Tag: M.W=150-200

Recommanded Product: 93-02-7. In 2020.0 J MOL STRUCT published article about ANTITUMOR-ACTIVITY; CELL-LINE; DERIVATIVES; ANTICANCER; PC3; INHIBITION; COMPLEXES; APOPTOSIS; DOCKING; NI(II) in [Gur, Mahmut] Kastamonu Univ, Dept Forest Ind Engn, Kastamonu, Turkey; [Yerlikaya, Serife; Baloglu, Mehmet Cengiz; Altunoglu, Yasemin Celik] Kastamonu Univ, Dept Genet & Bioengn, Kastamonu, Turkey; [Sener, Nesrin] Kastamonu Univ, Dept Chem, Kastamonu, Turkey; [Ozkinali, Sevil] Hitit Univ, Dept Chem, Corum, Turkey; [Baloglu, Mehmet Cengiz] Univ Florida, IFAS, Dept Agron, Gainesville, FL 32611 USA; [Gokce, Halil] Giresun Univ, Vocat Sch Hlth Serv, Giresun, Turkey; [Demir, Serkan] Giresun Univ, Dept Ind Engn, Giresun, Turkey; [Sener, Izzet] Kastamonu Univ, Dept Food Engn, Kastamonu, Turkey in 2020.0, Cited 69.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The 1,3,4-thiadiazole core has been mainly used as a pharmacological scaffold in medicinal chemistry. A series of Schiff bases derived from 5-substituted-1,3,4-thiadiazole-2-amine were designed and synthesized to investigate their biological activities. Structures of compounds were clarified with FTIR, H-1 NMR and elemental analysis. Due to the importance of this core in pharmacology, all these newly synthesized compounds were tested for different biological properties at the same time. Compound 3A ((E)-N-(2,5-dimethoxybenzylidene)-5-(4-methoxyquinolin-2-yl)-1,3,4-thiadiazol-2-amine) and compound 4A ((E)-N-(2,5-dimethoxybenzylidene)-5-(3-methylbenzofuran-2-yl)-1,3,4-thiadiazol-2-amine) possessed high DNA protective ability against oxidative Fenton mixture. Compound 1A ((E)-N-(2,5-dimethoxybenzylidene)-5-(benzo[b]thiophen-2-yl)-1,3,4-thiadiazol-2-amine) and compound 2B ((E)-2-((5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-ylimino)methyl)-6-methoxyphenol) showed strong antimicrobial activity against S. epidermidis. The most effective compound was detected as compound 3A which exhibited cytotoxicity on both PC-3 and MDA-MB-231 cancer cell lines. The IC50 of this compound was calculated as 370.7 mu M and 505.1 mu M for MDA-MB-231 and PC-3 cells, respectively. Molecular docking studies were also performed to examine the understanding of the mechanism behind the anti-cancer and anti-bacterial properties. For further study, compound 3A has the potential for utilization with chemotherapy drugs to establish a more efficient therapy strategy with minimum cytotoxicity against cancer cells. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gur, M; Yerlikaya, S; Sener, N; Ozkinali, S; Baloglu, MC; Gokce, H; Altunoglu, YC; Demir, S; Sener, I or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Design, synthesis and biological evaluation of novel alpha-aminophosphonate oxadiazoles via optimized iron triflate catalyzed reaction as apoptotic inducers WOS:000488307100025 published article about RESPONSE-SURFACE METHODOLOGY; KABACHNIK-FIELDS REACTION; ONE-POT SYNTHESIS; ANTITUMOR ACTIVITIES; PHOSPHONATE DERIVATIVES; PLATINUM(II) COMPLEXES; CELL BIOLOGY; CYTOTOXICITY; MECHANISM; TRIFLUOROMETHANESULFONATE in [Ewies, Ewies F.; El-Hussieny, Marwa; El-Sayed, Naglaa F.] Natl Res Ctr, Organometall & Organometalloid Chem Dept, 33 ElBohouth St, Giza 12622, Egypt; [Fouad, Marwa A.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Kasr El Aini St, Cairo 11562, Egypt in 2019.0, Cited 84.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 93-02-7

