Tag: M.W:200-300

Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 76-84-6, Name is Triphenylmethanol, molecular formula is C19H16O, Product Details of 76-84-6, belongs to isothiazole compound, is a common compound. In a patnet, author is Lipnicka, U, once mentioned the new application about 76-84-6.

Several new amides 4 of 5-substituted 3-methyl-4-isothiizolecarboxylic acid were obtained, These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4. the carboxylic group was transformed in the amides using amino-acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 76-84-6, Name is Triphenylmethanol, molecular formula is C19H16O, belongs to isothiazole compound. In a document, author is Ignatovich, Zh. V., introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/76-84-6.html.

By acylation of substituted 2-aminoarylpyrimidines with 5-phenyl(p-tolyl)isoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides new amides of pyrimidine series were obtained.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New research progress on 93-97-0 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 93-97-0, Name is Benzoic anhydride, formurla is C14H10O3. In a document, author is DOBLE, A, introducing its new discovery. Recommanded Product: Benzoic anhydride.

1 RP 62203 (2-[3-(4-(4-fluorophenyl)-piperazinyl)propyl]naphto[1,8-ca]isothiazole-1,1-dioxide) is a novel naphtosultam derivative which shows very high affinity for 5-HT2 receptors in the rat cerebral cortex (K(i) = 50.0 pM). 2 RP 62203 is relatively selective for this sub-type of 5-hydroxytryptamine (5-HT) receptor, having lower affinity for the 5-HT1A receptor and very low affinity for the 5-HT3 receptor. RP 62203 displayed low to moderate affinity for alpha(1)-adrenoceptors, dopamine D2 receptors and histamine H-1 receptors. 3 In vivo binding experiments demonstrated that oral administration of low doses of RP 62203 led to a long-lasting (> 6 h) occupation of cortical 5-HT2 receptors (ID50 = 0.39 mg kg-1). 4 In cortical slices from the neonatal rat, RP 62203 potently inhibited inositol phosphate formation evoked by 5-HT, with an IC50 of 7.76 nM. 5 The activity of neurones in the raphe and their responses to microiontophoretically applied 5-HT were studied with extracellular recording electrodes in the anaesthetized rat. RP 62203 potently and dose-dependently blocked excitations evoked by 5-HT when administered at doses of 0.5-4.0 mg kg-1, i.p. In contrast, neither 5-HT-evoked depressions nor glutamate-evoked excitations of raphe neuronal firing were blocked by RP 62203 at doses as high as 8.0 mg kg-1, i.p. 6 Head twitches induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) could be abolished by low doses of RP 62203 in mice (ED50 = 0.44 mg kg-1, p.o.) and in rats (ED50 = 1.54 p.o.). Similar results were obtained with mescaline and 5-hydroxytryptophan (5-HTP). 7 The potency of RP 62203 was compared with that of three other 5-HT2 receptor antagonists, ritanserin, ICI 169,369 and ICI 170,809. In all models, RP 62203 showed similar activity to ritanserin, whilst either ICI 169,369 or ICI 170,809 was several fold less active. 8 It is concluded that RP 62203 is a potent and selective antagonist at 5-HT2 receptors in the rodent central nervous system.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 827-25-8, Name is 2-Bromo-4-chloro-6-nitrophenylamine, molecular formula is C6H4BrClN2O2, belongs to isothiazole compound. In a document, author is Kassimi, NEB, introduce the new discover, Recommanded Product: 827-25-8.

Ab initio calculations of dipole moments and static dipole polarizabilities are reported for nine heteroaromatic five-membered rings-thiophene, thiazole, isothiazole, the four thiadiazoles, and the two thiatriazoles-all at their MP2/6-31G** geometries. Extensive basis sets have been used, and the approximate applicability of the variational principle to the Hartree-Fock polarizability has been discussed. Electron correlation effects have been investigated up to the MP4(SDQ) level for a representative subset of the series of the molecules considered. Our best polarizability determinations are expected to be accurate within a few percent.

Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 827-25-8, Recommanded Product: 827-25-8.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 104-66-5, Name is 1,2-Diphenoxyethane, molecular formula is C14H14O2, belongs to isothiazole compound. In a document, author is Luyten, I, introduce the new discover, Recommanded Product: 1,2-Diphenoxyethane.

2′-Deoxy-5-(isothiazol-5-yl)uridine (12) was synthesized starting from 2′-deoxy-5-iodouridine using a Pd-catalysed cross-coupling reaction with propiolaldehyde diethyl acetal followed by deprotection and ring closure using thiosulfate. 2′-Deoxyuridine 12 has a particular place among the 5-heteroaryl-substituted 2′-deoxyuridines in that it has a high affinity for herpes simplex virus type 1(HSV-1)-encoded thymidine kinase (TK) without antiviral activity. Biochemical studies revealed that 12 is a substrate for viral TK. We further investigated the interaction of 12 with the HSV-1 thymidine kinase. The conformation of 12 in solution was established by NMR spectroscopy. The most stable conformer 12A has the S-atom of the isothiazole ring placed in the neighbourhood of the C(4)=O group of the pyrimidine moiety. The compound was docked in its most stable conformation in the active site of HSV-1 TK and subjected to energy minimization. This demonstrated that the isothiazole moiety binds in a cavity lined by the side chains of Tyr-132, Arg-163, Ala-167, and Ala-168 and that the C(3) atom of the isothiazole moiety is located in close proximity of the phenolic O-atom of Tyr-132 and the aliphatic part of the Arg-163 side chain.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021. Reference of 93-97-0, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 93-97-0, Name is Benzoic anhydride, SMILES is O=C(OC(C1=CC=CC=C1)=O)C2=CC=CC=C2, belongs to isothiazole compound. In a article, author is Vicini, Paola, introduce new discover of the category.

