Tag: M.W:100-200

Related Products of 700-12-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 700-12-9, Name is 1,2,3,4,5-Pentamethylbenzene, SMILES is CC1=CC(C)=C(C)C(C)=C1C, belongs to isothiazole compound. In a article, author is Zhao, MX, introduce new discover of the category.

Reaction of ketene aminals with aryl isothiocyanates – A simple route to isothiazole compounds

Cyclic and acyclic ketene aminals with different electron withdrawing groups reacted with aryl isothiocyanates to give the corresponding alpha – carbon adducts in high yield which underwent oxidative cyclization with bromine to afford isothiazole compounds in moderate yield.

Related Products of 700-12-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 700-12-9 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

In an article, author is Pasha, F. A., once mentioned the application of 1975-51-5, Name: 2-Methyl-4-nitrobenzoic acid, Name is 2-Methyl-4-nitrobenzoic acid, molecular formula is C8H7NO4, molecular weight is 181.15, MDL number is MFCD00210697, category is isothiazole. Now introduce a scientific discovery about this category.

In silico ligand-based (LB) and docking-based (DB) 3D-QSAR study of potent Chk2 inhibitors

Isothiazole carboxamidine compounds are potent ATP competitive Chk2 inhibitors. A series of compounds with Chk2 inhibitory activity were taken from literature and different 3D-QSAR models have been generated with Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (COMSIA). In first scheme LB-QSAR models were generated using fully optimized geometries by PM3 approach giving reasonable statistics of CoMFA (q(2)=0.88, r(2)=0.96 and r(predictive)(2) = 0.60) and CoMSIA(q(2)=0.918 r(2)=0.99 and r(predictive)(2) = 0.55). In second and third scheme the ligands 7 docked in to receptor protein (PDB 2CN8). Consequently, two most plausible modes were identified and used as initial templates. The docked conformer based CoMFA model shows good correlation with activity (q(2)=0.91, r2=0.99 and r(predictive)(2) =0.84). Whereas in CoMSIA, the steric and hydrophobic and donor field jointly give a better statistics (q(2)=0.92 r(2)=0.99 and r(predictive)(2) =0.53). These findings might be helpful to design more potent Chk2 inhibitors.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

In an article, author is Ivanova, Jekaterina, once mentioned the application of 39515-51-0, Safety of 3-Phenoxybenzaldehyde, Name is 3-Phenoxybenzaldehyde, molecular formula is C13H10O2, molecular weight is 198.2173, MDL number is MFCD00003353, category is isothiazole. Now introduce a scientific discovery about this category.

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 3034-86-4, Name is Methyl 4-ethynylbenzoate, molecular formula is C10H8O2. In an article, author is Cutri, CCC,once mentioned of 3034-86-4, Name: Methyl 4-ethynylbenzoate.

Synthesis and antiviral activity of a new series of 4-isothiazolecarbonitriles

A series of 4-isothiazolecarbonitriles was synthesized and screened for in vitro antiviral activity. The effect of various substituents on the phenyl ring, as well as the substitution of the phenyl for other aromatic and heteroaromatic rings, was examined to establish the requirements for optimum activity. The most active member of the series, 3-methylthio-5-phenyl-4-isothiazolecarbonitrile, exhibited a high level of activity against enteroviruses polio 1 and ECHO 9. Preliminary studies on its mechanism of action indicated that this compound had an effect on an early event in the replication of poliovirus type 1. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

Interested yet? Keep reading other articles of 3034-86-4, you can contact me at any time and look forward to more communication. Name: Methyl 4-ethynylbenzoate.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 530-48-3, Name is Ethene-1,1-diyldibenzene, SMILES is C=C(C1=CC=CC=C1)C2=CC=CC=C2, in an article , author is Ke, Shaoyong, once mentioned of 530-48-3, HPLC of Formula: C14H12.

Convenient Structural Diversity-Guided Synthesis of Functionalized Sulfur-Containing Heterocycles via alpha-Substituted Cyanoacetamides

A convenient molecular diversity-oriented synthesis of various functional sulfur-containing heterocyclic scaffolds mainly including isothiazole, 2H-1,3-thiazine, and thiazolidine via different methods from-substituted cyanoacetamides is described. The target molecules have been identified on the basis of analytical spectral data, which may serve as useful structural subunits in the fields of drug discovery.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Application of 455-19-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 455-19-6, Name is 1-Formyl-4-trifluoromethylbenzene, SMILES is O=CC1=CC=C(C(F)(F)F)C=C1, belongs to isothiazole compound. In a article, author is GUILLOTEAU, F, introduce new discover of the category.

A CONVENIENT REGIOSPECIFIC SYNTHESIS OF ISOTHIAZOL-4-YL DERIVATIVES

Synthesis of derivatives resulting from the formation of a carbon-carbon bond in 4-position of the isothiazole is easily obtained by using the 4-magnesioisothiazole prepared via metal halogen exchange.

Application of 455-19-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 455-19-6 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3034-86-4, Name is Methyl 4-ethynylbenzoate, formurla is C10H8O2. In a document, author is Incerti, Matteo, introducing its new discovery. Computed Properties of C10H8O2.

