Tag: M.W=150-200

Name: 2,6-Difluorobenzoic acid. In 2020 BIOORGAN MED CHEM published article about BRAF MUTATIONS; SIGNALING PATHWAY; RAF KINASE; MULTIKINASE INHIBITOR; MAPK PATHWAY; MELANOMA; MUTANT; SENSITIVITY; ACTIVATION; SORAFENIB in [Abdel-Maksoud, Mohammed S.] Natl Res Ctr NRC ID 60014618, Pharmaceut & Drug Ind Res Div, Med & Pharmaceut Chem Dept, Giza 12622, Egypt; [Ali, Eslam M. H.; Ammar, Usama M.; Mersal, Karim I.; Oh, Chang-Hyun] KIST Sch, Korea Inst Sci & Technol, Ctr Biomat, Seoul 02792, South Korea; [Ali, Eslam M. H.; Ammar, Usama M.; Mersal, Karim I.; Oh, Chang-Hyun] Univ Sci & Technol UST, Daejeon 34113, South Korea; [Ali, Eslam M. H.] Modern Univ Technol & Informat MTI, Pharmaceut Chem Dept, Fac Pharm, Cairo 12055, Egypt; [Ammar, Usama M.] Ahram Canadian Univ, Pharmaceut Chem Dept, Fac Pharm, Giza 12566, Egypt; [Yoo, Kyung Ho] Korea Inst Sci & Technol, Chem Kinom Res Ctr, Seoul, South Korea in 2020, Cited 37. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved B-V600E-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent B-V600E-RAF inhibitors. The 38 synthesized compounds were biologically evaluated for their B-V600E-RAF inhibitory effect at single dose (10 mu M). Compounds with high percent inhibition were tested to determine their IC50 over (V600E)BRAF. Compounds 34e and 35 showed the highest inhibitory effect with IC50 values of 0.085 mu M and 0.080 mu M, respectively. Headed for excessive biological evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35 emerged as a potent cytotoxic agent against different panel of human cancer cell lines.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Abdel-Maksoud, MS; Ali, EMH; Ammar, UM; Mersal, KI; Yoo, KH; Oh, CH or concate me.. Name: 2,6-Difluorobenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 93-02-7. In 2020.0 POLYCYCL AROMAT COMP published article about HIGHLY EFFICIENT; ANTIBACTERIAL ACTIVITY; 3-COMPONENT SYNTHESIS; BIOLOGICAL-ACTIVITY; INHIBITORS; CATALYST; DYES; HETEROCYCLES; RESISTANCE; ZALEPLON in [Krishnammagari, Suresh Kumar; Jeong, Yeon Tae] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea in 2020.0, Cited 52.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

An efficient and concise practical protocol for the synthesis of novel aza-fused polysubstituted pyrido[2 ‘,3 ‘:3,4]pyrazolo[1,5-a]pyrimidine derivatives from a readily available aromatic aldehyde, acetophenone and 1H-pyrazolo[3,4-b]pyridin-3-amine in presence of Ba(OH)(2), under transition metal-free conditions, has been established. This transformation presumably occurs through a sequential Aldol reaction, imine-formation, intramolecularN-cyclization, auto-oxidation sequence of reactions. This protocol, which includes the formation of new C-C and C-N bonds, features a wide substrate scope with a broad range of functional group tolerance.

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Krishnammagari, SK; Jeong, YT or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020 EUR J MED CHEM published article about MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; CANCER; REVERSAL; MODULATORS; MECHANISMS; AGENTS; CELLS in [Wan, Qi; Guo, Yalan; Yu, Zhihui; Guo, Shiqi; Chen, Ying] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai, Peoples R China; [Jin, Xin; Liu, Hongrui] Fudan Univ, Sch Pharm, Dept Pharmacol & Biochem, Shanghai, Peoples R China; [Morris-Natschke, Susan; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan in 2020, Cited 21. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Quality Control of 2,6-Difluorobenzoic acid

