Tag: M.W=150-200

Safety of 2,5-Dimethoxybenzaldehyde. Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V in [Shalini; Pankaj; Kumar, Vipan] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India; [Saha, Sourav Taru; Kaur, Mandeep] Univ Witwatersrand, Sch Mol & Cell Biol, Private Bag 3, ZA-2050 Johannesburg, South Africa; [Oluwakemi, Ebenezer; Awolade, Paul; Singh, Parvesh] Univ Kwazulu Natal, Sch Chem & Phys, P Bag X54001, ZA-4000 Durban, South Africa published Synthesis and in vitro anti-proliferative evaluation of naphthalimide-chalcone/pyrazoline conjugates as potential SERMs with computational validation in 2020.0, Cited 39.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced based on the influence of linker length, substituents on the phenyl ring and the generated functionalities, on anti-proliferative activities. Docking simulations further delineate the type of interactions of the designed molecules with the selected targets. This report discloses the scope of triazole tethered naphthalimide-chalcone/pyrazoline conjugates as anti breast cancer agents.

Safety of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V or send Email.

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Recently I am researching about ALLYLIC AMINES; ARYL IODIDES; POLYMERIZATION; POLYMERS; COMPLEX; ETHYLENE; CYCLOPOLYMERIZATION; COPOLYMERIZATION; POLYETHYLENES; ALKYLENE)S, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP15H03814]. Published in WILEY in HOBOKEN ,Authors: Tan, LY; Takeuchi, D; Osakada, K. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Recommanded Product: 93-02-7

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

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Isothiazole – Wikipedia,
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An article 2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation WOS:000480235700064 published article about P53; ANTAGONISTS; ACTIVATION; DISCOVERY; GROWTH; CANCER in [Bazanov, Daniil R.; Savitskaya, Victoria Yu; Proskurnina, Marina, V; Lozinskaya, Natalia A.] Moscow MV Lomonosov State Univ, Dept Chem, 1 Leninskie Gory, Moscow 119992, Russia; [Pervushin, Nikolay, V; Kopeina, Gelina S.] Moscow MV Lomonosov State Univ, Dept Med, 1 Leninskie Gory, Moscow 119992, Russia; [Anikina, Lada, V; Proskurnina, Marina, V; Lozinskaya, Natalia A.] RAS, Inst Physiol Act Subst, 1 Northern Passage, Chernogolovka 142432, Moscow Region, Russia in 2019.0, Cited 26.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

Imidazoline-based small molecule inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents in cis-imidazoline core for biological activity of nutlin family compounds. Although the necessity of the substituents in the phenyl rings of cis-imidazoline has been shown, there are no studies in which the replacements of a halogen by other substituents have been investigated. A series of simple cis-imidazoline derivatives containing halogen, hydroxy and alkoxy-substituents were synthesized. The biological activity of the compounds was studied using assays of cytotoxicity (MTT) and p53 level. It was found that the hydroxyl-derivatives were not cytotoxic whereas the alkoxy analogues were the same or more active as halogen-substituted compounds in cell viability test. The synthesized alkoxy derivatives induced an increase of p53 level and did not promote necrotic cell death in the concentration up to 40 mu M.

Computed Properties of C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Bazanov, DR; Pervushin, NV; Savitskaya, VY; Anikina, LV; Proskurnina, MV; Lozinskaya, NA; Kopeina, GS or send Email.

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Authors Lin, TT; Li, JC; Liu, LP; Li, YQ; Jiang, HL; Chen, KX; Xu, P; Luo, C; Zhou, B in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China; [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Xu, Pan; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Chem Biol,Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Zhou, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng; Zhou, Bing] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China in 2021, Cited 39. Name: 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Cyclin-dependent kinases play significant roles in cell cycle progression and are promising targets for cancer therapy. However, most potent CDK inhibitors lack the balance between efficacy and safety because of poor selectivity. Given the roles of CDK2 in tumorigenesis, selective CDK2 inhibition may provide therapeutic benefits against certain cancer. In this study, a series of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives were designed, synthesized, and evaluated. The most selective compound DC-K2in212 in this series exhibited high potency towards CDK2 and had effective anti-proliferative activity against A2058 melanoma cell line and MV4-11 leukemia cell line while exhibiting low toxic effect on human normal cell lines MRC5 and LX2. The molecular modeling illustrated that compound DC-K2in212 had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1. Further biological studies revealed that compound DC-K2in212 suppressed CDK2-associated downstream signaling pathway, blocked cell cycle progression, and induced cellular apoptosis. Therefore, compound DC-K2in212 could serve as a potential CDK2 inhibitor for further development. (c) 2021 Elsevier Masson SAS. All rights reserved.

Name: 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Lin, TT; Li, JC; Liu, LP; Li, YQ; Jiang, HL; Chen, KX; Xu, P; Luo, C; Zhou, B or send Email.

