal- and oxidant-free electrochemical synthesis of aryl sulfides was developed through a C-H sulfidation reaction of arenes and disulfides. Compared with traditional organic synthesis methods, this direct electrochemical approach efficiently generates aryl sulfides under catalyst- and oxidant-free conditions with the superiorities of wide substrate compatibility, mild reaction condition and waster free. At room temperature, various aryl thiols could be transformed smoothly in an undivided cell. Based on cyclic voltammetry (CV) and control experiments, the possible reaction mechanism was also proposed. The gram-scale synthesis emphasizes the practicability of this electrochemical strategy. (c) 2021 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Wang, XX; Chen, C; Shi, HZ; Zhang, GW; Tang, Y; Zhang, CG; Wu, MY; Feng, S or concate me.. Product Details of 151-10-0

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Henrichs, C; Hebestreit, ML; Krugler, D; Schmitt, M in ELSEVIER published article about in [Henrichs, Christian; Hebestreit, Marie-Luise; Schmitt, Michael] Heinrich Heine Univ, Inst Phys Chem 1, D-40225 Dusseldorf, Germany; [Krugler, Daniel] Bruker Daltonik GmbH, D-28359 Bremen, Germany in 2021, Cited 42. Recommanded Product: 151-10-0. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

The geometry changes of two rotamers of 1,3-dimethoxybenzene were determined from a combined fit of line intensities in fluorescence emission spectra, obtained via pumping different vibronic transition and the changes of rotational constants upon electronic excitation. The so determined changes are compared to the results of ab initio approximate coupled cluster singles and doubles (CC2) calculations. The bond length variations in the aromatic ring follow the calculated electron density differences from the coupled cluster wavefunctions and are in agreement with excitation to an L-1(b)-state for the C-2v symmetric B-conformer. (C) 2021 Elsevier B.V. All rights reserved.

Recommanded Product: 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Henrichs, C; Hebestreit, ML; Krugler, D; Schmitt, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of Novel (9S)-Acyloxy Derivatives of Quinidine and Dihydroquinidine as Insecticidal Agents published in 2020. Name: 3-Methylbenzoic acid, Reprint Addresses Che, ZP (corresponding author), Henan Univ Sci & Technol, Coll Forestry, Dept Plant Protect, Lab Pesticidal Design & Synth, Luoyang 471023, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Endeavor to discover biorational natural products-based insecticides, two series (30) of novel (9S)-acyloxy derivatives of quinidine and dihydroquinidine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially four derivatives exhibited the best insecticidal activity with final mortality rates of 71.4 %, 75.0 %, 71.4 %, and 75.0 %, respectively. Relatively speaking, 9-hydroxy group is well tolerated, and the results showed that after modification of the hydroxy group with an acyloxy group, the insecticidal activity was significantly increased; the configuration at C8/9 position is important for insecticidal activity, and the (9S)-configuration is optimal; modification of the out-ring double bond is acceptable, and hydrogenation of the double bond enhances insecticidal activity. These preliminary results will pave the way for further modification of quinidine in the development of potential new insecticides.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Che, ZP; Yang, JM; Sun, D; Tian, Y; Liu, SM; Lin, XM; Jiang, J; Chen, GQ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about C-H AMINATION; ORGANIC-SYNTHESIS; IODINE(V) REAGENTS; BORONIC ACIDS; BRONSTED ACID; BONDS; DELIVERY; NITROSOBENZENES; HETEROCYCLES; DERIVATIVES, Saw an article supported by the SERB, DST, India [ECR/2018/000098]; IIT Ropar; UGC, New DelhiUniversity Grants Commission, India; Indian Institute of Technology, Ropar. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Pradhan, S; Roy, S; Ghosh, S; Chatterjee, I. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene. Recommanded Product: 151-10-0

A metal-free aromatic electrophilic substitution reaction using nitrosoarenes as the electrophile in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is reported. HFIP activates nitrosoarene towards the electrophilic C-H amination followed by a concomitant N-O bond cleavage to deliver diarylamines without requiring any extra reagent or further treatment. The dual electrophilic nature of nitrosoarene permits a switchover of selectivity to C-H oxygenation furnishing dearomatizedp-iminoquinones following a unique mechanistic rationale of two consecutive [2,3] sigmatropic rearrangement in nitroso-chemistry.

