Tag: M.W=150-200

An article Tetrabutylammonium-Bromide-Promoted Synthesis of Spirooxindoles through Alkyne-Aldehyde C-C Coupling and 1,3-Dipolar Cycloaddition Using Ytterbium Triflate Catalyst WOS:000542426900029 published article about HECK REACTION; AZOMETHINE YLIDES; AMINO-ACIDS; DERIVATIVES; SPIROPYRROLIZIDINES; HETEROCYCLES; CHEMISTRY; PALLADIUM; PROTOCOL; KETONES in [Teja, Chitrala; Khan, Fazlur Rahman Nawaz] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India in 2020.0, Cited 37.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 93-02-7

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

Recommanded Product: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Teja, C; Khan, FRN or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Efficient Synthesis of Medicinally Important Benzylidene-indolin-2-one Derivatives Catalyzed by Biodegradable Amino Sugar Meglumine WOS:000469516900013 published article about 3-COMPONENT COMBINATORIAL SYNTHESIS; ONE-POT; INHIBITORS; DESIGN in [Patel, Chetananda; Kumar, Amit; Patil, Pooja; Sharma, Abha] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Raebareli, India in 2019.0, Cited 23.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

An efficient synthesis of biologically important benzylidene-indolin-2-one derivatives using meglumine as green catalyst and ethanol:water as reaction media at 78 degrees C has been developed. The effects of reaction conditions such as solvents, temperature, and amount of catalyst were investigated. The present methodology offers many advantages such as simple procedure, less time taking to complete the reaction, high yield of products, and clean reaction profile.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Patel, C; Kumar, A; Patil, P; Sharma, A or concate me.. Recommanded Product: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

HPLC of Formula: C7H4F2O2. In 2021 CHEM LETT published article about ARYLATION in [Doi, Ryohei; Hayashi, Kanako; Sato, Yoshihiro] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan in 2021, Cited 33. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

Herein, we report palladium-catalyzed decarboxylative alpha-polyfluoroarylation of ketones. As a result of reaction condition screening, XPhos and Ruphos were selected as ancillary ligands for Pd(0) catalysts. The reaction was applied to a variety of substrates. A cross-over experiment was conducted to gain insight into the reaction mechanism.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Doi, R; Hayashi, K; Sato, Y or concate me.. HPLC of Formula: C7H4F2O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 93-02-7. Maddila, S; Abafe, OA; Bandaru, HN; Maddila, SN; Lavanya, P; Seshadri, N; Jonnalagadda, SB in [Maddila, S.; Abafe, O. A.; Bandaru, H. N.; Maddila, S. N.; Jonnalagadda, S. B.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chilten Hills,Private Bag 54001, ZA-4000 Durban, South Africa; [Lavanya, P.] JNT Univ, Annamacharya Inst Technol & Sci, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Seshadri, Nuthangi] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India published V-CaHAp as a recyclable catalyst for the green multicomponent synthesis of benzochromenes in 2019.0, Cited 48.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A simple and efficient one-pot method has been developed for the synthesis of benzochromenes (4a-k) using V-CaHAp as a heterogeneous catalyst by the condensation of aldehydes, beta-naphthol and malononitrile in ethanol as solvent at room temperature for 20 min. The reaction, with this catalyst was carried out under mild reaction conditions with very good to excellent yields (89-98%). The material can be recycled very easily and reused for at least 6 runs without substantial loss in activity, which makes this methodology environmentally benign. We achieved a feasible and cost-effective synthesis by using non-toxic materials and minimal catalyst which is easy to handle. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Maddila, S; Abafe, OA; Bandaru, HN; Maddila, SN; Lavanya, P; Seshadri, N; Jonnalagadda, SB or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019 ACTA CRYSTALLOGR E published article about HYDROGEN-BOND PATTERNS; GRAPH-SET ANALYSIS; ABSOLUTE-STRUCTURE; PHENYLPHOSPHONIC ACID; 4,4′-SULFONYLDIPHENOL; 4,4′-THIODIPHENOL; PIRIBEDIL; ADDUCTS in [Mahesha, Ninganayaka; Sagar, Belakavadi K.; Yathirajan, Hemmige S.] Univ Mysore, Dept Studies Chem, Mysuru 570006, India; [Furuya, Tetsundo; Haraguchi, Tomoyuki; Akitsu, Takashiro] Tokyo Univ Sci, Fac Sci, Dept Chem, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; [Glidewell, Christopher] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland in 2019, Cited 27. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Recommanded Product: 2,6-Difluorobenzoic acid