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Isothiazole – Wikipedia,
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An article Ultrasound assisted, synthesis of N-(7-(R)-2-oxa-8-azabicyclo[4.2.0]octan-8-yl)isonicotinamide derivatives and their biological evaluation WOS:000506521500001 published article about ANTIMICROBIAL ACTIVITY; BETA-LACTAMS; ANTIBACTERIAL; DESIGN in [Chavan, Pravin; Salve, Amol] DoshiVakil Coll, Dept Chem, Goregaon Raigad, India; [Jadhav, Shivaji] Tarai Coll, Dept Chem, Aurangabad, Maharashtra, India; [Pansare, Dattatraya] Deogiri Coll, Dept Chem, Aurangabad, Maharashtra, India; [Rai, Megha] Dr Rafiq Zakaria Coll Woman, Dept Chem, Aurangabad, Maharashtra, India in 2020.0, Cited 30.0. Name: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

In this study, new series of azetidine derivatives were synthesized (4a-n) from isoniazide (1), Aromatic aldehydes (2a-n), dihydropyran (3) using SnCl2 catalyst, via one pot multicomponent reaction/cycloaddition reaction. The synthesized azetidine derivatives were characterized by IR, H-1 NMR and C-13 NMR and have been screened for antimicrobial, antituberculosis and anti-inflammatory activities. In relation to Staphylococcus aureus (ATCC 25923) promising antibacterial activity was shown, compounds 4e and 4k, followed by compounds 4h, 4n, 4f, 4g and 4l. The synthesized azetidine derivatives, 4a, 4e, 4j and 4m (with zone 12 mm) displayed antituberculosis activity. But its lower potential than, the standard streptomycin (with zone 18 mm). Further 4d compound alone displayed similar activity.

Name: 2,5-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

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Isothiazole – Wikipedia,
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I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Mechanochemical Synthesis of Amides with Uronium-Based Coupling Reagents: A Method for Hexa-amidation of Biotin[6]uril published in 2020. Formula: C7H4F2O2, Reprint Addresses Kananovich, DG; Aav, R (corresponding author), Tallinn Univ Technol, Sch Sci, Dept Chem & Biotechnol, EE-12618 Tallinn, Estonia.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

Solvent-free, atom-efficient, and mechanochemically activated reactions have emerged as synthetic strategy for sustainable chemistry. Herein we report a new mechanochemical approach for the amide coupling of carboxylic acids and amines, mediated by combination of (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)-dimethylaminomorpholinocarbenium hexafluorophosphate (COMU) or N,N,N’,N’-tetramethylchloroformamidinium hexa-fluorophosphate (TCFH) and K2HPO4. The method delivers a range of amides in high yields (70-96%) and fast reaction rates. The reaction protocol is mild, keeps stereochemical integrity of the adjacent to carbonyl stereocenters, and streamlines isolation procedure for solid amide products. Minimal waste is generated due to the absence of bulk solvent. We show that K2HPO4 plays a dual role, acting as a base and a precursor of reactive acyl phosphate species. Amide bonds from hindered carboxylic acids and low-nucleophilic amines can be assembled within 90 minutes by using TCFH in combination with K2HPO4 or N-methylimidazole. The developed mechanochemical liquid-assisted amidation protocols were successfully applied to the challenging couplings of all six carboxylate functions of biotin[6]uril macrocycle with phenylalanine methyl ester, resulting in 80% yield of highly pure hexa-amide-biotin[6]uril. In addition, fast and high-yielding synthesis of peptides and versatile amide compounds can be performed in a safe and environmentally benign manner, as verified by green metrics.

Welcome to talk about 385-00-2, If you have any questions, you can contact Dalidovich, T; Mishra, KA; Shalima, T; Kudrjasova, M; Kananovich, DG; Aav, R or send Email.. Formula: C7H4F2O2

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Isothiazole – Wikipedia,
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In 2020.0 BIOORG MED CHEM LETT published article about QUINAZOLINE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; ANTITUMOR; REARRANGEMENT; ANALOGS; SERIES; AGENTS in [Rasapalli, Sivappa; Murphy, Zachary F.; Sammeta, Vamshikrishna Reddy; Golen, James A.] Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA; [Weig, Alexander W.; Melander, Roberta J.; Melander, Christian] Univ Notre Dame, Dept Chem & Biochem, 252A McCourtney Hall, Notre Dame, IN 46556 USA; [Macha, Prathyushakrishna; Vasudev, Milana C.] Univ Massachusetts Dartmouth, Dept Biomed Engn, 285 Old Westport Rd, N Dartmouth, MA 02747 USA in 2020.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. SDS of cas: 93-02-7

Synthesis of novel 4(3H)-quinazolinonyl aminopyrimidine derivatives has been achieved via quinazolinonyl enones which in turn were obtained from 2-acyl-4(3H)-quinazolinone. They have been assayed for biofilm inhibition against Gram-positive (methicillin-resistant Staphylococcus aureus (MRSA)) and Gram-negative bacteria (Acinetobacter baumannii). The analogues with 2,4,6-trimethoxy phenyl, 4-methylthio phenyl, and 3-bromo phenyl substituents (5h, 5j & 5k) have been shown to inhibit biofilm formation efficiently in MRSA with IC50 values of 20.7-22.4 mu M). The analogues 5h and 5j have demonstrated low toxicity in human cells in vitro and can be investigated further as leads.

