Tag: M.W=150-200

COA of Formula: C9H10O3. Authors Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM in TAYLOR & FRANCIS LTD published article about in [Moosavi-Zare, Ahmad R.; Afshar-Hezarkhani, Hadis; Rezaei, Mohammad M.] Sayyed Jamaleddin Asadabadi Univ, Dept Chem, Asadabad, Iran in 2020.0, Cited 32.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized tandem four-component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate to give pyranopyrazole derivatives. By the reaction of boric acid with water, H+ was prepared and efficiently catalyzed the reaction under mild and green condition.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L in [Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Miao, Jing; Tang, Lei] Guizhou Med Univ, Sch Pharm, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Guizhou, Peoples R China; [Wang, Jian-Ta] Guizhou Med Univ, Sch Basic Med Sci, Guiyang 550004, Guizhou, Peoples R China; [Zhou, Xun-Rong] Guizhou Chinese Tradit Med, Affiliated Hosp 2, Guiyang 550001, Guizhou, Peoples R China; [Wang, Jian-Ta; Zhang, Ji-Quan; Zhang, Yi; Tang, Lei] Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Guizhou, Peoples R China published Novel berberine-based derivatives with potent hypoglycemic activity in 2019.0, Cited 25.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound 20b exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, respectively. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Diaw, PA; Mbaye, OMA; Thiare, DD; Oturan, N; Gaye-Seye, MD; Coly, A; Le Jeune, B; Giamarchi, P; Oturan, MA; Aaron, JJ in WILEY published article about PHOTOCHEMICALLY-INDUCED FLUORESCENCE; LIQUID-CHROMATOGRAPHY; PHENYLUREA HERBICIDES; EXPOSURE; HEALTH; WATER; DEGRADATION; RESIDUES; SAMPLES in [Diaw, Pape A.] Univ Alioune Diop, Lab Mat Electrochim & Photochim Analyt, Bambey, Senegal; [Diaw, Pape A.; Mbaye, Olivier M. A.; Thiare, Diene D.; Gaye-Seye, Mame Diabou; Coly, Atanasse] Univ Cheikh Anta Diop, Lab Photochim & Anal, Dakar, Senegal; [Oturan, Nihal; Gaye-Seye, Mame Diabou; Oturan, Mehmet A.; Aaron, Jean-Jacques] Univ Paris Est Mame la Vallee, LGE, 5 Blvd Descartes, F-77454 Champs Sur Marne 2, Marne La Vallee, France; [Le Jeune, Bernard; Giamarchi, Philippe] Univ Brest, Lab OPTIMAG, Fac Sci, EA 938, 6 Ave Victor le Gorgeu, Brest, France in 2019, Cited 35. Recommanded Product: 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Diflubenzuron (DFB) and fenuron (FEN) are benzoylurea and phenylurea pesticides, widely used in Senegal, that do not exhibit any natural fluorescence, but can be determined by means of photoinduced fluorescence (PIF) methods. Photodegradation of DFB and FEN yielded a number of fluorescent and non-fluorescent photoproducts. For both pesticides, at least 10 photoproducts were detected and identified by gas chromatography-mass spectrometry (GC/MS). To identify the formed fluorescent DFB and FEN photoproducts, their fluorescence spectra were compared with those of standard compounds, including phenol and p-hydroxyaniline.

Recommanded Product: 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Diaw, PA; Mbaye, OMA; Thiare, DD; Oturan, N; Gaye-Seye, MD; Coly, A; Le Jeune, B; Giamarchi, P; Oturan, MA; Aaron, JJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Dyachenko, IV; Dyachenko, VD; Dorovatovskii, PV; Khrustalev, VN; Nenajdenko, VG in SPRINGER published article about in [Dyachenko, Ivan, V; Dyachenko, Vladimir D.] Luhansk T Shevchenko Natl Univ, 2 Oboronnaya St, UA-91011 Lugansk, Ukraine; [Dorovatovskii, Pavel, V; Khrustalev, Victor N.] Kurchatov Inst, Natl Res Ctr, 1 Akad Kurchatova Sq, Moscow 123182, Russia; [Khrustalev, Victor N.] RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia; [Nenajdenko, Valentine G.] Moscow MV Lomonosov State Univ, 1 Build 3 Leninskie Gory, Moscow 119991, Russia in 2019.0, Cited 24.0. Computed Properties of C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