alpha-aminophosphonate oxadiazoles (5a-m) were prepared in high yields by reacting of 1,3,4-oxadiazole acetohydrazide (3) with appropriate aldehydes and diethyl phosphite under Kabachnik-Fields conditions using Iron triflate as a catalyst. The reaction conditions were optimized using D-optimal experimental design. Possible reaction mechanisms were considered, and structures of the new products were based upon compatible elementary and spectroscopic evidence. In vitro antitumor activities of these compounds were evaluated against human cancer cell lines of colon (HCT116), breast (MCF7) and liver (HepG2) and compared with anticancer drug, Doxorubicin, employing standard MIT assay. Compounds 5i and 5l demonstrated good antiproliferative activities against HCT116 tumor cells comparable to doxorubicin with low cytotoxicity towards normal fetal colon cell (FHC). Additionally, their capacity to activate apoptosis cascade was studied in HCT116 cell line by investigating the activation of proteolytic caspases cascade, the levels of Cytochrome C, Bax and Bcl-2. Active caspase-3 level was enhanced by 6-8-folds in HCT116 cell line when stimulated with compounds 5i and 5l compared to the control. The level of Caspases 8 & 9 was also increased signifying that intrinsic and extrinsic pathways are both activated. They also induced Bax and down regulated Bcl-2 protein level in addition to over-expressing Cytochrome C level in HCT116 cell line. Also, HCT116 cell cycle was mainly arrested at the Pre-G1 and G2/M phases when treated with compounds 5i and 5l. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Ewies, EF; El-Hussieny, M; El-Sayed, NF; Fouad, MA or concate me.. Recommanded Product: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Bhutia, ZT; Das, D; Chatterjee, A; Banerjee, M in [Bhutia, Zigmee T.; Das, Dharmendra; Chatterjee, Amrita; Banerjee, Mainak] BITS Pilani, Dept Chem, KK Birla Goa Campus, Zuarinagar 403726, Goa, India published Efficient and Green Synthetic Route to Imidazo[1,2-a]pyridine by Cu(II)-Ascorbate-Catalyzed A(3)-Coupling in Aqueous Micellar Media in 2019.0, Cited 52.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

An efficient and environmentally sustainable method for the synthesis of imidazo[1,2-a]pyridine derivatives by domino A(3)-coupling reaction catalyzed by Cu(II)-ascorbate was developed in aqueous micellar media in the presence of sodium dodecyl sulfate (SDS). The catalyst, a dynamic combination of Cu(II)/Cu(I), was generated in situ in the reaction mixture by mixing CuSO4 with sodium ascorbate and aided a facile 5-exo-dig cycloisomerization of alkynes with the condensation products of 2-aminopyridines and aldehydes to afford a variety of imidazo[1,2-a]pyridines in good overall yields. A simple experimental setup, water as the green medium, and inexpensive catalyst and auxiliary are some of the merits of this protocol.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Bhutia, ZT; Das, D; Chatterjee, A; Banerjee, M or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH in [Gandhi, Sahaj A.] Bhavans Shri IL Pandya Arts Sci & Smt JM Shah Com, Dakor 388225, Gujarat, India; [Barot, V. M.; Patel, M. C.] Smt SM Panchal Sci Coll, PG Ctr Chem, Talod 383215, Gujarat, India; [Malek, T. J.] Kadi Sarva Vishwavidhayalay Univ, LDRP Inst Technol & Res, Gandhinagar 382024, Gujarat, India; [Patel, U. H.] Sardar Patel Univ, Dept Phys, Vallabh Vidyanagar 388120, Gujarat, India published MOLECULAR DOCKING, PHARMACOPHORE MODELLING AND 3D QSAR ANALYSIS OF NOVEL CHALCONE DERIVATIVES in 2019.0, Cited 18.0. Category: isothiazole. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-11) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone derivative (2-Br- and 4OCH(3)- group) against specific bacteria are quite significant. 3D QSAR, three dimensional quantitative structure activity is one of the most powerful technique which involves the quantitative relationship between the biological activity of a set of compounds and their three dimensional structural properties, using statistical correlation methods. Pharmacophore modelling and molecular docking play an important role in drug design. To elucidate the relationship between structures and its activity, field-based 3D QSAR analysis has been carried out of novel chalcone derivatives. Structural properties such as electrostatic, hydrophobic, aromatic, and hydrogen-bond donor and acceptor have been worked out for novel chalcone derivatives. To investigate the influence of drugstore, chalcone derivatives (1a-11) have docked with receptor 210K and results displayed the highest Gscore of ligand If (3-OCH2C6H5-4-OCH3- group).

