What I Wish Everyone Knew About Benzoic anhydride

About Benzoic anhydride, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or concate me.. Name: Benzoic anhydride

In 2019 J MED CHEM published article about ANTI-AIDS AGENTS; DITERPENOIDS; REPLICATION; ELIMINATION in [Liu, Qingbo; Li, Wei; Asada, Yoshihisa; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan; [Liu, Qingbo] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan; [Huang, Li; Chen, Chin-Ho] Duke Univ, Med Ctr, Dept Surg, Surg Sci, Durham, NC 27710 USA in 2019, Cited 21. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Name: Benzoic anhydride

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gnidimacrin derivatives were synthesized and evaluated in assays for HIV replication and latency activation to establish which molecular structures must be maintained and which can tolerate changes that may be needed for better pharmacological properties. The results indicated that hydroxyl substituents at C-5 and C-20 are essential, while derivatives modified at 3-OH with aromatic esters retain anti-HIV replication and latent activation activities. The half-lives of the potent GM derivatives are over 20 h, which implies that they are stable in the plasm even though they contain ester linkages. The established structure activity relationship should be useful in the development of gnidimacrin or structurally related compounds as clinical trial candidates.

About Benzoic anhydride, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or concate me.. Name: Benzoic anhydride

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

You Should Know Something about Benzoic anhydride

Recommanded Product: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Zhang, LH; Zhang, ZH; Li, MY; Wei, ZY; Jin, XJ; Piao, HR or concate me.

Recommanded Product: Benzoic anhydride. Zhang, LH; Zhang, ZH; Li, MY; Wei, ZY; Jin, XJ; Piao, HR in [Zhang, Lin-Hao; Zhang, Zhi-Hong; Li, Ming-Yue; Jin, Xue-Jun; Piao, Hu-Ri] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China; [Wei, Zhi-Yu] Dalian Univ, Coll Med, Dalian 116622, Liaoning, Peoples R China published Synthesis and evaluation of the HIF-1 alpha inhibitory activities of novel ursolic acid tetrazole derivatives in 2019, Cited 37. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

The hypoxia-inducible factor-la (HIF-1 alpha) pathway has been implicated in tumor angiogenesis, growth, and metastasis. Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of various types of cancers. Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-la transcriptional inhibitors. Of these, compound 14d (IC50 0.8 +/- 0.2 mu M) displayed the most potent activity and compounds 14a (IC50 4.7 +/- 0.2 mu M) exhibited the most promising biological profile. Analysis of the structure-activity relationships of these compounds with HIF-1 alpha suggested that the presence of a tetrazole group located at C-28 of the UA derivatives was critical for their inhibitory activities.

Recommanded Product: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Zhang, LH; Zhang, ZH; Li, MY; Wei, ZY; Jin, XJ; Piao, HR or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Top Picks: new discover of 93-97-0

About Benzoic anhydride, If you have any questions, you can contact Weldu, WD; Wang, CC or concate me.. Category: isothiazole

Recently I am researching about ONE-POT PROTECTION; STEREOSELECTIVE-SYNTHESIS; REGIOSELECTIVE ACETYLATION; ACETAL-GLYCOSIDES; ALPHA-GLUCOSIDES; HYDROXYL-GROUPS; GLYCOSYLATION; DERIVATIVES; ACYLATION; CATALYSIS, Saw an article supported by the Academia SinicaAcademia Sinica – Taiwan [MOST 108-3114-Y-001002, AS-SUMMIT-109]; Ministry of Science and Technology [MOST 108-2113-M-001-019-, MOST 109-2113M-001-005-]. Category: isothiazole. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Weldu, WD; Wang, CC. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride

Selective modification of the hydroxyl groups of sugars has been a long-standing challenge due to their proximate relative reactivity. Herein, we report a TMSOTf-catalyzed selective acetylation of the non-anomeric hydroxyl groups of several per-O-TMS-protected sugar substrates while leaving their anomeric group unaffected. In addition to standing versatile by itself, the anomeric O-TMS group left intact can be functionalized to afford key sugar precursors such as imidate donors, which could otherwise be synthesized via a stepwise anomeric deprotection-functionalization procedure.

About Benzoic anhydride, If you have any questions, you can contact Weldu, WD; Wang, CC or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Interesting scientific research on C14H10O3

Computed Properties of C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Domon, K; Puripat, M; Fujiyoshi, K; Hatanaka, M; Kawashima, SA; Yamatsugu, K; Kanai, M or concate me.

