Tag: M.W=100-150

Authors Guo, Y; Xu, T; Bao, CN; Liu, ZY; Fan, JP; Yang, RG; Qin, SS in ELSEVIER published article about ANTIMICROBIAL ACTIVITY; 1,3,4-OXADIAZOLE; DERIVATIVES; QUINOLONES; DISCOVERY; ANALOGS in [Guo, Yong; Xu, Ting; Bao, Chongnan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige; Qin, Shangshang] Zhengzhou Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Adv Drug Preparat Technol, 100 KeXue Ave, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 27. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), a class of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities against drug-sensitive bacteria S. aureus and clinical drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2 mu g/mL) and MRSA1-3 (MIC: 0.25-1 mu g/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time, and showed very low cytotoxicity to NRK-52E cells. Some interesting structure-activity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA.

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Recommanded Product: 3-Methylbenzoic acid. Kadam, AA; Metz, TL; Qian, YQ; Stanley, LM in [Kadam, Abhishek A.; Metz, Tanner L.; Qian, Yiqiu; Stanley, Levi M.] Iowa State Univ, Dept Chem, Ames, IA 50011 USA published Ni-Catalyzed Three-Component Alkene Carboacylation Initiated by Amide C-N Bond Activation in 2019, Cited 45. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

The nickel-catalyzed intermolecular carboacylation of alkenes with amides and tetraarylborates is presented. Bicyclic alkenes are readily functionalized with a variety of N-benzoyl-N-phenylbenzamides and triarylboranes, which are generated in situ from the corresponding tetraarylborates, to synthesize ketone products in up to 91% yield. Preliminary mechanistic studies suggest that migratory insertion precedes transmetalation and that reductive elimination is the turnover-limiting step. These reactions occur with excellent chemoselectivity and diastereoselectivity in the absence of a directing/chelating group and further demonstrate amides as practical acyl electrophiles for alkene dicarbofunctionalization reactions.

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Isothiazole – Wikipedia,
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Authors Yadav, MS; Singh, SK; Agrahari, AK; Singh, AS; Tiwari, VK in GEORG THIEME VERLAG KG published article about in [Yadav, Mangal S.; Singh, Sumt K.; Agrahari, Anand K.; Singh, Anoop S.; Tiwari, Vinod K.] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 64.0. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A diverse range of ureas, N-acylureas, carbamates, and thiocarbamates has been synthesized in good to excellent yields by reacting N-acylbenzotriazoles individually with amines or amides or phenols or thiols in the presence of diphenylphosphoryl azide (DPPA) as a suitable azide donor in anhydrous toluene at 110 degrees C for 3-4 hours. In this route, DPPA was found to be a good alternative to trimethylsilyl azide and sodium azide for the azide donor in Curtius degradation. The high reaction yields, one-pot and metal-free conditions, straightforward nature, easy handling, use of readily available reagents, and in many cases avoidance of column chromatography are the notable features of the devised protocol.

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Authors Liu, CW; Ji, CL; Zhou, TL; Hong, X; Szostak, M in WILEY-V C H VERLAG GMBH published article about in [Liu, Chengwei; Zhou, Tongliang; Szostak, Michal] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA; [Ji, Chong-Lei; Hong, Xin] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China in 2021, Cited 92. HPLC of Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Cooperative bimetallic catalysis is a fundamental approach in modern synthetic chemistry. We report bimetallic cooperative catalysis for the direct decarbonylative heteroarylation of ubiquitous carboxylic acids via acyl C-O/C-H coupling. This novel catalytic system exploits the cooperative action of a copper catalyst and a palladium catalyst in decarbonylation, which enables highly chemoselective synthesis of important heterobiaryl motifs through the coupling of carboxylic acids with heteroarenes in the absence of prefunctionalization or directing groups. This cooperative decarbonylative method uses common carboxylic acids and shows a remarkably broad substrate scope (>70 examples), including late-stage modification of pharmaceuticals and streamlined synthesis of bioactive agents. Extensive mechanistic and computational studies were conducted to gain insight into the mechanism of the reaction. The key step involves intersection of the two catalytic cycles via transmetallation of the copper-aryl species with the palladium(II) intermediate generated by oxidative addition/decarbonylation.

