Tag: M.W=150-200

Mane, KD; Mukherjee, A; Vanka, K; Suryavanshi, G in [Mane, Kishor D.; Suryavanshi, Gurunath] CSIR, Chem Engn & Proc Dev Div, Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Mukherjee, Anagh; Vanka, Kumar] CSIR, Phys & Mat Chem Div, Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Mane, Kishor D.; Mukherjee, Anagh; Vanka, Kumar; Suryavanshi, Gurunath] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India published Metal-Free Regioselective Cross Dehydrogenative Coupling of Cyclic Ethers and Aryl Carbonyls in 2019.0, Cited 53.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted alpha-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The regioselectivity of this CDC reaction was confirmed by density functional theory (DFT)-based calculations.

Safety of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Mane, KD; Mukherjee, A; Vanka, K; Suryavanshi, G or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 385-00-2. Authors Lin, TT; Li, JC; Liu, LP; Li, YQ; Jiang, HL; Chen, KX; Xu, P; Luo, C; Zhou, B in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China; [Lin, Tingting; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Xu, Pan; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Chem Biol,Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Zhou, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lin, Tingting; Li, Jiacheng; Liu, Liping; Li, Yuanqing; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng; Zhou, Bing] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China in 2021, Cited 39. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Cyclin-dependent kinases play significant roles in cell cycle progression and are promising targets for cancer therapy. However, most potent CDK inhibitors lack the balance between efficacy and safety because of poor selectivity. Given the roles of CDK2 in tumorigenesis, selective CDK2 inhibition may provide therapeutic benefits against certain cancer. In this study, a series of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives were designed, synthesized, and evaluated. The most selective compound DC-K2in212 in this series exhibited high potency towards CDK2 and had effective anti-proliferative activity against A2058 melanoma cell line and MV4-11 leukemia cell line while exhibiting low toxic effect on human normal cell lines MRC5 and LX2. The molecular modeling illustrated that compound DC-K2in212 had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1. Further biological studies revealed that compound DC-K2in212 suppressed CDK2-associated downstream signaling pathway, blocked cell cycle progression, and induced cellular apoptosis. Therefore, compound DC-K2in212 could serve as a potential CDK2 inhibitor for further development. (c) 2021 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 385-00-2. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Sameri, F; Mobinikhaledi, A; Bodaghifard, MA in [Sameri, Fatemeh; Mobinikhaledi, Akbar; Bodaghifard, Mohammad Ali] Arak Univ, Fac Sci, Dept Chem, Arak 3815688138, Iran; [Sameri, Fatemeh; Mobinikhaledi, Akbar; Bodaghifard, Mohammad Ali] Arak Univ, Inst Nanosci & Nanotechnol, Arak 3815688138, Iran published High-efficient synthesis of 2-imino-2H-chromenes and dihydropyrano[c]chromenes using novel and green catalyst (CaO@SiO2@AIL) in 2021, Cited 54. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

In this work, 1,3,5,7-tetraazaadamantan-1-ium chloride (AIL) functionalized silica-coated calcium oxide hybrid nanocatalyst (CaO@SiO2@AIL) as a novel, efficient, green and recyclable heterogeneous ionic liquid catalyst was synthesized. Catalytic activity of the CaO@SiO2@AIL hybrid nanoparticles was investigated for synthesis of the pharmaceutically valuable 2-imino-2H-chromene and dihydropyrano[c]chromene derivatives. A wide range of amines and aromatic aldehydes containing either electron-withdrawing or electron-donating substituent were examined using optimized conditions to produce the desired products. 2-Imino-2H-chromenes were synthesized under solvent-free condition, and dihydropyrano[c]chromenes were prepared in aqueous medium as green conditions within short reaction times, high yields and using easy workup procedures. Structure confirmation and surface properties of the core/shell hybrid nanoparticles were considered via Fourier transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscope, energy-dispersive X-ray spectroscopy, WDS map scan, thermogravimetric and elemental analyses. This IL-supported heterogeneous nanocatalyst can be reused at least six times without considerable loss of its performance.