In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19 FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl)piperazine, C19H19Cl2N2O3 (III), the piperazine rings adopt a chair conformation with the (1,3-benzodioxol-5-yl)methyl substituent occupying an equatorial site: the five-membered rings are all slightly folded across the O center dot center dot center dot O line leading to envelope conformations. The dihedral angle between the planar amidic fragment and the haloaryl ring is 62.97 (5)degrees in (I) but 77.72 (12)degrees and 75.50 (5)degrees in (II) and (III), respectively. Despite their similarity in constitution and conformation, the supramolecular interactions in (I)-(III) differ: in (I), a combination of C-H center dot center dot center dot O and C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into a three-dimensional framework structure, but there are no hydrogen bonds of any sort in either (II) or (III), although the structure of (III) contains a short Cl center dot center dot center dot Cl contact between inversion-related pairs of molecules.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C or concate me.. Recommanded Product: 2,6-Difluorobenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2021 J IRAN CHEM SOC published article about CATALYST; GREEN; NANOCOMPOSITE; NANOPARTICLES; EFFICIENT; DESIGN; SHELL in [Shafe-Mehrabadi, Sayed Rasul; Sadeghi, Bahareh; Mosslemin, Mohammad Hossein; Hashemian, Saeedeh] Islamic Azad Univ, Yazd Branch, Dept Chem, POB 89195-155, Yazd, Iran in 2021, Cited 35. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3

According to the Food and Agriculture Organization (FAO), Iran is the largest pistachio (Pistacia vera) producer in the world. Nevertheless, pistachio by-products (PBs) contain a high level of phenolic and cellulose compounds, it can be used as a substrate for the preparation of solid acid catalysts. In this work, the novel pistachio hull-OxTiCl4 (-) (x) catalyst was synthesized via preparing pistachio hull, product of Kerman, as a support followed by treatment with titanium tetrachloride (TiCl4) and identified by Fourier transform infrared spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction spectroscopy (EDX), thermogravimetric analysis (TG), Brunauer-Emmett-Teller (BET) and X-ray powder diffraction (XRD). The size of the nano-pistachio hull-OxTiCl4 (-) (x) nanocatalyst was shown by a scanning electron microscope below 100 nm. The catalytic activity of the solid acid catalyst has been successfully examined in a one-pot, three-component condensation reaction of aromatic aldehydes, dimedone and kojic acid in refluxing ethanol to furnish dihydropyrano[3,2-b]chromendione derivatives. Consequently, pyran annulated heterocycles were obtained. The proposed approach has some advantages as excellent yields, mild reaction conditions, short reaction times, use of agricultural waste and eco-friendly.

COA of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Shafe-Mehrabadi, SR; Sadeghi, B; Mosslemin, MH; Hashemian, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 385-00-2. Recently I am researching about ACETYLSALICYLIC-ACID; ABSORPTION-SPECTROMETRY; PROTEIN-BINDING; MOLECULAR ABSORPTION; METAL-COMPLEXES; CHEMISTRY; EFFICACY; IMPACT; DRUGS; CELLS, Saw an article supported by the Tiroler Wissenschaftsfonds (TWF) [GZ: UNI-0404/1982]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Baecker, D; Obermoser, V; Kirchner, EA; Hupfauf, A; Kircher, B; Gust, R. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2). Since COX-2 participates in carcinogenesis, a selective inhibition of that isoenzyme is aimed. To study if fluorination increases the COX-2/COX-1 inhibition ratio of the lead, substitution was respectively performed in the positions 3, 4, 5, and 6 of the aromatic moiety. The complexes 3/4/5F-Co-ASS and to a much lower extent also 6F-Co-ASS showed cytotoxic, antimetabolic, and apoptotic effects in COX-1/2-positive HT-29 and MDA-MB-231 cells and remarkably less activity in the COX-1/2-negative MCF-7 cell line. The metabolic activity in MCF-7 cells was even unaffected up to a concentration of 40 mu M. With exception of 6F-Co-ASS, the complexes strongly reduced the PGE(2) synthesis in HT-29 cells and all complexes inhibited COX-2 more effectively than COX-1 in an assay at isolated enzymes. These findings point to an interference in the COX cascade as part of the mode of antitumor action. The limited cellular effects of 6F-Co-ASS are related to its poor uptake as determined by HR CS AAS/MAS. Moreover, the cellular uptake studies confirm fluorination as beneficial tool for bioanalytical labeling. The higher quantification of fluorine by HR CS MAS makes this method about 5-fold more sensitive than HR CS AAS measuring cobalt. As a further positive result, 3/4/5/6-Co-ASS demonstrated high selectivity to tumor cells due to lack of antimetabolic activity against the non-tumorigenic bone marrow stromal cell line HS-5.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Baecker, D; Obermoser, V; Kirchner, EA; Hupfauf, A; Kircher, B; Gust, R or concate me.. Product Details of 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,6-Difluorobenzoic acid. Recently I am researching about MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS; CANCER-CELLS; GLYCOPROTEIN; BIOAVAILABILITY; REVERSAL, Saw an article supported by the Major New Drugs Innovation and Development of National Science and Technology Major Projects [2018ZX09711002-007-005]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Guo, YL; Wang, K; Chen, XY; Li, HH; Wan, Q; Morris-Natschke, S; Lee, KH; Chen, Y. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

Twenty-five seco-4-methyl-DCK derivatives were designed, synthesized and evaluated for chemoreversal activity when combined with paclitaxel or vincristine in two drug-resistant cancer cell lines (A2780/T and KB-V) respectively. Most of the new compounds displayed moderate to significant MDR reversal activities in the P-gp overexpressing A2780/T and KB-V cells. Especially, compounds 7o and 7y showed the most potent chemosensitization activities with more than 496 and 735 reversal ratios at a concentration of 10 mu M. Unexpectedly the newly synthesized compounds did not show chemosensitization activities observed in a non-P-gp overexpressing cisplatin resistant human ovarian cancer cell line (A2780/CDDP), implying that the MDR reversal effects might be associated with P-gp overexpression. Moreover, these compounds did not exhibit significant antiproliferative activities against nontumorigenic cell lines (HUVEC, HOSEC and T29) compared to the positive control verapamil at the tested concentration, which suggested better safety than verapamil. The pharmacological actions of the compounds will be studied further to explore their merit for development as novel candidates to overcome P-gp mediated MDR cancer.