Welcome to talk about 99-04-7, If you have any questions, you can contact Liu, CW; Ji, CL; Zhou, TL; Hong, X; Szostak, M or send Email.. HPLC of Formula: C8H8O2

Reference:
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Authors Zhao, XC; Ding, TQ; Jiang, LQ; Yi, WB in SCIENCE PRESS published article about ALPHA-FLUORINATED ETHERS; TRIFLUOROMETHYL ETHERS; DIFLUOROMETHYL ETHERS; MEDICINAL CHEMISTRY; REACTIVITY; ALCOHOLS; THIOETHERS; REAGENTS; PHARMACEUTICALS; NUCLEOPHILES in [Zhao Xiaochun; Ding Tianqi; Jiang Luqi; Yi Wenbin] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Peoples R China in 2019, Cited 49. Safety of 1,3-Dimethoxybenzene. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

Fluorine-containing compounds have been widely used in the fields of pharmaceuticals, agrochemicals and functional materials, mainly due to the well-known fluorine effect of the fluoroalkyl groups on the physical, chemical and biological properties of molecules. Tri- and difluoromethyl ethers play an important role in many medicinally compounds. Among various fluorinated moieties, ORf-containing groups have attracted much more attention very recently owing to the impressive conformational changes and maximal shifts in electron distribution brought by fluorine. The alpha-fluorine substitution of ethers shortens and strengthens the C-O bond and thus improves the in vivo oxidative stability of the ether moiety of a drug. Over the past few decades, there are some reliable ways on accessing trifluoromethyl ethers and difluomethyl ethers. Considering the importance of synthesis of monofluoromethoxy arenes and the substrate limitation (phenols or alcohols) of current state, a method was developed to access monofluoromethoxy arenes from aryl halides, arylboronic acids and arenes via a one-pot synthesis. Phenols can be prepared by the hydroxylation of aryl halides catalyzed by transition-metal complexes. In this work, a new strategy was envisioned a two-step sequence for the conversion of aryl halides to monofluoromethoxy arenes based on the palladium-catalyzed conversion of aryl phenols and in situ conversion of the resulting phenoxides with monofluoromethylating reagents. The investigation began with optimization of the conversion of 1-chloro-4-methoxy-benzene. The approach was achieved by using Pd-2(dba)(3) (2 mol%) as the catalyst under an inert atmosphere, di-tertbuty1(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane (8 mol%) as the ligand, KOH (1 equiv.) as the nucleophile, and 1,4-dioxane/H2O (V : V=5 : 3) as the solvent. Further monofluoromethylation used fluoromethyl iodide (2 equiv.) as the monofluoromethylating reagent and CH3CN as the co-solvent. Finally, the desired product was obtained in 82% yield. Therefore, this method was also applied to drugs, for example, Loratadine could be converted to the corresponding product (2o) in 53% yield and Fenofibrate, reacting to form the monofluoromethoxy arenes (2p) in modest yield. One-pot method to access aryl monofluoromethyl ethers from arylboronic acids and arenes were also under consideration and the yields were objective.

Safety of 1,3-Dimethoxybenzene. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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An article A simple method for the synthesis of sulfonic esters WOS:000550938700001 published article about ESTROGEN-RECEPTOR LIGANDS; CROSS-COUPLING REACTIONS; CONSTRAINED ANALOGS; PROTECTING GROUP; FACILE SYNTHESIS; ARYL TOSYLATES; ACID ESTERS; SULFONYLATION; CATALYST; PHENOLS in [Bhatthula, Bharath Kumar Goud; Kanchani, Janardhan Reddy; Arava, Veera Reddy] Suven Life Sci Ltd, Res & Dev Ctr, Hyderabad, India; [Kanchani, Janardhan Reddy; Marata Chenna Subbarao, Subha] Sri Krishnadevaraya Univ, Dept Chem, Anantapur, Andhra Pradesh, India in 2020, Cited 71. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Safety of 1,3-Dimethoxybenzene

An efficient and simple approach for the direct synthesis of aryl and heteroaryl sulfonic esters was developed using DMS and DES as alkoxysulfonylation reagents. The reaction is operationally simple and scalable. This protocol does not require solvent, expensive catalysts, base, ligand additives or other reagents. A wide range of sulfonic esters were synthesized in moderate to good chemical yields. This method has the advantage of low cost, facile and tolerated a wide range of substrates.

Welcome to talk about 151-10-0, If you have any questions, you can contact Bhatthula, BKG; Kanchani, JR; Arava, VR; Subbarao, SMC or send Email.. Safety of 1,3-Dimethoxybenzene

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Recently I am researching about C-H OLEFINATION; BOND ACTIVATION; CATALYZED OLEFINATION; AROMATIC-SUBSTITUTION; MIZOROKI-HECK; PD; ARYLATION; ALKENYLATION; DERIVATIVES; ETHYLENE, Saw an article supported by the Irish Research Council (IRC)Irish Research Council for Science, Engineering and Technology [PD/2011/2132]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Jones, RC. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene. Computed Properties of C8H10O2

A palladium-catalysed direct alkenation of electron rich arenes in the presence of K2S2O8 with an acetic acid/1,4-dioxane solvent combination has been developed. The 1,4-dioxane co-solvent dramatically influences the rate of reaction, giving selectively disubstituted alkenes, while the addition of acetylacetone ligands was shown to increase site selectivity for the alkenation of monofunctionalized arenes. The participation of these carbonyl ligands has been confirmed by ESI-MS studies, with some key in situ intermediates in the catalytic cycle identified. A variety of electron rich arenes and olefinic substrates can be utilised in the direct oxidative coupling to give disubstituted alkenes in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