Welcome to talk about 93-02-7, If you have any questions, you can contact Sameri, F; Mobinikhaledi, A; Bodaghifard, MA or send Email.. Recommanded Product: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2021 ANGEW CHEM INT EDIT published article about VISIBLE-LIGHT PHOTOREDOX; CROSS-COUPLING REACTIONS; ORGANIC AZIDES; CURTIUS REARRANGEMENT; PROTECTED AMINES; CARBOXYLIC-ACIDS; H AMINATION; CHEMISTRY; MILD; DIVERSITY in [Zhang, Yipin; Ge, Xia; Lu, Hongjian; Li, Guigen] Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, Inst Chem & Biomed Sci, Nanjing 210093, Peoples R China; [Li, Guigen] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA in 2021, Cited 80. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Recommanded Product: 2,6-Difluorobenzoic acid

Transition-metal-catalyzed sp(2) C-N bond formation is a reliable method for the synthesis of aryl amines. Catalytic sp(3) C-N formation reactions have been reported occasionally, and methods that can realize both sp(2) and sp(3) C-N formation are relatively unexplored. Herein, we address this challenge with a method of catalytic decarboxylative C-N formation that proceeds through a cascade carboxylic acid activation, acyl azide formation, Curtius rearrangement and nucleophilic addition reaction. The reaction uses naturally abundant organic carboxylic acids as carbon sources, readily prepared azidoformates as the nitrogen sources, and 4-dimethylaminopyridine (DMAP) and Cu(OAc)(2) as catalysts with as low as 0.1 mol % loading, providing protected alkyl, alkenyl and aryl amines in high yields with gaseous N-2 and CO2 as the only byproducts. Examples are demonstrated of the late-stage functionalization of natural products and drug molecules, stereospecific synthesis of useful alpha-chiral alkyl amines, and rapid construction of different ureas and primary amines.

Recommanded Product: 2,6-Difluorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019.0 NEW J CHEM published article about FUNCTIONAL IONIC LIQUID; MEDIATED SYNTHESIS; CHEMISTRY; KETONES in [Srivastava, Suman] Natl Inst Technol, Dept Appl Sci, NILERD Campus,Sec A-7, Delhi 110040, India in 2019.0, Cited 25.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

An efficient synthesis of ferrocene-tagged propargyl amine derivatives via one-pot three-component domino amination/alkynylation in water is reported. The synthesis involves a single Cu(i) catalyst without addition of a ligand, has broad substrate applicability and gives excellent yields.

Computed Properties of C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Srivastava, S or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C9H10O3. In 2019.0 ORG LETT published article about RING in [Blitz, Michel; Harms, Klaus; Koert, Ulrich] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany; [Heinze, Robert C.] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany in 2019.0, Cited 17.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A stereoselective synthetic approach to the natural product (+)-nivetetracyclate A is reported. The tetracyclic skeleton was assembled in a convergent manner by an alkylation to a diarylmethane and subsequent Friedel-Crafts acylation. Further key steps are an asymmetric Sharpless epoxidation and the boron trifluoride-mediated diastereoselective rearrangement of an epoxy alcohol to a beta-hydroxy aldehyde. Optimized timing for the deprotection step and the chemo- and stereoselective Noyori-transfer hydrogenation of a 1,4-diketone allowed the late stage introduction of the C4 stereocenter.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Blitz, M; Heinze, RC; Harms, K; Koert, U or concate me.. Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019.0 CURR TOP MED CHEM published article about BIOLOGICAL EVALUATION; DERIVATIVES; ANTIBACTERIAL; INFECTIONS; INHIBITION; ANTIFUNGAL; AGENTS in [Tratrat, Christophe; Haroun, Michelyne; Aldhubiab, Bandar; Attimarad, Mahesh; Venugopala, Katharigatta N.; Harsha, Sree; Elsewedy, Heba S.] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia; [Xenikakis, Iakovos; Liaras, Konstantinos; Tsolaki, Evangelia; Petrou, Anthi; Geronikaki, Athina] Aristotle Univ Thessaloniki, Fac Pharm, Sch Hlth, Thessaloniki 54124, Greece; [Eleftheriou, Phaedra] Alexander Technol Educ Inst Thessaloniki, Sch Hlth & Med Care, Dept Med Lab Studies, Thessaloniki 54700, Greece; [Venugopala, Katharigatta N.] Durban Univ Technol, Fac Appl Sci, Dept Biotechnol & Food Technol, ZA-4001 Durban, South Africa; [Sokovic, Marina] Univ Belgrade, Mycol Lab, Inst Biol Res S Stankovic, Belgrade 11000, Serbia in 2019.0, Cited 30.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Category: isothiazole

