Tag: M.W=150-200

In 2019 J ENZYM INHIB MED CH published article about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA in [Zhang, Qing-Wen; Ye, Zi-Dan; Shen, Chang; Tie, Hong-Xia; Wang, Lei; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 31. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. HPLC of Formula: C7H4F2O2

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

HPLC of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about NANOPARTICLE-CATALYZED SYNTHESIS; ONE-POT SYNTHESIS; IN-VITRO; ANTIBACTERIAL ACTIVITY; HIGHLY EFFICIENT; SERIES; CHROMONE; COMPLEX; ANTIOXIDANT; CHEMISTRY, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Hosseinzadegan, S; Hazeri, N; Maghsoodlou, MT; Moghaddam-Manesh, M; Shirzaei, M. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Recommanded Product: 93-02-7

New derivatives of chromeno[4,3-b]quinolin-6-one were synthesized using novel SO3H-tryptamine supported on Fe3O4@SiO2@CPS which could be recycled as an effective magnetic nanocatalyst. SEM, EDX, XRD, FT-IR, TGA, VSM and BET analyses were utilized to confirm the magnetic nanocatalyst structure. Evaluation of Antimicrobial (antibacterial and antifungal) function of magnetic nanocatalyst as well as derivatives undergone synthesis was carried out according to MIC, MBC and MFC values. Moreover, evaluation of the derivatives subject to synthesis was performed according to DPPH free radical besides the biological features, in order to obtain justifiable biological features. [GRAPHICS] .

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Hosseinzadegan, S; Hazeri, N; Maghsoodlou, MT; Moghaddam-Manesh, M; Shirzaei, M or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Novel berberine-based derivatives with potent hypoglycemic activity published in 2019.0. Application In Synthesis of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Tang, L (corresponding author), Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Guizhou, Peoples R China.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound 20b exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, respectively. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

HPLC of Formula: C7H4F2O2. I found the field of Chemistry very interesting. Saw the article Machine learning-based prediction of toxicity of organic compounds towards fathead minnow published in 2020, Reprint Addresses Chen, XM; Huang, XW; Yu, XL (corresponding author), Hunan Inst Engn, Coll Mat & Chem Engn, Hunan Prov Key Lab Environm Catalysis & Waste Reg, Xiangtan 411104, Hunan, Peoples R China.; Yu, XL (corresponding author), Donghu Rd 18, Xiangtan 411104, Hunan, Peoples R China.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

