Tag: M.W=150-200

Safety of 2,5-Dimethoxybenzaldehyde. Authors Krishnaraj, C; Jena, HS; Bourda, L; Laemont, A; Pachfule, P; Roeser, J; Chandran, CV; Borgmans, S; Rogge, SMJ; Leus, K; Stevens, CV; Martens, JA; Van Speybroeck, V; Breynaert, E; Thomas, A; Van der Voort, P in AMER CHEMICAL SOC published article about in [Krishnaraj, Chidharth; Jena, Himanshu Sekhar; Bourda, Laurens; Laemont, Andreas; Leus, Karen; Van der Voort, Pascal] Univ Ghent, COMOC Ctr Ordered Mat Organometall & Catalysis, Dept Chem, B-9000 Ghent, Belgium; [Krishnaraj, Chidharth; Pachfule, Pradip; Roeser, Jerome; Thomas, Arne] Tech Univ Berlin, Dept Chem Funct Mat, D-10623 Berlin, Germany; [Bourda, Laurens] Univ Ghent, Dept Chem, XStruct Bioinorgan Chem, B-9000 Ghent, Belgium; [Chandran, C. Vinod; Martens, Johan A.; Breynaert, Eric] NMRCoRe, B-3001 Leuven, Belgium; [Chandran, C. Vinod; Martens, Johan A.; Breynaert, Eric] Katholieke Univ Leuven, Dept Microbial & Mol Syst M2S, Ctr Surface Chem & Catalysis Characterisat & Appl, B-3001 Leuven, Belgium; [Borgmans, Sander; Rogge, Sven M. J.; Van Speybroeck, Veronique] Univ Ghent, Ctr Mol Modeling CMM, B-9052 Zwijnaarde, Belgium; [Stevens, Christian, V] Univ Ghent, Dept Green Chem & Technol, Synth Bioresources & Bioorgan Chem Res Grp SynBio, B-9000 Ghent, Belgium in 2020.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Photocatalytic reduction of molecular oxygen is a promising route toward sustainable production of hydrogen peroxide (H2O2). This challenging process requires photoactive semiconductors enabling solar energy driven generation and separation of electrons and holes with high charge transfer kinetics. Covalent organic frameworks (COFs) are an emerging class of photoactive semiconductors, tunable at a molecular level for high charge carrier generation and transfer. Herein, we report two newly designed two-dimensional COFs based on a (diarylamino)benzene linker that form a Kagome (kgm) lattice and show strong visible light absorption. Their high crystallinity and large surface areas (up to 1165 m(2)center dot g(-1)) allow efficient charge transfer and diffusion. The diarylamine (donor) unit promotes strong reduction properties, enabling these COFs to efficiently reduce oxygen to form H2O2. Overall, the use of a metal-free, recyclable photocatalytic system allows efficient photocatalytic solar transformations.

Safety of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Krishnaraj, C; Jena, HS; Bourda, L; Laemont, A; Pachfule, P; Roeser, J; Chandran, CV; Borgmans, S; Rogge, SMJ; Leus, K; Stevens, CV; Martens, JA; Van Speybroeck, V; Breynaert, E; Thomas, A; Van der Voort, P or send Email.

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Quality Control of 2,6-Difluorobenzoic acid. Currie, I; Sleebs, BE in [Currie, Iain; Sleebs, Brad E.] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia; [Currie, Iain; Sleebs, Brad E.] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia published Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction in 2021, Cited 24. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

Quality Control of 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Currie, I; Sleebs, BE or send Email.

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In 2020 J MED CHEM published article about CYSTEINE PROTEASE; ALDEHYDE INHIBITORS; IN-VITRO; BIOLOGICAL EVALUATION; ANTIVIRAL ACTIVITY; SARS-CORONAVIRUS; FORMAZAN ASSAY; DESIGN; AG7088; PAPAIN in [Hoffman, Robert L.; Kania, Robert S.; Brothers, Mary A.; Davies, Jay F.; Ferre, Rose A.; Gajiwala, Ketan S.; He, Mingying; Kozminski, Kirk; Li, Lilian Y.; Lockner, Jonathan W.; Lou, Jihong; Marra, Michelle T.; Mitchell, Lennert J., Jr.; Murray, Brion W.; Nieman, James A.; Noell, Stephen; Planken, Simon P.; Ryan, Kevin; Smith, George J., III; Solowiej, James E.; Steppan, Claire M.] Pfizer Worldwide Res & Dev, San Diego, CA 92121 USA; [Hogan, Robert J.; Rowe, Thomas; Taggart, Barbara] Southern Res Inst, Birmingham, AL 35205 USA in 2020, Cited 45. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Application In Synthesis of 2,6-Difluorobenzoic acid

