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Authors Dussart-Gautheret, J; Deschamp, J; Monteil, M; Gager, O; Legigan, T; Migianu-Griffoni, E; Lecouvey, M in AMER CHEMICAL SOC published article about in [Dussart-Gautheret, Jade; Deschamp, Julia; Monteil, Maelle; Gager, Olivier; Legigan, Thibaut; Migianu-Griffoni, Evelyne; Lecouvey, Marc] Univ Sorbonne Paris Nord, CSPBAT, CNRS, UMR 7244, F-93017 Bobigny, France in 2020, Cited 45. Category: isothiazole. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

An easily handled one-pot synthetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlorides. Herein, other trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphinates. This modulation of the reactivity can be controlled according to the nature of the acid derivative for the use of sensitive and functionalized substrates.

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An article Synthetic hyperacetylation of nucleosomal histones WOS:000616560700002 published article about CHROMATIN; COMPLEX; DISSOCIATION; CONSTANTS; PROTEINS in [Kajino, Hidetoshi; Oi, Miku; Yamatsugu, Kenzo; Kawashima, Shigehiro A.; Kanai, Motomu] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; [Nagatani, Tomomi; Nishiyama, Atsuya; Nakanishi, Makoto] Univ Tokyo, Div Canc Cell Biol, Inst Med Sci, Minato Ku, 4-6-1 Shiroganedai, Tokyo 1088639, Japan; [Kujirai, Tomoya; Kurumizaka, Hitoshi] Univ Tokyo, Inst Quantitat Biosci, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1130032, Japan; [Kujirai, Tomoya; Kurumizaka, Hitoshi] KURUMIZAKA Chromatin Atlas, JST ERATO, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1130032, Japan in 2020, Cited 20. Application In Synthesis of Benzoic anhydride. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopus laevis sperm chromatin.

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

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Quality Control of Benzoic anhydride. Welcome to talk about 93-97-0, If you have any questions, you can contact Zou, LL; Sun, WQ; Khan, R; Lv, HP; Yang, Y; Xu, JB; Zhan, Y; Fan, BM or send Email.

An article Palladium Catalyzed Tandem Reaction of Oxabenzonorbornadienes with Anhydrides WOS:000457450900020 published article about RING-OPENING REACTIONS; OXABICYCLIC ALKENES; 2+2 CYCLOADDITIONS; BICYCLIC ALKENES; BORONIC ACIDS; ASYMMETRIC CYCLODIMERIZATION; HETEROBICYCLIC ALKENES; AZABICYCLIC ALKENES; GRIGNARD-REAGENTS; ARYLBORONIC ACIDS in [Zou, Lingling; Sun, Weiqing; Khan, Ruhima; Lv, Haiping; Xu, Jianbin; Fan, Baomin] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China; [Yang, Yong; Zhan, Yong] Chongqing Acad Chinese Mat Med, Chongqing 400065, Peoples R China; [Fan, Baomin] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China in 2019, Cited 63. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Quality Control of Benzoic anhydride

Palladium catalyzed ring-opening reaction of oxabenzonorbornadienes with anhydrides, leading to the synthesis of the di- and trimerization products in a single step have been demonstrated. The dimerization product was obtained as the major product as compared to the trimer. The reaction proceeded in the absence of additional ligands. The effect of different palladium catalysts, bases, and solvents on the yield of the reaction has been studied. The scope of the developed protocol was investigated based on various oxabicyclic alkenes and different anhydrides.

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Separation of bovine serum albumin (BSA) and hemoglobin (Hb), two proteins with almost identical molecular weight, has been a big challenge for more than two decades. Using traditional ultrafiltraion membranes separation of these proteins is possible only at the isoelectric point of one protein via electrostatic repulsion between the membrane and the other protein. Here we introduce an integral asymmetric isoporous membrane from polystyrene-block-poly(2-hydroxyethyl meth-acrylate-ran-2-(succinyloxy)ethyl methacrylate) (PS-b-P(HEMA-r-SEMA)) having random-OH and-COOH groups along the pore walls prepared by a method which combines solvent induced self-assembly of the block copolymer and nonsolvent induced phase separation (SNIPS). The membrane consists of soft isoporous channels due to swelling of the P(HEMA-r-SEMA) blocks in a hydrated state. The effective pore size of the membrane in a hydrated state is significantly lower compared to that in a dry state. These soft channels allow the permeation of BSA while retaining Hb at constant pH 7.4 where both proteins are negatively charged. In comparison to 22 commercial and in-house prepared membranes the PS-b-P(HEMA-r-SEMA) membrane presents unprecedented ideal selectivity of BSA over Hb (psi(BSA/Hb) = 16). Unlike the conventional technique in this case the electroneutrality of one protein is not mandatory which will provide significantly easier handling.

