Tag: M.W=150-200

An article Methoxychalcones: Effect of Methoxyl Group on the Antifungal Antibacterial and Antiproliferative Activities WOS:000589443500004 published article about CHALCONE DERIVATIVES; BIOLOGICAL-ACTIVITIES; MOLECULAR-PROPERTIES; LICOCHALCONE; PREDICTION; DISCOVERY; GROWTH; SERIES; AGENTS in [Marques, Beatriz C.; Santos, Mariana B.; Anselmo, Daiane B.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Monteiro, Diego A.; Gomes, Eleni; Saiki, Marilia F. C.; Rahal, Paula] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Rosalen, Pedro L.; Sardi, Janaina C. O.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13083970 Piracicaba, SP, Brazil in 2020.0, Cited 43.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Background: Chalcones substituted by methoxyl groups have presented a broad spectrum of bioactivities, including antifungal, antibacterial and antiproliferative effects. However, a clear and unambiguous investigation about the relevance of this substituent on the chalcone framework has not been described. Objective: The purpose of this work is to assess the antibacterial, antifungal and antiproliferative activities of the two series of seventeen synthesized regioisomeric methoxychalcones. Series I and II were constituted by cbalcones substituted by methoxyl groups on rings A (5-12) and B (13-21), respectively. In addition, the library of methoxychalcones was submitted to in silico drug-likeness and pharmacokinetics properties predictions. Methods: Methoxychalcones were synthesized and their structures were confirmed by NMR spectral data analyses. Evaluations of antimicrobial activity were performed against five species of Candida, two Gram-negative and five Gram-positive species. For antiproliferative activity, methoxychalcones were evaluated against four human tumorigenic cell lines, as well as human non-tumorigenic keratinocytes. Drug-likeness and pharmacokinetics properties were predicted using Molinspiration and PreADMET toolkits. Results: In general, chalcones of series I are the most potent antifungal, antibacterial and antiproliferative agents. 3′, 4′, 5′-Trimethoxychalcone (12) demonstrated potent antifungal activity against Candida krusei (MIC = 3.9 mu g/mL), eight times more potent than fluconazole (reference antifungal drug). 3′-Methoxychalcone (6) displayed anti-Pseudomonas activity (MIC = 7.8 mu g/mL). 2′,5′-Dimethoxychalcone (9) displayed potent antiproliferative effect against C-33A (cervix), A-431 (skin) and MCF-7 (breast), with IC50 values ranging from 7.7 to 9.2 mu M. Its potency was superior to curcumin (reference antiproliferative compound), which exhibited IC50 values ranging from 10.4 to 19.0 mu M. Conclusion: Our studies corroborated the relevance of methoxychalcones as antifungal, antibacterial and antiproliferative agents. In addition, we elucidated influence of the position and number of methoxyl groups toward bioactivity. In silico predictions indicated good drug-likeness and pharmacokinetics properties to the library of methoxychalcones.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Marques, BC; Santos, MB; Anselmo, DB; Monteiro, DA; Gomes, E; Saiki, MFC; Rahal, P; Rosalen, PL; Sardi, JCO; Regasini, LO or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

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Recently I am researching about PHARMACOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; DERIVATIVES; INDAZOLE; 1,3,4-OXADIAZOLE; ANTIBACTERIAL; BEARING, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Raut, S; Hadi, A; Pathan, MA. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid. Category: isothiazole

This study presents an efficient synthesis of 3-[6-(substituted-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-3-yl]-1H-indazole via dehydrative condensation with cyclization of 4-amino-5-(1H-indazol-3-yl)-4H-[1,2,4]triazole-3-thiol and fluorinated or nonfluorinated carboxylic acids in presence of phosphorous oxychloride. The multistep reaction pathway proceeds through different compounds. Present synthesis has the advantages of easily accessible starting materials, convenient synthesis, simple reaction condition, wider substrate scope, and higher yield (75% to 90% isolated).

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Raut, S; Hadi, A; Pathan, MA or concate me.. Category: isothiazole

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Computed Properties of C9H10O3. I found the field of Chemistry very interesting. Saw the article Asymmetric Synthesis of 3,3 ‘-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators published in 2020.0, Reprint Addresses Kumar, K (corresponding author), Max Planck Inst Mol Physiol, Abt Chem Biol, Otto Hahn Str 11, D-44227 Dortmund, Germany.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

An enantioselective hetero-Diels-Alder reaction of alkylidene- oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes withN,N ‘-dioxide ligands offered an efficient access to natural-product-based 3,3 ‘-piperidinoyl spiroox-indole class of small molecules.exo-Cycloadducts formed via stereospecific cycloaddition withZ-olefin displayed potent activity in modulation of hedgehog pathway.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rehan, M; Flegel, J; Heitkamp, F; Pergomet, JL; Otte, F; Strohmann, C; Kumar, K or concate me.. Computed Properties of C9H10O3

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Formula: C9H10O3. I found the field of Chemistry very interesting. Saw the article Tetrabutylammonium-Bromide-Promoted Synthesis of Spirooxindoles through Alkyne-Aldehyde C-C Coupling and 1,3-Dipolar Cycloaddition Using Ytterbium Triflate Catalyst published in 2020.0, Reprint Addresses Khan, FRN (corresponding author), Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Teja, C; Khan, FRN or concate me.

