Tag: M.W=150-200

Recently I am researching about AROMATIC POLYIMIDES; OPTICAL-PROPERTIES; SULFUR; INDEX; TRANSPARENT; RESIN, Saw an article supported by the Korea Institute of Science and Technology Information; Ministry of Trade, Industry and Energy (MOTIE, Korea) [10076849]; Space Core Technology Development Program through the National Research Foundation of Korea – Ministry of Science, ICT and Future Planning [NRF-2017M1A3A3A02016310]; Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) – Ministry of Science and ICT; Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [17H03112]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Oh, N; Nam, KH; Goh, M; Ku, BC; Kim, JG; You, NH. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid. Recommanded Product: 385-00-2

Totally colorless, transparent, and highly refractive poly(phenylene thioether ether)s (PPTEs) containing thianthrene-2,7-disulfanyl moiety were developed in this study. A new 4,4′-diol aromatic compound, 2,7-(4,4′-diphenol)thiothianthrene (DPTT), with a high sulfur content was designed and synthesized to develop polymers with high refractive indices and high thermal stabilities. The PPTEs were prepared by polycondensation of DPTT with organic dihalogen compounds, such as 2,6-difluorobenzonitrile (DFBN) and 4,6-dichloro-2-(methylthio) pyrimidine (DCMP). The obtained polymers showed good thermal stabilities such as relatively high glass transition temperatures (T(g)s) in the range of 153-176 degrees C and 5% weight loss temperatures (T-5%) over 344 degrees C. The cut-off wavelengths (lambda(0)) of the PPTE films are shorter than 343 nm, and they have a transmittance higher than 93% at 550 nm. The combination of the pyrimidine and high sulfur-containing thianthrene derivatives provides the PPTEs with a high refractive index of 1.7204 and a small birefringence of 0.0106 at 637 nm.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Oh, N; Nam, KH; Goh, M; Ku, BC; Kim, JG; You, NH or concate me.. Recommanded Product: 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Recently I am researching about COLLOID TRANSPORT; SILVER NANOPARTICLES; ANAEROBIC BIOREMEDIATION; MINERALIZATION PATHWAYS; FLOW CONDITIONS; ORGANIC-MATTER; POROUS-MEDIA; HEAVY-METALS; MOBILIZATION; TRANSFORMATION, Saw an article supported by the United States Strategic Environmental Research and Development Program (SERDP) [ER-2130]; China Scholarship CouncilChina Scholarship Council. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Liang, XL; Radosevich, M; Loffler, F; Schaeffer, SM; Zhuang, J. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

In subsurface bioremediation, electron donor addition promotes microbial Fe(lII)-oxide mineral reduction that could change soil pore structure, release colloids, and alter soil surface properties. These processes in turn may impact bioremediation rates and the ultimate fate of contaminants. Columns packed with water-stable, Fe-oxide-rich soil aggregates were infused with acetate-containing artificial groundwater and operated for 20 d or 60 d inside an anoxic chamber. Soluble Fe(II) and soil colloids were detected in the effluent within one week after initiation of the acetate addition, demonstrating Fe(III)-bioreduction and colloid formation. Diffusible Br-, less diffusible 2,6-difluorobenzoate (DFBA), and non-diffusible silica-shelled silver nanoparticles (SSSNP) were used as tracers in transport experiments before and after the bioreduction. The transport of Br- was not influenced by the bioreduction. DFBA showed earlier breakthrough and less tailing after the bioreduction, suggesting alterations in flow paths and soil surface chemistry during the 20-d bioreduction treatment. Similarly, the bioreduction increased the transport of SSSNP very significantly, with mass recovery increasing from 1.7% to 25.1%. Unexpectedly, the SSSNP was completely retained in the columns when the acetate injection was extended from 20 to 60 d, while the mass recovery of DFBA decreased from 89.1% to 84.1% and Br showed no change. The large change in the transport of SSSNP was attributed to soil aggregate breakdown and colloid release (causing mechanical straining of SSSNP) and the exposure of iron oxide surfaces previously unavailable within aggregate interiors (facilitating attachment of SSSNP). These results suggest a time dependent fashion of microbial effect on the transport of diffusivity-varying tracers. (C) 2018 Elsevier Ltd. All rights reserved.