Investigation of the Reaction between 3-Benzisothiazolones, an Isoindole Isoster and Activated Acetylenes: Synthesis of Heterocyclic Backbones for Building Bioactive Molecules

Investigation of the reaction between benzo[d]isothiazol-3-one, 2-aminobenzo[d]isothiazol-3-one, its isoster 2-aminoisoindolin-1-one, and activated acetylenes, in the presence of triphenylphosphine, led us to synthesize novel heterocyclic compounds that could be attractive for the building of biologically active molecules. A one-pot PPh3-promoted tandem reaction, with acetylene dicarboxylates and dibenzoylacetylene, afforded new tricyclic pyrazolo-fused benzisothiazoles. The PPh3-promoted reaction between benzisothiazolones and methyl propiolate afforded 1,4-benzothiazepine-5-one derivatives, via an isothiazole ring expansion. These studies are providing additional insights in benzisothiazolone chemistry and describe simple and original synthetic accesses to novel derivatives.

If you are hungry for even more, make sure to check my other article about 3034-86-4, Computed Properties of C10H8O2.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 122-59-8, Name is 2-Phenoxyacetic acid, molecular formula is C8H8O3. In an article, author is CARUGO, O,once mentioned of 122-59-8, Application In Synthesis of 2-Phenoxyacetic acid.

ISOTHIAZOLES .2. REACTION OF 3-DIETHYLAMINO-4-(4-METHOXYPHENYL)-ISOTHIAZOLE-1,1-DIOXIDE WITH SODIUM-AZIDE

3-Diethylamino-4-(4-methoxyphenyl)-isothiazole-1,1-dioxide 1, was reacted with the azide ion in different solvents. Depending on reaction conditions 4-diethylamino-3a,6a-dihydro-3a-(4-methoxyphenyl)-1H-isothiazole-[4,5-d]-1,2,3-triazole-6,6-dioxide 3 and/or 4-diethylamino-1-[3-diethylamino-4,5-dihydro-4-(4-methoxyphenyl)-5-isothiazolyl-1,1-dioxide]-3a,6a-dihydro-3a-(4-methoxyphenyl)-1H-isothiazole-[4,5-d]- 1,2,3- triazole-6,6-dioxide 4 were formed. When ethanol or acetone were used as reaction solvent the formation of the above compounds was accompanied by solvent addition forming 3-diethylamino-4,5-dihydro-4-(4-methoxyphenyl)-5-ethoxy-isothiazole-1,1-dioxide 2 and 3-diethylamino-4,5-dihydro-4-(4-methoxyphenyl)-5-(2-oxopropyl)-isothiazole-1,1-dioxide 6, respectively. Reaction mechanisms and structures of products are discussed.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry, like all the natural sciences, Safety of 3,4-Dimethoxyphenylacetonitrile, begins with the direct observation of nature¡ª in this case, of matter.93-17-4, Name is 3,4-Dimethoxyphenylacetonitrile, SMILES is C1=C(CC#N)C=CC(=C1OC)OC, belongs to isothiazole compound. In a document, author is Da Settimo, F, introduce the new discover.

Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors

Acetic acid derivatives of naphtho[1,2-dlisothiazole (NiT) were synthesized and tested as novel aldose reductase (ALR2) inhibitors. The parent compound 11 exhibited a fair inhibitory activity (IC50 = 10 mu M), which was enhanced by 2 orders of magnitude by introducing a second carboxylic group at position 4 (13 and 14: IC50 = 0.55 and 0.14 mu M, respectively). Substitution of the acetic acid function with an apolar group gave inactive (29) or poorly active (25, 26, 30) compounds, thus demonstrating that the 2-acetic group is involved in the enzyme pharmacophoric recognition while the 4-carboxylic moiety has only an accessory role. The potent compounds 11, 13, 14, 26 all proved to be selective for ALR2, since none of them inhibited aldehyde reductase, sorbitol dehydrogenase, or glutathione reductase. The isopropyl. ester 31, a prodrug of 14, was found to be effective in preventing cataract development in severely galactosemic rats, when administered as an eyedrop solution. The theoretical binding mode of 13 and 14, obtained by docking simulations into the ALR2 crystal structure, was fully consistent with the structure-activity relationships in the NiT series.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 93-17-4. Safety of 3,4-Dimethoxyphenylacetonitrile.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: isothiazole385-00-2, Name is 2,6-Difluorobenzoic acid, SMILES is O=C(O)C1=C(F)C=CC=C1F, belongs to isothiazole compound. In a article, author is Yang, Zhanhui, introduce new discover of the category.

Synthesis of benzo-gamma-sultams via the Rh-catalyzed aromatic C-H functionalization of diazosulfonamides

An efficient synthesis of 1-aryl-benzo-gamma-sultams, 1-aryl-1,3-dihydrobenzo[c] isothiazole-2,2-dioxides, was achieved in 65-99% yields via the Rh-catalyzed intramolecular aromatic C-H functionalization of N, N-diaryl diazosulfonamides with 0.5 mol% Rh-2(oct)(4) as the catalyst.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 385-00-2. Category: isothiazole.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com