Tag: M.W=150-200

In 2019.0 J AM CHEM SOC published article about H REDUCTIVE ELIMINATION; C-H; OXIDATION LEVEL; ARYL BROMIDES; CARBONYL ALLYLATION; AROMATIC-ALDEHYDES; O-H; ENANTIOSELECTIVE ADDITION; DIRECT ACYLATION; ORGANIC HALIDES in [Swyka, Robert A.; Zhang, Wandi; Krische, Michael J.] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA; [Richardson, Jeffery] Eli Lilly & Co Ltd, Discovery Chem Res & Technol, Windlesham GU20 6PH, Surrey, England; [Ruble, J. Craig] Eli Lilly & Co, Discovery Chem Res & Technol, Indianapolis, IN 46285 USA in 2019.0, Cited 82.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Product Details of 93-02-7

The first intermolecular carbonyl arylations via transfer hydrogenative reductive coupling are described. Using rhodium catalysts modified by (Bu2PMe)-Bu-t, sodium formate-mediated reductive coupling of aryl iodides with aldehydes occurs in a chemoselective fashion in the presence of protic functional groups and lower halides. This work expands the emerging paradigm of transfer hydrogenative coupling as an alternative to preformed carbanions or metallic reductants in C=X addition.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Swyka, RA; Zhang, WD; Richardson, J; Ruble, JC; Krische, MJ or concate me.

Reference:
Isothiazole – Wikipedia,
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In 2019.0 J ENZYM INHIB MED CH published article about ALZHEIMERS-DISEASE; BUTYRYLCHOLINESTERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASE-1; POTENT; ACETYLCHOLINESTERASE; DERIVATIVES; DISCOVERY; THERAPY; CANCER; CHALCONE in [Gao, Cheng-Zhi; Dong, Wei; Cui, Zhi-Wen; Yuan, Qiong; Wu, Qing-Ming; Min, Zhen-Li] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430081, Hubei, Peoples R China; [Hu, Xia-Min] Shanghai Univ Med & Hlth Sci, Coll Pharm, Shanghai, Peoples R China; [Han, Xianlin; Min, Zhen-Li] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA; [Xu, Yao] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan, Hubei, Peoples R China in 2019.0, Cited 37.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. HPLC of Formula: C9H10O3

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 +/- 1.25 nM) and MDA-MB-436 cancer cell (11.62 +/- 2.15 mu M), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 +/- 0.91 mu M) which was stronger than neostigmine (12.01 +/- 0.45 mu M) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.

HPLC of Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Gao, CZ; Dong, W; Cui, ZW; Yuan, Q; Hu, XM; Wu, QM; Han, XL; Xu, Y; Min, ZL or send Email.

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Isothiazole – Wikipedia,
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Safety of 2,5-Dimethoxybenzaldehyde. Authors Chauhan, D; George, G; Sridhar, SNC; Bhatia, R; Paul, AT; Monga, V in WILEY-V C H VERLAG GMBH published article about in [Chauhan, Divya; Bhatia, Rohit; Monga, Vikramdeep] ISF Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India; [George, Ginson; Sridhar, S. N. C.; Paul, Atish T.] Birla Inst Technol & Sci, Dept Pharm, Lab Nat Prod Chem, Pilani Campus, Pilani 333031, Rajasthan, India in 2019.0, Cited 27.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of rhodanine-3-acetic acid derivatives were synthesized via Knoevenagel condensation of rhodanine-3-acetic acid with various substituted aromatic aldehydes. The synthesized derivatives were screened in vitro for understanding the inhibitory potential towards pancreatic lipase (PL), a key enzyme responsible for the digestion of dietary fats. Derivative 8f exhibited a potential inhibitory activity towards PL (IC50 =( )5.16 mu M), comparable to that of the standard drug, orlistat (0.99 mu M). An increase in the density of the aromatic ring resulted in potential PL inhibition. The enzyme kinetics of 8f exhibited a reversible competitive-type inhibition, similar to that of orlistat. Derivative 8f exhibited a MolDock score of -125.19 kcal/mol in docking studies, and the results were in accordance with their PL inhibitory potential. Furthermore, the reactive carbonyl group of 8f existed at a distance adjacent to Ser152 (approximate to 3 angstrom) similar to that of orlistat. Molecular dynamics simulation (10 ns) of the 8f-PL complex revealed a stable binding conformation of 8f in the active site of PL (maximum root mean square displacement of approximate to 2.25 angstrom). The present study identified novel rhodanine-3-acetic acid derivatives with promising PL inhibitory potential, and further lead optimization might result in potent PL inhibitors.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Chauhan, D; George, G; Sridhar, SNC; Bhatia, R; Paul, AT; Monga, V or concate me.