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COA of Formula: C14H10O3. Welcome to talk about 93-97-0, If you have any questions, you can contact Tolan, D; Almotairy, ARZ; Howe, O; Devereux, M; Montagner, D; Erxleben, A or send Email.

An article Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid WOS:000467386900031 published article about PLATINUM(IV) COMPLEXES; CISPLATIN; CANCER; PRODRUG; DESIGN; AGENTS in [Tolan, Dina; Almotairy, Awatif Rashed Z.; Erxleben, Andrea] Natl Univ Ireland, Sch Chem, Galway, Ireland; [Almotairy, Awatif Rashed Z.; Howe, Orla; Devereux, Michael] Technol Univ Dublin, Sch Biol & Hlth Sci, City Campus, Dublin, Ireland; [Montagner, Diego] Maynooth Univ, Dept Chem, Maynooth, Kildare, Ireland; [Tolan, Dina] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt in 2019, Cited 34. COA of Formula: C14H10O3. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(II) anticancer drugs allows the co-delivery and simultaneous activation of two pro-drugs for combination therapy. Pt(IV) complexes with a redox modulator as an axial ligand can kill cancer cells by a mechanism combining DNA platination and generation of oxidative stress. In this study we evaluated the cytotoxicity of Pt(IV) complexes based on the oxaliplatin scaffold and the pro-oxidant indole-3-propionate in cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. A series of five complexes was synthesized and characterized by H-1 and Pt-195 NMR spectroscopy, IR spectroscopy, mass spectrometry and elemental analysis; trans-[Pt(DACH)(ox)(IPA)(OH)] (1), trans-[Pt(DACH)(ox)(IPA)(2)] (2), trans-[Pt(DACH)(ox)(IPA)(bz)] (3), trans-[Pt(DACH)(ox)(IPA)(suc)] (4), and trans-[Pt(DACH)(ox)(IPA)(ac)] (5) (DACH = 1,2-diaminocyclohexane (1R, 2R)-(-), ox = oxalate, IPA = indole 3-propionate, bz = benzoate, suc = succinate and ac = acetate). The complexes were shown to produce cellular reactive oxygen species (ROS) in a time-dependent manner. The most potent ROS producer, complex 1, also elicited the highest cytotoxicity. Complex 1 was shown to form the mono-and bis-adducts [Pt(DACH)(guanosine)( OH)](+) and [Pt(DACH)(guanosine)(2)](2+) in the presence of ascorbic acid, suggesting that on activation the released oxaliplatin will interact with DNA.

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Cellulose benzoate propionates (CBzP) were prepared via a staged addition of Pr2O followed by Bz(2)O to cellulose dissolved in tributylmethylammonium dimethyl phosphate (TBMADMP) providing regioselectively substituted cellulose esters in which the benzoate was preferentially installed at C2 and C3. By systematically varying the DSPr, DSBz, and DSOH (DS = degree of substitution), we synthesized CBzP that could potentially be utilized as a unique compensation film in optical displays.

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Welcome to talk about 93-97-0, If you have any questions, you can contact Eidi, E; Kassaee, MZ; Nasresfahani, Z or send Email.. Category: isothiazole

Category: isothiazole. Authors Eidi, E; Kassaee, MZ; Nasresfahani, Z in SPRINGER WIEN published article about in [Eidi, Esmaiel; Kassaee, Mohamad Z.; Nasresfahani, Zahra] Tarbiat Modares Univ, Dept Chem, Tehran, Iran in 2021, Cited 46. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

Nano copper ferrite catalyst is prepared and characterized by scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, vibrational sample magnetometry, and Fourier transform infrared. The catalytic activity is probed for cross-dehydrogenative coupling of aromatic aldehydes in the presence of tert-butyl hydroperoxide as the oxidant. This catalytic protocol appears as a simple, rather cheap, clean, and efficient practical strategy for the synthesis of symmetrical anhydrides, with proper efficiency (66%). The catalyst can be easily separated from the reaction mixture by an external magnet and reused several times in subsequent reactions, without any measurable loss of its efficiency. [GRAPHICS] .

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Isothiazole – Wikipedia,
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In 2020 CHEM COMMUN published article about C-H FUNCTIONALIZATION; ARYL IODIDES; BOND FUNCTIONALIZATIONS; ARYLATION; PD/NORBORNENE; AMINATION; ALKYLATION; ANILINES; PD; MECHANISM in [Zhang, Bo-Sheng] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China; [Zhang, Bo-Sheng; Gou, Xue-Ya; Zhang, Zhe; An, Yang; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2020, Cited 47. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Recommanded Product: 93-97-0

This report described the first DMAP and PivOH-promotedortho-C-H amination andipso-allenization reaction of iodobenzenes realized by Pd/norbornene cooperative catalysis. Based on control experiments and DFT calculations, we speculated that the three ligands have different functions and mechanism paths in the reaction.

