Tag: M.W=150-200

In 2019.0 J HETEROCYCLIC CHEM published article about MOLECULAR DOCKING; INHIBITORS; AGENTS; SPIRO in [Gouhar, Rasha S.] Natl Res Ctr, Therapeut Chem Dept, PO 12622, Giza, Egypt; [Haneen, David S. A.] Ain Shams Univ, Fac Sci, Chem Dept, PO 11566, Cairo, Egypt; [El-Hallouty, Salwa M.] Natl Res Ctr, Dept Pharmacognosy, Drug Bioassay Cell Culture Lab, PO 12622, Giza, Egypt in 2019.0, Cited 26.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Formula: C9H10O3

A new series of quinazolinone derivatives bearing pyridine, pyrimidine, pyrazole, or pyran moieties were synthesized for the purpose of anticancer cell line evaluation. Synthesis of these derivatives was achieved by the reaction of the ketone 2 with the appropriate aldehydes in the presence of either ethylcyanoacetate or malononitrile and ammonium acetate in one-pot reaction. Chalcones 6 reacted also with hydrazine hydrate to give the corresponding pyrazolines 7 and reacted with urea or thiourea to give the 2-oxopyrimidines or the 2-thioxopyrimidines 8, respectively. Evaluation of some representative examples of the newly synthesized compounds against cancer cell lines showed promising activity as anticancer agents.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gouhar, RS; Haneen, DSA; El-Hallouty, SM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020 J AM CHEM SOC published article about VISIBLE-LIGHT PHOTOREDOX; OXIDATIVE ADDITION; LIGAND DESIGN; ARYL HALIDES; COMPLEXES; REACTIVITY; ACTIVATION; PALLADIUM; PROTODEBORONATION; ARENES in [Daley, Ryan A.; Topczewski, Joseph J.] Univ Minnesota Twin Cities, Dept Chem, Minneapolis, MN 55455 USA; [Morrenzin, Aaron S.; Neufeldt, Sharon R.] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA in 2020, Cited 92. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. COA of Formula: C7H4F2O2

This report details a decarboxylative cross-coupling of (hetero)aryl carboxylates with iodoarenes in the presence of a gold catalyst (>25 examples, up to 96% yield). This reaction is site specific, which overcomes prior limitations associated with gold catalyzed oxidative coupling reactions. The reactivity of the (hetero)aryl carboxylate correlates qualitatively to the field effect parameter (F-ortho). Reactions with isolated gold complexes and DFT calculations support a mechanism proceeding through oxidative addition at a gold(I) cation with decarboxylation being viable at either a gold(I) or a silver(I) species.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Daley, RA; Morrenzin, AS; Neufeldt, SR; Topczewski, JJ or concate me.. COA of Formula: C7H4F2O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article The Design of Potent, Selective and Drug-Like RGD alpha v beta 1 Small-Molecule Inhibitors Derived from non-RGD alpha 4 beta 1 Antagonists WOS:000474036600001 published article about ALPHA-5-BETA-1 INTEGRIN; PULMONARY-FIBROSIS; RECEPTOR; INTEGRIN-ALPHA-V-BETA-6; ALPHA(V)BETA(3); DERIVATIVES; BIPHENYLS; DISCOVERY; BILIARY in [Hatley, Richard J. D.; Barrett, Tim N.; Slack, Robert J.; Watson, Morag E.; Baillache, Daniel J.; Gruszka, Anna; Washio, Yoshiaki; Rowedder, James E.; Pogany, Peter; Pal, Sandeep; Macdonald, Simon J. F.] GlaxoSmithKline GSK, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England in 2019, Cited 39. COA of Formula: C7H4F2O2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Up to 45 % of deaths in developed nations can be attributed to chronic fibroproliferative diseases, highlighting the need for effective therapies. The RGD (Arg-Gly-Asp) integrin alpha v beta 1 was recently investigated for its role in fibrotic disease, and thus warrants therapeutic targeting. Herein we describe the identification of non-RGD hit small-molecule alpha v beta 1 inhibitors. We show that alpha v beta 1 activity is embedded in a range of published alpha 4 beta 1 (VLA-4) ligands; we also demonstrate how a non-RGD integrin inhibitor (of alpha 4 beta 1 in this case) was converted into a potent non-zwitterionic RGD integrin inhibitor (of alpha v beta 1 in this case). We designed urea ligands with excellent selectivity over alpha 4 beta 1 and the other alpha v integrins (alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha v beta 8). In silico docking models and density functional theory (DFT) calculations aided the discovery of the lead urea series.