Reference:
Isothiazole – Wikipedia,
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Authors Huang, C; Zhu, KF; Zhang, YY; Lu, GZ; Shao, ZC; Gao, K; Mi, LW; Hou, HW in ROYAL SOC CHEMISTRY published article about METAL-ORGANIC FRAMEWORKS; HETEROGENEOUS CATALYSTS; SOLID CATALYSTS; NEF REACTION; SITE; POLYMERS; FABRICATION; LAYERS; HYDROGENATION; NANOPARTICLES in [Huang, Chao; Zhu, Kaifang; Zhang, Yingying; Lu, Guizhen; Mi, Liwei] Zhongyuan Univ Technol, Ctr Adv Mat Res, Zhengzhou 450007, Henan, Peoples R China; [Shao, Zhichao; Gao, Kuan; Hou, Hongwei] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 62. Product Details of 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Precise control over the morphology and size of coordination polymers (CPs) is crucial for extending these inorganic-organic materials to many advanced applications, in particular for heterogeneous catalysis. In this work, two Zn-based CPs, {[Zn-3(idbt)(2)(4,4 ‘-dmbpy)(2)]center dot H2O}(n) (1) and {[Zn-3(idbt)(2)(H2O)(3)]center dot H2O}(n) (2) (H(3)idbt = 5,5 ‘-(1H-imidazole-4,5-diyl)-bis-(2H-tetrazole), 4,4 ‘-dmbpy = 4,4 ”-dimethyl-2,2 ‘-bipyridine), were synthesized through solvothermal reactions. The morphologies and particle sizes of 1 and 2 could be controlled from large scale to nanoscale by regulating the amount of poly(vinyl alcohol) (PVA). Furthermore, for the conversion reactions of nitromethylbenzenes into benzoic acids, the catalytic properties of nanoscale 1 and 2 were much more efficient than those of large size of 1 and 2, because of the benefit of readily accessible active sites in the nanoscale sized particles, which provide a tunable and functionalizable platform for the conversion reaction by minimizing the diffusion distance but do little for the selectivity.

Product Details of 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Huang, C; Zhu, KF; Zhang, YY; Lu, GZ; Shao, ZC; Gao, K; Mi, LW; Hou, HW or concate me.

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Isothiazole – Wikipedia,
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Authors Liu, J; Wang, SM; Qin, HL in PERGAMON-ELSEVIER SCIENCE LTD published article about CATIONIC-AMPHIPHILIC POLYMERS; PRIMARY ALCOHOLS; MEDICINAL CHEMISTS; DRUG DISCOVERY; BOND FORMATION; PEPTIDE; PHENOLS; REAGENTS; TRANSFORMATION; CONVERSION in [Liu, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Peoples R China; [Wang, Shi-Meng] Wuchang Univ Technol, Sch Life Sci, Wuhan 430223, Peoples R China in 2020, Cited 86. HPLC of Formula: C7H4F2O2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

A method for the synthesis of difficult-to-access amides was developed through the coupling of sterically hindered carboxylic acids and electron deficient amines via SO2F2-mediated dehydration. The method feathers with broad substrate scope, mild conditions, excellent functional group compatibility and high yields. (C) 2020 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Liu, J; Wang, SM; Qin, HL or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 93-02-7. Authors Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP in MDPI published article about in [Ximenis, Marta; Gonzalez-Muniz, Rosario; Perez de Vega, Maria Jesus] CSIC, IQM, Inst Quim Med, Juan Cierva 3, Madrid 28006, Spain; [Mulet, Jose; Sala, Salvador; Sala, Francisco; Criado, Manuel] Univ Miguel Hernandez, CSIC, Inst Neurociencias, Sant Joan dAlacant 03050, Spain in 2021.0, Cited 65.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

The alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain, and inflammation. Allosteric modulation of this receptor might be advantageous to reduce the toxicity in comparison with full agonists. Our previous results obtained with some hydroxy-chalcones, which were identified as positive allosteric modulators (PAMs) of alpha 7 nAChR, prompted us to evaluate the potential of some structurally related naturally occurring flavonoids and curcuminoids and some synthetic curcumin analogues, with the aim of identifying new allosteric modulators of the alpha 7 nAChR. Biological evaluation showed that phloretin, demethoxycurcumin, and bis-demethoxicurcuming behave as PAMs of alpha 7 nAChR. In addition, some new curcumin derivatives were able to enhance the signal evoked by ACh; the activity values found for the tetrahydrocurcuminoid analog 23 were especially promising.

Product Details of 93-02-7. Welcome to talk about 93-02-7, If you have any questions, you can contact Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP or send Email.

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Isothiazole – Wikipedia,
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Recently I am researching about CHALCONE DERIVATIVES; BIOLOGICAL-ACTIVITIES; MOLECULAR-PROPERTIES; LICOCHALCONE; PREDICTION; DISCOVERY; GROWTH; SERIES; AGENTS, Saw an article supported by the Coordination for the Improvement of Higher Education Personnel (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; National Council for Scientific and Technological Development (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [471129/2013-5, 309957/2019-2, 306251/2016-7, 429322/2018-6]; State of Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/18330-0, 2018/15083-2]; Fundacao de Apoio a Pesquisa e Extensa de Sao Jose do Rio Preto (FAPERP); Multiuser Centre for Biomolecular Innovation (FAPESP) [2009/53989-4]; National Institute of Science and Technology – INCT BioNat Biodiversity and Natural Products [CNPq 465637/2014-0, FAPESP 2014/50926-0]; FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/18577-5, 2016/08084-7, 2017/09245-7]. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Marques, BC; Santos, MB; Anselmo, DB; Monteiro, DA; Gomes, E; Saiki, MFC; Rahal, P; Rosalen, PL; Sardi, JCO; Regasini, LO. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. HPLC of Formula: C9H10O3

Background: Chalcones substituted by methoxyl groups have presented a broad spectrum of bioactivities, including antifungal, antibacterial and antiproliferative effects. However, a clear and unambiguous investigation about the relevance of this substituent on the chalcone framework has not been described. Objective: The purpose of this work is to assess the antibacterial, antifungal and antiproliferative activities of the two series of seventeen synthesized regioisomeric methoxychalcones. Series I and II were constituted by cbalcones substituted by methoxyl groups on rings A (5-12) and B (13-21), respectively. In addition, the library of methoxychalcones was submitted to in silico drug-likeness and pharmacokinetics properties predictions. Methods: Methoxychalcones were synthesized and their structures were confirmed by NMR spectral data analyses. Evaluations of antimicrobial activity were performed against five species of Candida, two Gram-negative and five Gram-positive species. For antiproliferative activity, methoxychalcones were evaluated against four human tumorigenic cell lines, as well as human non-tumorigenic keratinocytes. Drug-likeness and pharmacokinetics properties were predicted using Molinspiration and PreADMET toolkits. Results: In general, chalcones of series I are the most potent antifungal, antibacterial and antiproliferative agents. 3′, 4′, 5′-Trimethoxychalcone (12) demonstrated potent antifungal activity against Candida krusei (MIC = 3.9 mu g/mL), eight times more potent than fluconazole (reference antifungal drug). 3′-Methoxychalcone (6) displayed anti-Pseudomonas activity (MIC = 7.8 mu g/mL). 2′,5′-Dimethoxychalcone (9) displayed potent antiproliferative effect against C-33A (cervix), A-431 (skin) and MCF-7 (breast), with IC50 values ranging from 7.7 to 9.2 mu M. Its potency was superior to curcumin (reference antiproliferative compound), which exhibited IC50 values ranging from 10.4 to 19.0 mu M. Conclusion: Our studies corroborated the relevance of methoxychalcones as antifungal, antibacterial and antiproliferative agents. In addition, we elucidated influence of the position and number of methoxyl groups toward bioactivity. In silico predictions indicated good drug-likeness and pharmacokinetics properties to the library of methoxychalcones.

