Tag: M.W=150-200

SDS of cas: 93-02-7. Taha, M; Alkadi, KAA; Ismail, NH; Imran, S; Adam, A; Kashif, SM; Shah, SAA; Jamil, W; Sidiqqui, S; Khan, KM in [Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia; [Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul] Univ Teknol MARA UiTM, Fac Appl Sci, Shah Alam 40450, Selangor, Malaysia; [Alkadi, Khaled A. A.; Adam, Aishah; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Fac Pharm, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Kashif, Syed Muhammad; Jamil, Waqas] Univ Sindh, Inst Adv Res Studies Chem Sci, Jamshoro 76080, Pakistan; [Sidiqqui, Salman; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan published Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones in 2019.0, Cited 45.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones have been synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involves a 3-step reaction in which a pyridine diamine was being converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target molecules after treating them with the appropriate benzohydrazone derivatives. The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound 25 (140.16 +/- 0.36 mu M) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. (C) 2015 The Authors. Published by Elsevier B.V.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Taha, M; Alkadi, KAA; Ismail, NH; Imran, S; Adam, A; Kashif, SM; Shah, SAA; Jamil, W; Sidiqqui, S; Khan, KM or concate me.. SDS of cas: 93-02-7

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An article Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)-O Bonds Enabled by Chromium Catalysis WOS:000529959000001 published article about CARBON-HETEROATOM BONDS; GRIGNARD-REAGENTS; AROMATIC KETONES; ARYL HALIDES; NI; ETHERS; ACTIVATION; CLEAVAGE; EXPLORATION; ANISOLES in [Tang, Jinghua; Yang, Shangru; Cong, Xuefeng; Luo, Meiming; Zeng, Xiaoming] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China; [Liu, Liu Leo] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA in 2020.0, Cited 60.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

We report here the first example of cross-coupling between two different and unactivated C(aryl)-O bonds with chromium catalysis. The combination of a low-cost Cr(II) salt, 4,4′-di-tart-butyl-2,2′-dipyridyl (dtbpy) as the ligand, and magnesium as the reductant shows high reactivity in promoting the reductive cross-coupling of aryl methyl ether derivatives with aryl esters by cleavage and coupling of two different C(aryl)-O bonds under mild conditions. The formation of active low-valent Cr species by reduction of CrCl2 with Mg can be considered, which prefers to initially activate the C(aryl)-O bond of phenyl methyl ether with the chelation help of dtbpy and an o-imine auxiliary. The subsequent consecutive reduction, second C(aryl)-O activation, and reductive elimination allow for the achievement of selective cross-coupling of C(aryl)-O/C(aryl)-O bonds.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Tang, JH; Liu, LL; Yang, SR; Cong, XF; Luo, MM; Zeng, XM or concate me.