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SDS of cas: 93-97-0. Authors Sakai, T; Matsuo, Y; Okuda, K; Hirota, K; Tsuji, M; Hirayama, T; Nagasawa, H in NATURE RESEARCH published article about in [Sakai, Takayuki; Tsuji, Mieko; Hirayama, Tasuku; Nagasawa, Hideko] Gifu Pharmaceut Univ, Lab Pharmaceut & Med Chem, Gifu, Gifu 5011196, Japan; [Matsuo, Yoshiyuki; Hirota, Kiichi] Kansai Med Univ, Inst Biomed Sci, Dept Human Stress Response Sci, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan; [Okuda, Kensuke] Kobe Pharmaceut Univ, Lab Bioorgan & Nat Prod Chem, 4-19-1 Motoyama Kita, Kobe, Hyogo 6588558, Japan in 2021, Cited 52. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold. We then conducted biological screening using hypoxia inducible factor (HIF)-1- and unfolded protein response (UPR)-dependent reporter assays and selective cytotoxicity assay under low glucose conditions. Homologation studies of aryl-(CH2)(n)-biguanides (n=0-6) yielded highly potent derivatives with an appropriate alkylene linker length (n=5, 6). The o-chlorophenyl derivative 7l (n=5) indicated the most potent inhibitory effects on HIF-1- and UPR-mediated transcriptional activation (IC50; 1.0 +/- 0.1 mu M, 7.5 +/- 0.1 mu M, respectively) and exhibited selective cytotoxicity toward HT29 cells under low glucose condition (IC50; 1.9 +/- 0.1 mu M). Additionally, the protein expression of HIF-1 alpha induced by hypoxia and of GRP78 and GRP94 induced by glucose starvation was markedly suppressed by the biguanides, thereby inhibiting angiogenesis. Metabolic flux and fluorescence-activated cell sorting analyses of tumor cells revealed that the biguanides strongly inhibited oxidative phosphorylation and activated compensative glycolysis in the presence of glucose, whereas both were strongly suppressed in the absence of glucose, resulting in cellular energy depletion and apoptosis. These findings suggest that the pleiotropic effects of these biguanides may contribute to more selective and effective killing of cancer cells due to the suppression of various stress adaptation systems in the tumor microenvironment.

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In 2020 ACS CENTRAL SCI published article about ASYMMETRIC PHOSPHORYLATION; SELECTIVE PHOSPHORYLATION; OLIGONUCLEOTIDE SYNTHESIS; PHOSPHORIC-ACID; FUNCTIONALIZATION; PHOSPHOPEPTIDES; PENTAPHOSPHATES; CONDENSATION; EXPLORATION; CONVERSION in [Domon, K.; Fujiyoshi, K.; Kawashima, S. A.; Yamatsugu, K.; Kanai, M.] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan; [Puripat, M.; Hatanaka, M.] Nara Inst Sci & Technol NAIST, Inst Res Initiatives, Div Res Strategy, Ikoma 6300192, Japan; [Hatanaka, M.] NAIST, Grad Sch Sci & Technol, Data Sci Ctr, Ikoma 6300192, Japan in 2020, Cited 41. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Name: Benzoic anhydride

Phosphorylation of alcohols is a fundamentally important reaction in both life science and physical science. Product phosphate monoesters play key roles in living organisms, natural products, pharmaceuticals, and organic materials. Most of the chemical methods to date for synthesizing phosphate monoesters, however, require multistep sequences or are limited to specific types of substrates possibly due to harsh conditions. An alternative way to enable the simple production of phosphate monoesters from highly functionalized precursor alcohols is, thus, highly desired. We report herein a catalytic phosphorylation of alcohols with high functional group tolerance using tetrabutylammonium hydrogen sulfate (TBAHS) and phosphoenolpyruvic acid monopotassium salt (PEP-K) as the catalyst and phosphoryl donor, respectively. This method enables the direct introduction of a nonprotected phosphate group to the hydroxy group of a diverse menu of alcohol substrates, including functionalized small molecules, carbohydrates, and unprotected peptides. Nuclear magnetic resonance, mass spectrometric, and density functional theory analyses suggest that an unprecedented mixed anhydride species, generated from PEP-K and TBAHS, acts as an active phosphoryl donor in this reaction. This operationally simple and chemoselective catalytic phosphorylation allows for the efficient production of densely functionalized O-phosphorylated compounds, which are useful in diverse fields including biology and medicine.

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Reference:
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,Isothiazole – ScienceDirect.com