Welcome to talk about 93-02-7, If you have any questions, you can contact Marques, BC; Santos, MB; Anselmo, DB; Monteiro, DA; Gomes, E; Saiki, MFC; Rahal, P; Rosalen, PL; Sardi, JCO; Regasini, LO or send Email.. HPLC of Formula: C9H10O3

Reference:
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Authors Dyachenko, IV; Dyachenko, VD; Dorovatovskii, PV; Khrustalev, VN; Nenajdenko, VG in SPRINGER published article about in [Dyachenko, Ivan, V; Dyachenko, Vladimir D.] Luhansk T Shevchenko Natl Univ, 2 Oboronnaya St, UA-91011 Lugansk, Ukraine; [Dorovatovskii, Pavel, V; Khrustalev, Victor N.] Kurchatov Inst, Natl Res Ctr, 1 Akad Kurchatova Sq, Moscow 123182, Russia; [Khrustalev, Victor N.] RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia; [Nenajdenko, Valentine G.] Moscow MV Lomonosov State Univ, 1 Build 3 Leninskie Gory, Moscow 119991, Russia in 2019.0, Cited 24.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

The multicomponent reaction of aromatic and heteroaromatic aldehydes, malonodithioamide, 1-(cyclohex-1-en-1-yl)piperidine, and alkylating reagents was studied. A wide range of new 2-(alkylsulfanyl)-4-aryl(hetaryl)-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized, and their molecular and crystalline structures were studied by X-ray structural analysis.

Welcome to talk about 93-02-7, If you have any questions, you can contact Dyachenko, IV; Dyachenko, VD; Dorovatovskii, PV; Khrustalev, VN; Nenajdenko, VG or send Email.. Safety of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C in [Mahesha, Ninganayaka; Sagar, Belakavadi K.; Yathirajan, Hemmige S.] Univ Mysore, Dept Studies Chem, Mysuru 570006, India; [Furuya, Tetsundo; Haraguchi, Tomoyuki; Akitsu, Takashiro] Tokyo Univ Sci, Fac Sci, Dept Chem, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; [Glidewell, Christopher] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland published Three closely related 1-[(1,3-benzodioxol-5-yl)-methyl]-4-(halobenzoyl)pinerazines: similar molecular structures but different intermolecular interactions in 2019, Cited 27. SDS of cas: 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19 FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl)piperazine, C19H19Cl2N2O3 (III), the piperazine rings adopt a chair conformation with the (1,3-benzodioxol-5-yl)methyl substituent occupying an equatorial site: the five-membered rings are all slightly folded across the O center dot center dot center dot O line leading to envelope conformations. The dihedral angle between the planar amidic fragment and the haloaryl ring is 62.97 (5)degrees in (I) but 77.72 (12)degrees and 75.50 (5)degrees in (II) and (III), respectively. Despite their similarity in constitution and conformation, the supramolecular interactions in (I)-(III) differ: in (I), a combination of C-H center dot center dot center dot O and C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into a three-dimensional framework structure, but there are no hydrogen bonds of any sort in either (II) or (III), although the structure of (III) contains a short Cl center dot center dot center dot Cl contact between inversion-related pairs of molecules.

SDS of cas: 385-00-2. Welcome to talk about 385-00-2, If you have any questions, you can contact Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C or send Email.

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COA of Formula: C7H4F2O2. Authors Chernoburova, EI; Shchetinina, MA; Dzhafarov, MK; Krylov, VB; Zavarzin, IV in SPRINGER published article about in [Chernoburova, E., I; Shchetinina, M. A.; Dzhafarov, M. Kh; Krylov, V. B.; Zavarzin, I., V] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia in 2019, Cited 20. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4 ”-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.

COA of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Chernoburova, EI; Shchetinina, MA; Dzhafarov, MK; Krylov, VB; Zavarzin, IV or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com