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Authors Golla, R; Kumar, PR; Suchethan, PA; Foro, S; Nagaraju, G in ELSEVIER published article about SUPRAMOLECULAR INTERACTIONS; RUTHENIUM(II) COMPLEXES; REVERSIBLE REDOX; METAL-COMPLEXES; TERPYRIDINE; LIGAND; HETEROCYCLES in [Golla, Ramesh; Kumar, P. Raghavendra; Suchethan, P. A.] Tumkur Univ, Univ Coll Sci, Dept Studies & Res Chem, Tumakuru 572103, Karnataka, India; [Foro, Sabine] Tech Univ Darmstadt, Inst Mat Sci, Petersenstr 23, D-64287 Darmstadt, Germany; [Nagaraju, G.] Siddaganga Inst Technol, Dept Chem, Tumakuru 572103, Karnataka, India in 2020.0, Cited 55.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Four new 4′-dimethoxyphenyl-(2,6-di-2-pyrazinyl) pyridines (1-4) were synthesised by a facile one-pot method using 2-acetylpyrazine and n,n’-dimethoxybanzaldehydes. All compounds (1-4) were characterised by H-1 and C-13{H-1} NMR, and FT-IR spectroscopy. The molecular structure of compounds 1, 2, and 3 was also confirmed by single crystal X-ray diffraction. There exists CH center dot center dot center dot N, CH center dot center dot center dot O and C center dot center dot center dot C aromatic stacking type of intermolecular secondary interactions which resulted into supramolecular structures in compounds 1-3. The Hirshfeld surface analysis was carried out for the confirmation of intermolecular secondary interactions. The dihedral angles between substituted dimethoxyphenyl ring (B) and central pyridine (A) and pyrazine rings (C and D) are in the range of 33-45 degrees. The photophysical properties were studied by UV-Visible and fluorescence spectroscopy and electrochemical properties by cyclic voltammetry. In the UV-Visible spectra, the compounds, 1-4 showed two strong bands at lambda(max), 236-238 and 284-293 nm attributed to the intramolecular charge transfer (pi-pi*) transitions. When these compounds were excited at 350 nm observed emission bands at lambda(em), 463, 511, 462, and 407 nm respectively. The compounds, 1-3 were showed an oxidation peak, (E-OX, 1.18, 1.57 and 1.25 V) but compound 4 showed two oxidation peaks (E-OX, 1.20 and 1.84 V). Astonishingly, only compound, 3 have shown a reduction peak at (E-red, 1.33 V) but there was no reduction peak in 1, 2 and 4. This shows that the compound, 3 undergo reversible redox reaction. (C) 2019 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Golla, R; Kumar, PR; Suchethan, PA; Foro, S; Nagaraju, G or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

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Formula: C9H10O3. Authors Przhevalskii, NM; Laypanov, RK; Tokmakov, GP; Lukina, IV; Vershinkin, DA; Tafeenko, VA in SPRINGER published article about in [Przhevalskii, N. M.; Laypanov, R. K.; Tokmakov, G. P.; Lukina, I., V; Vershinkin, D. A.] Russian State Agr Univ, Moscow Timiryazev Agr Acad, 49 Ul Timiryazevskaya, Moscow 127434, Russia; [Tafeenko, V. A.] Lomonosov Moscow State Univ, Dept Chem, Build 3,1 Leninskie Gory, Moscow 119992, Russia in 2021.0, Cited 24.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

New pyranopyridonotryptamines 3 were synthesized by a three-component reaction of pyridonotryptamines 1, aromatic aldehydes 2, and malononitrile. The structures of compounds 3 were confirmed by X-ray crystallography. A series of compounds 3 underwent primary screening for the effect on the course of mitosis in seeds of plants of the species Allium cepa L.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Przhevalskii, NM; Laypanov, RK; Tokmakov, GP; Lukina, IV; Vershinkin, DA; Tafeenko, VA or concate me.. Formula: C9H10O3

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Teja, C; Khan, FRN in [Teja, Chitrala; Khan, Fazlur Rahman Nawaz] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India published Tetrabutylammonium-Bromide-Promoted Synthesis of Spirooxindoles through Alkyne-Aldehyde C-C Coupling and 1,3-Dipolar Cycloaddition Using Ytterbium Triflate Catalyst in 2020.0, Cited 37.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Teja, C; Khan, FRN or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

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I found the field of Chemistry very interesting. Saw the article Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction published in 2021.0. Category: isothiazole, Reprint Addresses Kadu, VD (corresponding author), Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ or concate me.