Computed Properties of C14H10O3. In 2020 ACS CENTRAL SCI published article about ASYMMETRIC PHOSPHORYLATION; SELECTIVE PHOSPHORYLATION; OLIGONUCLEOTIDE SYNTHESIS; PHOSPHORIC-ACID; FUNCTIONALIZATION; PHOSPHOPEPTIDES; PENTAPHOSPHATES; CONDENSATION; EXPLORATION; CONVERSION in [Domon, K.; Fujiyoshi, K.; Kawashima, S. A.; Yamatsugu, K.; Kanai, M.] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan; [Puripat, M.; Hatanaka, M.] Nara Inst Sci & Technol NAIST, Inst Res Initiatives, Div Res Strategy, Ikoma 6300192, Japan; [Hatanaka, M.] NAIST, Grad Sch Sci & Technol, Data Sci Ctr, Ikoma 6300192, Japan in 2020, Cited 41. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

Phosphorylation of alcohols is a fundamentally important reaction in both life science and physical science. Product phosphate monoesters play key roles in living organisms, natural products, pharmaceuticals, and organic materials. Most of the chemical methods to date for synthesizing phosphate monoesters, however, require multistep sequences or are limited to specific types of substrates possibly due to harsh conditions. An alternative way to enable the simple production of phosphate monoesters from highly functionalized precursor alcohols is, thus, highly desired. We report herein a catalytic phosphorylation of alcohols with high functional group tolerance using tetrabutylammonium hydrogen sulfate (TBAHS) and phosphoenolpyruvic acid monopotassium salt (PEP-K) as the catalyst and phosphoryl donor, respectively. This method enables the direct introduction of a nonprotected phosphate group to the hydroxy group of a diverse menu of alcohol substrates, including functionalized small molecules, carbohydrates, and unprotected peptides. Nuclear magnetic resonance, mass spectrometric, and density functional theory analyses suggest that an unprecedented mixed anhydride species, generated from PEP-K and TBAHS, acts as an active phosphoryl donor in this reaction. This operationally simple and chemoselective catalytic phosphorylation allows for the efficient production of densely functionalized O-phosphorylated compounds, which are useful in diverse fields including biology and medicine.

Computed Properties of C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Domon, K; Puripat, M; Fujiyoshi, K; Hatanaka, M; Kawashima, SA; Yamatsugu, K; Kanai, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An update on the compound challenge: 93-97-0

COA of Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Xin, G; Ming, Y; Ji, CJ; Wei, ZL; Li, SY; Morris-Natschke, SL; Zhang, XY; Yu, K; Li, YP; Zhang, BL; Zhang, JH; Xing, ZH; He, YR; Chen, Z; Yang, XJ; Niu, H; Lee, KH; Huang, W or concate me.

Authors Xin, G; Ming, Y; Ji, CJ; Wei, ZL; Li, SY; Morris-Natschke, SL; Zhang, XY; Yu, K; Li, YP; Zhang, BL; Zhang, JH; Xing, ZH; He, YR; Chen, Z; Yang, XJ; Niu, H; Lee, KH; Huang, W in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about VON-WILLEBRAND-FACTOR; PLATELET ACTIVATION; PREVENTS THROMBOSIS; LACTIC-ACIDOSIS; METFORMIN; RISK; ADHESION; PRODRUG in [Xin, Guang; Ming, Yue; Wei, Zeliang; Li, Shiyi; Zhang, Xiaoyu; Yu, Kui; Li, Youping; Xing, Zhihua; He, Yarong; Chen, Zhen; Niu, Hai; Huang, Wen] Sichuan Univ, West China Hosp, West China Sch Med, Lab Ethnopharmacol, Chengdu, Peoples R China; [Ji, Chengjie] Hosp Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Clin Lab, Chengdu, Sichuan, Peoples R China; [Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA; [Zhang, Boli; Zhang, Junhua] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China; [Yang, Xijing] Sichuan Univ, West China Hosp, Anim Expt Ctr, West China Sch Med, Chengdu, Sichuan, Peoples R China; [Niu, Hai] Sichuan Univ, Coll Math, Chengdu, Sichuan, Peoples R China in 2020, Cited 46. COA of Formula: C14H10O3. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three biguanide derivatives were designed and synthesized based on the principles of bioisosteres. These derivatives were evaluated for the activity of antiplatelet thrombosis in vivo. We found that N-tri-fluoromethanesulfonyl biguanide derivative, compound b10, uniquely prevented cerebral infarction as well as neuronal function injury, and significantly decrease the mortality rate of ischemic stroke in the middle cerebral artery occlusion mice without significant side effects. We verified that b10 directly inhibited platelets thrombus formation and decreased the compactness of stroke thrombi. Particularly, b10 exhibited good potency to inhibit human platelet activation including platelet aggregation, adhesion, pseudopodia formation, integrin GPIIb/IIIa activation, CD62P expression and clot retraction. Meanwhile, the pharmacokinetics assessment showed that b10 had satisfying pharmacological characteristics including a longer duration and a higher oral absorption ratio than its parent compound. In addition, b10 remarkably ameliorated not only stroke related to platelet thrombosis but also carotid artery thrombus formation. It is concluded that the novel potent antiplatelet thrombotic agent derived from biguanide is a promising candidate for stroke treatment. (C) 2020 Elsevier Masson SAS. All rights reserved.