The multicomponent reaction of aromatic and heteroaromatic aldehydes, malonodithioamide, 1-(cyclohex-1-en-1-yl)piperidine, and alkylating reagents was studied. A wide range of new 2-(alkylsulfanyl)-4-aryl(hetaryl)-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized, and their molecular and crystalline structures were studied by X-ray structural analysis.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Dyachenko, IV; Dyachenko, VD; Dorovatovskii, PV; Khrustalev, VN; Nenajdenko, VG or concate me.. Computed Properties of C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019.0 ACS CATAL published article about C BOND FORMATION; CARBONYL ALLYLATION; QUATERNARY STEREOCENTERS; H FUNCTIONALIZATION; ALCOHOL; HYDROGEN; PARAFORMALDEHYDE; CHEMISTRY in [Kim, Seung Wook; Meyer, Cole C.; Krische, Michael J.] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA; [Mai, Binh Khanh; Liu, Peng] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA in 2019.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. HPLC of Formula: C9H10O3

The use of gaseous allene as an ally! pronu-cleophile in enantioselective aldehyde reductive coupling is described. Notably, using the same antipode of chiral ligand, (S)-tol-BINAP, an inversion of enantioselectivity is observed for allene versus allyl acetate pronucleophiles. Experimental and computational studies corroborate intervention of diastereo-meric pi-allyliridium-C,O-benzoate complexes, which arise via allene hydrometalation (from a pentacoordinate iridium hydride) versus ally! acetate ionization (from a square planar iridium species).

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kim, SW; Meyer, CC; Mai, BK; Liu, P; Krische, MJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Upare, AA; Gadekar, PK; Sivaramakrishnan, H; Naik, N; Khedkar, VM; Sarkar, D; Choudhari, A; Roopan, SM in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about DRUG-RESISTANT TUBERCULOSIS; TRANS-CINNAMIC ACID; PARALLEL SYNTHESIS; DERIVATIVES; INHIBITORS; DOCKING in [Upare, Abhay Atmaram; Gadekar, Pradip K.; Sivaramakrishnan, H.] Piramal Enterprises Ltd, Dept Proc Dev, Lighthall A Wing, Hiranandani Business PK, Sakivihar Rd, Mumbai 400072, Maharashtra, India; [Naik, Nishigandha] Haffkine Inst Training Res & Testing, Acharya Donde MargPorel, Mumbai 400012, Maharashtra, India; [Khedkar, Vijay M.] Shri Vile Parle Kelavani Mandars Inst Pharm, Dept Pharmaceut Chem, Mumbai Agra Natl Hwy, Dhule 424001, Maharashtra, India; [Sarkar, Dhiman; Choudhari, Amit] CSIR, Natl Chem Lab, Combi Chem Bio Resource Ctr, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Upare, Abhay Atmaram; Roopan, S. Mohana] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Chem Heterocycles & Nat Prod Res Lab, Vellore 632014, Tamil Nadu, India in 2019.0, Cited 26.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with oxadiazole. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound 32 displayed potent anti-tubercular activity (IC50= 0.045 mu g/mL). Molecular docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the experimental findings providing a platform for structure based hit-to-lead development.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Upare, AA; Gadekar, PK; Sivaramakrishnan, H; Naik, N; Khedkar, VM; Sarkar, D; Choudhari, A; Roopan, SM or concate me.. HPLC of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Discovery of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as prospective microtubule affinity regulating kinase 4 inhibitors published in 2020.0. Name: 2,5-Dimethoxybenzaldehyde, Reprint Addresses Husain, M (corresponding author), Jamia Millia Islamia, Dept Biotechnol, New Delhi 110025, India.; Hassan, MI (corresponding author), Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.; Azam, A (corresponding author), Jamia Millia Islamia, Dept Chem, New Delhi 110025, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Microtubule affinity regulating kinase 4 (MARK4) is a Ser/Thr kinase, considered as a potential drug target for cancer, diabetes and neurodegenerative diseases. Due to its significant role in the development and progression of cancer, different in-house libraries of synthesized small molecules were screened to identify potential MARK4 inhibitors. A small library of hydrazone compounds showed a considerable binding affinity to MARK4. The selected compounds were further scrutinized using an enzyme inhibition assay and finally two hydrazone derivatives (H4 and H19) were selected that show excellent inhibition (nM range). These compounds have a strong binding affinity for MARK4 and moderate binding with human serum albumin. Anticancer studies were performed on MCF-7 and A549 cells, suggesting H4 and H19 selectively inhibit the growth of cancer cells. The IC50 value of compound H4 and H19 was found to be 27.39 mu M and 34.37 mu M for MCF-7 cells, while for A549 cells it was 45.24 mu M and 61.50 mu M, respectively. These compounds inhibited the colonogenic potential of cancer cells and induced apoptosis. Overall findings reflect that hydrazones/hydrazone derivatives could be exploited as potential lead molecules for developing effective anticancer therapies via targeting MARK4.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Khan, NS; Khan, P; Inam, A; Ahmad, K; Yousuf, M; Islam, A; Ali, S; Azam, A; Husain, M; Hassan, MI or concate me.. Name: 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies WOS:000479184600017 published article about BIOLOGICAL EVALUATION; ANTICANCER; DERIVATIVES; COMPLEXES; CYTOTOXICITY; COMPARE; LIGAND; PROBE; TOOL in [El-Wakil, Marwa H.; Ashour, Hayam M. A.; Khalil, Mounir A.; Ismail, Khadiga A.; Labouta, Ibrahim M.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt; [El-Yazbi, Amira F.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Alexandria 21521, Egypt in 2019.0, Cited 47.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Product Details of 93-02-7