Application In Synthesis of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Guo, YL; Wang, K; Chen, XY; Li, HH; Wan, Q; Morris-Natschke, S; Lee, KH; Chen, Y or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Mechanochemical Synthesis of Amides with Uronium-Based Coupling Reagents: A Method for Hexa-amidation of Biotin[6]uril published in 2020. Recommanded Product: 385-00-2, Reprint Addresses Kananovich, DG; Aav, R (corresponding author), Tallinn Univ Technol, Sch Sci, Dept Chem & Biotechnol, EE-12618 Tallinn, Estonia.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

Solvent-free, atom-efficient, and mechanochemically activated reactions have emerged as synthetic strategy for sustainable chemistry. Herein we report a new mechanochemical approach for the amide coupling of carboxylic acids and amines, mediated by combination of (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)-dimethylaminomorpholinocarbenium hexafluorophosphate (COMU) or N,N,N’,N’-tetramethylchloroformamidinium hexa-fluorophosphate (TCFH) and K2HPO4. The method delivers a range of amides in high yields (70-96%) and fast reaction rates. The reaction protocol is mild, keeps stereochemical integrity of the adjacent to carbonyl stereocenters, and streamlines isolation procedure for solid amide products. Minimal waste is generated due to the absence of bulk solvent. We show that K2HPO4 plays a dual role, acting as a base and a precursor of reactive acyl phosphate species. Amide bonds from hindered carboxylic acids and low-nucleophilic amines can be assembled within 90 minutes by using TCFH in combination with K2HPO4 or N-methylimidazole. The developed mechanochemical liquid-assisted amidation protocols were successfully applied to the challenging couplings of all six carboxylate functions of biotin[6]uril macrocycle with phenylalanine methyl ester, resulting in 80% yield of highly pure hexa-amide-biotin[6]uril. In addition, fast and high-yielding synthesis of peptides and versatile amide compounds can be performed in a safe and environmentally benign manner, as verified by green metrics.

Recommanded Product: 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Dalidovich, T; Mishra, KA; Shalima, T; Kudrjasova, M; Kananovich, DG; Aav, R or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about BISCOUMARIN DERIVATIVES; MOLECULAR DOCKING; GLYCATION; COMPLEXES; ENZYME; ACID, Saw an article supported by the Higher Education Commission (HEC), Pakistan under National Research Program for Universities [20-1910]; Higher Education Commission, Pakistan, through Indigenous 5000 Scholarship Programme Batch-VII. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Salar, U; Nizamani, A; Arshad, F; Khan, KM; Fakhri, MI; Perveen, S; Ahmed, N; Choudhary, MI. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Formula: C9H10O3

The current study is concerned with the identification of lead molecules based on the bis-coumarin scaffold having selective urease inhibitory and antiglycation activities. For that purpose, bis-coumarins (1-44) were synthesized and structurally characterized by different spectroscopic techniques. Eight derivatives 4, 8-10, 14, 17, 34, and 40 demonstrated urease inhibition in the range of IC50=4.4 +/- 0.21-115.6 +/- 2.13 mu M, as compared to standard thiourea (IC50=21.3 +/- 1.3 mu M). Especially, compound 17 (IC50=4.4 +/- 0.21 mu M) was found to be five-fold more potent than the standard. Kinetic studies were also performed on compound 17 in order to identify the mechanism of inhibition. Kinetic studies revealed that compound 17 is a competitive inhibitor. Antiglycation activity was evaluated using glycation of bovine serum albumin by methylglyoxal in vitro. Compounds 2, 11-13, 16, 17, 19-22, 35, 37, and 42 showed good to moderate antiglycation activities with IC50 values of 333.63-919.72 mu M, as compared to the standard rutin (IC50=294.46 +/- 1.5 mu M). Results of both assays showed that the compounds with urease inhibitory activity did not show any antiglycation potential, and vice versa. Only compound 17 showed dual inhibition potential. All compounds were also evaluated for cytotoxicity. Compounds 17, 19, and 37 showed a weak toxicity towards 3 T3 mouse fibroblast cell line. All other compounds were found to be non-cytotoxic. Urease inhibition is an approach to treat infections caused by ureolytic bacteria whereas inhibition of glycation of proteins is a strategy to avoid late diabetic complications. Therefore, these compounds may serve as leads for further research.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Salar, U; Nizamani, A; Arshad, F; Khan, KM; Fakhri, MI; Perveen, S; Ahmed, N; Choudhary, MI or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com