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode two overlapping large polyproteins, which are cleaved at specific sites by a 3C-like cysteine protease (3CL(pro)) in a post-translational processing step that is critical for coronavirus replication. The 3CL(pro) sequences for CoV-1 and CoV-2 viruses are 100% identical in the catalytic domain that carries out protein cleavage. A research effort that focused on the discovery of reversible and irreversible ketone-based inhibitors of SARS CoV-1 3CL(pro) employing ligand-protease structures solved by X-ray crystallography led to the identification of 3 and 4. Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CL(pro) with suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.

Application In Synthesis of 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Hoffman, RL; Kania, RS; Brothers, MA; Davies, JF; Ferre, RA; Gajiwala, KS; He, MY; Hogan, RJ; Kozminski, K; Li, LLY; Lockner, JW; Lou, JH; Marra, MT; Mitchell, LJ; Murray, BW; Nieman, JA; Noell, S; Planken, SP; Rowe, T; Ryan, K; Smith, GJ; Solowiej, JE; Steppan, CM; Taggart, B or send Email.

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An article Vanadyl Acetylacetonate-Copper (II) Trifluoro Methane Sulfonate Catalyzed Eco-friendly Synthesis of Substituted Benzimidazoles in Aqueous Media WOS:000567844000013 published article about ONE-POT SYNTHESIS; SOLID-PHASE SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; EFFICIENT METHOD; SOLVENT; WATER; BENZOXAZOLES; DERIVATIVES; ACID; 2-ARYLBENZIMIDAZOLES in [Halder, Samiran] Charuchandra Coll, Dept Chem, 22 Lake Rd, Kolkata 700029, India in 2020.0, Cited 68.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Safety of 2,5-Dimethoxybenzaldehyde

Various substituted benzimidazoles have been successfully synthesized in aqueous medium by developing VO(acac)(2)-Cu(OTf)(2) catalytic system. A green synthetic protocol has been created in presence of water and cetyltrimethyl ammonium bromide (CTAB) system in an organic solvent free condition. This chemoselective cyclocondensation cumoxidation process occurred in aqueous media. In this suitable method easily synthesized 2-Substituted benzimidazoles with good yields and no 1,2-disubstituted by-products were noticed. Excellent yields, environmentally benign and mild reaction condition, easy purification of the desired products are the main attractive features of this newly devised method. [GRAPHICS]

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In 2019 CHEMOSPHERE published article about COLLOID TRANSPORT; SILVER NANOPARTICLES; ANAEROBIC BIOREMEDIATION; MINERALIZATION PATHWAYS; FLOW CONDITIONS; ORGANIC-MATTER; POROUS-MEDIA; HEAVY-METALS; MOBILIZATION; TRANSFORMATION in [Liang, Xiaolong; Radosevich, Mark; Loffler, Frank; Schaeffer, Sean M.; Zhuang, Jie] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA; [Loffler, Frank] Univ Tennessee, Dept Microbiol, Dept Civil & Environm Engn, Ctr Environm Biotechnol, Knoxville, TN 37996 USA; [Loffler, Frank] Oak Ridge Natl Lab, Biosci Div, Oak Ridge, TN 37831 USA in 2019, Cited 60. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Formula: C7H4F2O2

