Tag: M.W=100-150

Recently I am researching about COUPLING REACTIONS; ALLYLIC ALCOHOLS; GAMMA-LACTONES; ALKENES; ARYLATION; 1,2-DIFUNCTIONALIZATION; HYDROARYLATION; CYCLIZATION, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51878326, 21762030, 21625203, 21871126]; China Scholarship CouncilChina Scholarship Council [201908360088]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Luo, SZ; Min, MY; Wu, YC; Jiang, SS; Xiao, YT; Song, RJ; Li, JH. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene. Formula: C8H10O2

A copper and silver-promoted intermolecular 1,2-alkylarylation of styrenes with alpha-carbonyl alkyl bromides and arenes for producing highly bulky 1,1-diarylalkane derivatives has been developed. In this transformations, two new C-C bonds were formed in a single reaction step through C-Br bond cleavage and C(sp(2))-H functionalization. This protocol tolerates a variety of alpha-carbonyl alkyl bromides, including primary, secondary and tertiary alpha-bromoalkyl ketone esters.

Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Luo, SZ; Min, MY; Wu, YC; Jiang, SS; Xiao, YT; Song, RJ; Li, JH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Guerra, J; Bajwa, B; Kumar, P; Vazquez, S; Krishnan, VV; Maitra, S in AMER CHEMICAL SOC published article about NUCLEAR-MAGNETIC-RESONANCE; CHEMICAL-EXCHANGE; NMR; BARRIERS in [Guerra, Jacob; Bajwa, Bhvandip; Kumar, Prarthana; Vazquez, Salvador; Krishnan, Viswanathan V.; Maitra, Santanu] Calif State Univ Fresno, Dept Chem, Fresno, CA 93740 USA; [Krishnan, Viswanathan V.] Univ Calif Davis, Dept Pathol & Lab Med, Davis, CA 95616 USA in 2020.0, Cited 40.0. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The concept of enthalpy-entropy compensation (EEC) is one of the highly debated areas of thermodynamics. The conformational change due to restricted double-bond rotation shows a classic two-site chemical exchange phenomenon and has been extensively studied. Fifty-four analogs of N,N-diethyl-m-toluamide (DEET) as a model system were synthesized to study the thermodynamics of the partial amide bond character using nuclear magnetic resonance (NMR) spectroscopy. Line-shape analysis as a function of temperature is used to estimate the chemical exchange. Eyring analysis was then used to convert the chemical exchange rates to determine the transition state enthalpy and entropy of the molecules. The experimental design follows selective variations that perturb one aspect of the molecular system and its influence on the observed thermodynamic effect. The results of the study demonstrate that amide bond resonance in analogs of DEET follows an EEC mechanism. Simple modifications made to DEET’s structural motif alter both the enthalpy and entropy of the system and were limited overall to a temperature compensation factor, T-beta = 292.20 K, 95% CI [290.66, 293.73]. We suggest EEC as a model to describe the kinetic compensation seen in chemical exchange phenomena in analogs of DEET.

About 3-Methylbenzoic acid, If you have any questions, you can contact Guerra, J; Bajwa, B; Kumar, P; Vazquez, S; Krishnan, VV; Maitra, S or concate me.. SDS of cas: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Abel-Snape, X; Whyte, A; Lautens, M in [Abel-Snape, Xavier; Whyte, Andrew; Lautens, Mark] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada published Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis in 2020, Cited 49. Name: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

An ortho-amination, ipso-C-H arylation mediated by palladium/norbornene cooperative catalysis is reported. This reaction proceeds through a sequential intermolecular C-N bond formation process followed by intramolecular C-H activation of a tethered arene. The products, aminated phenanthridinones, were generated in moderate to good yields. This method is also applicable to the formation of dibenzazepinones.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Abel-Snape, X; Whyte, A; Lautens, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Controlling reactivity in the Fujiwara-Moritani reaction: Examining solvent effects and the addition of 1,3-dicarbonyl ligands on the oxidative coupling of electron rich arenes and acrylates WOS:000512482000005 published article about C-H OLEFINATION; BOND ACTIVATION; CATALYZED OLEFINATION; AROMATIC-SUBSTITUTION; MIZOROKI-HECK; PD; ARYLATION; ALKENYLATION; DERIVATIVES; ETHYLENE in [Jones, Roderick C.] Univ Coll Dublin, Sch Chem & Bioproc Engn, Dublin 4, Ireland in 2020, Cited 73. Computed Properties of C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A palladium-catalysed direct alkenation of electron rich arenes in the presence of K2S2O8 with an acetic acid/1,4-dioxane solvent combination has been developed. The 1,4-dioxane co-solvent dramatically influences the rate of reaction, giving selectively disubstituted alkenes, while the addition of acetylacetone ligands was shown to increase site selectivity for the alkenation of monofunctionalized arenes. The participation of these carbonyl ligands has been confirmed by ESI-MS studies, with some key in situ intermediates in the catalytic cycle identified. A variety of electron rich arenes and olefinic substrates can be utilised in the direct oxidative coupling to give disubstituted alkenes in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