COA of Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Xin, G; Ming, Y; Ji, CJ; Wei, ZL; Li, SY; Morris-Natschke, SL; Zhang, XY; Yu, K; Li, YP; Zhang, BL; Zhang, JH; Xing, ZH; He, YR; Chen, Z; Yang, XJ; Niu, H; Lee, KH; Huang, W or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Why do aromatic interactions matter of compound:93-97-0

COA of Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Winterling, E; Ivlev, S; Meggers, E or concate me.

An article Chiral-at-Ruthenium Catalysts with Mixed Normal and Abnormal N-Heterocyclic Carbene Ligands WOS:000644732000015 published article about MEDIATED ASYMMETRIC-SYNTHESIS; C-H AMINATION; IMIDAZOLIUM SALT; METAL; COMPLEX; BINDING in [Winterling, Erik; Ivlev, Sergei; Meggers, Eric] Philipps Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany in 2021, Cited 28. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. COA of Formula: C14H10O3

We recently reported a new class of chiral ruthenium catalysts in which two achiral bidentate N-(2-pyridyl)-substituted N-heterocyclic carbene ligands in addition to two labile acetonitriles are coordinated to a central ruthenium and generate a stereogenic metal center which is responsible for the overall chirality (Zheng et al. J. Am. Chem. Soc. 2017, 139, 4322). Here we now report our discovery of related chiral-at-ruthenium catalysts in which normal and abnormal N-heterocyclic carbene (NHC) ligands are present at the same time. The synthesis of racemic complexes, their resolution into individual enantiomers by a chiral auxiliary approach, and a catalytic application are reported. The mixed normal/abnormal NHC complexes display significantly increased turnover numbers and turnover frequencies for a nitrene-mediated enantioselective C(sp(3))-H amination.

COA of Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Winterling, E; Ivlev, S; Meggers, E or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New explortion of 93-97-0

Name: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Xu, QL; Fan, HC; Yao, HM; Wang, DH; Yu, HW; Chen, BB; Yu, ZQ; Su, WK or concate me.

Name: Benzoic anhydride. Xu, QL; Fan, HC; Yao, HM; Wang, DH; Yu, HW; Chen, BB; Yu, ZQ; Su, WK in [Xu, Qilin; Su, Weike] Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Hangzhou 310014, Peoples R China; [Fan, Huachun; Yao, Hongmiao; Wang, Duoheng; Yu, Hangwei; Chen, Bingbing; Yu, Zhiqun; Su, Weike] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Natl Engn Res Ctr Proc Dev Act Pharmaceut Ingredi, Hangzhou 310014, Peoples R China published Understanding monoacylation of symmetrical diamines: A kinetic study of acylation reaction of m-phenylenediamine and benzoic anhydride in microreactor in 2020, Cited 41. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

Monoacylated symmetrical diamines are building blocks or intermediates of several well-established drugs. However, for the symmetrical diamines, the two amine groups located in a similar chemical environment make the selective monoacylation rather difficult and no kinetics study has ever been reported before. To comprehend this kind of reaction more deeply, a continuous flow microfluidic system was developed to evaluate the reaction kinetics of m-phenylenediamine and benzoic anhydride. At first, the reaction order of each reactant, pre-exponential factors and activation energies were determined in turn. The possible reaction mechanism was postulated from the reaction order. Then, a series of validation experiments were designed to show the accuracy and the applied range (concentration and temperature) of the kinetic model. Next, to obtain a controlled selectivity, the effects of initial concentration, reaction temperature and molar ratio on the selectivity were investigated through the model simulation. In the end, under the conditions optimized by the kinetic model, 96.9% selectivity and 92.5% yield were obtained in the microreactor.

Name: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Xu, QL; Fan, HC; Yao, HM; Wang, DH; Yu, HW; Chen, BB; Yu, ZQ; Su, WK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Top Picks: new discover of 93-97-0

Quality Control of Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Zheng, XM; Liu, S; Rehman, S; Li, ZH; Zhang, PY or concate me.