In subsurface bioremediation, electron donor addition promotes microbial Fe(lII)-oxide mineral reduction that could change soil pore structure, release colloids, and alter soil surface properties. These processes in turn may impact bioremediation rates and the ultimate fate of contaminants. Columns packed with water-stable, Fe-oxide-rich soil aggregates were infused with acetate-containing artificial groundwater and operated for 20 d or 60 d inside an anoxic chamber. Soluble Fe(II) and soil colloids were detected in the effluent within one week after initiation of the acetate addition, demonstrating Fe(III)-bioreduction and colloid formation. Diffusible Br-, less diffusible 2,6-difluorobenzoate (DFBA), and non-diffusible silica-shelled silver nanoparticles (SSSNP) were used as tracers in transport experiments before and after the bioreduction. The transport of Br- was not influenced by the bioreduction. DFBA showed earlier breakthrough and less tailing after the bioreduction, suggesting alterations in flow paths and soil surface chemistry during the 20-d bioreduction treatment. Similarly, the bioreduction increased the transport of SSSNP very significantly, with mass recovery increasing from 1.7% to 25.1%. Unexpectedly, the SSSNP was completely retained in the columns when the acetate injection was extended from 20 to 60 d, while the mass recovery of DFBA decreased from 89.1% to 84.1% and Br showed no change. The large change in the transport of SSSNP was attributed to soil aggregate breakdown and colloid release (causing mechanical straining of SSSNP) and the exposure of iron oxide surfaces previously unavailable within aggregate interiors (facilitating attachment of SSSNP). These results suggest a time dependent fashion of microbial effect on the transport of diffusivity-varying tracers. (C) 2018 Elsevier Ltd. All rights reserved.

Welcome to talk about 385-00-2, If you have any questions, you can contact Liang, XL; Radosevich, M; Loffler, F; Schaeffer, SM; Zhuang, J or send Email.. Formula: C7H4F2O2

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In 2021 J BIOMOL STRUCT DYN published article about BIOLOGICAL EVALUATION; IN-VITRO; DESIGN; 1,2,3-TRIAZOLES; INSIGHTS; ANALOGS; HYBRIDS; VIVO in [Khan, Bushra; Naiyer, Abdullah; Athar, Fareeda; Thakur, Sonu Chand] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi, India; [Ali, Shakir] Jamia Hamdard, Sch Chem & Life Sci, Dept Biochem, New Delhi, India; [Ali, Shakir] Jamia Hamdard, BIF, DBT BTISNet Bioinformat Infrastruct Facil, New Delhi, India in 2021, Cited 42. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Quality Control of 2,5-Dimethoxybenzaldehyde

Substituted 1,2,4-triazole nucleus is common in several drugs used in a variety of clinical conditions including infections, hypoglycemia, hypertension and cancer. In this study, we synthesized 1,2,4-triazole and its 16 hydrazone derivatives (B1-B16), characterized them by IR, NMR and Mass spectroscopy, and evaluated their radical scavenging and anti-inflammatory activities in vitro and in vivo. Out of 16 derivatives, five (B1, B5, B6, B9, and B13) demonstrated a significant radical scavenging and anti-inflammatory activity in vitro. B6, which possessed two electron-donating hydroxyl groups, was most active among all. Molecular docking and MD simulation of the complex of B6 with prostaglandin-endoperoxide synthase (PTGS) or cyclooxygenase (COX) showed that B6 occupied celecoxib binding site in COX with high affinity (the binding free energy of the complex with COX-1 was -10.5, and -11.2 kcal/mol with COX-2). Maximum anti-inflammatory activity was also shown by the B6 derivative in vivo, in the rat model of carrageenan-induced inflammation. B6, along with four other derivatives (B1, B5, B9 and B13) exhibited 80-90% free radical scavenging activity. The IC50 values of these compounds were >= 40 mu M. Griess nitrite and dichloro-dihydro-fluorescein-diacetate assays suggested a significant inhibition of nitric oxide and reactive oxygen species, especially by B6 and B9. Taken together, out of 16 derivatives, B6 is reported to have highest anti-inflammatory and antioxidant activity at a low dose level, which may be attributed to its two electron-donating hydroxyls. B6 is proposed to be an important scaffold for the synthesis of new drugs against PTGS for use in a myriad of inflammatory and infectious diseases. Communicated by Ramaswamy H. Sarma

Welcome to talk about 93-02-7, If you have any questions, you can contact Khan, B; Naiyer, A; Athar, F; Ali, S; Thakur, SC or send Email.. Quality Control of 2,5-Dimethoxybenzaldehyde