Recommanded Product: 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Pradhan, S; Roy, S; Ghosh, S; Chatterjee, I or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Lin, HS; Okawa, S; Ma, Y; Yotsumoto, S; Lee, C; Tan, S; Manzhos, S; Yoshizawa, M; Chiashi, S; Lee, HM; Tanaka, T; Kataura, H; Jeon, I; Matsuo, Y; Maruyama, S in AMER CHEMICAL SOC published article about BASE ADDUCT; EFFICIENT; CRYSTALLIZATION; ANTHRACENE; RECOMBINATION; SEPARATION; IMPACT; FILMS; WATER; SIZE in [Jeon, Il] Pusan Natl Univ, Inst Plast Informat & Energy Mat, Grad Sch Chem Mat, Dept Chem Educ, Busan 46241, South Korea; [Lin, Hao-Sheng; Okawa, Shunhei; Yotsumoto, Satoshi; Chiashi, Shohei; Jeon, Il; Matsuo, Yutaka; Maruyama, Shigeo] Univ Tokyo, Dept Mech Engn, Tokyo 1138656, Japan; [Matsuo, Yutaka] Nagoya Univ, Inst Mat Innovat, Inst Innovat Future Soc, Nagoya, Aichi 4648603, Japan; [Tanaka, Takeshi; Kataura, Hiromichi; Maruyama, Shigeo] Natl Inst Adv Ind Sci & Technol, Nanomat Res Inst, Tsukuba, Ibaraki 3058565, Japan; [Ma, Yue] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China; [Lee, Changsoo; Lee, Hyuck Mo] Korea Adv Inst Sci & Technol KAIST, Dept Mat Sci & Engn, Daejeon 34141, South Korea; [Tan, Shaun] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA; [Manzhos, Sergei] Inst Natl Rech Sci, Ctr Energie Mat Telecommun, Varennes, PQ, Canada; [Yoshizawa, Michito] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Yokohama, Kanagawa 2268503, Japan in 2020, Cited 55. Product Details of 151-10-0. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

Perovskite crystal grain size control, grain boundary passivation, and grain bridging are the keys to obtaining high efficiency in perovskite solar cells. A small amount of semi-conducting single-walled carbon nanotubes added to a perovskite active layer can achieve this. In particular, the surfactants attached to the semiconducting single-walled carbon nanotubes a crucial role. In this work, we synthesized a new surfactant, 4,6-di(anthracen-9-yl)-1,3-phenylene bis(dimethylcarbamate), which has a polyaromatic group on one end and a urea-analogue carbamate group on the other end. The polyaromatic anthracene end functions as a nanotweezer clenching the carbon nanotubes strongly via pi-pi interaction while the carbamate end interacts with Pb2+, functioning as a strong Lewis base. In addition, the new surfactant has conjugated double bonds with a suitable bandgap, resulting in enhanced charge mobility in the perovskite film. Overall, the new surfactant-clenched semiconducting carbon nanotubes showcase superior effectiveness as passivators and charge bridges in perovskite solar cells as compared to the conventional deoxycholate surfactant-wrapped semiconducting single-walled carbon nanotubes. The new surfactant-attached semiconducting carbon nanotube-added NH3CH3PbI3-based perovskite solar cells exhibited a power conversion efficiency of 20.7%, which is higher than that of the reference devices with no additives (18.4%) and the previously reported semiconducting single-walled carbon nanotube-added devices (19.7% in this work and 19.5% in the literature).

Product Details of 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Lin, HS; Okawa, S; Ma, Y; Yotsumoto, S; Lee, C; Tan, S; Manzhos, S; Yoshizawa, M; Chiashi, S; Lee, HM; Tanaka, T; Kataura, H; Jeon, I; Matsuo, Y; Maruyama, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 99-04-7. Recently I am researching about REDUCTIVE DICARBOFUNCTIONALIZATION; ARYL-ALKENYLATION; FUNCTIONALIZATION; PHOTOREDOX; ARYLATION; FLUORINE; ALKENES; ACCESS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21991123, 21971036, 21702029]; Thousand Plan Youth program; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Analytical Instrumentation Center at ShanghaiTech University [SPST-AIC10112914]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Tu, HY; Wang, F; Huo, LP; Li, YB; Zhu, SQ; Zhao, X; Li, H; Qing, FL; Chu, LL. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A nickel-catalyzed, enantioselective, three-component fluoroalkylarylation of unactivated alkenes with aryl halides and perfluoroalkyl iodides has been described. This cross-electrophile coupling protocol utilizes a chiral nickel/BiOx system as well as a pendant chelating group to facilitate the challenging three-component, asymmetric difunctionalization of unactivated alkenes, providing direct access to valuable chiral beta-fluoroalkyl arylalkanes with high efficiency and excellent enantioselectivity. The mild conditions allow for a broad substrate scope as well as good functional group toleration.