Computed Properties of C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Jones, RC or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

COA of Formula: C8H10O2. In 2020 EUR J ORG CHEM published article about CHLORINATION; CHEMISTRY; CHLORIDE; ALKYNES; SUBSTITUTION; HALOGENATION; ACTIVATION; CATALYSIS; EFFICIENT; ALPHA in [Duesel, Simon Josef Siegfried; Koenig, Burkhard] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany in 2020, Cited 41. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

Electron-rich arenes are oxidatively photochlorinated in the presence of catalytic amounts of bromide ions, visible light, and 4CzIPN as organic photoredox catalyst. The substrates are brominated in situ in a first photoredox-catalyzed oxidation step, followed by a photocatalyzed ipso-chlorination, yielding the target compounds in high ortho/para regioselectivity. Dioxygen serves as a green and convenient terminal oxidant. The use of aqueous hydrochloric acid as the chloride source reduces the amount of saline by-products.

COA of Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Dusel, SJS; Konig, B or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells WOS:000519540800028 published article about EFFICIENT SYNTHESIS; TRICHLOROACETIMIDATE; ANTICANCER; NANOPARTICLES; APOPTOSIS in [El Rayes, Samir M.; Aboelmagd, Ahmed; Ali, Ibrahim A. I.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt; [Gomaa, Mohamed S.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmaceut, POB 1982, Dammam 31441, Saudi Arabia; [Fathalla, Walid] Port Said Univ, Dept Phys & Math, Fac Engn, Port Said, Egypt; [Pottoo, Faheem H.] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmacol, POB 1982, Dammam 31441, Saudi Arabia; [Khan, Firdos Alam] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Stem Cell Res, POB 1982, Dammam 31441, Saudi Arabia in 2020, Cited 38. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Recommanded Product: 1,3-Dimethoxybenzene

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was transformed into the corresponding trichloroacetimidate or acetate by the reaction with trichloroacetonitrile and acetic anhydride, respectively. N-Alkyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropan-amides and methyl-2-[(3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoyl)amino] alkanoates were obtained by the reaction of corresponding acid or hydrazide with amines and amino acid esters via DCC and azide coupling methods. Methyl-3-aryl-3-(4-chlorophenyl)-2,2-dimethylpropanoates were obtained in good yields and short reaction time from the corresponding trichloroacetimidate or acetate by the reaction with C-active nucleophiles in the presence of TMSOTf (0.1 eq.%) via C-C bond formation. The antiproliferative and apoptotic activity were further studied with molecular docking. The 48 post-treatments showed that out of 24 compounds, 12 compounds showed inhibitory actions on HCT-116 cells, we have calculated the inhibitory action (IC50) of these compounds on HCT-116 and we have found that the IC50 values were in between 0.12 mg mL(-1) to 0.81 mg mL(-1). The compounds (7a & 7g) showed highest inhibitory activity (0.12 mg mL(-1)), whereas compound 7d showed the lowest inhibitory activity (0.81 mg mL(-1)). We have also examined inhibitory action on normal and non-cancerous cells (HEK-293 cells) and confirmed that action of these compounds was specific to cancerous cells. The cancerous cells were also examined for nuclear disintegration through staining with DAPI, (4 ‘,6-diamidino-2-phenylindole) is a blue-fluorescent DNA stain, and we have found that there was loss of DAPI staining in the compound treated cancerous cells. The compounds were found to potentially act through the HSP90 and TRAP1 mediated signaling pathway. Compounds 7a and 7g showed the highest selectivity to TRAP1 which explained its superior activity.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact El Rayes, SM; Aboelmagd, A; Gomaa, MS; Fathalla, W; Ali, IAI; Pottoo, FH; Khan, FA or concate me.. Recommanded Product: 1,3-Dimethoxybenzene