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Authors Gomes, LR; Low, JN; Turner, AB; Wardell, JL; Pinheiro, AC in ELSEVIER published article about CHALCONE in [Gomes, Ligia R.] Univ Fernando Pessoa, FP ENAS Fac Ciencias Saude, Escola Super Saude UFP, Rua Carlos do Maia 296, P-4200150 Porto, Portugal; [Gomes, Ligia R.] Univ Porto, Dept Quim & Bioquim, REQUIMTE, Fac Ciencias, Rua Campo Alegre 687, P-4169007 Porto, Portugal; [Low, John N.; Turner, Alan B.; Wardell, James L.] Univ Aberdeen, Dept Chem, Meston Walk, Old Aberdeen AB24 3UE, Scotland; [Wardell, James L.; Pinheiro, Alessandra C.] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos & Farmanguinhos, BR-21041250 Rio De Janeiro, RJ, Brazil in 2020.0, Cited 52.0. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A detailed structural analysis has been carried out on four chalcone (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives, having a varying number of methoxy substituents, namely (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one, (1), (E)-3-(4-methoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one, 2, (E)-3-(2,5-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one, 3, and (E)-3-(2,5-dimethoxyphenyl)-1-(2-hydroxy-3,4-dimethoxyphenyl)prop-2-en-1-one, 4. Crystal structures were determined at 100 K by single crystal X-ray diffraction. Compound 2 displayed an unexpectedly large interplanar angle of 25 and 28(,o) between the phenyl groups in the two independent molecules, due to the formation of a dimeric substructure requiring a pronounced phenyl group rotation to minimise steric hindrance. Such a substructure was absent in 1, 3 and 4. In all cases the 2-hydroxyl substituent forms intramolecular hydrogen bonds with its neighbouring carbonyl group. Different combinations of C-H center dot center dot center dot O, C-H center dot center dot center dot pi and/or pi center dot center dot center dot pi interactions are displayed by 1, 3 and 4, with also C=O center dot center dot center dot pi intermolecular interactions present in 2. The relative contributions of various intermolecular contacts in these structures were investigated using Hirshfeld surfave analysis and the associated two dimensional fringerprint plots. Important molecule pairs were identified in the crystal structures using the PIXEL method. The PIXEL lattice energy calculations revealed that in all cases the dispersion contribution was the major contributor to the packing stabilization, followed by the Coulombic contribution. A search of structures of alkoxy derivatives of (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives in the CCDC data base has also been carried out. (C) 2020 Published by Elsevier B.V.

COA of Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Gomes, LR; Low, JN; Turner, AB; Wardell, JL; Pinheiro, AC or send Email.

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COA of Formula: C7H4F2O2. In 2021 EUR J ORG CHEM published article about ANTI-MARKOVNIKOV ADDITION; CARBOXYLIC-ACIDS; ENOL ESTERS; TERMINAL ALKYNES; CATALYZED ADDITION; GOLD(I)-CATALYZED ADDITION; STEREOSPECIFIC SYNTHESIS; RUTHENIUM COMPLEX; INTERNAL ALKYNES; VINYL ESTERS in [Kumari, Chandresh; Goswami, Avijit] Indian Inst Technol Ropar, Dept Chem, Nangal Rd, Rupnagar 140001, Punjab, India in 2021, Cited 96. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

We report an efficient and straight forward access to nitrile substituted enol esters via ionic liquid [BMIM]OH mediated hydrocarboxylation of alkynylnitriles under mild conditions. This atom economical transition metal-free protocol gives an easy access to a variety of such enol esters with excellent regio and Z-stereoselectivity. Reusability of [BMIM]OH without losing of significant amount of yield is another noticeable feature of this article.

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COA of Formula: C7H4F2O2. I found the field of Agriculture; Entomology very interesting. Saw the article Design, synthesis, and insecticidal activities of novel 5-substituted 4,5-dihydropyrazolo[1,5-a]quinazoline derivatives published in 2021, Reprint Addresses Zhao, C; Xu, HH (corresponding author), South China Agr Univ, Minist Educ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Peoples R China.; Zhao, C; Xu, HH (corresponding author), South China Agr Univ, Minist Educ, Key Lab Nat Pesticide & Chem Biol, Guangzhou 510642, Peoples R China.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