SDS of cas: 93-02-7. Welcome to talk about 93-02-7, If you have any questions, you can contact Rasapalli, S; Murphy, ZF; Sammeta, VR; Golen, JA; Weig, AW; Melander, RJ; Melander, C; Macha, P; Vasudev, MC or send Email.

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Isothiazole – Wikipedia,
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An article Surfactant-assisted assembly of nanoscale zinc coordination compounds to enhance tandem conversion reactions in water WOS:000493493400026 published article about METAL-ORGANIC FRAMEWORKS; HETEROGENEOUS CATALYSTS; SOLID CATALYSTS; NEF REACTION; SITE; POLYMERS; FABRICATION; LAYERS; HYDROGENATION; NANOPARTICLES in [Huang, Chao; Zhu, Kaifang; Zhang, Yingying; Lu, Guizhen; Mi, Liwei] Zhongyuan Univ Technol, Ctr Adv Mat Res, Zhengzhou 450007, Henan, Peoples R China; [Shao, Zhichao; Gao, Kuan; Hou, Hongwei] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 62. Application In Synthesis of 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Precise control over the morphology and size of coordination polymers (CPs) is crucial for extending these inorganic-organic materials to many advanced applications, in particular for heterogeneous catalysis. In this work, two Zn-based CPs, {[Zn-3(idbt)(2)(4,4 ‘-dmbpy)(2)]center dot H2O}(n) (1) and {[Zn-3(idbt)(2)(H2O)(3)]center dot H2O}(n) (2) (H(3)idbt = 5,5 ‘-(1H-imidazole-4,5-diyl)-bis-(2H-tetrazole), 4,4 ‘-dmbpy = 4,4 ”-dimethyl-2,2 ‘-bipyridine), were synthesized through solvothermal reactions. The morphologies and particle sizes of 1 and 2 could be controlled from large scale to nanoscale by regulating the amount of poly(vinyl alcohol) (PVA). Furthermore, for the conversion reactions of nitromethylbenzenes into benzoic acids, the catalytic properties of nanoscale 1 and 2 were much more efficient than those of large size of 1 and 2, because of the benefit of readily accessible active sites in the nanoscale sized particles, which provide a tunable and functionalizable platform for the conversion reaction by minimizing the diffusion distance but do little for the selectivity.

Application In Synthesis of 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Huang, C; Zhu, KF; Zhang, YY; Lu, GZ; Shao, ZC; Gao, K; Mi, LW; Hou, HW or send Email.

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SDS of cas: 385-00-2. I found the field of Chemistry very interesting. Saw the article Synthesis of novel 8-nitro-substituted 1,3-benzothiazin-4-ones published in 2020, Reprint Addresses Nosova, EV (corresponding author), Ural Fed Univ, Inst Chem Engn, Ekaterinburg 620002, Russia.; Nosova, EV (corresponding author), Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620990, Russia.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

New 2,5-bis(azacyclohex-1-yl)-8-nitro-1,3-benzothiazin-4-ones were synthesized from 2,6-difluorobenzoic acid in two preparative stages. The ethoxycarbonylpiperazino derivative surpasses in tuberculostatic activity (MIC 4 mu g ml(-1)) its 5-fluoro-8-H-counterpart. The first representative of 5-fluoro-8-nitro-1,3-benzothiazin-4-ones was obtained through the condensation of 2,6-difluoro-3-nitrobenzoyl isothiocyanate and N-methylindole.

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Isothiazole – Wikipedia,
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Name: 2,5-Dimethoxybenzaldehyde. Recently I am researching about DRUG-RESISTANT TUBERCULOSIS; TRANS-CINNAMIC ACID; PARALLEL SYNTHESIS; DERIVATIVES; INHIBITORS; DOCKING, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Upare, AA; Gadekar, PK; Sivaramakrishnan, H; Naik, N; Khedkar, VM; Sarkar, D; Choudhari, A; Roopan, SM. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with oxadiazole. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound 32 displayed potent anti-tubercular activity (IC50= 0.045 mu g/mL). Molecular docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the experimental findings providing a platform for structure based hit-to-lead development.

Welcome to talk about 93-02-7, If you have any questions, you can contact Upare, AA; Gadekar, PK; Sivaramakrishnan, H; Naik, N; Khedkar, VM; Sarkar, D; Choudhari, A; Roopan, SM or send Email.. Name: 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com