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COA of Formula: C9H10O3. In 2020.0 BIOORG CHEM published article about CELL-GROWTH INHIBITORS; CYCLOOXYGENASE-2 INHIBITORS; BIOLOGICAL EVALUATION; ALPHA; CONSEQUENCES; METABOLISM; ANALOGS in [Abdel-Halim, Mohammad; Weam, Mohammed; Atta, Noha H.; Hammam, Mennatallah A.; Hefnawy, Amr; Abadi, Ashraf H.] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Chem, Cairo 11835, Egypt; [Tinsley, Heather] Univ Montevallo, Dept Biol, Montevallo, AL USA; [Keeton, Adam B.; Piazza, Gary A.] Univ S Alabama, Mitchell Canc Inst, Dept Pharmacol, Drug Discovery Res Ctr, Mobile, AL 36608 USA; [Hartmann, Rolf W.; Engel, Matthias] Saarland Univ, Pharmaceut & Med Chem, Campus C2-3, D-66123 Saarbrucken, Germany in 2020.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Celecoxib, is a selective cyclooxygenase-2 (COX2) inhibitor with a 1,5-diaryl pyrazole scaffold. Celecoxib has a better safety profile compared to other COX2 inhibitors having side effects of systemic hypertension and thromboembolic complications. This may be partly attributed to an off-target activity involving phosphodiesterase 5 (PDE5) inhibition and the potentiation of NO/cGMP signalling allowing coronary vasodilation and aortic relaxation. Inspired by the structure of celecoxib, we synthesized a chemically diverse series of compounds containing a 1,3,5-trisubstituted pyrazoline scaffold to improve PDE5 inhibitory potency, while eliminating COX2 inhibitory activity. SAR studies for PDE5 inhibition revealed an essential role for a carboxylic acid functionality at the 1-phenyl and the importance of the non-planar pyrazoline core over the planar pyrazole with the 5-phenyl moiety tolerating a range of substituents. These modifications led to new PDE5 inhibitors with approximately 20-fold improved potency to inhibit PDE5 and no COX-2 inhibitory activity compared with celecoxib. PDE isozyme profiling of compound 11 revealed a favorable selectivity profile. These results suggest that trisubstituted pyrazolines provide a promising scaffold for further chemical optimization to identify novel PDE5 inhibitors with potential for less side effects compared with available PDE5 inhibitors used for the treatment of penile erectile dysfunction and pulmonary hypertension.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abdel-Halim, M; Tinsley, H; Keeton, AB; Weam, M; Atta, NH; Hammam, MA; Hefnawy, A; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH or concate me.. COA of Formula: C9H10O3

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about ACETYLSALICYLIC-ACID; ABSORPTION-SPECTROMETRY; PROTEIN-BINDING; MOLECULAR ABSORPTION; METAL-COMPLEXES; CHEMISTRY; EFFICACY; IMPACT; DRUGS; CELLS, Saw an article supported by the Tiroler Wissenschaftsfonds (TWF) [GZ: UNI-0404/1982]. Application In Synthesis of 2,6-Difluorobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Baecker, D; Obermoser, V; Kirchner, EA; Hupfauf, A; Kircher, B; Gust, R. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2). Since COX-2 participates in carcinogenesis, a selective inhibition of that isoenzyme is aimed. To study if fluorination increases the COX-2/COX-1 inhibition ratio of the lead, substitution was respectively performed in the positions 3, 4, 5, and 6 of the aromatic moiety. The complexes 3/4/5F-Co-ASS and to a much lower extent also 6F-Co-ASS showed cytotoxic, antimetabolic, and apoptotic effects in COX-1/2-positive HT-29 and MDA-MB-231 cells and remarkably less activity in the COX-1/2-negative MCF-7 cell line. The metabolic activity in MCF-7 cells was even unaffected up to a concentration of 40 mu M. With exception of 6F-Co-ASS, the complexes strongly reduced the PGE(2) synthesis in HT-29 cells and all complexes inhibited COX-2 more effectively than COX-1 in an assay at isolated enzymes. These findings point to an interference in the COX cascade as part of the mode of antitumor action. The limited cellular effects of 6F-Co-ASS are related to its poor uptake as determined by HR CS AAS/MAS. Moreover, the cellular uptake studies confirm fluorination as beneficial tool for bioanalytical labeling. The higher quantification of fluorine by HR CS MAS makes this method about 5-fold more sensitive than HR CS AAS measuring cobalt. As a further positive result, 3/4/5/6-Co-ASS demonstrated high selectivity to tumor cells due to lack of antimetabolic activity against the non-tumorigenic bone marrow stromal cell line HS-5.