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Authors Hatley, RJD; Barrett, TN; Slack, RJ; Watson, ME; Baillache, DJ; Gruszka, A; Washio, Y; Rowedder, JE; Pogany, P; Pal, S; Macdonald, SJF in WILEY-V C H VERLAG GMBH published article about ALPHA-5-BETA-1 INTEGRIN; PULMONARY-FIBROSIS; RECEPTOR; INTEGRIN-ALPHA-V-BETA-6; ALPHA(V)BETA(3); DERIVATIVES; BIPHENYLS; DISCOVERY; BILIARY in [Hatley, Richard J. D.; Barrett, Tim N.; Slack, Robert J.; Watson, Morag E.; Baillache, Daniel J.; Gruszka, Anna; Washio, Yoshiaki; Rowedder, James E.; Pogany, Peter; Pal, Sandeep; Macdonald, Simon J. F.] GlaxoSmithKline GSK, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England in 2019, Cited 39. Product Details of 385-00-2. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

Up to 45 % of deaths in developed nations can be attributed to chronic fibroproliferative diseases, highlighting the need for effective therapies. The RGD (Arg-Gly-Asp) integrin alpha v beta 1 was recently investigated for its role in fibrotic disease, and thus warrants therapeutic targeting. Herein we describe the identification of non-RGD hit small-molecule alpha v beta 1 inhibitors. We show that alpha v beta 1 activity is embedded in a range of published alpha 4 beta 1 (VLA-4) ligands; we also demonstrate how a non-RGD integrin inhibitor (of alpha 4 beta 1 in this case) was converted into a potent non-zwitterionic RGD integrin inhibitor (of alpha v beta 1 in this case). We designed urea ligands with excellent selectivity over alpha 4 beta 1 and the other alpha v integrins (alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha v beta 8). In silico docking models and density functional theory (DFT) calculations aided the discovery of the lead urea series.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Hatley, RJD; Barrett, TN; Slack, RJ; Watson, ME; Baillache, DJ; Gruszka, A; Washio, Y; Rowedder, JE; Pogany, P; Pal, S; Macdonald, SJF or concate me.. Product Details of 385-00-2

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Isothiazole – Wikipedia,
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Doi, R; Hayashi, K; Sato, Y in [Doi, Ryohei; Hayashi, Kanako; Sato, Yoshihiro] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan published Palladium-catalyzed Decarboxylative alpha-Polyfluoroarylation of Ketones in 2021, Cited 33. Quality Control of 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

Herein, we report palladium-catalyzed decarboxylative alpha-polyfluoroarylation of ketones. As a result of reaction condition screening, XPhos and Ruphos were selected as ancillary ligands for Pd(0) catalysts. The reaction was applied to a variety of substrates. A cross-over experiment was conducted to gain insight into the reaction mechanism.

Quality Control of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Doi, R; Hayashi, K; Sato, Y or concate me.

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Isothiazole – Wikipedia,
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Computed Properties of C7H4F2O2. Yang, S; Lai, QQ; Lai, FW; Jiang, XY; Zhao, C; Xu, HH in [Zhao, Chen; Xu, Hanhong] South China Agr Univ, Minist Educ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Peoples R China; [Zhao, Chen; Xu, Hanhong] South China Agr Univ, Minist Educ, Key Lab Nat Pesticide & Chem Biol, Guangzhou 510642, Peoples R China published Design, synthesis, and insecticidal activities of novel 5-substituted 4,5-dihydropyrazolo[1,5-a]quinazoline derivatives in 2021, Cited 40. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

BACKGROUND: Chemical pesticides are the main measures for pest control, but have caused growing resistance of pests and brought a series of environmental problems. Development of high-efficient insecticidal molecules with novel scaffolds is therefore particularly urgent. RESULTS: Based on a [5 + 1] annulation reaction with 5-amino-1H-phenylpyrazole and dialkyl bromomalonate, 27 novel five-substituted 4,5-dihydropyrazolo[1,5-a]quinazolines were designed following the intermediate derivatization method and synthesized. Bioassay results indicated that most of the test compounds displayed good insecticidal activities against Plutella xylostella, Spodoptera frugiperda, and Solenopsis invicta. In particular, the insecticidal activities of compounds 4a, 4f, and 4m against P. xylostella [median lethal concentration (LC50) values ranged from 3.87 to 5.10 mg L-1] were comparable to that of indoxacarb (LC50 = 4.82 mg L-1). In addition, compounds 4a and 9e showed similar high insecticidal activities against Spodoptera frugiperda (mortality rate = 79.63% and 72.12%) at 100 mg L-1, comparable to that of fipronil (mortality rate: 68.44%); compound 9a showed possible delayed toxicity against Solenopsis invicta (mortality rate: 95.66%) after 5 days of treatment at 1.0 mg L-1. CONCLUSION: Due to their high insecticidal activities against P. xylostella, compound 4m, 4a, and 4f could be considered as qualified candidates for novel insecticide. Several other 4,5-dihydropyrazolo[1,5-a]quinazolines with relatively high bioactivity, such as compounds 9a and 9e, are also worth further optimization as potential insecticide or anticide candidates.