Predicting the acute toxicity of a large dataset of diverse chemicals against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approximate ratio of 1 : 1. Only six molecular descriptors were used to establish the quantitative structure-activity/toxicity relationship (QSAR/QSTR) model for 96 hourpLC(50)through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R-2= 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (q(int)(2)= 0.699 andq(ext)(2)= 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six molecular descriptors and a large data set for the test set consisting of 481 compounds.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Chen, XM; Dang, LM; Yang, H; Huang, XW; Yu, XL or concate me.. HPLC of Formula: C7H4F2O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors WOS:000450396900001 published article about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA in [Zhang, Qing-Wen; Ye, Zi-Dan; Shen, Chang; Tie, Hong-Xia; Wang, Lei; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 31. Safety of 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 2,5-Dimethoxybenzaldehyde. Recently I am researching about ALDEHYDE HYDRAZONES; ALKENES; BOND; ALKYLIDENECYCLOPROPANES; DIFLUOROMETHYLATION; TRANSFORMATIONS; CHEMISTRY; FUNCTIONALIZATION; FLUORINATION; BROMIDES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21702087, 21801105]; Natural Science Foundation of Liaoning ProvinceNatural Science Foundation of Liaoning Province [2015020196, 20170520353, 20180510033]; Program for Liaoning Innovative Talents in University [LR2017021]; Research Project Fund of Liaoning Provincial Department of Education [L2017LQN010, L2017LZD001]; Talent Scientific Research Fund of Liaoning Shihua University [2016XJJ-078, 2016XJJ-079]; open project of Jilin Province Key Laboratory of Organic Functional Molecular Design Synthesis [130028836, 130028911]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, C; Yang, YJ; Dong, JY; Zhou, MD; Li, L; Wang, H. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Novel copper/B(2)pin(2)-catalyzed difluoroalkylation of methylenecyclopropanes with bromodifluorinated acetates and acetamides via a tandem radical process involving ring-opening/intramolecular cyclization has been reported. This protocol is not only tolerated to a diverse range of substrates but also applicable to the synthesis of useful difluoromethylated compounds. Moreover, the reaction could be performed on a gram scale with a high yield, which opens up the possibility for practical applications.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Liu, C; Yang, YJ; Dong, JY; Zhou, MD; Li, L; Wang, H or concate me.. Name: 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Godugu, K; Gundala, TR; Bodapati, R; Yadala, VDS; Loka, SS; Nallagondu, CGR in [Godugu, Kumar; Gundala, Thrivikram Reddy; Yadala, Venkata Divya Sri; Loka, Subramanyam Sarma; Nallagondu, Chinna Gangi Reddy] Yogi Vemana Univ, Sch Phys Sci, Dept Chem, Kadapa 516003, Andhra Pradesh, India; [Bodapati, Ramakrishna] Univ Hyderabad, Sch Chem, Cent Univ PO, Hyderabad 500046, India published Synthesis, photophysical and electrochemical properties of donor-acceptor type hydrazinyl thiazolyl coumarins in 2020, Cited 108. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A water-mediated MCR strategy has been developed for the synthesis of donor (D)-acceptor(A) type hydrazinyl thiazolyl coumarins (HTCs) (4) in excellent isolated yields (90-98%) from a three component reaction of aromatic aldehydes/ketones (1), thiosemicarbazide (2) and 3-(2-bromoacetyl)-2H-chromen-2-one (3) catalyzed by an environmentally compatible montmorillonite (MMT) K10 clay at RT for 20-40 min. The present MCR strategy has several advantages that include its wide-spread substrate scope, eco-compatibility, short reaction times and products that do not require chromatographic purification. Besides, the method is simple to perform, it is easy to construct C-N, C=N and C-S bonds in one pot and the reaction can be scaled up to a gram level. Moreover, the catalyst can be reused 7 times without significant change of activity. The photophysical properties of the synthesized D-A type HTCs are also studied and it was noticed that the fluorescence properties can be varied with the position of electron donating group on the aromatic ring of aldehyde/ketone of HTCs. Most of the compounds exhibited bright fluorescence in chloroform (1.0 x 10(-5) M) with emission maxima ranging from 409 to 511 nm and large Stokes shifts. Further, the HOMO and LUMO energy levels of the HTCs are found in the range from -5.65 eV to -5.22 eV and -2.67 eV to -2.17 eV, respectively, and in good agreement with the reported hole transporting materials.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Godugu, K; Gundala, TR; Bodapati, R; Yadala, VDS; Loka, SS; Nallagondu, CGR or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

COA of Formula: C9H10O3. In 2019.0 BIOORG CHEM published article about GROWTH-FACTOR RECEPTOR; MOLECULAR DOCKING; KINASE INHIBITORS; BREAST-CANCER; IN-VITRO; DERIVATIVES; ANTICANCER; DISCOVERY in [Abbas, Hebat-Allah S.] King Khalid Univ, Coll Sci, Chem Dept, Abha, Saudi Arabia; [Abbas, Hebat-Allah S.] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt; [Abd El Karim, Somaia S.] Natl Res Ctr, Dept Therapeut Chem, Cairo 12622, Egypt in 2019.0, Cited 35.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

This study represents the synthetic approaches of a new set of 2-(((3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yemethylene)hydrazono)-5-(aryl)thiazolidin-4-one derivatives 4-22 aiming to obtain new antiproliferative candidates against human cervix carcinoma cells (Hela) of EGFR PK inhibiting potency. The cancer cells represented promising sensitivity towards the compounds 6, 7, 11, 13, 14, 16, 17 more than or equal to that against the reference drug doxorubicin. In addition, the latter compounds were tested as EGFR protein kinase inhibitors. The results revealed that compound 14 showed more significant EGFR PK inhibitory activity than the reference drug erlotinib (IC50; 0.07, 0.08 mu M, respectively). Moreover, cell cycle analysis and apoptosis assay were performed for compound 14 proving its ability to cause G1/S phase arrest and apoptosis in Hela cancer cells, in addition to its activation of the caspases-7 and -3. In addition, derivative 14 increased the expression level of p53 and the ratio of Bax/Bcl-2 which confirmed its mode of action. Molecular docking study of 14 was performed to investigate its binding mode of interaction with EGFR PK in the active site with the aim of rationalizing its promising inhibitory activity. Accordingly, compound 14 might be considered as a promising scaffold anticervical cancer chemotherapeutic and deserves further optimization and in-depth biological studies.