Thirty-four seco-3’R,4’R-disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (seco-DSP) derivatives were designed, synthesized and evaluated for chemo-reversal activity when combined with paclitaxel or vincristine in P-gp overexpressing A2780/T and KB-VIN drug-resistant cancer cell lines. Most of the compounds displayed moderate to significant MDR reversal activities. Compound 7e showed the most potent chemo-sensitization activity with more than 1471 reversal ratio at a concentration of 10 mu M, which was higher than verapamil (VRP) (212-fold). Unexpectedly the newly synthesized compounds did not show chemosensitization activities in a non-P-gp overexpressing cisplatin resistant human ovarian cancer cell line (A2780/CDDP), implying that the MDR reversal effects might be associated with P-gp overexpression. Moreover, the compounds did not exhibit significant anti-proliferative activities against non-tumorigenic cell lines (HUVEC, HOSEC and T29) compared to VRP at the tested concentration and might be safer than VRP. In preliminary pharmacological mechanism studies, the compounds increased accumulation of DOX and promoted P-gp ATPase activity in A2780/T cell lines. Western blot analysis indicated they did not affect the expression level of P-gp in the tested MDR cell lines. Thus, further studies on these seco-DSP derivatives are merited with the goal of developing a desirable chemosensitizer drug candidate. (C) 2020 Elsevier Masson SAS. All rights reserved.

Quality Control of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Wan, Q; Jin, X; Guo, YL; Yu, ZH; Guo, SQ; Morris-Natschke, S; Lee, KH; Liu, HR; Chen, Y or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 385-00-2. Authors Wang, R; Liu, H; You, YY; Wang, XY; Lv, BB; Cao, LQ; Xue, JY; Xu, YG; Shi, L in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Wang, Ru; Liu, Hu; You, Yuan-Yuan; Wang, Xin-Yu; Lv, Bing-Bing; Cao, Li-Qin; Xu, Yun-Gen; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China; [Xue, Jia-Yu] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Jiangsu Prov Key Lab Plant Ex Situ Conservat, Nanjing 210014, Peoples R China in 2021, Cited 29. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

VEGF/VEGFR-2 signaling plays a critical part in tumor angiogenesis. Inhibition of this pathway has been considered as a promising approach for cancer treatment. In this work, a series of 6,7-dimethoxy-4-anilinoquinazoline derivatives bearing diarylamide moiety were designed, synthesized and evaluated as potent inhibitors of VEGFR-2 kinase. Their in vitro antiproliferation activities against two human cancer cell lines Hep-G2 and MCF-7 have also been determined. Among them, compound 14b exhibited the most potent inhibitory activity against VEGFR-2 with IC50 value of 0.016 +/- 0.002 mu M and it showed the most potent antiproliferative effect against Hep-G2 and MCF-7 with IC50 values at low-micromolar range. Molecular docking studies revealed that these compounds represented by the most potent compound 14b could bind well to the ATP-binding site of VEGFR-2, which suggested that compound 14b could be a potential anticancer agent targeting VEGFR-2.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Wang, R; Liu, H; You, YY; Wang, XY; Lv, BB; Cao, LQ; Xue, JY; Xu, YG; Shi, L or concate me.. Product Details of 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Suresh, M; Kumari, A; Singh, RB in PERGAMON-ELSEVIER SCIENCE LTD published article about CATALYZED OXIDATIVE CLEAVAGE; ONE-POT SYNTHESIS; CONJUGATE ADDITION; CARBONYL-COMPOUNDS; CHLOROPERBENZOIC ACID; MICHAEL ADDITION; SODIUM-CHLORITE; CLEAN SYNTHESIS; ALKENES; EPOXIDATION in [Suresh, Muthiah; Kumari, Anusueya; Singh, Raj Bahadur] Cent Univ Jharkhand, Dept Chem, Ranchi 835205, Bihar, India in 2019.0, Cited 82.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A transition metal free expedient approach for the C=C bond cleavage of electron deficient alkenes such as arylidene Meldrum’s acid and malononitrile derivatives are discussed. The C=C bond of these compound were cleaved to benzoic acid in good yield at high temperature. Most importantly, with oxone in CH3CN/H2O at 45 degrees C or m-CPBA in DCM or NaClO2 in THE/H2O or PIDA in THE at room temperature furnished benzaldehyde derivatives selectively in excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Suresh, M; Kumari, A; Singh, RB or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article An Efficient and Transition Metal-Free Base-Promoted Multi-Component Synthesis of Aza-Fused Polysubstituted Pyrido[2 ‘,3 ‘:3,4]Pyrazolo[1,5-a]Pyrimidine Derivatives WOS:000561108100015 published article about HIGHLY EFFICIENT; ANTIBACTERIAL ACTIVITY; 3-COMPONENT SYNTHESIS; BIOLOGICAL-ACTIVITY; INHIBITORS; CATALYST; DYES; HETEROCYCLES; RESISTANCE; ZALEPLON in [Krishnammagari, Suresh Kumar; Jeong, Yeon Tae] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea in 2020.0, Cited 52.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