Recommanded Product: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Tu, HY; Wang, F; Huo, LP; Li, YB; Zhu, SQ; Zhao, X; Li, H; Qing, FL; Chu, LL or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Chi-MIC-share: a new feature selection algorithm for quantitative structure-activity relationship models WOS:000541906600014 published article about SUPPORT VECTOR REGRESSION; DESCRIPTOR SELECTION; QSAR ANALYSIS; INFORMATION; PREDICTION; INHIBITORS; TOXICITY in [Li, Yuting; Dai, Zhijun; Cao, Dan; Chen, Yuan; Yuan, Zheming] Hunan Agr Univ, Hunan Engn & Technol Res Ctr Agr Big Data Anal &, Changsha 410128, Peoples R China; [Luo, Feng] Clemson Univ, Sch Comp, Clemson, SC USA; [Yuan, Zheming] Hunan Agr Univ, Hunan Prov Key Lab Crop Germplasm Innovat & Utili, Changsha 410128, Hunan, Peoples R China in 2020, Cited 39. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. COA of Formula: C8H10O2

Quantitative structure-activity relationship models are used in toxicology to predict the effects of organic compounds on aquatic organisms. Common filter feature selection methods use correlation statistics to rank features, but this approach considers only the correlation between a single feature and the response variable and does not take into account feature redundancy. Although the minimal redundancy maximal relevance approach considers the redundancy among features, direct removal of the redundant features may result in loss of prediction accuracy, and cross-validation of training sets to select an optimal subset of features is time-consuming. In this paper, we describe the development of a feature selection method, Chi-MIC-share, which can terminate feature selection automatically and is based on an improved maximal information coefficient and a redundant allocation strategy. We validated Chi-MIC-share using three environmental toxicology datasets and a support vector regression model. The results show that Chi-MIC-share is more accurate than other feature selection methods. We also performed a significance test on the model and analyzed the single-factor effects of the reserved descriptors.

COA of Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Li, YT; Dai, ZJ; Cao, D; Luo, F; Chen, Y; Yuan, ZM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Enhanced Acidity and Activity of Aluminum/Gallium-Based Ionic Liquids Resulting from Dynamic Anionic Speciation WOS:000494549700010 published article about CHLOROALUMINATE; MIXTURES; PROGRESS in [Li, Kai; Choudhary, Hemant; Mishra, Manish Kumar; Rogers, Robin D.] Univ Alabama, Coll Arts & Sci, Tuscaloosa, AL 35487 USA; [Rogers, Robin D.] 525 Solut Inc, POB 2206, Tuscaloosa, AL 35403 USA; [Li, Kai] Oak Ridge Natl Lab, Chem Sci Div, 1 Bethel Valley Rd, Oak Ridge, TN 37831 USA; [Choudhary, Hemant] Joint BioEnergy Inst, Emeryville, CA 94608 USA; [Mishra, Manish Kumar] Univ Minnesota, Coll Pharm, Dept Pharmaceut, Pharmaceut Mat Sci & Engn Lab, 9-127B Weaver Densford Hall,308 Harvard St SE, Minneapolis, MN 55455 USA in 2019, Cited 29. Computed Properties of C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

To explore if the catalytic activity of single-metal species in halometallate catalysts can be enhanced with mixed-metal species, aluminum and gallium were simultaneously introduced to prepare a mixed-metal ionic liquid (IL) through a one pot reaction of [HN222]Cl, AlCl3, and GaCl3 in various amounts. The Lewis acidity in Friedel-Crafts acylation and alkylation reactions of these IL compositions were evaluated and all mixed-metal [HN222][xAlCl(3) + (2 – x)GaCl3]Cl ILs exhibited higher catalytic activity than AlCl3, GaCl3, [HN222][Al2Cl7], or [HN222][Ga2Cl7]. The broadening in Al-27 nuclear magnetic resonance (NMR) of these ILs indicates the presence of dynamic anionic species, whereas matrix-assisted laser-desorption ionization time of-flight (MALDI-TOF) and acetonitrile-probed Fourier transform infrared (FT-IR) analyses correlates the structure-activity relationship, for instance, identifying the presence of mixed-metal-containing [Cl2GaOClAlClOGaCl2](-) species in the better-performing ILs.

Computed Properties of C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Li, K; Choudhary, H; Mishra, MK; Rogers, RD or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com