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 385-00-2. Singh, AS; Agrahari, AK; Mishra, N; Singh, M; Tiwari, VK in [Singh, Anoop S.; Agrahari, Anand K.; Mishra, Nidhi; Singh, Mala; Tiwari, Vinod K.] Banaras Hindu Univ, Dept Chem, Inst Sci, Varanasi 221005, Uttar Pradesh, India published An Improved N-Acylation of 1 H -Benzotriazole Using 2,2-Dipyridyldisulfide and Triphenylphosphine in 2019, Cited 40. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

A novel path has been developed for the conversion of carboxylic acids into the corresponding N -acylbenzotriazoles by using 2,2-dipyridyl disulfide/PPh (3) in anhydrous dichloromethane in the presence of 1 H -benzotriazole. Mild reaction conditions, short reaction time, easy in handling, wide substrate scope, availability of reagents involved, and moreover avoiding the use of base makes this protocol quite useful for the laboratory practices for N -acylbenzotriazole synthesis.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Singh, AS; Agrahari, AK; Mishra, N; Singh, M; Tiwari, VK or concate me.. Recommanded Product: 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about CROSS-COUPLING REACTIONS; DIBENZO-ALPHA-PYRONES; DIELS-ALDER APPROACH; NATURAL-PRODUCTS; INHIBITORS; PALLADIUM; ANTIBACTERIAL; CHEMISTRY; ANALOGS, Saw an article supported by the Universita degli Studi di Perugia within program Fondo per la Ricerca di Base 2017. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Temperini, A; Lanari, D; Colognese, F; Piazzolla, F. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

In the context of the growing interest of the scientific community for the development of sustainable synthetic strategies to access aromatic structures, we present a practical and metal-free approach to (hetero)biaryls which exploits the advantages of multicomponent reactions in sustainable solvents. In situ acid-catalysed generation of (hetero)aryl acetoxy dienes from the corresponding (hetero)arylidene acetones in a metal vessel, followed by Diels-Alder reaction using an electron-poor alkyne as dienophile, delivers the expected aromatic products after final oxidation of the cycloadduct. This protocol has been demonstrated as a convenient alternative to the previously reported synthetic strategies, considering its scalability and environmental sustainability and the low cost of substrates and equipment. Moreover, it has been successfully applied to the metal-free regioselective synthesis of (hetero)aryl-substituted-phenyls, 2-unsubstituted-3-aryl-indoles, and to the total synthesis of isourolithine A.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Temperini, A; Lanari, D; Colognese, F; Piazzolla, F or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. In 2021.0 FOOD CHEM published article about CHROMATOGRAPHY-MASS SPECTROMETRY; KEY AROMA COMPOUNDS; ERH TEA; GC-OLFACTOMETRY; OOLONG TEA; ODORANTS; FERMENTATION; CHEMOMETRICS; ELUCIDATION; EXTRACTION in [Xu, Shanshan; Wu, Huiting; Shen, Shanshan; Yang, Xiaogen; Deng, Wei-Wei; Ning, Jingming] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, 130 Changjiang West Rd, Hefei 230036, Anhui, Peoples R China; [Zeng, Xinsheng] Menghai Tea Factory, Xishuangbanna 666200, Yunnan, Peoples R China in 2021.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The aroma profile of raw pu?er tea (RPT) depends on its storage duration (2?10 years) and storage conditions (wet-hot or dry-cold environment). We analyzed the major odorants of RPT samples by performing metabolomic analysis and by using the molecular sensory science approach. Under dry-cold storage conditions, tea leaves had more carotenoid derivatives, glycoside-derived volatiles, and phenolic volatiles, resulting in ?fresh,? ?floral,? and ?sweet? aroma. Under wet-hot storage conditions, tea leaves had more methoxybenzenes, which contributed considerably to their ?stale? and ?woody? aroma. We identified 11 and 4 compounds as the odor markers of RPTs when stored in dry-cold and wet-hot environments, respectively. Our findings provide a scientific basis for optimal storage that yields the desired aroma profile.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Xu, SS; Zeng, XS; Wu, HT; Shen, SS; Yang, XG; Deng, WW; Ning, JM or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Formula: C9H10O3. Patil, RC; Patil, UP; Jagdale, AA; Shinde, SK; Patil, SS in [Patil, Rupesh C.; Jagdale, Ashutosh A.; Shinde, Sachinkumar K.; Patil, Suresh S.] PDVP Coll, PG Dept Chem, Synthet Res Lab, Tasgaon 416312, India; [Patil, Rupesh C.; Patil, Uttam P.; Jagdale, Ashutosh A.; Shinde, Sachinkumar K.; Patil, Suresh S.] Shivaji Univ, Kolhapur 416004, Maharashtra, India; [Patil, Uttam P.] ACS Coll, Dept Chem, Palus 416310, India published Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of alpha,alpha ‘-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones in 2020.0, Cited 56.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