2-Heteroarylimino-5-benzylidene-4-thiazolidinones, unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesised and assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria, yeasts and mould. The antimicrobial activity of the 2-benzo[d] thiazolyl-and of the 2-benzo[d] isothiazolyl-imino-5-benzylidene- 4-thiazolidinones is, on the whole, lower in comparison with the high activity detected for the derivatives of the 2-thiazolylimino5- benzylidene-4-thiazolidinone class. Nevertheless most of the benzo[d] thiazole analogues display good inhibition of the growth of Gram positive bacilli and staphylococci, including methicillin-resistant Staphylococcus strains. Among the 2-benzo[d] isothiazole analogues a few derivatives show a strong and selective activity against bacilli. Moreover, it is worth noting that the replacement of the thiazole nucleus for the benzo[d] thiazole bicyclic system in the parent 2-(benzo[d] thiazol-2-ylimino) thiazolidin-4-one leads to significant antifungal properties against both yeasts and moulds, properties not shown by the analogous 2-thiazolyl-and 2-benzo[d] isothiazolyl-imino) thiazolidin-4-ones. The structure-activity relationship of 33 analogues possessing the 2-heteroarylimino-4- thiazolidinone structure is analysed through QSAR models. (C) 2008 Elsevier Ltd. All rights reserved.

Reference of 93-97-0, Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.I hope my blog about 93-97-0 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New research progress on 1775-95-7 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1775-95-7, Name is (2-Amino-5-nitrophenyl)(phenyl)methanone, formurla is C13H10N2O3. In a document, author is Jeskowiak, Izabela, introducing its new discovery. Category: isothiazole.

Thanks to the progress in oncology, pharmacological treatment of cancer is gaining in importance and in the near future anti-cancer chemotherapeutics are expected to be the main method of treatment for cancer diseases. What is more, the search for new anti-cancer compounds with the desired application properties is constantly underway. As a result of designed syntheses, we obtained some new N’-substituted 5-chloro-3-methylisothiazole-4-carboxylic acid hydrazide derivatives with anticancer activity. The structure of new compounds was determined by mass spectrometry (MS), elemental analysis, proton nuclear magnetic resonance spectroscopy (H-1-NMR), carbon nuclear magnetic resonance spectroscopy (C-13-NMR), H-1-C-13 NMR correlations and infrared spectroscopy (IR). Moreover, the structures of the compounds were confirmed by crystallographic examination. The antiproliferative MTT tests for 11 prepared compounds was conducted towards human biphenotypic B cell myelomonocytic leukemia MV4-11. SRB test was used to examine their potential anticancer activity towards human colon adenocarcinoma cell lines sensitive LoVo, resistant to doxorubicin LoVo/DX, breast adenocarcinoma MCF-7 and normal non-tumorigenic epithelial cell line derived from mammary gland MCF-10A. The most active compound was 5-chloro-3-methyl-N’-[(1E,2E)-(3-phenyloprop-2-en-1-ylidene]isothiazole-4-carbohydrazide, which showed the highest antiproliferative activity against all tested cell lines.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New research progress on 4397-53-9 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 4397-53-9, Name is 4-Benzyloxybenzaldehyde, formurla is C14H12O2. In a document, author is CLERICI, F, introducing its new discovery. Product Details of 4397-53-9.

3-Dialkylaminoisothiazole 1,1-dioxides 1 readily undergo cycloadditions with diazoalkanes 2. The reaction is characterized by high site- and regio-selectivity. Cycloadducts 3 and 4 were found to undergo straightforward thermolysis reactions at elevated temperature through two different paths characterized respectively by loss of nitrogen or sulfur dioxide and diethylcyanamide. The different transformations affording pyrazoles 6 and derivatives of the new heterocycle 2-thia-3-azabicyclo[3.1.0]hex-3-ene 2,2-dioxide 5 are discussed.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 870-50-8, Name is Di-tert-butyl diazene-1,2-dicarboxylate, molecular formula is C10H18N2O4, COA of Formula: https://www.ambeed.com/products/870-50-8.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Liu, ZP, once mentioned the new application about 870-50-8.

A novel method for the synthesis of benzo[d]isothiazole 1,1-diones with a secondary alkyl substituent at the 3-position is described. Treatment of N-tert-butylbenzenesulfonamide (1) with an excess of BuLi, followed by the reaction with methyl 2-arylpropanoate, gave the corresponding ortho-functionalized benzenesulfonamides 2a-d, which underwent cyclization under TMSCl-NaI-MeCN reflux conditions to afford 3-substituted benzo[d]isothiazole 1,1-diones 3a-d.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis,and research on the structure and performance of functional materials. 827-25-8, Name is 2-Bromo-4-chloro-6-nitrophenylamine, molecular formula is C6H4BrClN2O2, belongs to isothiazole compound. In a document, author is Chen, Lai, introduce the new discover, Product Details of 827-25-8.

A series of novel 3,4-dichloroisothiazole based 1,2,4-triazole derivatives were rationally designed and synthesized. Their structures were confirmed by H-1 NMR, C-13 NMR, HRMS or elemental analysis; the typical crystal structure was determined by X-ray diffraction for validation. All target compounds were evaluated for their in vitro fungicidal and in vivo anti-TMV activities. The bioassay results indicated that compound 6b, namely 1-(3,4-dichloroisothiazol-5-yl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol, exhibited excellent growth inhibition against B. cinerea, C. arachidicola and P. piricola with median effective concentrations (EC50) of 6.98, 2.73 and 3.07 g/mL, respectively, and good in vivo anti-TMV activity of over 60% of inactivation and induction activity at 100 g/mL. These data demonstrate that compound 6b is both a fungicide and an anti-TMV lead, deserving further studies.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com