Tag: M.W:200-300

HPLC of Formula: https://www.ambeed.com/products/4397-53-9.html, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 4397-53-9, Name is 4-Benzyloxybenzaldehyde, SMILES is C2=C(OCC1=CC=CC=C1)C=CC(=C2)C=O, belongs to isothiazole compound. In a article, author is Clerici, Francesca, introduce new discover of the category.

By reacting 4,5-unsubstituted isothiazole dioxides with diazoalkanes and nitrile oxides bicyclic pyrazolo[3,4-d]isothiazole and isothiazolo[5,4-d]isoxazole SS-dioxides were obtained in good yield through a regioselective cycloaddition reaction. Through cycloaddition reaction of 3-benzylamino-4-bromo-isothiazole SS-dioxide labile cycloadducts were formed that underwent in situ dehydrobromination affording the corresponding aromatized compounds.

Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 4397-53-9, HPLC of Formula: https://www.ambeed.com/products/4397-53-9.html.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research, April 2021. Reference of 103-60-6, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 103-60-6, Name is 2-Phenoxyethyl isobutyrate, SMILES is CC(C)C(OCCOC1=CC=CC=C1)=O, belongs to isothiazole compound. In a article, author is Elsayed, Mohamed S. A., introduce new discover of the category.

This study is concerned with the implementation of structure-based techniques for the design of new heterocyclic compounds based on pseudosaccharine scaffold with protein kinase inhibition activity. This nucleus was exploited based on the well-known quinazoline core and its interactions with several protein kinases. Two series of compounds employing this new scaffold were synthesized and evaluated at enzymatic and cellular levels. Compound 9b displayed broad spectrum antiproliferative activity on NCI 60-cell lines panel with mean GI(50) of 5.4 mu M. Investigation of the molecular mechanism showed probable inhibitory activity against Src kinase. (C) 2012 Elsevier Masson SAS. All rights reserved.

Reference of 103-60-6, Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.I hope my blog about 103-60-6 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

94594-90-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. (3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, cas is 94594-90-8,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

[00124] [3aS-[1(E),3a,6,7a]]-1-[3-(3,4-difluorophenyl)-1-oxo-2-propenyl]-hexahydro-8,8-dimethyl-3H-3a,6-methano-2,l-benzisothiazole-2,2-dioxide: At 0-5 0C, a solution of 3-(3,4-difluoro-phenyl)-acryloyl chloride in dichloromethane (30 mL) was added to a mixture of (2R)-bornane-10,2-sultam (14.5 g, 67.35 mmol, 1.00 equiv), triethylamine (20.4 g, 201.98 mmol, 3.00 equiv), and dichloromethane (120 mL). The resulting solution was stirred at ambient temperature for about 3 hours and then water (40 mL) was added. Standard extractive workup with dichloromethane (2 x 40 mL) gave the title product as an off-white solid (18.5 g; yield = 72 percent). 1H NMR (300 MHz, CDCl3) delta: 7.68 (d, / = 15.6 Hz, 1 H), 7.15- 7.45 (m, 3 H), 7.19 (d, J = 15.6 Hz, 1 H), 4.00 (m, 1 H), 3.55 (q, J1 =13.8 Hz, J2 = 24.0 Hz ), 2.18 (m, 2 H), 1.93 (m, 2 H), 1.37-1.48 (m, 2 H), 1.22 (s, 3 H), 0.96 (s, 3 H).

The chemical industry reduces the impact on the environment during synthesis,94594-90-8,(3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide,I believe this compound will play a more active role in future production and life.

Reference：
Patent; AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi; WO2011/17108; (2011); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3-Piperazinobenzisothiazole hydrochloride, and cas is 87691-88-1, its synthesis route is as follows.

To a solution of N- [5-CHLORO-4- (2-CHLORO-ACETYL)-2-METHYL-PHENYL]- acetamide (1.375 g, 5.286 mmol), in acetonitrile (50 mL) was added 3- PIPERAZIN-1-YL-BENZO [d] isothiazole hydrochloride (1.352 g, 5.286 mmol), potassium iodide (1EQ), and potassium carbonate (1.5eq). The reaction was stirred as a suspension at rt overnight. The reaction was diluted with H20 and the filtered. After drying at 50 C under high vacuum overnight, N- {4- [2- (4-BENZO [d] isothiazol-3-yl-peperazin-1-yl)-acetyl]-5-chloro-2- METHYL-PHENYL)-ACETAMIDE was collected as a white solid (2.034 g, 4.598 mmol). Yield = 87%. 100% pure at 254 nM; LCMS (APCI) : 443.3 [M+H] + ; ‘H NMR (400 MHz, DMSO-d6) B 9.41 (s, 1H), 8.02 (d, J = 8. 80HZ, 2H), 7.81 (s, 1H), 7.59 (s, 1H), 7.52 (t, J = 7.34Hz, 1H), 7.39 (t, J = 7.34Hz, 1H), 3.80 (s, 2H), 3.44-3. 37 (m, 4H), 3.30 (s, H20), 2.77-2. 68 (m, 4H), 2.23 (s, 3H), 2.08 (s, 3H).