An efficient and concise practical protocol for the synthesis of novel aza-fused polysubstituted pyrido[2 ‘,3 ‘:3,4]pyrazolo[1,5-a]pyrimidine derivatives from a readily available aromatic aldehyde, acetophenone and 1H-pyrazolo[3,4-b]pyridin-3-amine in presence of Ba(OH)(2), under transition metal-free conditions, has been established. This transformation presumably occurs through a sequential Aldol reaction, imine-formation, intramolecularN-cyclization, auto-oxidation sequence of reactions. This protocol, which includes the formation of new C-C and C-N bonds, features a wide substrate scope with a broad range of functional group tolerance.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Krishnammagari, SK; Jeong, YT or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 385-00-2. In 2019 INORG CHEM published article about METAL-ORGANIC-FRAMEWORK; ENERGY MIGRATION; UIO-66; MODULATOR; DESIGN; AREAS in [Morris, Amanda J.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA; Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USA in 2019, Cited 44. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

The reaction of zirconium salts with meso-tetra(4-carboxyphenyl)porphyrin (TCPP) in the presence of different modulators results in the formation of a diverse set of metal-organic frameworks (MOFs), each displaying distinct crystalline topologies. However, the synthesis of phase-pure crystalline frameworks remains challenging due to the concurrent formation of different polymorphs. The acidity and concentration of the modulator greatly influence the outcome of the MOF synthesis. By systematically varying these two parameters, selective framework formation can be achieved. In the present study, we aimed to elucidate the effect of modulator on the synthesis of zirconium-based TCPP MOFs. With the help of powder X-ray diffraction and scanning electron microscopy, modulator candidates and the optimal synthetic conditions yielding phase-pure PCN-222, PCN-223, and MOF-525 were identified. H-1 nuclear magnetic resonance analysis, thermogravimetric analysis, and N-2 gas sorption measurements were performed on select MOFs to gain insight into the relationship between their defectivity and modulator properties.

Product Details of 385-00-2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Shaikh, SM; Usov, PM; Zhu, J; Cai, M; Alatis, J; Morris, AJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 93-02-7. I found the field of Chemistry very interesting. Saw the article Efficient Microwave-Assisted Synthesis, In Vitro Antimicrobial Evaluation of Furo[3,2-c]pyrones and Furo[3,2-c]coumarins along with Molecular Docking Studies published in 2020.0, Reprint Addresses Kumar, D (corresponding author), Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

A series of furo[3,2-c]pyrones and furo[3,2-c]coumarins agents were efficiently synthesized and structure recognizable proof was performed by FTIR and NMR. The furo[3,2-c]pyrones and furo[3,2-c]coumarins were evaluated against three bacterial strains (Bacillus subtilis, Staphylococcus aureus and Escherichia coli) and two parasitic strains (Aspergillus niger and Candida albicans). The antimicrobial results demonstrated that a couple of compounds showed noteworthy outcomes relating to the standard medications. Compounds 6 b and 9 f indicated great action against Escherichia coli and Bacillus subtilis with MIC value 0.0108 mu mol/ml and 0.0120 mu mol/ml, respectively. Compound 9 f also showed better activity against fungal strains with MIC value 0.0120 mu mol/ml. Based on the outcomes of antimicrobial activities, docking study was performed to know the binding interface of furo[3,2-c]pyrones and furo[3,2-c]coumarins with DNA gyrase topoisomerase II.