COA of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Hatley, RJD; Barrett, TN; Slack, RJ; Watson, ME; Baillache, DJ; Gruszka, A; Washio, Y; Rowedder, JE; Pogany, P; Pal, S; Macdonald, SJF or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about DIELS-ALDER REACTION; NATURAL-PRODUCTS; EFFICIENT SYNTHESIS; SMALL MOLECULES; DRUGS; ALDEHYDES; CYCLOADDITIONS; INHIBITORS; CHEMISTRY; STRATEGY, Saw an article supported by the . Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Rehan, M; Flegel, J; Heitkamp, F; Pergomet, JL; Otte, F; Strohmann, C; Kumar, K. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Quality Control of 2,5-Dimethoxybenzaldehyde

An enantioselective hetero-Diels-Alder reaction of alkylidene- oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes withN,N ‘-dioxide ligands offered an efficient access to natural-product-based 3,3 ‘-piperidinoyl spiroox-indole class of small molecules.exo-Cycloadducts formed via stereospecific cycloaddition withZ-olefin displayed potent activity in modulation of hedgehog pathway.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rehan, M; Flegel, J; Heitkamp, F; Pergomet, JL; Otte, F; Strohmann, C; Kumar, K or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents WOS:000540547000016 published article about TOPOISOMERASE-I INHIBITION; ANTIPROLIFERATIVE ACTIVITY; ANTITUMOR-ACTIVITY; BENZIMIDAZOLES; CYTOTOXICITY; DOCKING in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam in 2020.0, Cited 36.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. HPLC of Formula: C9H10O3

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.. HPLC of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about HYDROGEN-SULFIDE; FLUORESCENT CHEMOSENSOR; SELECTIVE DETECTION; GOLD NANOPARTICLES; CU2+; SENSOR; CHEMISTRY; GAS; H2S; CHEMODOSIMETER, Saw an article supported by the Deanship of Scientific Research, Najran University [NU/MID/16/091]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Mahnashi, MH; Mahmoud, AM; Alkahtani, SA; Ali, R; El-Wekil, MM. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. COA of Formula: C9H10O3

Herein, a novel ON-OFF colorimetric and fluorometric chemosensor; 1N-allyl-2-(2, 5-dimethoxyphenyl)-4, 5-diphenyl-1H-imidazole (ADPPI), was constructed for sequential determination of Cu2+ and S2- ions in aqueous media. The interaction between chemosensor ADPPI and different metal cations was investigated using UV-VIS and fluorimetric spectroscopy. ADPPI showed a favorable and good interaction with Cu2+ ions producing blue colored solution peaked at 610 nm with blue fluorescence at lambda(em) = 447 nm. The produced complex between Cu2+ ions and ADPPI can be used as a cascade probe for detection of S2- ions. The detection limits (LODs) were 1.01 nM and 1.25 mu M for Cu2+ and S2- ions, respectively (the lowest between the family of colorimetric and fluorometric chemosensors). To further increase the applicability of the proposed method, Cu2+ and S2- ions concentrations were measured in environmental water samples. (c) 2019 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Mahnashi, MH; Mahmoud, AM; Alkahtani, SA; Ali, R; El-Wekil, MM or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Efficient and Green Synthetic Route to Imidazo[1,2-a]pyridine by Cu(II)-Ascorbate-Catalyzed A(3)-Coupling in Aqueous Micellar Media WOS:000462921900001 published article about ONE-POT SYNTHESIS; 3-COMPONENT REACTION; BIOLOGICAL-ACTIVITY; COUPLING REACTION; CATALYST; 2-AMINOPYRIDINES; IMIDAZOPYRIDINES; NANOPARTICLES; INHIBITION; PREVENTS in [Bhutia, Zigmee T.; Das, Dharmendra; Chatterjee, Amrita; Banerjee, Mainak] BITS Pilani, Dept Chem, KK Birla Goa Campus, Zuarinagar 403726, Goa, India in 2019.0, Cited 52.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