Category: isothiazole. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Liang, XL; Radosevich, M; Loffler, F; Schaeffer, SM; Zhuang, J or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Antiproliferative-antimicrobial properties and structural analysis of newly synthesized Schiff bases derived from some 1,3,4-thiadiazole compounds WOS:000569381800011 published article about ANTITUMOR-ACTIVITY; CELL-LINE; DERIVATIVES; ANTICANCER; PC3; INHIBITION; COMPLEXES; APOPTOSIS; DOCKING; NI(II) in [Gur, Mahmut] Kastamonu Univ, Dept Forest Ind Engn, Kastamonu, Turkey; [Yerlikaya, Serife; Baloglu, Mehmet Cengiz; Altunoglu, Yasemin Celik] Kastamonu Univ, Dept Genet & Bioengn, Kastamonu, Turkey; [Sener, Nesrin] Kastamonu Univ, Dept Chem, Kastamonu, Turkey; [Ozkinali, Sevil] Hitit Univ, Dept Chem, Corum, Turkey; [Baloglu, Mehmet Cengiz] Univ Florida, IFAS, Dept Agron, Gainesville, FL 32611 USA; [Gokce, Halil] Giresun Univ, Vocat Sch Hlth Serv, Giresun, Turkey; [Demir, Serkan] Giresun Univ, Dept Ind Engn, Giresun, Turkey; [Sener, Izzet] Kastamonu Univ, Dept Food Engn, Kastamonu, Turkey in 2020.0, Cited 69.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. SDS of cas: 93-02-7

The 1,3,4-thiadiazole core has been mainly used as a pharmacological scaffold in medicinal chemistry. A series of Schiff bases derived from 5-substituted-1,3,4-thiadiazole-2-amine were designed and synthesized to investigate their biological activities. Structures of compounds were clarified with FTIR, H-1 NMR and elemental analysis. Due to the importance of this core in pharmacology, all these newly synthesized compounds were tested for different biological properties at the same time. Compound 3A ((E)-N-(2,5-dimethoxybenzylidene)-5-(4-methoxyquinolin-2-yl)-1,3,4-thiadiazol-2-amine) and compound 4A ((E)-N-(2,5-dimethoxybenzylidene)-5-(3-methylbenzofuran-2-yl)-1,3,4-thiadiazol-2-amine) possessed high DNA protective ability against oxidative Fenton mixture. Compound 1A ((E)-N-(2,5-dimethoxybenzylidene)-5-(benzo[b]thiophen-2-yl)-1,3,4-thiadiazol-2-amine) and compound 2B ((E)-2-((5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-ylimino)methyl)-6-methoxyphenol) showed strong antimicrobial activity against S. epidermidis. The most effective compound was detected as compound 3A which exhibited cytotoxicity on both PC-3 and MDA-MB-231 cancer cell lines. The IC50 of this compound was calculated as 370.7 mu M and 505.1 mu M for MDA-MB-231 and PC-3 cells, respectively. Molecular docking studies were also performed to examine the understanding of the mechanism behind the anti-cancer and anti-bacterial properties. For further study, compound 3A has the potential for utilization with chemotherapy drugs to establish a more efficient therapy strategy with minimum cytotoxicity against cancer cells. (C) 2020 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gur, M; Yerlikaya, S; Sener, N; Ozkinali, S; Baloglu, MC; Gokce, H; Altunoglu, YC; Demir, S; Sener, I or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Shaikh, S; Pavale, G; Dhavan, P; Singh, P; Uparkar, J; Vaidya, SP; Jadhav, BL; Ramana, MMV in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about INDOLE-DERIVATIVES; BIOLOGICAL EVALUATION; ACETYLCHOLINESTERASE; AGENTS; ANTIOXIDANT; RAT in [Shaikh, Sarfaraz; Pavale, Ganesh; Uparkar, Jasmin; Ramana, M. M., V] Univ Mumbai, Dept Chem, Santacruz E, Mumbai 400098, Maharashtra, India; [Dhavan, Pratik; Jadhav, B. L.] Univ Mumbai, Dept Life Sci, Santacruz E, Mumbai 400098, Maharashtra, India; [Singh, Pinky; Vaidya, S. P.] Haffkine Inst, Dept Microbiol, Mumbai 400012, Maharashtra, India in 2021, Cited 41. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of novel dihydropyranoindole derivatives containing sulphonamide group were designed, synthesized and evaluated for in-vitro anti-cholinesterase activity. The result showed that all the compounds exhibited potent acetylcholinesterase (AChE) activity (IC50 = 0.41-8.79 mu M) while demonstrated moderate to good activity for butyrylcholinesterase (BuChE) (IC50 = 1.17-30.17 mu M). The tested compounds exhibited selectivity towards AChE over BuChE. Compound 5o was most potent towards both AChE (IC50 = 0.41 mu M) and BuChE (IC50 = 1.17 mu M) when compared to standard galantamine and rivastigmine. Enzyme kinetics and molecular docking studies revealed that compound 5o shows mixed type inhibition and binds to peripheral anionic site (PAS) and the catalytic sites (CAS) of both the enzymes. Furthermore, cell viability studies were also performed against N2a cells along with neuroprotection studies against H2O2 in the same cell line. Antioxidant studies using DPPH radical and H2O2 were also performed which revealed that all compounds possessed some antioxidant activity. Also, DNA damage protection assay for compound 5o was performed implying that compound 5o was protective in nature. ADME studies were also performed which demonstrated good pharmacokinetics. These findings indicated that dihydropyranoindole derivatives could be possible drug lead in the search for new multifunctional AD drugs.