New series of furan-thiazole hybrids (3a-f), thiazolo[2,3-c]-1,2,4-triazines (4a-f), their bioisosteres 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazines (8a-d) and 1,2,4-triazino[4,3-b]-1,2,4-triazines (13a-e) were designed, synthesized and evaluated for their in vitro antitumor activities at the National Cancer Institute (NCI, USA). Among the synthesized compounds, 3d was found to exhibit promising broad spectrum antitumor activity (GI(50) MG-MID = 14.22 mu M) in a five-dose assay against the full panel NCI-cancer cell lines. 3d displayed higher antitumor activity against most tested cancer cell lines than 5-FU as reference. COMPARE analysis and molecular electrostatic potential computational study revealed that 3d probably exerts its antitumor properties through DNA binding similar to Clomesone. Further DNA binding studies using fluorescent terbium (Tb+3) probe revealed increased fluroresence of DNA-3d-Tb+3 mixture due to damage of the double-stranded DNA. Also, UV-vis absorption study was conducted which showed hyperchromic shift in DNA absorption confirming 3d-induced DNA damage. The assessed potency of 3d-induced DNA damage of calf thymus DNA showed a concentration as low as 2.04 ng/mL for a detectable DNA damage. Moreover, in silico calculation of physicochemical properties and druglikeness were in compliance to Lipinski’s rule.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact El-Wakil, MH; El-Yazbi, AF; Ashour, HMA; Khalil, MA; Ismail, KA; Labouta, IM or concate me.

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation WOS:000500984600001 published article about GREEN SYNTHESIS; MULTICOMPONENT SYNTHESIS; DERIVATIVES-SYNTHESIS; BIOLOGICAL-ACTIVITY; REUSABLE CATALYST; EFFICIENT in [Khumalo, Mandlenkosi Robert; Maddila, Surya Narayana; Maddila, Suresh; Jonnalagadda, Sreekantha B.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills, ZA-4000 Durban, South Africa in 2019.0, Cited 47.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. SDS of cas: 93-02-7

Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (H-1 NMR, C-13 NMR, N-15 NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89-98%). Additionally, this method provides a clean access to the desired products by simple workup.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Khumalo, MR; Maddila, SN; Maddila, S; Jonnalagadda, SB or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

COA of Formula: C7H4F2O2. In 2020 J MED CHEM published article about CYSTEINE PROTEASE; ALDEHYDE INHIBITORS; IN-VITRO; BIOLOGICAL EVALUATION; ANTIVIRAL ACTIVITY; SARS-CORONAVIRUS; FORMAZAN ASSAY; DESIGN; AG7088; PAPAIN in [Hoffman, Robert L.; Kania, Robert S.; Brothers, Mary A.; Davies, Jay F.; Ferre, Rose A.; Gajiwala, Ketan S.; He, Mingying; Kozminski, Kirk; Li, Lilian Y.; Lockner, Jonathan W.; Lou, Jihong; Marra, Michelle T.; Mitchell, Lennert J., Jr.; Murray, Brion W.; Nieman, James A.; Noell, Stephen; Planken, Simon P.; Ryan, Kevin; Smith, George J., III; Solowiej, James E.; Steppan, Claire M.] Pfizer Worldwide Res & Dev, San Diego, CA 92121 USA; [Hogan, Robert J.; Rowe, Thomas; Taggart, Barbara] Southern Res Inst, Birmingham, AL 35205 USA in 2020, Cited 45. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode two overlapping large polyproteins, which are cleaved at specific sites by a 3C-like cysteine protease (3CL(pro)) in a post-translational processing step that is critical for coronavirus replication. The 3CL(pro) sequences for CoV-1 and CoV-2 viruses are 100% identical in the catalytic domain that carries out protein cleavage. A research effort that focused on the discovery of reversible and irreversible ketone-based inhibitors of SARS CoV-1 3CL(pro) employing ligand-protease structures solved by X-ray crystallography led to the identification of 3 and 4. Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CL(pro) with suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Hoffman, RL; Kania, RS; Brothers, MA; Davies, JF; Ferre, RA; Gajiwala, KS; He, MY; Hogan, RJ; Kozminski, K; Li, LLY; Lockner, JW; Lou, JH; Marra, MT; Mitchell, LJ; Murray, BW; Nieman, JA; Noell, S; Planken, SP; Rowe, T; Ryan, K; Smith, GJ; Solowiej, JE; Steppan, CM; Taggart, B or concate me.. COA of Formula: C7H4F2O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com