Application In Synthesis of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Baecker, D; Obermoser, V; Kirchner, EA; Hupfauf, A; Kircher, B; Gust, R or concate me.

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Isothiazole – Wikipedia,
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An article An Atom-Economic Efficient Synthesis of 1-Amidoalkyl-2-Naphthols Mediated By Hexachlorocyclotriphosphazene (HCCP) as a Novel Catalyst WOS:000483301600008 published article about ONE-POT PREPARATION; REUSABLE CATALYST; RECYCLABLE NANOCATALYST; CHEMISTRY; ACID in [Singh, Rajesh K.; Chaudhary, Shallu; Prasad, D. N.] Shivalik Coll Pharm, Dept Pharmaceut Chem, Nangal 140126, Punjab, India; [Kumar, Sahil] GD Goenka Univ, Sch Med & Allied Sci, Dept Pharm, Sohna 122103, Haryana, India in 2019.0, Cited 25.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

A multicomponent one-pot atom-economic reaction is performed for an efficient synthesis of 1-amidoalkyl-2-naphthol from aromatic aldehydes, beta-naphthol and amide/urea promoted by hexachlorocyclotriphosphazene (HCCP). Various techniques such as stirring, microwave irradiation and thermal technique (hot plate and oil bath) were used in different solvents for the synthesis of 1-amidoalkyl-2-naphthol derivatives with moderate to excellent yield. Among the four methods, microwave irradiation and oil bath heating provide high yield as compared to the hot plate heating and stirring method. The low yield may be due to the formation of undesired side-products due to non-uniform heating.

Computed Properties of C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Singh, RK; Chaudhary, S; Prasad, DN; Kumar, S or concate me.

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An article New Seco-DSP derivatives as potent chemosensitizers WOS:000573916100010 published article about MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; CANCER; REVERSAL; MODULATORS; MECHANISMS; AGENTS; CELLS in [Wan, Qi; Guo, Yalan; Yu, Zhihui; Guo, Shiqi; Chen, Ying] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai, Peoples R China; [Jin, Xin; Liu, Hongrui] Fudan Univ, Sch Pharm, Dept Pharmacol & Biochem, Shanghai, Peoples R China; [Morris-Natschke, Susan; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan in 2020, Cited 21. Recommanded Product: 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Thirty-four seco-3’R,4’R-disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (seco-DSP) derivatives were designed, synthesized and evaluated for chemo-reversal activity when combined with paclitaxel or vincristine in P-gp overexpressing A2780/T and KB-VIN drug-resistant cancer cell lines. Most of the compounds displayed moderate to significant MDR reversal activities. Compound 7e showed the most potent chemo-sensitization activity with more than 1471 reversal ratio at a concentration of 10 mu M, which was higher than verapamil (VRP) (212-fold). Unexpectedly the newly synthesized compounds did not show chemosensitization activities in a non-P-gp overexpressing cisplatin resistant human ovarian cancer cell line (A2780/CDDP), implying that the MDR reversal effects might be associated with P-gp overexpression. Moreover, the compounds did not exhibit significant anti-proliferative activities against non-tumorigenic cell lines (HUVEC, HOSEC and T29) compared to VRP at the tested concentration and might be safer than VRP. In preliminary pharmacological mechanism studies, the compounds increased accumulation of DOX and promoted P-gp ATPase activity in A2780/T cell lines. Western blot analysis indicated they did not affect the expression level of P-gp in the tested MDR cell lines. Thus, further studies on these seco-DSP derivatives are merited with the goal of developing a desirable chemosensitizer drug candidate. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Wan, Q; Jin, X; Guo, YL; Yu, ZH; Guo, SQ; Morris-Natschke, S; Lee, KH; Liu, HR; Chen, Y or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com