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article A simple method for the synthesis of sulfonic esters WOS:000550938700001 published article about ESTROGEN-RECEPTOR LIGANDS; CROSS-COUPLING REACTIONS; CONSTRAINED ANALOGS; PROTECTING GROUP; FACILE SYNTHESIS; ARYL TOSYLATES; ACID ESTERS; SULFONYLATION; CATALYST; PHENOLS in [Bhatthula, Bharath Kumar Goud; Kanchani, Janardhan Reddy; Arava, Veera Reddy] Suven Life Sci Ltd, Res & Dev Ctr, Hyderabad, India; [Kanchani, Janardhan Reddy; Marata Chenna Subbarao, Subha] Sri Krishnadevaraya Univ, Dept Chem, Anantapur, Andhra Pradesh, India in 2020, Cited 71. Formula: C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

An efficient and simple approach for the direct synthesis of aryl and heteroaryl sulfonic esters was developed using DMS and DES as alkoxysulfonylation reagents. The reaction is operationally simple and scalable. This protocol does not require solvent, expensive catalysts, base, ligand additives or other reagents. A wide range of sulfonic esters were synthesized in moderate to good chemical yields. This method has the advantage of low cost, facile and tolerated a wide range of substrates.

Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Bhatthula, BKG; Kanchani, JR; Arava, VR; Subbarao, SMC or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 1,3-Dimethoxybenzene. I found the field of Chemistry very interesting. Saw the article Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow published in 2020, Reprint Addresses Knochel, P (corresponding author), Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13,Haus F, D-81377 Munich, Germany.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene.

We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 m in hexane) complexed with TMEDA (N,N,N ‘,N ‘-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78 degrees C and 25 degrees C with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min(-1) using a commercial flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl-substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale-up was possible without further optimization.

Safety of 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Harenberg, JH; Weidmann, N; Knochel, P or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Hameed, S; Kanwal; Seraj, F; Rafique, R; Chigurupati, S; Wadood, A; Rehman, AU; Venugopal, V; Salar, U; Taha, M; Khan, KM in [Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Chigurupati, Sridevi] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 52571, Saudi Arabia; [Wadood, Abdul; Rehman, Ashfaq Ur] Abdul Wali Khan Univ, Dept Biochem, Computat Med Chem Lab, UCSS, Mardan, Pakistan; [Venugopal, Vijayan] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia; [Salar, Uzma] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan; [Taha, Muhammad; Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia published Synthesis of benzotriazoles derivatives and their dual potential as alpha-amylase and alpha-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies in 2019, Cited 29. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Benzotriazoles (4-6) were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7-40). The synthetic compounds (7-40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS, H-1-, and C-13 NMR. These molecules were examined for their anti-hyperglycemic potential hence were evaluated for alpha-glucosidase and alpha-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 mu M against alpha-glucosidase and alpha-amylase enzymes, respectively. The synthetic compounds were divided into two categories A and B, in order to understand the structure-activity relationship. Compounds 25 (IC50 = 2.41 +/- 131 mu M), (IC50 = 2.5 +/- 1.21 mu M), 36 (IC50= 2.12 +/- 1.35 M), (IC50 = 2.21 +/- 1.08 mu M), and 37 (IC50 = 2.00 +/- 1.22 mu M), (IC50 = 2.04 +/- 1.4 mu M) with chloro substitution/s at aryl ring were found to be most active against alpha-glucosidase and alpha-amylase enzymes. Molecular docking studies on all compounds were performed which revealed that chloro substitutions are playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic molecules have shown competitive mode of inhibition against alpha-amylase and non-competitive mode of inhibition against alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 3-Methylbenzoic acid, If you have any questions, you can contact Hameed, S; Kanwal; Seraj, F; Rafique, R; Chigurupati, S; Wadood, A; Rehman, AU; Venugopal, V; Salar, U; Taha, M; Khan, KM or concate me.. Recommanded Product: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 3-Methylbenzoic acid. In 2020 CHEM-EUR J published article about THERMAL-DECOMPOSITION; NITRILE IMINES; DERIVATIVES; SELECTIVITY; LIGHT in [Green, Luke; Livingstone, Keith; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland; [Green, Luke; Bertrand, Sophie; Peace, Simon] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England in 2020, Cited 38. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

About 3-Methylbenzoic acid, If you have any questions, you can contact Green, L; Livingstone, K; Bertrand, S; Peace, S; Jamieson, C or concate me.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com