Background: Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial. Objectives: The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiaz,ole-based chalcones. Methods: The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. Results: All compounds have shown antibacterial properties better than that of ampicillin and in many cases better than streptomycin. As far as the antifungal activity is concerned, all compounds possess much higher activity than reference drugs bifonazole and ketoconazole. The most sensitive bacterial species was B. cereus (MIC 6.5-28.4 mu mol x 10(-2)/mL and MBC 14.2-105.0 mu mol x 10(-2)/mL) while the most resistant ones were L. monocytogenes (MIC 21.4-113.6 mu mol x 10(-2)/mL) and E. coli (MIC 10.7113.6 mu mol x 10(-2)/mL) and MBC at 42.7-358.6 mu mol x 10(-2)/mL and 21.4-247.2 mu mol x 10(-2)/mL, respectively. All the compounds exhibited antibacterial activity against the three resistant strains, MRSA, P. aeruginosa and E.coli. with MIC and MBC in the range of 0.65-11.00 mu mol/mL x 10(-2) and 1.30-16.50 mu mol/mL x 10(-2). Docking studies were performed. Conclusion: Twenty-eight novel thiazole-based chalcones were designed, synthesized and evaluated for antimicrobial activity. The results showed that these derivatives could be lead compounds in search of new potent antimicrobial agents. Docking studies indicated that DNA gyrase, GyrB and MurA inhibition may explain the antibacterial activity.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020.0 FRONT PHARMACOL published article about GASTRIC-CANCER; GENE AMPLIFICATION; BREAST-CANCER; PHASE-I; GROWTH; DISCOVERY; TERAMEPROCOL; CHALLENGES; AGENTS in [Chen, Qian; Li, Wulan] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; [Chen, Qian; Zhu, Min; Xie, Jingwen; Dong, Zhaojun; Khushafah, Fatehi; Yun, Di; Fu, Weitao; Wei, Tao; Liu, Zhiguo; Qiu, Peihong; Wu, Jianzhang; Li, Wulan] Wenzhou Med Univ, Coll Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou, Peoples R China; [Wang, Ledan] Wenzhou Med Univ, Affiliated Hosp 2, Dept Gynecol & Obstet, Wenzhou, Peoples R China in 2020.0, Cited 49.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues usingAf23and NDGA as lead compounds by retaining the basic structural framework (bisaryl-1,4-dien-3-one) and the unilateral active functional groups (3,4-dihydroxyl). Thereinto,Y14showed considerable inhibitory activity against FGFR1. Next, pharmacological experiments showed thatY14could significantly inhibit the phosphorylation of FGFR1 and its downstream kinase AKT and ERK, thus inhibiting the growth, survival, and migration of gastric cancer cells. Furthermore, compared with 5-FU treatment alone, the combination ofY14and 5-FU significantly reduced the phosphorylation level of FGFR1, and enhanced the anti-cancer effect by inhibiting the viability and colony formation in two gastric cancer cell lines. These results confirmed thatY14exerted anti-gastric activity and chemosensitizing effect by inhibiting FGFR1 phosphorylation and its downstream signaling pathwayin vitro. This work also provides evidence thatY14, an effective FGFR1 inhibitor, could be used alone or in combination with chemotherapy to treat gastric cancer in the future.