In 2020 CHEM ENG J published article about GASEOUS TOLUENE; HIGH-CAPACITY; INDOOR AIR; VOCS; SELECTIVITY; COMPOUND; REMOVAL; WATER; BREAKTHROUGH; STABILITY in [Zheng, Xianming; Liu, Shuai; Rehman, Sadia; Li, Zehui; Zhang, Pengyi] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China; [Zhang, Pengyi] Beijing Key Lab Indoor Air Qual Evaluat & Control, Beijing 100084, Peoples R China in 2020, Cited 46. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Quality Control of Benzoic anhydride

Trace volatile organic compounds (VOCs) such as aldehydes and aromatics significantly deteriorate the indoor air quality especially in newly-decorated buildings. The universal water vapor would greatly decrease the adsorption capacity of ad-sorbents for trace VOCs via competitive adsorption and capillary condensation. Herein, we developed a strategy to subsequently modify the internal and external surface of CAU-1, an aluminum-based metal-organic framework (MOF), to significantly improve its humidity resistance. First, anhydrides were used to transfer amino groups of CAU-1 into hydrophobic groups via amide reaction. Second, polydimethylsiloxane was used to form a hydorphobic coating on its external surface. The adsorption capacity of as-modified CAU-1 for 1 ppm toluene increased about 6 times under 50% relative humidity (RH) at 298 K, even much higher than those of common adsorbents including hydrophobic ZSM-5. In addition, it could be completely regenerated below 373 K, about 65 K lower than that required for regenerating ZSM-5 under the same condition, which not only greatly reduces the energy consumption but also improves the safety and feasibility of in-situ regeneration of adsorbents in indoor environment.

Quality Control of Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Zheng, XM; Liu, S; Rehman, S; Li, ZH; Zhang, PY or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Discover the magic of the 93-97-0

Computed Properties of C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Zhou, JY; Tao, SW; Liu, RQ; Zhu, YM or concate me.

Computed Properties of C14H10O3. Zhou, JY; Tao, SW; Liu, RQ; Zhu, YM in [Zhou, Jing-Ya; Tao, Shou-Wei; Liu, Rui-Qing; Zhu, Yong-Ming] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China published Forging C-S Bonds through Nickel-Catalyzed Aryl Anhydrides with Thiophenols: Decarbonylation or Decarbonylation Accompanied by Decarboxylation in 2019, Cited 46. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

A nickel-catalyzed decarbonylation or decarbonylation accompanied by decarboxylation cross-coupling reaction of aryl anhydrides with thiophenols as coupling partners was disclosed. This method is promoted by a commercially available, moisture-stable, and inexpensive nickel(II) precatalyst. The process can tolerate a variety of functional groups using ubiquitous aryl anhydrides as cross-coupling precursors to produce thioethers in moderate to excellent yields.

Computed Properties of C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Zhou, JY; Tao, SW; Liu, RQ; Zhu, YM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An overview of features, applications of compound:C14H10O3

Recommanded Product: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Wang, XZ; Zhang, CH; Chang, Q; Wang, LC; Lv, BL; Xu, J; Xiang, HW; Yang, Y; Li, YW or concate me.

I found the field of Chemistry; Engineering very interesting. Saw the article Enhanced Fischer-Tropsch synthesis performances of Fe/h-BN catalysts by Cu and Mn published in 2020. Recommanded Product: Benzoic anhydride, Reprint Addresses Zhang, CH (corresponding author), Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride

A series of Fe/h-BN catalysts promoted with Cu or Mn were prepared for Fischer-Tropsch synthesis (FTS). The physicochemical properties, crystal structures and morphologies of the catalysts were characterized by N-2 physisorption, FT-IR, TPR, XPS, XRD, MES and TEM. It is found that iron oxide nanoparticles are highly dispersed on h-BN matrix due to the anchoring effect of surface defects and the accommodation of porous structures of h-BN. The characterization results indicate that strong interaction between iron oxide and h-BN is present on un-promoted catalyst, which endows the h-BN supported iron catalyst with stable properties under FTS conditions but severely retards reduction of the catalyst. The addition of Cu to Fe/h-BN can to some extent overcome the strong interaction by introducing more sites for dissociating H-2. It is observed that Cu promoter can increase the reduction or carburization degree and thus enhance the FTS activity. The addition of Mn to Fe/h-BN can weaken the strong interaction by altering the electron structure of iron species. And the electron-rich Fe species are responsible for easy reduction and the enhanced FTS performance. Besides, a higher activity can be realized by co-adding Cu and Mn to the Fe/h-BN catalyst. These results suggest that the synergistic effect of Mn and Cu can largely improve the performance of Fe/h-BN catalyst without impairing the stability of the catalyst. The present study paves a way to tailor the performances of FTS catalysts with h-BN as support.

Recommanded Product: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Wang, XZ; Zhang, CH; Chang, Q; Wang, LC; Lv, BL; Xu, J; Xiang, HW; Yang, Y; Li, YW or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com