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

It is a common heterocyclic compound, the isothiazole compound, 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1 its synthesis route is as follows.

EXAMPLE 75; 5-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ACETYL]- 1, 1, 3, 3-TETRAMETHYL-INDAN-2-ONE A mixture of 5- (2-Chloro-acetyl)-1, 1,3, 3-tetramethyl-indan-2-one (7.85 g, 29.6 mmol), 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (7.95 g, 31.1 mmol), potassium carbonate (13.5 g, 97.7 mmol), sodium iodide (4.50 g, 30.0 mmol) in acetonitrile (550 mL) was stirred at rt for 24 h. The reaction was quenched with water (120 mL), and acetonitrile was evaporated. The residue was extracted with methylene chloride (2 x 250 mL). The combined organic extracts were washed with water, brine, dried over Na2SO4, evaporated, and purified by chromatography (silica gel, 7: 3 to 6: 4 hexanes/ethyl acetate) to give 5-[2-(4-Benzo [agisothiazol-3-yl- piperazin-1-yl)-acetyl]-1, 1,3, 3-tetramethyl-indan-2-one (11.2 g, 85%) as an off-white solid :’H NMR (300 MHz, CDC13) 8 8.02 (dd, J= 8.0, 1.6 Hz, 1 H), 7.96 (s, 1 H), 7.91 (d, J = 8.0 Hz, 1 H), 7.83 (d, J = 8.0 Hz, 1 H), 7.47 (t, J = 7.0 Hz, 1 H), 7.38-7. 34 (m, 2H), 3.94 (br s, 2H), 3.67-3. 65 (m, 4H), 2.90- 2.88 (m, 4H), 1.38 (s, 6H), 1.37 (s, 6H).

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference：
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

It is a common heterocyclic compound, the isothiazole compound, 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1 its synthesis route is as follows.

EXAMPLE 6 The mixture of 2.1 g of 4-(1,2-benzisothiazol-3-yl)piperazine hydrochloride, 2.0 g of 3-(3-chloropropionyl)-2-methyl-4,6,7,8-tetrahydro-5H-thieno[3,2-b]azepin-5-one, 2,2 g of potassium carbonate and 1.2 g of potassium iodide in 15 ml of N,N-dimethylformamide and 15 ml of toluene was stirred at 60 C. for 5 hours. After the mixture was cooled in a water bath, water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with saline solution, dried over magnesium sulfate and concentrated. The residue was purified by column chromatography on a silica gel, dissolved in isopropyl alcohol and crystallized from isopropyl alcohol-isopropyl ether. The resulting crystals were recrystallized from ethanol to give 1.30 g of 3-(3-(4-(1,2-benzisothiazol-3-yl)piperazin-1-yl)propionyl)-2-methyl-4,6,7,8-tetrahydro-5H-thieno[3,2-b]azepin-5-one as white crystals, m.p. 146-147 C.

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference：
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5532240; (1996); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3-Piperazinobenzisothiazole hydrochloride, and cas is 87691-88-1, its synthesis route is as follows.

A heterogeneous mix of 6-(chloromethylcarbonyl)-4,4,8-trimethyl-3,4-dihydro-1H-quinolin-2-one (2.200g, 8.739mmole, 1.0eq), sodium carbonate (1.158g, 10.924mmole, 1.25 eq), sodium iodide (0.131 g, 0.874mmole, cat.), and added 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (3.353g, 13.110mmole, 1.5eq) in acetonitrile (35ml) was heated to 150C under microwave assistance for 30min. The reaction was diluted with H2O (100ml), CH2CI2 (100ml) and the layers separated. The aqueous layer was extracted with CH2Cl2 (2x, 50ml) and the organic layer dried over magnesium sulfate (MgSO4), concentrated, and the residue purified by MPLC (25 % EA/CH2CI2 – 50 % EA gradient over 20min and hold for 20min – 100 % EA gradient over 20min). The title compound was obtained as a white crystalline solid in 63 % yield with 30 % recovered starting material (6-(2-chloro-ethyl)-4,4,8-trimethyl-3,4-dihydro-1H-quinolin-2-one). 1H NMR (400 MHz, CDCl3) delta 7.90 (d, 1H, J = 7.94 Hz), 7.80 (d, 1H, J = 7.94 Hz), 7.46 (t, 1H, J = 7.94 Hz), 7.34 (t, 1H, J = 7.94 Hz), 7.02 (s, 1H), 6.91 (s, 1H), 4.78 (s, 1H), 3.69-3.55 (m, 4H), 2.86-2.59 (m, 8H), 2.45 (s, 2H), 2.21 (s, 3H), 1.30 (s, 6H)