COA of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaikh, S; Pavale, G; Dhavan, P; Singh, P; Uparkar, J; Vaidya, SP; Jadhav, BL; Ramana, MMV or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 385-00-2. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones published in 2021, Reprint Addresses Seidel, RW (corresponding author), Martin Luther Univ Halle Wittenberg, Inst Pharm, Wolfgang Langenbeck Str 4, D-06120 Halle, Saale, Germany.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-beta-d-ribose-2 ‘-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacterium tuberculosis. Synthesis, structural characterization and in vitro testing against Mycobacterium aurum DSM 43999 and M. tuberculosis H(37)Rv of halogenated 2-(4-ethoxycarbonylpiperazin-1-yl)-1,3-benzothiazin-4-ones lacking a nitro group are reported. X-ray crystallography reveals that the structure of the BTZ scaffold can significantly deviate from planarity. In contrast to recent reports, the results of the present study indicate that further investigation of halogenated non-nitro BTZs for antitubercular activity is less than a promising approach.

SDS of cas: 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Madikizela, B; Eckhardt, T; Goddard, R; Richter, A; Lins, A; Lehmann, C; Imming, P; Seidel, RW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about HYDROGEN-BOND PATTERNS; GRAPH-SET ANALYSIS; ABSOLUTE-STRUCTURE; PHENYLPHOSPHONIC ACID; 4,4′-SULFONYLDIPHENOL; 4,4′-THIODIPHENOL; PIRIBEDIL; ADDUCTS, Saw an article supported by the UGC, New DelhiUniversity Grants Commission, India; UGCUniversity Grants Commission, India. Published in INT UNION CRYSTALLOGRAPHY in CHESTER ,Authors: Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid. Computed Properties of C7H4F2O2

In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19 FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl)piperazine, C19H19Cl2N2O3 (III), the piperazine rings adopt a chair conformation with the (1,3-benzodioxol-5-yl)methyl substituent occupying an equatorial site: the five-membered rings are all slightly folded across the O center dot center dot center dot O line leading to envelope conformations. The dihedral angle between the planar amidic fragment and the haloaryl ring is 62.97 (5)degrees in (I) but 77.72 (12)degrees and 75.50 (5)degrees in (II) and (III), respectively. Despite their similarity in constitution and conformation, the supramolecular interactions in (I)-(III) differ: in (I), a combination of C-H center dot center dot center dot O and C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into a three-dimensional framework structure, but there are no hydrogen bonds of any sort in either (II) or (III), although the structure of (III) contains a short Cl center dot center dot center dot Cl contact between inversion-related pairs of molecules.

