Tag: M.W:100-200

Synthetic Route of C5H7N3S. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Guanine phosphoribosyltransferase from Escherichia coli. Specificity and properties. Author is Miller, Richard L.; Ramsey, Gwendolyn A.; Krenitsky, Thomas A.; Elion, Gertrude B..

The specificity and properties of a novel guanine phosphoribosyltransferase of E. coli were studied and compared to those of the hypoxanthine-guanine phosphoribosyltransferase from other sources. The structural requirements for binding of purines to this enzyme were explored by the determination of the Ki values for 100 purines and purine analogs. The most effective binding occurred when the purine contained an oxo or SH group in the 6 position and an NH2 or OH group in the 2 position. Unlike the hypoxanthine-guanine phosphoribosyltransferase from other sources, this enzyme bound hypoxanthine 67 times less effectively than guanine and 4 times less effectively than xanthine. Rates of nucleotide formation from a number of purines and purine analogs were also determined The enzyme had a pH optimum from 7.4 to 8.2. From secondary double-reciprocal plots derived from an initial velocity anal., the Km values were 0.037mM for guanine and 0.33mM for 5-phosphoribosyl 1-pyrophosphate. The enzyme was sensitive to inhibition by p-chloromercuribenzoate, and this inhibition could be reversed by either dithiothreitol or β-mercaptoethanol. The apparent activation energy with guanine as substrate was 12,800 cal/mole below 23° and 3370 cal/mole above 23°. Using isoelec. focusing, the guanine phosphoribosyltransferase had an apparent pI of 5.50, while the pI of a 2nd enzyme which was specific for hypoxanthine was 4.8.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic (S)-Isothiazolidinone Phosphotyrosine Mimetic, published in 2006-06-29, which mentions a compound: 119639-24-6, Name is 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, Molecular C7H11NO3S, Recommanded Product: 119639-24-6.

Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide containing the novel (S)-isothiazolidinone ((S)-IZD) phosphotyrosine (pTyr) mimetic. An x-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 Å resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp-48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole. The ortho substitution to the (S)-IZD on the aryl ring afforded low nanomolar enzyme inhibitors of PTP1B that also displayed low caco-2 permeability and cellular activity in an insulin receptor (IR) phosphorylation assay and an Akt phosphorylation assay. The design, synthesis, and SAR of this novel series of benzimidazole sulfonamide containing (S)-IZD inhibitors of PTP1B are presented herein.

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Hurst, Derek T.; Beaumont, Claire; Jones, Derek T. E.; Kingsley, Deborah A.; Partridge, Julian D.; Rutherford, Trevor J. published the article 《The chemistry of pyrimidinethiols. II. The preparation and reactions of some 2-arenecarbonylmethylthiopyrimidines》. Keywords: pyrimidinone phenacylthio; phenacylthiopyrimidinone.They researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).COA of Formula: C5H7N3S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6307-44-4) here.

2-Pyrimidinethiones were treated with phenacyl halides to give (phenacylthio)pyrimidines I (R1= Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenyl, Cl2C6H3, naphthyl; R2 = Me, H, Ph, Pr, NH2). Some I were heated in Ph2O to give phenacylidenepyrimidinones II (R3 = Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenylyl, naphthyl; R4 = Me, H, Pr).

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hambardzumyan, E. N.; Vorskanyan, A. S.; Shahbazyan, L. V.; Yengoyan, A. P. researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).Reference of 2-Amino-6-methylpyrimidine-4-thiol.They published the article 《Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives》 about this compound( cas:6307-44-4 ) in Russian Journal of General Chemistry. Keywords: aminomethylpyrimidinethione plant growth stimulant. We’ll tell you more about this compound (cas:6307-44-4).

A series of new pyrimidine derivatives, e.g., I including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43-96% compared to heteroauxin.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide(SMILESS: O=C(C=C1)N(C(C)(C)C)S1(=O)=O,cas:119639-24-6) is researched.Synthetic Route of C9H9NO. The article 《Tilcotil studies. [3+2]Additions with isothiazol-3(2H)-one 1,1-dioxide》 in relation to this compound, is published in Helvetica Chimica Acta. Let’s take a look at the latest research on this compound (cas:119639-24-6).

Derivatives of isothiazol-3(2H)-one 1,1-dioxide (I) react regiospecifically with 1,3-dipolar agents. The main regiocontrolling factor is the C:O group of the dipolarophile. The topol. of the adducts is also in general agreement with predictions based on perturbation theory. Several adducts can be aromatized to heterocyclic equivalents of saccharin, and can then be elaborated into structural analogs of tenoxicam (Tilcotil) and piroxicam (Feldene).