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/26864; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 121; 3-f4-[2-(3′, 4′-DIHYDRO-1’H-SPI RO [91, 31DIOXOLANE-2. 2′- NAPHTHALEN1-6′-YL)-ETHYL1-PI PERAZI N-1-YLi- BENZOrDlISOTHIAZOLE; A mixture of 3- (piperazin-1-yl) benzo [d] isothiazole hydrochloride (349 mg, 1.36 mmol) and the title compound from Preparation 36 (530 mg, 1.36 mmol) with anhydrous K2CO3 (376 mg, 2.72 mmol) in acetonitrile (20 ml) was heated at reflux for 24 hours. The reaction mixture was filtered and the filtrate was concentrated. The crude product was purified by elution through a flash column (silica gel 60,230-400 mesh, 1: 1 hexanes: EtOAc) to give a clear oil which crystallized on standing, 497 mg (84%). MS (APCI) : (M + 1) + = 436.’H-NMR (CDCI3, a) : 7.89 (d, 1 H, J = 7.8 Hz), 7.80 (d, 1 H, J = 8. 1 Hz), 7.46 (t, 1 H, J = 7. 3,7. 3 Hz), 7.34 (t, 1 H, J = 7. 3, 7.3 Hz), 6.98 (s, 3H), 4.01 (s, 4H), 3.58 (br s, 4H), 2.95-2. 65 (m, 12H), 1.93 (t, 2H, J = 6.8, 6.8 Hz). CHN, calc’d for C25H29N302S : C, 68.94% ; H, 6. 71% ; N, 9.65% ; found: C, 68.75% ; H, 6.70% ; N, 9.54%.

The chemical industry reduces the impact on the environment during synthesis,87691-88-1,3-Piperazinobenzisothiazole hydrochloride,I believe this compound will play a more active role in future production and life.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 67; 1-(2-Acetyl-2, 3-dihvdro-1 H-isoindol-5-vl)-2-(4-benzordlisothiazol-3-ylpiperazin- 1-vl) ethanone; A mixture (suspension) of the title compound of Preparation 38 (2.10 g, 8.84 mmol), 3-piperazin-1-yl-benzo [cisothiazole hydrochloride (2.49 g, 9.72 mmol), K2CO3 (3.63 g, 26.3 mmol), and Nal (1.40 g, 9.34 mmol) in anhyd CH3CN (90 mL) under N2 was stirred at 25 C for 20 h, then the solvent was removed in vacuo. The residue was suspended in H2O, then extracted twice with EtOAc, however a solid remained undissolved in the aqueous phase. The solid was collected by suction filtration, washing and triturating with H2O, then dried in a vacuum oven at 50C for 3 d to give the title compound (2.68 g, 72%) as a light brown amorphous solid. Both TLC and ‘H NMR analyses indicated that the product was of high purity :’H NMR (300 MHz, CDCl3) # 8. 02 (d, J= 8.1 Hz, 1 H), 7.98 (br s, 1 H), 7.90 (d, J = 8. 2 Hz, 1 H), 7.82 (d, J= 8.0 Hz, 1 H), 7.48 (t, J= 7.5 Hz, 1 H), 7.32-7. 43 (m, 2 H), 4.87 (br s, 2 H), 4.85 (br s, 2 H), 3.91 (s, 1 H), 3.90 (s, 1 H), 3.59-3. 67 (m, 4 H), 2.81-2. 89 (m, 4 H), 2.20 (s, 1.5 H), 2.19 (s, 1.5 H); ESI MS milz421 [C23H24N402S + H] +.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Piperazinobenzisothiazole hydrochloride, 87691-88-1

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/66165; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

The above intermediate IV (0.01 mol) and the hydrochloride salt of the piperazine compound (V) (0.01 mol) were dissolved in DMF (100 mL), and K2CO3 (0.02 mol) was added.According to the general operation three,Preparation of 3-(3-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)propyl)-1H-indole-5-hydroxy(VI-10) hydrochloride 3.21g, yield 75%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Piperazinobenzisothiazole hydrochloride, 87691-88-1

Reference：
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Gu Zhengsong; Zhou Ainan; Xiao Ying; (26 pag.)CN109467554; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com