An efficient and environmentally sustainable method for the synthesis of imidazo[1,2-a]pyridine derivatives by domino A(3)-coupling reaction catalyzed by Cu(II)-ascorbate was developed in aqueous micellar media in the presence of sodium dodecyl sulfate (SDS). The catalyst, a dynamic combination of Cu(II)/Cu(I), was generated in situ in the reaction mixture by mixing CuSO4 with sodium ascorbate and aided a facile 5-exo-dig cycloisomerization of alkynes with the condensation products of 2-aminopyridines and aldehydes to afford a variety of imidazo[1,2-a]pyridines in good overall yields. A simple experimental setup, water as the green medium, and inexpensive catalyst and auxiliary are some of the merits of this protocol.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Bhutia, ZT; Das, D; Chatterjee, A; Banerjee, M or concate me.. HPLC of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction published in 2021. COA of Formula: C7H4F2O2, Reprint Addresses Currie, I; Sleebs, BE (corresponding author), Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia.; Currie, I; Sleebs, BE (corresponding author), Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

COA of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Currie, I; Sleebs, BE or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

HPLC of Formula: C9H10O3. Recently I am researching about QUINOXALINE DERIVATIVES; EFFICIENT SYNTHESIS; PHOTOCLEAVAGE; ANTICANCER; FAMILY; DRUGS; PHOTOSENSITIZERS; PHOTONUCLEASES; BENZOTRIAZOLES; INTERCALATORS, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Sumran, G; Aggarwal, R; Mittal, A; Aggarwal, A; Gupta, A. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

An expedient and eco-friendly synthesis of 1-aryl/heteroaryl-[1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones (4) has been accomplished via iodobenzene diacetate mediated oxidative intramolecular cyclization of 3-(2-(aryl/heteroarylidene)hydrazinyl)-quinoxalin-2(1H)-ones (3). Ten synthesized compounds 3 and 4 (10-40 mu g) on irradiation with UV light at lambda(max) 312 nm could lead to cleavage of supercoiled pMaxGFP DNA (Form I) into the relaxed DNA (Form II) without any additive. Further, DNA cleaving ability of triazoles was quantitatively evaluated and was found to be dependent on its structure, concentration, and strictly on photoirradiation time. Mechanistic investigations using several additives as potential inhibitors/activator revealed that the DNA photocleavage reaction involves Type-I pathway leading to formation of superoxide anion radicals (O-2(-center dot)) as the major reactive oxygen species responsible for photocleavage process.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sumran, G; Aggarwal, R; Mittal, A; Aggarwal, A; Gupta, A or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents WOS:000552968100001 published article about OCTANOL/WATER PARTITION-COEFFICIENT; MULTIPLE-MYELOMA; IN-VITRO; CELL; BORTEZOMIB; RECEPTOR; GLIOBLASTOMA; INHIBITION; MODULATORS; PATHOGENESIS in [Listro, Roberta; Stotani, Silvia; Rossino, Giacomo; Rui, Marta; Rossi, Daniela; Di Giacomo, Marcello; Collina, Simona] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, Pavia, Italy; [Stotani, Silvia] Taros Chem GmbH & Co KG, Med Chem, Dortmund, Germany; [Malacrida, Alessio; Cavaletti, Guido; Miloso, Mariarosaria] Univ Milano Bicocca, Expt Neurol Unit, Sch Med & Surg, Monza, Italy; [Malacrida, Alessio; Cavaletti, Guido; Miloso, Mariarosaria] Univ Milano Bicocca, Milan Ctr Neurosci, Monza, Italy; [Cortesi, Michela; Arienti, Chiara; Tesei, Anna] Ist Sci Romagnolo Studio & Cura Tumori IRCCS, Biosci Lab, Meldola, Italy in 2020, Cited 65. Formula: C7H4F2O2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Despite the fact that significant advances in treatment of common cancers have been achieved over the years, orphan tumors still represent an important unmet medical need. Due to their complex multifactorial origin and limited number of cases, such pathologies often have very limited treatment options and poor prognosis. In the search for new anticancer agents, our group recently identifiedRC-106, a Sigma receptor modulator endowed with proteasome inhibition activity. This compound showed antiproliferative activity toward different cancer cell lines, among them glioblastoma (GB) and multiple myeloma (MM), two currently unmet medical conditions. In this work, we directed our efforts toward the exploration of chemical space aroundRC-106to identify new active compounds potentially useful in cancer treatment. Thanks to a combinatorial approach, we prepared 41 derivatives of the compound and evaluated their cytotoxic potential against MM and GB. Three novel potential anticancer agents have been identified.

Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Listro, R; Stotani, S; Rossino, G; Rui, M; Malacrida, A; Cavaletti, G; Cortesi, M; Arienti, C; Tesei, A; Rossi, D; Di Giacomo, M; Miloso, M; Collina, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com