COA of Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Chen, Q; Zhu, M; Xie, JW; Dong, ZJ; Khushafah, F; Yun, D; Fu, WT; Wang, LD; Wei, T; Liu, ZG; Qiu, PH; Wu, JZ; Li, WL or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Madikizela, B; Eckhardt, T; Goddard, R; Richter, A; Lins, A; Lehmann, C; Imming, P; Seidel, RW in [Madikizela, Balungile; Eckhardt, Tamira; Richter, Adrian; Lins, Anika; Lehmann, Christoph; Imming, Peter; Seidel, Ruediger W.] Martin Luther Univ Halle Wittenberg, Inst Pharm, Wolfgang Langenbeck Str 4, D-06120 Halle, Saale, Germany; [Madikizela, Balungile] Univ Pretoria, Dept Paraclin Sci, Phytomed Programme, Private Bag X04, ZA-0110 Onderstepoort, South Africa; [Goddard, Richard] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Richter, Adrian] Univ British Columbia, Dept Med, Vancouver, BC V6T 1Z3, Canada; [Richter, Adrian] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada published Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones in 2021, Cited 57. Recommanded Product: 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-beta-d-ribose-2 ‘-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacterium tuberculosis. Synthesis, structural characterization and in vitro testing against Mycobacterium aurum DSM 43999 and M. tuberculosis H(37)Rv of halogenated 2-(4-ethoxycarbonylpiperazin-1-yl)-1,3-benzothiazin-4-ones lacking a nitro group are reported. X-ray crystallography reveals that the structure of the BTZ scaffold can significantly deviate from planarity. In contrast to recent reports, the results of the present study indicate that further investigation of halogenated non-nitro BTZs for antitubercular activity is less than a promising approach.

Recommanded Product: 385-00-2. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Waaler, J; Leenders, RGG; Sowa, ST; Brinch, SA; Lycke, M; Nieczypor, P; Aertssen, S; Murthy, S; Galera-Prat, A; Damen, E; Wegert, A; Nazare, M; Lehtio, L; Krauss, S in AMER CHEMICAL SOC published article about SELECTIVE INHIBITORS; DISCOVERY; CATENIN; POTENT; GROWTH; CELLS; ASSAY; SITE in [Waaler, Jo; Brinch, Shoshy Alam; Lycke, Max; Krauss, Stefan] Univ Oslo, Inst Basic Med Sci, Ctr Excellence, Hybrid Technol Hub, N-0317 Oslo, Norway; [Waaler, Jo; Brinch, Shoshy Alam; Lycke, Max; Krauss, Stefan] Oslo Univ Hosp, Dept Immunol & Transfus Med, N-0424 Oslo, Norway; [Leenders, Ruben G. G.; Nieczypor, Piotr; Aertssen, Sjoerd; Damen, Eddy; Wegert, Anita] Mercachem BV, NL-6546 BB Nijmegen, Netherlands; [Sowa, Sven T.; Murthy, Sudarshan; Galera-Prat, Albert; Lehtio, Lari] Univ Oulu, Bioctr Oulu, Fac Biochem & Mol Med, Oulu 90014, Finland; [Nazare, Marc] Campus Berlin Buch, Leibniz Forschungsinst Mol Pharmakol, Med Chem, D-13125 Berlin, Germany in 2020, Cited 40. Name: 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Tankyrases 1 and 2 are central biotargets in the WNT/beta-catenin signaling and Hippo signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole moiety and binding predominantly to the adenosine binding site of the tankyrase catalytic domain. Here we describe a systematic structure-guided lead optimization approach of these tankyrase inhibitors. The central 1,2,4-triazole template and trans-cyclobutyl linker of the lead compound 1 were left unchanged, while side-group East, West, and South moieties were altered by introducing different building blocks defined as point mutations. The systematic study provided a novel series of compounds reaching picomolar IC50 inhibition in WNT/beta-catenin signaling cellular reporter assay. The novel optimized lead 13 resolves previous atropisomerism, solubility, and Caco-2 efflux liabilities. 13 shows a favorable ADME profile, including improved Caco-2 permeability and oral bioavailability in mice, and exhibits antiproliferative efficacy in the colon cancer cell line COLO 320DM in vitro.

Name: 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Waaler, J; Leenders, RGG; Sowa, ST; Brinch, SA; Lycke, M; Nieczypor, P; Aertssen, S; Murthy, S; Galera-Prat, A; Damen, E; Wegert, A; Nazare, M; Lehtio, L; Krauss, S or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com