Computed Properties of C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Settipalli, PC; Reddy, YP; Gudise, VB; Anwar, S in [Settipalli, Poorna Chandrasekhar; Reddy, Yeruva Pavankumar; Gudise, Veera Babu; Anwar, Shaik] Vignans Fdn Sci Technol & Res, Dept Sci & Humanities, Div Chem, Guntur 522213, Andhra Pradesh, India published Knoevenagel-Friedel-Crafts-Hemiketalization Triple Cascade Reaction: A Diastereoselective Formal [1+2+3] Cyclization Towards Indenonaphthopyran Scaffolds in 2021.0, Cited 70.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A simple and efficient cascade reaction via formal [1+2+3] cyclization of 1,3-indanedione, aldehyde and 2-naphthol is reported using K2CO3 as a base. The advantage includes metal-free conditions, varied substrate scope and shortened reaction duration with high diastereoselectivity (i. e., 99 : 1) resulting in the formation of two carbon-carbon as well as two carbon-oxygen bonds through Knoevenagel-Friedel-Crafts-Hemiketalization sequence resulting in three contiguous stereocenters.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Settipalli, PC; Reddy, YP; Gudise, VB; Anwar, S or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Biochemistry & Molecular Biology; Biophysics very interesting. Saw the article Synthesis, characterization and anti-inflammatory activity evaluation of 1,2,4-triazole and its derivatives as a potential scaffold for the synthesis of drugs against prostaglandin-endoperoxide synthase published in 2021. SDS of cas: 93-02-7, Reprint Addresses Thakur, SC (corresponding author), Cent Univ, Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.; Thakur, SC (corresponding author), Jamia Hamdard, BIF, DBT BTISNet Bioinformat Infrastruct Facil, New Delhi, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Substituted 1,2,4-triazole nucleus is common in several drugs used in a variety of clinical conditions including infections, hypoglycemia, hypertension and cancer. In this study, we synthesized 1,2,4-triazole and its 16 hydrazone derivatives (B1-B16), characterized them by IR, NMR and Mass spectroscopy, and evaluated their radical scavenging and anti-inflammatory activities in vitro and in vivo. Out of 16 derivatives, five (B1, B5, B6, B9, and B13) demonstrated a significant radical scavenging and anti-inflammatory activity in vitro. B6, which possessed two electron-donating hydroxyl groups, was most active among all. Molecular docking and MD simulation of the complex of B6 with prostaglandin-endoperoxide synthase (PTGS) or cyclooxygenase (COX) showed that B6 occupied celecoxib binding site in COX with high affinity (the binding free energy of the complex with COX-1 was -10.5, and -11.2 kcal/mol with COX-2). Maximum anti-inflammatory activity was also shown by the B6 derivative in vivo, in the rat model of carrageenan-induced inflammation. B6, along with four other derivatives (B1, B5, B9 and B13) exhibited 80-90% free radical scavenging activity. The IC50 values of these compounds were >= 40 mu M. Griess nitrite and dichloro-dihydro-fluorescein-diacetate assays suggested a significant inhibition of nitric oxide and reactive oxygen species, especially by B6 and B9. Taken together, out of 16 derivatives, B6 is reported to have highest anti-inflammatory and antioxidant activity at a low dose level, which may be attributed to its two electron-donating hydroxyls. B6 is proposed to be an important scaffold for the synthesis of new drugs against PTGS for use in a myriad of inflammatory and infectious diseases. Communicated by Ramaswamy H. Sarma

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Khan, B; Naiyer, A; Athar, F; Ali, S; Thakur, SC or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article The efficient synthesis of 3-[6-(substituted)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]-1H-indazole published in 2020. Recommanded Product: 385-00-2, Reprint Addresses Pathan, MA (corresponding author), Maulana Azad Coll Arts Sci & Commerce, Dept Chem, Aurangabad, Maharashtra, India.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

This study presents an efficient synthesis of 3-[6-(substituted-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-3-yl]-1H-indazole via dehydrative condensation with cyclization of 4-amino-5-(1H-indazol-3-yl)-4H-[1,2,4]triazole-3-thiol and fluorinated or nonfluorinated carboxylic acids in presence of phosphorous oxychloride. The multistep reaction pathway proceeds through different compounds. Present synthesis has the advantages of easily accessible starting materials, convenient synthesis, simple reaction condition, wider substrate scope, and higher yield (75% to 90% isolated).

Recommanded Product: 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Raut, S; Hadi, A; Pathan, MA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Additive-Free Palladium-Catalyzed Decarboxylative Cross-Coupling of Aryl Chlorides published in 2019. Quality Control of 2,6-Difluorobenzoic acid, Reprint Addresses Topczewski, JJ (corresponding author), Univ Minnesota Twin Cities, Dept Chem, Minneapolis, MN 55455 USA.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

The cross-coupling of sodium (hetero)aryl carboxylates with (hetero)aryl chlorides proceeds with 1 mol % palladium catalyst and does not require inorganic base, silver salts, or copper salts. This coupling uses two low energy partners, and the only stoichiometric byproducts are carbon dioxide and sodium chloride. The substrate scope includes less activated aryl chlorides and carboxylates (>25 examples). The palladium loading could be reduced to 0.1 mol %, and Buchwald-style precatalysts could be used.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Daley, RA; Liu, EC; Topczewski, JJ or concate me.. Quality Control of 2,6-Difluorobenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com