Computed Properties of C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Yang, S; Lai, QQ; Lai, FW; Jiang, XY; Zhao, C; Xu, HH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists WOS:000469304500025 published article about FUNCTIONAL SELECTIVITY; REPERFUSION INJURY; RESOLUTION; TARGET in [Baell, Jonathan B.] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211816, Jiangsu, Peoples R China; [Deora, Girdhar Singh; Debono, Aaron J.; Priebbenow, Daniel L.; Brady, Ryan M.; Beveridge, Julia; Teguh, Silvia C.; Baell, Jonathan B.] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville, Vic 3052, Australia; [Qin, Cheng Xue; Vecchio, Elizabeth A.; Minh Deo; Krippner, Guy; Ritchie, Rebecca H.] Baker Heart & Diabet Inst, 7S Commercial Rd, Melbourne, Vic 3004, Australia; [Qin, Cheng Xue; Ritchie, Rebecca H.] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic 3010, Australia; [May, Lauren T.] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol, Parkville, Vic 3052, Australia; [Ritchie, Rebecca H.] Monash Univ, Dept Diabet, Cent Clin Sch, Melbourne, Vic 3004, Australia; [Baell, Jonathan B.] Monash Univ, ARC Ctr Fragment Based Design, Parkville, Vic 3052, Australia in 2019.0, Cited 21.0. Category: isothiazole. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Ca-i(2+)) mobilization. Compound 50 showed an EC50 of 0.083 mu M for phosphorylation of ERK1/2 and an approximate 20-fold bias away from Ca-i(2+) mobilization at the hFPR1.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Deora, GS; Qin, CX; Vecchio, EA; Debono, AJ; Priebbenow, DL; Brady, RM; Beveridge, J; Teguh, SC; Deo, M; May, LT; Krippner, G; Ritchie, RH; Baell, JB or concate me.

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Isothiazole – Wikipedia,
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Product Details of 93-02-7. I found the field of Chemistry very interesting. Saw the article Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A-4: An Anticancer Agent published in 2020.0, Reprint Addresses Holla, H (corresponding author), Cent Univ Karnataka, Dept Chem, Kalaburagi 585367, India.; Singh, S (corresponding author), Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda 151001, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

A series of 30 small hybrid molecules are synthesized inspired from Combretastatin A-4 (CA-4), where ethylene-bridge of CA-4 is replaced with two five-membered heterocyclic rings, viz. isoxazoline and 1, 2, 3-triazole. These are joined by a methylene linker, with substitutions at A and B – ring position of CA-4. The new molecular entities have shown significant cytotoxicity to cancer cell from the IC(50)0.49 mu M-3.17 mu M with 1-((4,5-Dihydro-3-(2,5-dimethoxyphenyl)isoxazol-5-yl)methyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole displayed IC(50)0.422 +/- 0.07 mu M for A-549 -lung cancer cell line and IC(50)0.498 +/- 0.03 mu M for MDA-MB-231-breast cancer cell line. The western blot analysis, confocal staining and also byin vitrotubulin polymerization assay established the target specificity of the molecules as a tubulin polymerization inhibitor. Molecular docking & Molecular dynamics studies confirmed the binding interaction patterns of these molecules at the Colchicine binding site of tubulin and have correlated the observed experimental result with variation in structure satisfactorily.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sharma, A; Talimarada, D; Yadav, UP; Singh, N; Reddy, AS; Bag, D; Biswas, K; Baidya, A; Borale, AN; Shinde, D; Singh, S; Holla, H or concate me.. Product Details of 93-02-7

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An article Knoevenagel-Friedel-Crafts-Hemiketalization Triple Cascade Reaction: A Diastereoselective Formal [1+2+3] Cyclization Towards Indenonaphthopyran Scaffolds WOS:000605655800007 published article about ORGANOCATALYTIC ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; CYCLOADDITION; CONSTRUCTION; STRATEGY; ACCESS in [Settipalli, Poorna Chandrasekhar; Reddy, Yeruva Pavankumar; Gudise, Veera Babu; Anwar, Shaik] Vignans Fdn Sci Technol & Res, Dept Sci & Humanities, Div Chem, Guntur 522213, Andhra Pradesh, India in 2021.0, Cited 70.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Category: isothiazole

A simple and efficient cascade reaction via formal [1+2+3] cyclization of 1,3-indanedione, aldehyde and 2-naphthol is reported using K2CO3 as a base. The advantage includes metal-free conditions, varied substrate scope and shortened reaction duration with high diastereoselectivity (i. e., 99 : 1) resulting in the formation of two carbon-carbon as well as two carbon-oxygen bonds through Knoevenagel-Friedel-Crafts-Hemiketalization sequence resulting in three contiguous stereocenters.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Settipalli, PC; Reddy, YP; Gudise, VB; Anwar, S or concate me.

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