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rani, S; Kamra, N; Kumar, D; Kumar, A or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Vasava, MS; Bhoi, MN; Rathwa, SK; Shetty, SS; Patel, RD; Rajani, DP; Rajani, SD; Patel, A; Pandya, HA; Patel, HD in ELSEVIER SCIENCE BV published article about ONE-POT SYNTHESIS; CARRIER PROTEIN REDUCTASE; MULTICOMPONENT SYNTHESIS; GREEN SYNTHESIS; EFFICIENT; ANTIBACTERIAL; CATALYST; FACILE; VITRO; ACID in [Vasava, Mahesh S.; Rathwa, Sanjay K.; Patel, Hitesh D.] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad, Gujarat, India; [Bhoi, Manoj N.] Piramal Enterprise Ltd, Plot 18, Ahmadabad, Gujarat, India; [Shetty, Shilpa S.; Patel, Rikin D.; Pandya, Himanshu A.] Gujarat Univ, Sch Sci, Dept Bot Bioinformat & Climate Change Impacts Man, Ahmadabad, Gujarat, India; [Rajani, Dhanji P.; Rajani, Smita D.] Microcare Lab, Surat, Gujarat, India; [Rajani, Dhanji P.; Rajani, Smita D.] TB Res Ctr, Surat, Gujarat, India; [Patel, Alpesh] Genxplore Diagnost & Res Ctr Pvt Ltd, Ahmadabad, Gujarat, India in 2019.0, Cited 66.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

In the present study, a series of novel and biologically potent 6-amino-1-(2,4-dinitrophenyl)-4-phenyl-1,4-dihydropyrano [2,3-clpyrazole-5-carbonitrile derivatives (5a-5u) have been synthesized through multicomponent reaction between various substituted aromatic aldehyde derivative (4a-4u), 2, 4-dinitrophenyl hydrazine (1), ethyl acetoacetate (2) and malononitrile (3) in the presence of SnCl 2 as a prompt catalyst using both microwave irradiation method as well as conventional method. The structure of synthesized compounds were confirmed by various spectroscopic methods such as H-1 NMR, C-13 NMR, IR, Mass analysis and elemental analysis. All the synthesized compounds were subjected in vitro antibacterial, anti-tuberculosis screening and cytotoxicity MTT assay. In vitro biological study revealed that the synthesized compound 5a, 7a and 8a are showing good anti-bacterial and anti-tuberculosis activity. The in silico study of ADME pharmacokinetic properties were also predicted for synthesized compounds for checking their bioavailability. Furthermore, molecular docking study of synthesized compounds with enoyl-ACP reductase (oxidoreductase) was carry out to find out the binding affinity of compounds. Docking study demonstrated that compound 7b and 7a possessed superior binding affinity with target enzyme by strong hydrogen bonding. We have also carried out molecular dynamics simulation to check the stability of docked complex, conformational changes and primary molecular interaction. (C) 2018 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Vasava, MS; Bhoi, MN; Rathwa, SK; Shetty, SS; Patel, RD; Rajani, DP; Rajani, SD; Patel, A; Pandya, HA; Patel, HD or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

COA of Formula: C7H4F2O2. Recently I am researching about BENZOTRIAZOLE RING; FACILE SYNTHESIS; CLEAVAGE; BENZOTHIAZOLES; AMIDES; CONVERSION; PROTOCOL, Saw an article supported by the Science and Engineering Research Board (SERB), New Delhi [EMR/2016/001123]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Singh, M; Singh, AS; Mishra, N; Agrahari, AK; Tiwari, VK. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

N-Acylbenzotriazoles are achieved in good yields from the corresponding carboxylic acids by using only 0.35 equivalent of trichloroisocyanuric acid and 1.2 equivalents of PPh3. The salient features of the developed reaction path include an economic, facile, base-free, and equally useful method in milligram to gram scale.

COA of Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Singh, M; Singh, AS; Mishra, N; Agrahari, AK; Tiwari, VK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com