BACKGROUND: Chemical pesticides are the main measures for pest control, but have caused growing resistance of pests and brought a series of environmental problems. Development of high-efficient insecticidal molecules with novel scaffolds is therefore particularly urgent. RESULTS: Based on a [5 + 1] annulation reaction with 5-amino-1H-phenylpyrazole and dialkyl bromomalonate, 27 novel five-substituted 4,5-dihydropyrazolo[1,5-a]quinazolines were designed following the intermediate derivatization method and synthesized. Bioassay results indicated that most of the test compounds displayed good insecticidal activities against Plutella xylostella, Spodoptera frugiperda, and Solenopsis invicta. In particular, the insecticidal activities of compounds 4a, 4f, and 4m against P. xylostella [median lethal concentration (LC50) values ranged from 3.87 to 5.10 mg L-1] were comparable to that of indoxacarb (LC50 = 4.82 mg L-1). In addition, compounds 4a and 9e showed similar high insecticidal activities against Spodoptera frugiperda (mortality rate = 79.63% and 72.12%) at 100 mg L-1, comparable to that of fipronil (mortality rate: 68.44%); compound 9a showed possible delayed toxicity against Solenopsis invicta (mortality rate: 95.66%) after 5 days of treatment at 1.0 mg L-1. CONCLUSION: Due to their high insecticidal activities against P. xylostella, compound 4m, 4a, and 4f could be considered as qualified candidates for novel insecticide. Several other 4,5-dihydropyrazolo[1,5-a]quinazolines with relatively high bioactivity, such as compounds 9a and 9e, are also worth further optimization as potential insecticide or anticide candidates.

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Quality Control of 2,5-Dimethoxybenzaldehyde. In 2019 EUR J MED CHEM published article about PHOSPHOLIPID-TRANSFER PROTEIN; DECREASES ATHEROSCLEROSIS; SPHINGOLIPID METABOLISM; APOLIPOPROTEIN-B; RISK-FACTOR; CELLS; PLASMA; MICE; LIPOPROTEINS; INFLAMMATION in [Li, Yali; Huang, Taomin; Lou, Bin; Ye, Deyong; Qi, Xiangyu; Li, Xiaoxia; Hu, Shuang; Ding, Tingbo; Chen, Yan; Cao, Yang; Mo, Mingguang; Dong, Jibin; Wei, Min; Chu, Yong; Li, Huiti; Jiang, Xian-Cheng; Cheng, Nengneng; Zhou, Lu] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Li, Yali] Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, 1000 Jinqi Rd, Shanghai 201403, Peoples R China; [Huang, Taomin] Fudan Univ, Eye Ear Nose Throat Hosp, 83 Fenyang Rd, Shanghai 200031, Peoples R China; [Jiang, Xian-Cheng] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA in 2019, Cited 58. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxybenzamides were discovered as novel SMS2 inhibitors through scaffold hopping and structural optimization. Among them, Ly93 as one of the most potent inhibitors exhibited IC50 values of 91 nM and 133.9 mu M against purified SMS2 and SMS1 respectively. The selectivity ratio of Ly93 was more than 1400-fold for purified SMS2 over SMS1. The in vitro studies indicated that Ly93 not only dose-dependently diminished apoB secretion from Huh7 cells, but also significantly reduced the SMS activity and increased cholesterol efflux from macrophages. Meanwhile, Ly93 inhibited the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. The pharmacokinetic profiles of Ly93 performed on C57BL/6J mice demonstrated that Ly93 was orally efficacious. As a potent selective SMS2 inhibitor, Ly93 significantly decreased the plasma SM levels of C57BL/6J mice. Furthermore, Ly93 was capable of dose-dependently attenuating the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice treated with Ly93. In conclusion, we discovered a novel selective SMS2 inhibitor Ly93 and demonstrated its anti-atherosclerotic activities in vivo. The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis. (C) 2018 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 93-02-7, If you have any questions, you can contact Li, YL; Huang, TM; Lou, B; Ye, DY; Qi, XY; Li, XX; Hu, S; Ding, TB; Chen, Y; Cao, Y; Mo, MG; Dong, JB; Wei, M; Chu, Y; Li, HT; Jiang, XC; Cheng, NN; Zhou, L or send Email.. Quality Control of 2,5-Dimethoxybenzaldehyde

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