With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10271-85-9,Isothiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
Example-118; A solution of compound 117 (0.35 g, 2.67 mmol), diphenylphosphoryl azide (0.57 mL, 2.67 mmol) and triethylamine (0.37 mL, 2.67 mmol) in tert-butanol (10 mL) was heated at reflux for 5 hours, at which time thin layer chromatography (DCM/Hexanes) indicates the reaction is complete. The reaction mixture was cooled to room temperature, poured into water and extracted with diethyl ether (3¡Á). The combined ether extracts were washed with brine, dried over sodium sulfate, and concentrated to afford a beige solid. Purification by column chromatography (SiO2, 40% ethyl acetate/hexanes) afforded compound 121 as a white solid 0.245 g (46%). 1H-NMR (400 MHz, DMSO-d6) delta 8.15(d, 1H), 6.72 (d, 1H), 1.48 (s, 9H)., 10271-85-9
As the paragraph descriping shows that 10271-85-9 is playing an increasingly important role.
Reference£º
Patent; Schering Corporation; US2007/117804; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com