COA of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abbas, HAS; Abd El Karim, SS or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about BENCHMARK THERMODYNAMIC PROPERTIES; THERMOPHYSICAL PROPERTIES; VAPOR-PRESSURES; VAPORIZATION; ENTHALPIES; HEAT; CALORIMETRY; COMBUSTION, Saw an article supported by the Government of the Russian Federation [220, 14, Z50.31.0038]; German Science Foundation (DFG)German Research Foundation (DFG) [SPP 1708, VE 265-14/2]. SDS of cas: 93-02-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Verevkin, SP; Konnova, ME; Turovtsev, VV; Riabchunova, AV; Pimerzin, AA. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

The methoxy-, hydroxy-, and carbonyl-substituted benzenes are the simplest fragments from the lignin separation feedstocks. Extensive experimental thermochemical studies of these compounds were carried out, including combustion calorimetry, vapor pressure measurements, and differential scanning calorimetry. We have collected available primary experimental results on enthalpies of formation and vapor pressures as well as on phase transitions, liquid-gas, liquid-solid, and crystal-liquid. These data were evaluated using empirical, semiempirical, and quantum chemical methods. The consistent sets of evaluated thermodynamic data were used to design the method for predicting enthalpies of vaporization and enthalpies of formation of di- and trisubstituted benzenes. It is expected that parameters and pairwise interactions will be transferable to predict the thermochemical properties of poly methoxy-substituted and poly hydroxysubstituted benzenes that appear in reaction products of lignin transformations in the value-adding chemicals and materials.

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Verevkin, SP; Konnova, ME; Turovtsev, VV; Riabchunova, AV; Pimerzin, AA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Synthesis of colorless and highly refractive Poly(phenylene thioether ether) derived from 2,7-(4,4 ‘-diphenol)thiothianthrene WOS:000458405100021 published article about AROMATIC POLYIMIDES; OPTICAL-PROPERTIES; SULFUR; INDEX; TRANSPARENT; RESIN in [Oh, Nuri; Nam, Ki-Ho; Goh, Munju; Ku, Bon-Cheol; You, Nam-Ho] Korea Inst Sci & Technol, Carbon Composite Mat Res Ctr, Inst Adv Composites Mat, Chudong Ro 92, Wanju Gun 565905, Jeollabuk Do, South Korea; [Oh, Nuri; Kim, Jeung Gon] Chonbuk Natl Univ, Dept Chem, Jeonju 54896, South Korea; [Oh, Nuri; Kim, Jeung Gon] Chonbuk Natl Univ, Res Inst Phys & Chem, Jeonju 54896, South Korea in 2019, Cited 35. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. SDS of cas: 385-00-2

Totally colorless, transparent, and highly refractive poly(phenylene thioether ether)s (PPTEs) containing thianthrene-2,7-disulfanyl moiety were developed in this study. A new 4,4′-diol aromatic compound, 2,7-(4,4′-diphenol)thiothianthrene (DPTT), with a high sulfur content was designed and synthesized to develop polymers with high refractive indices and high thermal stabilities. The PPTEs were prepared by polycondensation of DPTT with organic dihalogen compounds, such as 2,6-difluorobenzonitrile (DFBN) and 4,6-dichloro-2-(methylthio) pyrimidine (DCMP). The obtained polymers showed good thermal stabilities such as relatively high glass transition temperatures (T(g)s) in the range of 153-176 degrees C and 5% weight loss temperatures (T-5%) over 344 degrees C. The cut-off wavelengths (lambda(0)) of the PPTE films are shorter than 343 nm, and they have a transmittance higher than 93% at 550 nm. The combination of the pyrimidine and high sulfur-containing thianthrene derivatives provides the PPTEs with a high refractive index of 1.7204 and a small birefringence of 0.0106 at 637 nm.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Oh, N; Nam, KH; Goh, M; Ku, BC; Kim, JG; You, NH or concate me.. SDS of cas: 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com