alpha,alpha ‘-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET techniques. The analysis revealed that the present catalyst has basic sites which promote the synthesis of desired products. The main attractions of our protocol are utilization of highly abundant bio-waste-derived catalyst and good-to-excellent yield in shortest reaction time. This green protocol was further extended for structurally diverse 2-arylidene-1-tetralones by condensation of equimolar quantity of aromatic aldehydes and 1-tetralone at low temperature. The catalyst could be quantitatively recovered and reused effectively for five times. [GRAPHICS] .

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Patil, RC; Patil, UP; Jagdale, AA; Shinde, SK; Patil, SS or concate me.. Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V in ROYAL SOC CHEMISTRY published article about DERIVATIVES; CHALCONE; DESIGN; AMONAFIDE; DOCKING; INHIBITORS; APOPTOSIS; BINDING; BCL-2 in [Shalini; Pankaj; Kumar, Vipan] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India; [Saha, Sourav Taru; Kaur, Mandeep] Univ Witwatersrand, Sch Mol & Cell Biol, Private Bag 3, ZA-2050 Johannesburg, South Africa; [Oluwakemi, Ebenezer; Awolade, Paul; Singh, Parvesh] Univ Kwazulu Natal, Sch Chem & Phys, P Bag X54001, ZA-4000 Durban, South Africa in 2020.0, Cited 39.0. Product Details of 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced based on the influence of linker length, substituents on the phenyl ring and the generated functionalities, on anti-proliferative activities. Docking simulations further delineate the type of interactions of the designed molecules with the selected targets. This report discloses the scope of triazole tethered naphthalimide-chalcone/pyrazoline conjugates as anti breast cancer agents.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article An expeditious one-pot multicomponent synthesis of sterically hindered bis-1,2,4-triazolopyridazines under solvent-free conditions WOS:000521363100019 published article about PYRIDAZINE DERIVATIVES; FACILE; INHIBITOR; MET in [Aggarwal, Ranjana; Mamta] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India; [Sumran, Garima] DAV Coll Lahore, Dept Chem, Ambala City 134003, Haryana, India in 2019.0, Cited 33.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Formula: C9H10O3

A simple and ecologically facile synthesis of sterically hindered 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b:3′,4′-f]pyridazines was accomplished via a three-component reaction sequence between 3,6-dihydrazinopyridazine, an aromatic or heteroaromatic aldehyde and iodobenzene diacetate (IBD) on grinding at room temperature. The 3,6-bis-arylidenehydrazinopyridazine intermediates, generated in situ, undergo oxidative cyclization to afford the title compounds. The present protocol has excellent yields, short reaction times, broad substrate scope, is a solvent-free greener synthesis, and has an easy purification of product. [GRAPHICS] .

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Aggarwal, R; Mamta; Sumran, G or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com