Computed Properties of C8H10O2. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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Formula: C8H8O2. I found the field of Chemistry very interesting. Saw the article Late-Stage Functionalization of Aromatic Acids with Aliphatic Aziridines: Direct Approach to Form beta-Branched Arylethylamine Backbones published in 2019, Reprint Addresses Zhao, YS (corresponding author), Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

A palladium-catalyzed carboxylic acid-directed cross-coupling of an ortho-C(sp(2)) atom of aromatic acids with aliphatic aziridines to construct the beta-arylethylamine skeleton via C-H activation has been developed. The reaction proceeded under mild conditions with great substrate scope. Meanwhile, the beta-arylethylamine skeleton in drugs or bioactive compounds could be easily generated in a single step. A catalytic amount of cesium carbonate was crucial to realizing the selective beta-arylethylamine synthesis.

Welcome to talk about 99-04-7, If you have any questions, you can contact Zhou, KH; Zhu, Y; Fan, WT; Chen, YJ; Xu, X; Zhang, JY; Zhao, YS or send Email.. Formula: C8H8O2

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 151-10-0. In 2020 J ORG CHEM published article about HYDROGEN-PEROXIDE; FLUORINATED ALCOHOLS; SELECTIVE OXIDATION; SUBSTITUTION; PROMOTERS; COMPLEX; PHENOL in [Llopis, Natalia; Baeza, Alejandro] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain; [Llopis, Natalia; Baeza, Alejandro] Univ Alicante, Fac Ciencias, Inst Sintesis Organ ISO, E-03080 Alicante, Spain in 2020, Cited 41. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

The straightforward oxidation of electron-rich arenes, namely, phenols, naphthols, and anisole derivatives, under mild reaction conditions, is described by means of the use of an environmentally benign HFIP-UHP system. The corresponding quinones or hydroxylated arenes were obtained in moderate to good yields.

SDS of cas: 151-10-0. Welcome to talk about 151-10-0, If you have any questions, you can contact Llopis, N; Baeza, A or send Email.

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Isothiazole – Wikipedia,
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An article Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against beta-glucuronidase and their interactions thereof WOS:000572832200005 published article about IN-VITRO EVALUATION; ALPHA-GLUCOSIDASE INHIBITION; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; SCHIFF-BASES; DERIVATIVES; ACETYLCHOLINESTERASE; THIOSEMICARBAZIDES; CHILDREN; ANALOGS in [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Uddin, Nizam] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ali, Muhammad] Univ Nizwa, Nat & Med Sci Res Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman; [Anouar, El Hassane] Prince Sattam bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Chem, Al Kharj 11942, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Gulraiz] Imam Abdulrahman Bin Faisal Univ, Environm Engn Dept, Coll Engn Bldg A13,POB 1982, Dammam 31441, Saudi Arabia; [Farooq, Rai Khalid] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Neurosci Res, POB 1982, Dammam 31441, Saudi Arabia; [Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, Coll Comp Sci & Informat Technol CCSIT, Dept Comp Informat Syst, POB 1982, Dammam 31441, Saudi Arabia; [Iqbal, Naveed] Univ Poonch Rawalakot AJK, Dept Chem, Rawalakot, Pakistan; [Farooq, Muhammad] Hazara Univ, Dept Phys, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan in 2020, Cited 54. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Category: isothiazole

beta-Glucuronidase is responsible for the catalytic deconjugation of beta-D-glucuronides. beta-Glucuronidase has evolved to be a viable molecular target for numerous therapeutic treatments. It plays a pivotal role in the metabolism of drugs and endogenous substances. Herein, we report the inhibitory potentials of newly developed and modular benzimidazole-triazolothiadiazole hybrids spaced through a phenyl linker (1-26) and their interactions with the beta-glucuronidase. All analogues showed IC50 values in the range of 1.30 +/- 0.10 to 44.10 +/- 0.80 mu M, and hence were found to have outstanding inhibitory potential as compare to the standard D-saccharic acid 1,4-lactone (IC50 = 48.4 +/- 1.25 mu M). These modular hybrids were successfully synthesized, rigorously characterized through various spectroscopic techniques. Molecular docking studies further revealed the potential interactions between the inhibitor and active amino acid site in beta-glucuronidase. These findings helped in identifying the potential for new drug candidates. A Plausible structure activity relationship (SAR) were established which suggested that variation in the inhibitory potential was mainly based upon the substituents attached to the phenyl ring. (C) 2020 Elsevier B.V. All rights reserved.

Category: isothiazole. Welcome to talk about 99-04-7, If you have any questions, you can contact Taha, M; Uddin, N; Ali, M; Anouar, E; Rahim, F; Khan, G; Farooq, RK; Gollapalli, M; Iqbal, N; Farooq, M; Khan, KM or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com