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 119639-24-6, is researched, Molecular C7H11NO3S, about Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)-H Activation, the main research direction is palladium catalyzed cycloaddition carbon hydrogen bond activation; amide lactam cycloaddition maleimide.Formula: C7H11NO3S.

Cycloaddition reactions provide an expeditious route to construct ring systems in a highly convergent and stereoselective manner. For a typical cycloaddition reaction to occur, however, the installation of multiple reactive functional groups (π-bonds, leaving group, etc.) is required within the substrates, compromising the overall efficiency or scope of the cycloaddition reaction. Here, we report a palladium-catalyzed [3 + 2] reaction that utilizes twofold C(sp3)-H activation to generate the three-carbon unit for formal cycloaddition The initial β-C(sp3)-H activation of aliphatic amide, followed by maleimide insertion, triggers a relayed, second C(sp3)-H activation to complete a formal [3 + 2] cycloaddition The key to success was the use of weakly coordinating amide as the directing group, as previous studies have shown that Heck or alkylation pathways are preferred when stronger-coordinating directing groups are used with maleimide coupling partners [e.g., N,N-dimethylpivalamide + N-(4-nitrophenyl)maleimide → I (87%, dr 6:1)]. To promote the amide-directed C(sp3)-H activation step, the use of pyridine-3-sulfonic acid ligands is crucial. This method is compatible with a wide range of amide substrates, including lactams, which lead to spiro-bicyclic products. The [3 + 2] product is also shown to undergo a reductive desymmetrization process to access chiral cyclopentane bearing multiple stereocenters with excellent enantioselectivity.

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Name: 2-Amino-6-methylpyrimidine-4-thiol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides. Author is Felczak, Krzysztof; Bretner, Maria; Kulikowski, Tadeusz; Shugar, David.

Convenient and high-yield regioselective thiation procedures based on the use of the Lawesson reagent in different solvents, are described for conversion of the 2- and 4-keto, and 2,4-diketo pyrimidines to the corresponding 2(4)-thio, and 2,4-dithio, derivatives This method is applicable to thiation of the 4-keto groups of 5,6-dihydropyrimidinones and pyrimidine nucleosides. The mild reaction conditions employed are such that it is the method of choice for compounds with labile glycosidic bonds, of choice for compounds with labile glycosidic bonds, such as 5,6-dihydropyrimidine nucleosides and the 2′,3′-dideoxynucleosides currently of interest as antiretroviral, including anti-HIV, agents.

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Reference:
Isothiazole – Wikipedia,
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Lee, Chang-Seok; Oh, Seong Ho; Ryu, Eun-Jung; Kim, Mu-Yong; Paek, Kyung-Sook published the article 《Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins》. Keywords: cephalosporin aminopyrimidinylthio antibacterial antimicrobial preparation; beta lactam aminopyrimidinylthio preparation.They researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).COA of Formula: C5H7N3S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6307-44-4) here.

A new class of cephalosporins with C(3)-aminopyrimidinylthio substituents was prepared and found to exhibit well balanced activities against Gram-neg. and Gram-pos. bacteria. The MIC data on some of these new β-lactams, e.g., I and II, prove that this type of cephalosporin deserves further evaluation as new antibiotics against respiratory tract pathogens.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

HPLC of Formula: 6307-44-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins. Author is Lee, Chang-Seok; Oh, Seong Ho; Ryu, Eun-Jung; Kim, Mu-Yong; Paek, Kyung-Sook.

A new class of cephalosporins with C(3)-aminopyrimidinylthio substituents was prepared and found to exhibit well balanced activities against Gram-neg. and Gram-pos. bacteria. The MIC data on some of these new β-lactams, e.g., I and II, prove that this type of cephalosporin deserves further evaluation as new antibiotics against respiratory tract pathogens.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 6307-44-4, is researched, Molecular C5H7N3S, about The chemistry of pyrimidinethiols. II. The preparation and reactions of some 2-arenecarbonylmethylthiopyrimidines, the main research direction is pyrimidinone phenacylthio; phenacylthiopyrimidinone.Recommanded Product: 6307-44-4.

2-Pyrimidinethiones were treated with phenacyl halides to give (phenacylthio)pyrimidines I (R1= Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenyl, Cl2C6H3, naphthyl; R2 = Me, H, Ph, Pr, NH2). Some I were heated in Ph2O to give phenacylidenepyrimidinones II (R3 = Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenylyl, naphthyl; R4 = Me, H, Pr).

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com